公开(公告)号：US4946781A

公开(公告)日：1990-08-07

申请号：US153488

申请日：1988-02-03

申请人： Shigeru Nakamori ,  Hiroshi Takagi ,  Masaaki Ishida ,  Takaaki Sato ,  Kiyoshi Miwa ,  Konosuke Sano

发明人： Shigeru Nakamori ,  Hiroshi Takagi ,  Masaaki Ishida ,  Takaaki Sato ,  Kiyoshi Miwa ,  Konosuke Sano

IPC分类号： C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12N9/12 ,  C12N15/77 ,  C12P13/06 ,  C12P13/08 ,  C12R1/13 ,  C12R1/15

CPC分类号： C12P13/08 ,  C12N15/77 ,  C12N9/12 ,  C12P13/06 ,  Y10S435/84 ,  Y10S435/843

摘要： A recombinant DNA molecule comprising a plasmid vector having operationally inserted therein a gene coding for homoserine kinase is disclosed along with bacteria containing this recombinant DNA molecule and methods of using these bacteria to produce amino acids in large quantities.

摘要翻译： 公开了包含可操作地插入其中编码高丝氨酸激酶的基因的质粒载体的重组DNA分子以及含有该重组DNA分子的细菌以及使用这些细菌大量生成氨基酸的方法。

公开(公告)号：US4541473A

公开(公告)日：1985-09-17

申请号：US582707

申请日：1984-02-23

申请人： Yoshinori Onoe ,  Hiroshi Takagi ,  Satoru Ikenaga ,  Hiraku Tsuchiya ,  Shohei Murakami ,  Masakazu Nakao

发明人： Yoshinori Onoe ,  Hiroshi Takagi ,  Satoru Ikenaga ,  Hiraku Tsuchiya ,  Shohei Murakami ,  Masakazu Nakao

IPC分类号： B05B7/04 ,  B22D11/124

CPC分类号： B22D11/1246

摘要： An exhaust hole is formed in an exhaust side wall of a mist atomizing nozzle of an apparatus for spraying the mist for cooling for and is used in continuous metal casting. An introduction inlet is provided in an introducing side wall on the side opposite the exhaust side wall at the height position different from that of the exhaust hole. An air-water mixture supply pipe is attached to the introduction inlet to communicate therewith. The air-water mixture of relatively large water droplets is formed and is introduced into the mist atomizing nozzle by that air-water mixture supply pipe. After the air-water mixture repeatedly collides in the mist atomizing nozzle, the large water droplets are made fine and are sequentially exhausted from the exhaust hole by being pressed by the supply pressure from the rear side.

摘要翻译： 在喷雾用于冷却的喷雾装置的雾化喷嘴的排气侧壁中形成排气孔，并用于连续铸造。 引导入口设置在与排气孔的高度位置不同的排气侧壁相对侧的导入​​侧壁中。 空气 - 水混合物供应管连接到引入口以与其连通。 形成相当大的水滴的空气 - 水混合物，并通过该空气 - 水混合物供应管被引入雾化喷嘴。 在空气 - 水混合物在雾化喷嘴中反复碰撞之后，通过从后侧的供给压力被按压，使大的水滴变细并且从排气孔依次排出。

公开(公告)号：US4257102A

公开(公告)日：1981-03-17

申请号：US953773

申请日：1978-10-19

申请人： Isao Horiba ,  Yasuo Kuwabara ,  Hiroshi Takagi ,  Shigeru Satou

发明人： Isao Horiba ,  Yasuo Kuwabara ,  Hiroshi Takagi ,  Shigeru Satou

IPC分类号： G01N23/04 ,  A61B6/03 ,  G06F17/10 ,  G01N23/00

CPC分类号： A61B6/032 ,  Y10S378/901

摘要： An apparatus for axial transverse tomography using piercing radiation such as X-ray and .gamma.-ray for displaying a tomographic image concerning variation of radiation absorption values at a given section of a subject under examination, comprising: a scanner effecting a revolution-scanning around said subject at uniform angles while maintaining constant relative positions of a radiation source and a radiation detector with said subject intervening therebetween; an input device for setting a region of interest for being enlarged based on parameters of central angle, inter-center distance and radius ratio, to locally enlarge said tomographic image; co-ordinate system transforming circuitry for carrying out, on information within said region of interest outputted from radiation detector, a transformation of co-ordinate system corresponding to enlarged co-ordinates, from information obtained by the scanner and outputted by the radiation detector and also from the set parameters; and convolution circuitry for carrying out a convolution operation on the resulting information representing the trnsformation of co-ordinate system.

