公开(公告)号：US20150245792A1

公开(公告)日：2015-09-03

申请号：US14713968

申请日：2015-05-15

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: A61B5/1468 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/1468 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6821 ,  A61B5/6867 ,  G01N27/3271 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting in front of a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.

Abstract translation: 可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置为安装在眼睛的表面之前。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可具有至少一个小于25微米的尺寸。 参考电极可以具有比工作电极的面积大至少五倍的面积。 聚合物材料的一部分可围绕工作电极和参考电极，使得在工作电极和参比电极之间输送的电流通过透明聚合材料的至少部分环绕的部分。

公开(公告)号：US20140206966A1

公开(公告)日：2014-07-24

申请号：US13621541

申请日：2012-09-17

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Babak Amirparviz

IPC: A61B5/1477

CPC classification number: A61B5/1477 ,  A61B5/0024 ,  A61B5/1486 ,  A61B5/4845 ,  A61B5/6821 ,  G02C7/04

Abstract: Apparatus, systems and methods employing contact lenses having an electrochemical sensor to detect ethanol concentration of a wearer of the contact lens are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and an electrochemical sensor, disposed on or within the substrate, that detects information related to concentration of alcohol present in blood of a wearer of the contact lens.

Abstract translation: 提供了使用具有电化学传感器的隐形眼镜来检测隐形眼镜佩戴者的乙醇浓度的装置，系统和方法。 在一些方面，隐形眼镜包括形成隐形眼镜的身体的至少一部分的基底和设置在基底上或内部的电化学传感器，其检测与存在于患者的血液中的酒精浓度相关的信息 隐形眼镜。

公开(公告)号：US20140107445A1

公开(公告)日：2014-04-17

申请号：US14031299

申请日：2013-09-19

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1468 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6821 ,  A61B5/6867 ,  G01N27/3271 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.

公开(公告)号：US20150282743A1

公开(公告)日：2015-10-08

申请号：US14742202

申请日：2015-06-17

Applicant: Google Inc.

Inventor： James Etzkorn ,  Zenghe Liu

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  G01N27/30 ,  G01N27/416

CPC classification number: A61B5/1486 ,  A61B3/101 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/6821 ,  A61B5/7264 ,  A61B2560/0214 ,  G01N27/30 ,  G01N27/3271 ,  G01N27/4166 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可以具有第一侧边缘和第二侧边缘。 参考电极可以被定位成使得工作电极的第一和第二侧边缘的至少一部分与参考电极的相应部分相邻。

公开(公告)号：US09095312B2

公开(公告)日：2015-08-04

申请号：US14056837

申请日：2013-10-17

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6821 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6803 ,  A61B5/742

Abstract: A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of pyruvate in a fluid to which the electrochemical sensor is exposed; the current is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的丙酮酸感测装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与丙酮酸反应的试剂。 在工作电极和参比电极之间施加电压引起与电化学传感器暴露于的流体中的丙酮酸盐浓度相关的电流; 电流由身体安装装置测量并进行无线通信。

公开(公告)号：US09044200B1

公开(公告)日：2015-06-02

申请号：US14109066

申请日：2013-12-17

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Jeffrey G. Linhardt

IPC: H01L23/29 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6832 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/682 ,  A61B5/6821 ,  A61B2560/0204 ,  A61B2562/12 ,  A61B2562/125 ,  G02C7/04 ,  H01L2224/16227 ,  H01L2224/18 ,  H01L2224/32225 ,  H01L2224/73204

Abstract: A method involving forming a sacrificial layer on a working substrate; forming a first bio-compatible layer on the sacrificial layer such that the first bio-compatible layer adheres to the sacrificial layer, wherein the first bio-compatible layer defines a first side of a bio-compatible device; forming a conductive pattern on the first bio-compatible layer, the conductive pattern comprising a metal; mounting an electronic component to the conductive pattern; forming a self-assembled monolayer (SAM) on the conductive pattern by contacting the conductive pattern with a functionalized sulfur compound or a functionalized selenium compound; forming an adhesion layer on the SAM by contacting the SAM with an adhesion promoter; forming a second bio-compatible layer over the first bio-compatible layer, the electronic component, and the conductive pattern having the adhesion layer, wherein the second bio-compatible layer defines a second side of the bio-compatible device; and removing the sacrificial layer to release the bio-compatible device from the working substrate. The first bio-compatible layer defines a first side of a bio-compatible device. The second bio-compatible layer defines a second side of the bio-compatible device.

