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31.发明授权Method and integrated device for analyzing liquid flow and liquid-solid interface interaction 有权用于分析液体流动和液 - 液界面相互作用的方法和集成装置公开(公告)号：US09310285B1
公开(公告)日：2016-04-12
申请号：US14502897
申请日：2014-09-30
发明人： Phaedon Avouris , Michael Engel , Claudius Feger , Ronaldo Giro , Rodrigo Ferreira , Mathias Steiner
IPC分类号： H01L21/768 , H01L21/762 , H01L21/02 , G01N11/04 , H01L29/16 , H01L29/49 , G06F17/50 , G01N11/00
CPC分类号： G01N11/04 , G01N21/71 , G01N33/24 , G01N2011/008 , G01N2201/08 , G06F17/5009 , G06F17/5072 , G06F2217/16 , H01L29/1606 , H01L29/4966
摘要： An Integrated Circuit (IC) chip with a lab-on-a-chip, a method of manufacturing the lab-on-a-chip and a method of using the lab-on-a-chip for fluid flow analysis in physical systems through combination with computer modeling. The lab-on-a-chip includes cavities in a channel layer and a capping layer, preferably transparent, covering the cavities. Gates control two dimensional (2D) lattice structures acting as heaters, light sources and/or sensors in the cavities, or fluid channels. The gates and two dimensional (2D) lattice structures may be at the cavity bottoms or on the capping layer. Wiring connects the gates and the 2D lattice structures externally.
摘要翻译： 具有片上实验室的集成电路（IC）芯片，制造芯片实验室的方法以及在物理系统中使用芯片上的实验室进行流体流分析的方法 结合计算机建模。 芯片实验室包括通道层中的空腔和覆盖空腔的封盖层，优选是透明的。 门控制二维（2D）格子结构，用作空腔或流体通道中的加热器，光源和/或传感器。 门和二维（2D）格子结构可以在空腔底部或覆盖层上。 接线连接外部的门和2D格子结构。
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公开(公告)号：US11150187B2
公开(公告)日：2021-10-19
申请号：US16515968
申请日：2019-07-18
发明人： Michael Engel , Jeannette M. Garcia , Ricardo L. Ohta , Ademir F. Silva , Mathias B. Steiner , Jaione Tirapu Azpiroz , Thomas G. Zimmerman
摘要： A system is provided for performing metal trace analysis on a liquid sample. A sample holder holds an analysis substrate that includes a reference region and at least one test region. An ultraviolet (UV) light source emits ultraviolet light illuminating the liquid sample. An optical sensor detects radiation emanating from the liquid sample and converting the detected radiation into an electrical signal. A microcontroller processes the electrical signal. An external interface transmits the processed electrical signal to an external device. The analysis substrate is configured for manual movement by a user. A tracking system detects a sample scanning location for the metal trace analysis, and includes a light source, other than the UV light source, and another optical sensor. The other optical sensor detects light emitted by the light source.
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公开(公告)号：US11060968B2
公开(公告)日：2021-07-13
申请号：US15941692
申请日：2018-03-30
发明人： Ricardo Luis Ohta , Ademir Ferreira da Silva , Andre de Oliveira Botelho , Matheus Esteves Ferreira , Jaione Tirapu Azpiroz , Michael Engel , Mathias Steiner
摘要： A target sample to be chemically analyzed is received at a microfluidic device which is part of an analysis card. The microfluidic device includes at least one input layer configured to receive the target sample, at least one intermediary layer, and at least one readout layer configured to present one or more color attributes at one or more readout regions in response to one or more colorimetric reactions to the target sample. An image of the readout layer of the microfluidic device is obtained. A calibration file that corresponds to the analysis card is obtained. The calibration file includes a calibrated model of at least one color attribute based on data from at least one known chemical attribute of at least one standard sample processed by a calibration card. A data processing function is executed on the obtained image by comparing the one or more color attributes at the one or more readout regions to the calibrated model of the at least one color attribute to determine at least one chemical attribute of the target sample.
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公开(公告)号：US10830745B2
公开(公告)日：2020-11-10
申请号：US15853884
申请日：2017-12-25
发明人： Michael Engel , Ademir Ferreira da Silva , Ado Jorio de Vasconcelos , Ricardo L. Ohta , Mathias B. Steiner
摘要： A growth chamber chip includes a base surrounding a growth chamber; a growth medium within the growth chamber; a sensor package within the growth chamber; a sensor feedthrough extending from the sensor package through a portion of the base to an outer surface of the base; and a transparent seal covering the growth chamber. In one or more embodiments, the base includes a nutrient channel connected in fluid communication with the growth medium and exposed to an outer surface of the base. One or more embodiments provide an array of growth chamber chips, with a movable arm that is movable across the array to individually scan each of the growth chamber chips.