摘要翻译： 一种使用穿刺辐射（例如X射线和γ射线）进行轴向横断层摄影的装置，用于显示关于受检对象的给定部分处的辐射吸收值变化的断层图像，该扫描图像包括：扫描器，围绕所述 在保持恒定的辐射源和辐射探测器的相对位置的同时保持对准，所述对象插入其间; 输入装置，用于基于中心角度，中心间距离和半径比率的参数来设置用于放大的兴趣区域，以局部放大所述断层图像; 坐标系统变换电路，用于对从放射线检测器输出的所述感兴趣区域内的信息进行与放大坐标相对应的坐标系的变换，由扫描仪获得并由放射线检测器输出的信息，以及 从设定参数; 以及卷积电路，用于对表示坐标系的trns信息的结果信息执行卷积运算。

公开(公告)号：US20140233116A1

公开(公告)日：2014-08-21

申请号：US14348860

申请日：2012-09-10

申请人： Shinichiro Hara ,  Toshiyuki Majima ,  Hiroshi Takagi ,  Akihiko Matsumoto

发明人： Shinichiro Hara ,  Toshiyuki Majima ,  Hiroshi Takagi ,  Akihiko Matsumoto

IPC分类号： G02B7/02

CPC分类号： G02B7/02 ,  B41J2/471 ,  G02B26/125 ,  G11B7/1372 ,  G11B7/1374 ,  H04N1/113

摘要： An optical element has a first surface, a second surface on the opposite side of the first surface, an optical surface, and a protruding part. The protruding part is held in a prescribed position by being in contact with a holding member. The protruding part comprises a first protruding part and a second protruding part, The first protruding part comprises a first contact part that is a convex circular arc shape on at least one longitudinal plane and partly comes into contact with the holding member. The second protruding part comprises a second contact part that is a convex circular arc shape on at least one longitudinal plane and partly comes into contact with the holding member. A circular arc constitutes the first contact part and a circular arc that constitutes the second contact part are present in at least one cross-section that passes through a contact point between the first contact part and the holding member as well as a contact point between the second contact part and the holding member, and the center of the circular arc that constitutes the first contact part is aligned with the center of the circular arc that constitutes the second protruding part.

摘要翻译： 光学元件具有第一表面，在第一表面的相对侧上的第二表面，光学表面和突出部分。 突起部通过与保持部件接触而保持在规定位置。 突出部包括第一突出部和第二突出部。第一突出部包括在至少一个纵向平面上呈凸圆弧形状并且部分地与保持部件接触的第一接触部。 第二突出部包括在至少一个纵向平面上是凸圆弧形状并且部分地与保持构件接触的第二接触部。 圆弧构成第一接触部分，并且构成第二接触部分的圆弧存在于穿过第一接触部分和保持部件之间的接触点的至少一个横截面以及接触点之间的接触点 第二接触部和保持构件，构成第一接触部的圆弧的中心与构成第二突出部的圆弧的中心对准。

公开(公告)号：US20120297060A1

公开(公告)日：2012-11-22

申请号：US13459439

申请日：2012-04-30

申请人： Hiroshi Takagi

发明人： Hiroshi Takagi

IPC分类号： G06F15/16

CPC分类号： H04L67/06 ,  H04L12/2809 ,  H04L12/2812 ,  H04L67/16 ,  H04L67/303 ,  H04L67/32 ,  H04L2012/2849 ,  H04N21/43615 ,  H04N21/43622 ,  H04N21/4516

摘要： There is provided an information processing device including a device information acquisition unit configured to acquire information on other devices connected via a network, and a setting file creation unit configured to, on the basis of the information on the other devices acquired by the device information acquisition unit, create a setting file by causing the information processing device to describe in the setting file information on content that is managed by the information processing device, the setting file being adapted to be forwarded to the other devices. The setting file creation unit describes in the setting file an order in which the setting file is to be forwarded.

摘要翻译： 提供了一种信息处理设备，包括：设备信息获取单元，被配置为获取经由网络连接的其他设备的信息;以及设置文件创建单元，被配置为基于通过设备信息获取获取的其他设备的信息 单元，通过使信息处理设备在设置文件中描述关于由信息处理设备管理的内容的信息来创建设置文件，该设置文件适于转发给其他设备。 设置文件创建单元在设置文件中描述要转发设置文件的顺序。

公开(公告)号：US08114649B2

公开(公告)日：2012-02-14

申请号：US12635404

申请日：2009-12-10

申请人： Hiroshi Takagi ,  Shigeru Nakamori ,  Masaru Wada ,  Hirotada Mori

发明人： Hiroshi Takagi ,  Shigeru Nakamori ,  Masaru Wada ,  Hirotada Mori

IPC分类号： C12N9/00 ,  C12N9/10 ,  C12P13/12 ,  C12N1/20

CPC分类号： C12P13/12

摘要： L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or eliminated. The bacterium is cultured in a medium to produce and cause accumulation of L-cysteine in the medium, and collecting L-cysteine from the medium.