Abstract translation: 一种涉及在工作基板上形成牺牲层的方法; 在所述牺牲层上形成第一生物相容层，使得所述第一生物相容层附着于所述牺牲层，其中所述第一生物相容层限定生物相容性装置的第一侧; 在所述第一生物相容层上形成导电图案，所述导电图案包括金属; 将电子部件安装到所述导电图案上; 通过使导电图案与官能化的硫化合物或官能化的硒化合物接触，在导电图案上形成自组装单层（SAM）; 通过使SAM与粘合促进剂接触而在SAM上形成粘合层; 在所述第一生物相容层上形成第二生物相容层，所述电子部件和所述导电图案具有所述粘附层，其中所述第二生物相容层限定所述生物相容性装置的第二侧; 以及去除所述牺牲层以从所述工作衬底释放所述生物相容性装置。 第一生物相容层限定生物相容装置的第一侧。 第二生物相容层限定生物相容装置的第二侧。

公开(公告)号：US20150112175A1

公开(公告)日：2015-04-23

申请号：US14056872

申请日：2013-10-17

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/6821 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6803

Abstract: A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的尿素感测装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与尿素反应的试剂。 工作电极和参比电极之间的电位电压与电化学传感器所暴露的流体中的尿素浓度有关; 电压由身体安装装置测量并进行无线通信。

公开(公告)号：US20150001074A1

公开(公告)日：2015-01-01

申请号：US13930890

申请日：2013-06-28

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: G01N27/40

CPC classification number: C12Q1/002 ,  C12Q1/003 ,  C12Q1/006 ,  G01N27/40

Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes an electrode, a sensing layer in contact with a surface of the electrode, and a protective membrane. The sensing layer is a crosslinked, hydrophilic copolymer including poly(alkylene oxide) and poly(vinyl pyridine), and an analyte sensing component is immobilized within the crosslinked, hydrophilic copolymer. The protective membrane is a crosslinked, hydrophilic copolymer including alkylene oxide, vinyl pyridine and styrene units. The method involves the formation of a sensing layer on a surface of an electrode, followed by the formation of a protective membrane on a surface of the sensing layer.

Abstract translation: 公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。 在一个方面，分析物传感器包括电极，与电极的表面接触的感测层和保护膜。 感测层是包括聚（环氧烷）和聚（乙烯基吡啶）的交联的亲水共聚物，并且分析物感测组分固定在交联的亲水共聚物内。 保护膜是包括环氧烷，乙烯基吡啶和苯乙烯单元的交联的亲水共聚物。 该方法涉及在电极表面上形成感测层，随后在感测层的表面上形成保护膜。

公开(公告)号：US20140107448A1

公开(公告)日：2014-04-17

申请号：US14031481

申请日：2013-09-19

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Brian Otis

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1486

CPC classification number: A61B5/1495 ,  A61B5/0004 ,  A61B5/0026 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6821 ,  A61B5/683

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 当眼睛安装的设备暴露于校准溶液时，可以获得校准溶液测量。 基于至少校准溶液测量和校准溶液的分析物浓度确定校准值。 当眼睛安装装置安装在眼睛上以暴露于泪膜时，获得泪膜测量。 基于至少泪液测量和校准值来确定泪膜的分析物浓度。

公开(公告)号：US09084561B2

公开(公告)日：2015-07-21

申请号：US13919764

申请日：2013-06-17

Applicant: Google Inc.

Inventor： James Etzkorn ,  Zenghe Liu

IPC: A61B5/00 ,  A61B3/10 ,  A61B5/1477 ,  A61B5/1486 ,  G01N27/327 ,  A61B5/145

CPC classification number: A61B5/1486 ,  A61B3/101 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/6821 ,  A61B5/7264 ,  A61B2560/0214 ,  G01N27/30 ,  G01N27/3271 ,  G01N27/4166 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可以具有第一侧边缘和第二侧边缘。 参考电极可以被定位成使得工作电极的第一和第二侧边缘的至少一部分与参考电极的相应部分相邻。