公开(公告)号：US09095312B2

公开(公告)日：2015-08-04

申请号：US14056837

申请日：2013-10-17

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6821 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6803 ,  A61B5/742

Abstract: A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of pyruvate in a fluid to which the electrochemical sensor is exposed; the current is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的丙酮酸感测装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与丙酮酸反应的试剂。 在工作电极和参比电极之间施加电压引起与电化学传感器暴露于的流体中的丙酮酸盐浓度相关的电流; 电流由身体安装装置测量并进行无线通信。

公开(公告)号：US20150112175A1

公开(公告)日：2015-04-23

申请号：US14056872

申请日：2013-10-17

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/6821 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6803

Abstract: A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的尿素感测装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与尿素反应的试剂。 工作电极和参比电极之间的电位电压与电化学传感器所暴露的流体中的尿素浓度有关; 电压由身体安装装置测量并进行无线通信。

公开(公告)号：US09282920B2

公开(公告)日：2016-03-15

申请号：US14011478

申请日：2013-08-27

Applicant: Google Inc.

Inventor： Harvey Ho ,  James Etzkorn ,  Huanfen Yao

IPC: H01L21/20 ,  A61B5/145 ,  A61B5/1486 ,  G02C7/04 ,  A61B5/00

CPC classification number: A61B5/14503 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6821 ,  A61B2560/0214 ,  A61B2562/125 ,  G02C7/04

Abstract: A method may involve: forming a sacrificial layer on a working substrate; forming a first bio-compatible layer on the sacrificial layer such that the first bio-compatible layer adheres to the sacrificial layer; forming a conductive pattern on the first bio-compatible layer; mounting an electronic component to the conductive pattern; forming a second bio-compatible layer over the first bio-compatible layer, the electronic component, and the conductive pattern; and removing the sacrificial layer to release the bio-compatible device from the working substrate. The first bio-compatible layer defines a first side of a bio-compatible device. The second bio-compatible layer defines a second side of the bio-compatible device.

Abstract translation: 一种方法可以包括：在工作衬底上形成牺牲层; 在所述牺牲层上形成第一生物相容层，使得所述第一生物相容层附着于所述牺牲层; 在所述第一生物相容层上形成导电图案; 将电子部件安装到所述导电图案上; 在所述第一生物相容层，所述电子部件和所述导电图案上形成第二生物相容层; 以及去除所述牺牲层以从所述工作衬底释放所述生物相容性装置。 第一生物相容层限定生物相容装置的第一侧。 第二生物相容层限定生物相容装置的第二侧。

公开(公告)号：US20150173658A1

公开(公告)日：2015-06-25

申请号：US14136895

申请日：2013-12-20

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: A61B5/145 ,  A61B5/1477 ,  A61B5/053

CPC classification number: A61B5/14507 ,  A61B3/101 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/1468 ,  A61B5/6821 ,  A61B2560/0219 ,  A61B2562/028 ,  A61B2562/12

Abstract: Disclosed herein is a fluid conductivity sensor that can be used to obtain in-vivo measurements of conductivity of biological fluid samples, for example, to determine osmolarity. The conductivity sensor can be disposed on a substrate that is at least partially embedded within a polymeric material of a body-mountable device. The conductivity sensor can include a frame having a trench formed therein that defines a fluid sample cell. First and second electrodes can be formed on sidewalls of the trench, such that the first and second electrodes are on opposite sides of the fluid sample cell. A controller in the body-mountable device can operate the sensor by applying a voltage to the electrodes and measuring a current through a fluid occupying the fluid sample cell. The body-mountable device may indicate the current measurements wirelessly using an antenna.

Abstract translation: 本文公开了一种流体电导率传感器，其可用于获得生物流体样品的导电性的体内测量，例如以确定渗透压。 电导率传感器可以设置在至少部分地嵌入在可体内安装的装置的聚合物材料中的基底上。 电导率传感器可以包括其中形成有沟槽的框架，其限定流体样本池。 第一和第二电极可以形成在沟槽的侧壁上，使得第一和第二电极在流体样品池的相对侧上。 身体安装装置中的控制器可以通过向电极施加电压并测量通过占据流体样品池的流体的电流来操作传感器。 身体安装设备可以使用天线无线地指示当前测量。

公开(公告)号：US20150148647A1

公开(公告)日：2015-05-28

申请号：US14092655

申请日：2013-11-27

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: H01M4/04 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/1486 ,  A61B5/6821 ,  C12Q1/001 ,  C12Q1/002 ,  C12Q1/005 ,  G01N27/3271 ,  G02C7/04

Abstract: An analyte sensor and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The method of making the analyte sensor includes depositing a precursor mixture containing monomers and an analyte sensing component onto an electrode, exposing the deposited precursor mixture to a controlled environment for a specified period of time, and photopolymerizing the deposited exposed precursor mixture into a copolymer layer in contact with a surface of the electrode. Exposing the deposited precursor mixture to a controlled environment can increase the sensitivity of the sensor by reducing the thickness of the copolymer layer and/or by causing the analyte sensitive component within the copolymer layer to have a non-uniform concentration within the layer.

