公开(公告)号：US20230279876A1

公开(公告)日：2023-09-07

申请号：US18196928

申请日：2023-05-12

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Erik D. Torniainen ,  Alexander Govyadinov ,  Pavel Kornilovich ,  David P. Markel

IPC: F04F7/00 ,  B01L3/00 ,  B81B1/00 ,  F04B53/10

CPC classification number: F04F7/00 ,  B01L3/50273 ,  B01L3/502738 ,  B81B1/006 ,  F04B53/10 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2400/0605 ,  B81B2201/051 ,  B81B2203/0338

Abstract: The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve clement, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element.

公开(公告)号：US11439963B2

公开(公告)日：2022-09-13

申请号：US16300182

申请日：2016-07-08

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： David P. Markel ,  Erik D. Torniainen ,  Alexander Govyadinov ,  Pavel Kornilovich

IPC: B01F13/00 ,  B01F15/02 ,  B01F15/04 ,  B01L3/00 ,  B41J2/175 ,  F04B19/00 ,  B01F33/30 ,  B41J2/14 ,  G01N35/10 ,  B01F33/301 ,  B01F35/82 ,  B01F35/71 ,  B01F35/83 ,  B01D15/16 ,  B01F101/23 ,  B01F101/00 ,  B81B1/00

Abstract: Examples include microfluidic devices. Example microfluidic devices include a first microfluidic channel, a second microfluidic channel, and a third microfluidic channel fluidly coupled to the first microfluidic channel and the second microfluidic channel via a fluid junction. A fluid actuator is disposed in the third microfluidic channel to actuate to thereby pump a first fluid and a second fluid into the third microfluidic channel.

公开(公告)号：US11318466B2

公开(公告)日：2022-05-03

申请号：US16618200

申请日：2017-07-19

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： David P. Markel ,  Erik D Torniainen ,  Alexander Govyadinov ,  Pavel Kornilovich

IPC: B01L3/00

Abstract: One example includes a device that may include a heating element and a molecular binding site. The heating element may heat a fluid volume, interfaced with the heating element, in response to a voltage being applied to the heating element, the heat transforming the fluid volume from a liquid state into a vaporized state to generate fluid motion within the fluid volume. The molecular binding site may be disposed proximate to the heating element, in which a portion of the fluid volume expands when the fluid volume transforms from the liquid state into the vaporized state, the vaporized state of the fluid volume generating the fluid motion within a target fluid that is disposed within the molecular binding site.

公开(公告)号：US11209102B2

公开(公告)日：2021-12-28

申请号：US15111361

申请日：2014-01-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Erik D. Torniainen ,  Pavel Kornilovich ,  David P. Markel

IPC: F16K99/00 ,  F04B19/00 ,  F04B19/24 ,  F04B49/06

Abstract: A microfluidic valve comprises a first reservoir, a second reservoir, an inertial pump and a channel connecting the first reservoir to the second reservoir. The second reservoir is to receive fluid from the first reservoir through the channel under a pressure gradient. The inertial pump is within the channel proximate the second reservoir and distant the first reservoir.

公开(公告)号：US11110456B2

公开(公告)日：2021-09-07

申请号：US16099246

申请日：2016-07-12

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Pavel Kornilovich ,  Alexander Govyadinov ,  David P. Markel ,  Erik D. Torniainen

IPC: B01L3/00 ,  G01N30/56 ,  G01N30/10 ,  B01D15/08 ,  G01N30/40 ,  G01N30/60 ,  B81C1/00

Abstract: A microfluidic bead-packing method includes activating a first micropump to transfer active microbeads through an inlet microchannel from a bead suspension reservoir to an adsorbing channel; packing the microbeads in the adsorbing channel; and activating a second micropump to reverse flow through at least a portion of the inlet microchannel and to transfer a sample fluid through the inlet microchannel from a sample reservoir to the adsorbing channel such that the sample fluid interacts with the packed microbeads.