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公开(公告)号：US20190371603A1
公开(公告)日：2019-12-05
申请号：US16539071
申请日：2019-08-13
摘要： A method of positioning nanomaterials includes patterning guiding dielectric features from a single layer of guiding dielectric material, and producing an electric field by at least one electrode disposed on a substrate that is attenuated through the guiding dielectric features to create an attractive dielectrophoretic force that guides at least one nanostructure abutting the guiding dielectric features to be positioned on a deposition surface of the substrate.
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公开(公告)号：US20190302008A1
公开(公告)日：2019-10-03
申请号：US15941692
申请日：2018-03-30
发明人： Ricardo Luis Ohta , Ademir Ferreira da Silva , Andre de Oliveira Botelho , Matheus Esteves Ferreira , Jaione Tirapu Azpiroz , Michael Engel , Mathias Steiner
摘要： A target sample to be chemically analyzed is received at a microfluidic device which is part of an analysis card. The microfluidic device includes at least one input layer configured to receive the target sample, at least one intermediary layer, and at least one readout layer configured to present one or more color attributes at one or more readout regions in response to one or more colorimetric reactions to the target sample. An image of the readout layer of the microfluidic device is obtained. A calibration file that corresponds to the analysis card is obtained. The calibration file includes a calibrated model of at least one color attribute based on data from at least one known chemical attribute of at least one standard sample processed by a calibration card. A data processing function is executed on the obtained image by comparing the one or more color attributes at the one or more readout regions to the calibrated model of the at least one color attribute to determine at least one chemical attribute of the target sample.
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37.发明授权公开(公告)号：US10386331B2
公开(公告)日：2019-08-20
申请号：US15093816
申请日：2016-04-08
IPC分类号： G01N27/447 , B01L3/00 , G01N35/00 , G01N15/00
摘要： Method, apparatus, and computer program product for a microfluidic channel having a cover opposite its bottom and having electrodes with patterned two-dimensional conducting materials, such as graphene sheets integrated into the top of its bottom. Using the two-dimensional conducting materials, once a fluid sample is applied into the channel, highly localized modulated electric field distributions are generated inside the channel and the fluid sample. This generated field causes the inducing of dielectrophoretic (DEP) forces. These DEP forces are the same or greater than DEP forces that would result using metallic electrodes because of the sharp edges enabled by the two-dimension geometry of the two-dimensional conducting materials. Because of the induced forces, micro/nano-particles in the fluid sample are separated into particles that respond to a negative DEP force and particles that respond to a positive DEP. Microfluidic chips with microfluidic channels can be made using standard semiconductor manufacturing technology.
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公开(公告)号：US20190195851A1
公开(公告)日：2019-06-27
申请号：US15853884
申请日：2017-12-25
发明人： Michael Engel , Ademir Ferreira da Silva , Ado Jorio de Vasconcelos , Ricardo L. Ohta , Mathias B. Steiner
摘要： A growth chamber chip includes a base surrounding a growth chamber; a growth medium within the growth chamber; a sensor package within the growth chamber; a sensor feedthrough extending from the sensor package through a portion of the base to an outer surface of the base; and a transparent seal covering the growth chamber. In one or more embodiments, the base includes a nutrient channel connected in fluid communication with the growth medium and exposed to an outer surface of the base. One or more embodiments provide an array of growth chamber chips, with a movable arm that is movable across the array to individually scan each of the growth chamber chips.
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公开(公告)号：US10283629B2
公开(公告)日：2019-05-07
申请号：US15298771
申请日：2016-10-20
发明人： Michael Engel , Mathias B. Steiner
IPC分类号： H01L29/06 , H01L29/08 , H01L35/24 , H01L51/00 , H01L29/66 , H01L29/16 , H01L29/786 , H01L29/417 , H01L29/775 , H01L29/778 , H01L51/05 , H01L29/24
摘要： A method of forming an electrical device that includes forming a gate dielectric layer over a gate electrode, forming source and drain electrodes on opposing sides of the gate electrode, wherein one end of the source and drain electrodes provides a coplanar surface with the gate dielectric, and positioning a 1D or 2D nanoscale material on the coplanar surface to provide the channel region of the electrical device.
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公开(公告)号：US09891084B2
公开(公告)日：2018-02-13
申请号：US15467084
申请日：2017-03-23
CPC分类号： G01R33/072 , G01F1/708 , G01F1/7088 , G01N27/745 , G01R33/07 , G01R33/1269 , H01L43/04 , H01L43/06 , H01L43/10 , H01L43/14
摘要： A method of detecting a particle comprises magnetizing a particle using an AC magnetic field; generating an AC voltage in a sensing device having a conductive substantially 2-dimensional lattice structure from the magnetized particle; superimposing a DC magnetic field on the generated AC voltage in the sensing device; and measuring an AC Hall voltage at the sensing device.
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