Abstract translation: 公开了分析物传感器和用于制造分析物传感器的方法。 一方面，分析物传感器包括与电极表面接触的交联的亲水共聚物和嵌入交联的亲水共聚物内的分析物感测组分。 制备分析物传感器的方法包括将含有单体和分析物感测组分的前体混合物沉积到电极上，将沉积的前体混合物暴露于受控环境达指定的时间段，并将沉积的暴露的前体混合物光聚合成共聚物层 与电极的表面接触。 将沉积的前体混合物暴露于受控环境可以通过减小共聚物层的厚度和/或通过使共聚物层内的分析物敏感组分在层内具有不均匀的浓度来增加传感器的灵敏度。

公开(公告)号：US20150160151A1

公开(公告)日：2015-06-11

申请号：US14098790

申请日：2013-12-06

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: G01N27/327

CPC classification number: G01N27/3271

Abstract: An analyte sensor and method of making are provided. The analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode; and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer, where the analyte sensing component is surrounded by a buffer having a predetermined buffering component and pH value and where the crosslinked, hydrophilic copolymer includes: backbone chains having first methacrylate-derived units, each having a first hydrophilic side chain; second methacrylate-derived units, each having a second hydrophilic side chain, where the first and second side chains are the same or different; third methacrylate-derived units; and hydrophilic crosslinks between third methacrylate-derived units in different backbone chains. The analyte sensor may be maintained at a humidity level of less than 25% to maintain its performance during storage.

Abstract translation: 提供分析物传感器和制造方法。 分析物传感器包括与电极表面接触的交联的亲水共聚物; 和分析物感测组件，其嵌入在交联的亲水共聚物内，其中分析物感测组分被具有预定缓冲组分和pH值的缓冲液包围，并且其中交联的亲水共聚物包括：具有第一甲基丙烯酸酯衍生单元的骨架链 具有第一亲水侧链; 第二甲基丙烯酸酯衍生单元，每个具有第二亲水侧链，其中第一和第二侧链相同或不同; 第三甲基丙烯酸酯衍生单元; 和在不同主链中的第三甲基丙烯酸酯衍生单元之间的亲水交联。 分析物传感器可以保持在小于25％的湿度水平以保持其在储存期间的性能。

公开(公告)号：US09028772B2

公开(公告)日：2015-05-12

申请号：US13931086

申请日：2013-06-28

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Jeffrey George Linhardt ,  Babak Parviz

IPC: G01N21/75 ,  G03F7/16

CPC classification number: G03F7/16 ,  B29D11/00826 ,  G02B1/04 ,  G02C7/04 ,  G02C11/10 ,  G03F7/425 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/25

Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.

Abstract translation: 方法可以包括在位于结构上的传感器上形成一个或多个光致抗蚀剂层，使得传感器被一个或多个光致抗蚀剂层覆盖。 传感器被配置为检测分析物。 该方法可以包括形成第一聚合物层。 此外，该方法可以包括将结构定位在第一聚合物层上。 此外，该方法可以包括在第一聚合物层和结构上形成第二聚合物层，使得该结构被第一聚合物层，第二聚合物层和一个或多个光致抗蚀剂层完全包围。 该方法还可以包括去除一个或多个光致抗蚀剂层以形成通过第二聚合物层的通道，其中传感器经配置以经由通道接收分析物。

公开(公告)号：US20150112173A1

公开(公告)日：2015-04-23

申请号：US14056837

申请日：2013-10-17

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6821 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6803 ,  A61B5/742

Abstract: A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of pyruvate in a fluid to which the electrochemical sensor is exposed; the current is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的丙酮酸感测装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与丙酮酸反应的试剂。 在工作电极和参比电极之间施加电压引起与电化学传感器暴露于的流体中的丙酮酸盐浓度相关的电流; 电流由身体安装装置测量并进行无线通信。

公开(公告)号：US20150005603A1

公开(公告)日：2015-01-01

申请号：US13930877

申请日：2013-06-28

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Jeffrey George Linhardt ,  Huanfen Yao

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/1486 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/682 ,  A61B5/6821

Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked copolymer network in contact with a surface of an electrode. The copolymer network has voids formed by the removal of a porogen, and an analyte sensing component is immobilized within the network. The method involves forming a solution of the precursors of the copolymer, depositing the mixture on a surface of an electrode, and curing the deposited mixture to provide the analyte sensor.

Abstract translation: 公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。 分析物传感器包括与电极表面接触的交联共聚物网络。 共聚物网络具有通过去除致孔剂形成的空隙，并且分析物感测组分固定在网络内。 该方法包括形成共聚物的前体溶液，将混合物沉积在电极的表面上，并固化沉积的混合物以提供分析物传感器。

公开(公告)号：US20150177179A1

公开(公告)日：2015-06-25

申请号：US14138368

申请日：2013-12-23

Applicant: GOOGLE INC.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: G01N27/327 ,  B05D3/00

CPC classification number: C12Q1/006 ,  G01N3/50

Abstract: An analyte sensor and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a sensing membrane having a crosslinked network with an embedded analyte sensing component. In another aspect, the analyte sensor includes a protective membrane adjacent to the surface of the sensing membrane. The protective membrane can be a crosslinked, hydrophilic copolymer having methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have hydrophilic side chains, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks. A method for making the analyte sensor is also disclosed.

Abstract translation: 公开了分析物传感器和用于制造分析物传感器的方法。 在一个方面，分析物传感器包括具有嵌入分析物感测部件的交联网络的感测膜。 在另一方面，分析物传感器包括与感测膜的表面相邻的保护膜。 保护膜可以是具有甲基丙烯酸酯衍生的第一个甲基丙烯酸酯单元的主链，第二个甲基丙烯酸酯衍生的单元和第三个甲基丙烯酸酯单元的交联的亲水共聚物。 第一和第二甲基丙烯酸酯衍生单元具有亲水侧链，并且不同主链中的第三甲基丙烯酸酯衍生单元通过亲水性交联连接。 还公开了制备分析物传感器的方法。