摘要翻译： 通过培养具有L-半胱氨酸生产能力的埃希氏菌属细菌并含有编码O-乙酰丝氨酸巯基酶B或MalY调节蛋白的基因来产生L-半胱氨酸，所述基因被修饰以使得半胱氨酸脱硫酸酶活性被降低或消除。 将细菌培养在培养基中以产生并引起培养基中L-半胱氨酸的积累，并从培养基中收集L-半胱氨酸。

公开(公告)号：US07314745B2

公开(公告)日：2008-01-01

申请号：US10469486

申请日：2002-03-01

申请人： Shigeru Nakamori ,  Hiroshi Takagi ,  Masakazu Takahashi ,  Kazuhisa Tsujimoto ,  Hideyuki Yamada

发明人： Shigeru Nakamori ,  Hiroshi Takagi ,  Masakazu Takahashi ,  Kazuhisa Tsujimoto ,  Hideyuki Yamada

IPC分类号： C12N9/64 ,  C12N15/57 ,  C12N15/79 ,  C12N15/85

CPC分类号： C12N9/64 ,  C12N9/6402

摘要： An objective of the present invention is to provide a new protein derived from the silkworm middle silk gland and a DNA encoding said protein. The present invention relates to a protein of the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 1; (b) a protein comprising a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having protease activity.

摘要翻译： 本发明的目的是提供一种来自蚕丝绸的新蛋白质和编码所述蛋白质的DNA。 本发明涉及以下（a）或（b）的蛋白质：（a）包含SEQ ID NO：1所示的氨基酸序列的蛋白质; （b）包含上述（a）中描述的氨基酸序列的修饰氨基酸序列的蛋白质，其中一个或多个氨基酸残基被缺失，取代，插入或添加并具有蛋白酶活性。

公开(公告)号：US20070203075A1

公开(公告)日：2007-08-30

申请号：US11710612

申请日：2007-02-26

申请人： Hiroshi Takagi ,  Yoshimitsu Hamano

发明人： Hiroshi Takagi ,  Yoshimitsu Hamano

IPC分类号： A61K31/7056 ,  C07H21/04 ,  C07H19/02 ,  C12P21/06 ,  C12P19/28 ,  C12N9/80

CPC分类号： C12N9/86 ,  C12P19/28

摘要： An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.

摘要翻译： 提供能够降低链霉素相对于真核细胞的抗生素活性（即毒性）而不牺牲相对于原核细胞的抗生素活性的酶以及相对于真核细胞毒性降低的链球菌素衍生物，同时保持抗生素活性 原核细胞及其制造方法。 通过打开链霉素的内酰胺环，具有根据本发明的SEQ ID NO：2,4,6,8,10,12,14或16的氨基酸序列的蛋白质可以降低链球菌D的抗生素活性，相对于 真核细胞，而不牺牲相对于原核细胞的抗生素活性。

公开(公告)号：US07157209B2

公开(公告)日：2007-01-02

申请号：US11055138

申请日：2005-02-09

申请人： Hiroshi Takagi

发明人： Hiroshi Takagi

IPC分类号： G03F7/09

CPC分类号： B41N1/083 ,  B41N3/034 ,  C25D11/024 ,  C25D11/06 ,  C25F3/04 ,  G03F7/16 ,  G03F7/3035 ,  Y10S430/145 ,  Y10S430/146

摘要： A process for manufacturing an aluminum support for a planographic printing plate material, the process containing the steps of: (a) electrolytically surface-roughening an aluminum plate in an electrolyte solution containing hydrochloric acid as a main component; and (b) anodizing the surface-roughened aluminum plate, wherein the step (a) contains: (i) a first stage which surface-roughens the aluminum plate employing a sine-wave alternating current; and (ii) a second stage which surface-roughens the aluminum plate employing a controlled sine-wave alternating current using a thyristor so that a current flow starts at a phase angle of 60 to 120 degree of an alternating current cycle.

摘要翻译： 一种用于制造平版印刷版材料的铝支架的方法，该方法包括以下步骤：（a）在以盐酸为主要成分的电解液中电解表面粗糙化铝板; （b）对表面粗糙化的铝板进行阳极氧化，其中步骤（a）包含：（i）使用正弦波交流电表面粗化铝板的第一阶段; 和（ii）使用晶闸管使用受控正弦波交流电表面粗化铝板的第二阶段，使得电流以交流循环的60至120度的相位角开始。

公开(公告)号：US07148047B2

公开(公告)日：2006-12-12

申请号：US10060218

申请日：2002-02-01

申请人： Hiroshi Takagi ,  Masaru Wada ,  Shigeru Nakamori

发明人： Hiroshi Takagi ,  Masaru Wada ,  Shigeru Nakamori

IPC分类号： C12N9/10 ,  C12N1/12 ,  C12P13/12 ,  C07K1/00 ,  C07H21/02

CPC分类号： C12P13/12

摘要： L-cysteine is produced by culturing a coryneform bacterium in which intracellular serine acetyltransferase activity is increased by transformation with a gene coding for serine acetyltransferase, such modification of an expression control sequence of a gene coding for serine acetyltransferase that expression of the gene in a cell should be enhanced and for forth, preferably in which L-cysteine decomposition system is further suppressed, in a medium to produce and accumulate L-cysteine in culture and collecting the L-cysteine from the culture.