公开(公告)号：US10882045B2

公开(公告)日：2021-01-05

申请号：US15748975

申请日：2016-01-08

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Erik D. Torniainen ,  Alexander Govyadinov ,  Pavel Kornilovich ,  David P. Markel

IPC: B01L7/00 ,  B01L3/02 ,  B01L3/00 ,  C12M1/42

Abstract: Examples include polymerase chain reaction (PCR) devices. Example PCR devices comprise a fluid input, ejection nozzles, and a set of microfluidic channels that fluidly connect the fluid input and the ejection nozzles. Each microfluidic channel comprises a reaction chamber, and examples further comprise at least one heating element, where the at least one heating element is positioned in the reaction chamber of each microfluidic channel. The at least one heating element is to heat fluid in the reaction chamber of each fluid channel. The device may eject fluid via the ejection nozzles.

公开(公告)号：US10696939B2

公开(公告)日：2020-06-30

申请号：US16079482

申请日：2016-04-22

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Alexander Govyadinov ,  Erik D. Torniainen ,  David P. Markel ,  Pavel Kornilovich

IPC: B01L3/00 ,  C12M1/00 ,  C12N1/06

Abstract: In an example implementation, a method of cell lysis includes moving cell fluid from a first reservoir through a microfluidic channel toward a second reservoir, activating a lysing element multiple times as a cell from the cell fluid passes through the microfluidic channel, and moving lysate fluid that results from the activating through the microfluidic channel and into the second reservoir.

公开(公告)号：US20180230518A1

公开(公告)日：2018-08-16

申请号：US15955364

申请日：2018-04-17

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Pavel Kornilovich ,  Erik D. Tornianinen ,  Alexander Govyadinov ,  David P. Markel

IPC: C12Q1/686

CPC classification number: C12Q1/686 ,  B01L3/50273 ,  B01L7/525 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/1827

Abstract: In one embodiment, a polymerase chain reaction (PCR) system includes a mixture chamber, a denature chamber, an annealing chamber, an extension chamber, and a product chamber, that are fluidically coupled to one another through a plurality of microfluidic channels. An inertial pump is associated with each microfluidic channel, and each inertial pump includes a fluid actuator integrated asymmetrically within its associated microfluidic channel. The fluid actuators are capable of selective activation to circulate fluid between the chambers in a controlled cycle.

公开(公告)号：US20180104953A1

公开(公告)日：2018-04-19

申请号：US15834353

申请日：2017-12-07

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： James A. Feinn ,  David P. Markel ,  Albert Nagao ,  Thomas R. Strand ,  Paul A. Richards ,  Lawrence H. White ,  Erik D. Torniainen

IPC: B41J2/14

CPC classification number: B41J2/1433 ,  B41J2/14016 ,  B41J2002/14387 ,  B41J2002/14475 ,  B41J2202/11

Abstract: In some examples, a fluid nozzle includes an aperture comprising a first lobe that is shaped as an ellipse, and a second lobe that has a non-circular shape and has a different size than a size of the first lobe. The fluid nozzle further includes protrusions between the first and second lobes extending inward and forming a throat between the first and second lobes.

公开(公告)号：US09604212B2

公开(公告)日：2017-03-28

申请号：US14737050

申请日：2015-06-11

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Erik D. Torniainen ,  David P. Markel

IPC: B41J2/18 ,  B01L3/00 ,  B41J2/14 ,  B41J2/175

CPC classification number: B41J2/18 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/088 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/082 ,  B41J2/1404 ,  B41J2/14201 ,  B41J2/1753 ,  B41J2002/14467 ,  B41J2202/12 ,  F04B19/006 ,  F04B19/20 ,  F04B19/24

Abstract: A fluid ejection device including, at least, one recirculation system is disclosed. Such recirculation system contains, at least, one drop generator, recirculation channels that include an inlet channel, an outlet channel and a connection channel and a fluid feedhole that communicates with the drop generator via the inlet channel and the outlet channel of the recirculation channel. The recirculation channels can be asymmetrical with reference to the drop generator.