利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

40 条记录 (耗时 0.029 秒)

    Solvent for a sparingly soluble gentamicin salt
    31.
    发明授权
    Solvent for a sparingly soluble gentamicin salt 失效
    溶于稀溶液的庆大霉素盐

    公开(公告)号：US5679646A

    公开(公告)日：1997-10-21

    申请号：US238086

    申请日：1994-05-04

    申请人： Monika Cimbollek ,  Berthold Nies

    发明人： Monika Cimbollek ,  Berthold Nies

    IPC分类号： A61K47/22 ,  A61L27/54 ,  A61K31/70

    CPC分类号： A61K31/70 ,  A61K47/22 ,  A61L27/54 ,  A61L2300/406

    摘要： A solvent for the salt of gentamicin with 3-p-methoxybenzylidene-6-hydroxy-4 '-methoxyflavanone-6-phosphate which is a mixture of from 6 to 9.75 parts by volume of tetrahydrofuran and from 4 to 0.25 parts by volume of water. In these solvents the active compound is soluble up to about 60% by weight. Such a solution is particularly suitable for loading pharmaceutical carriers with this active compound.

    摘要翻译： 用于庆大霉素盐与3-对甲氧基亚苄基-6-羟基-4'-甲氧基黄烷酮-6-磷酸盐的溶剂，其为6至9.75体积份四氢呋喃和4至0.25体积份水的混合物 。 在这些溶剂中，活性化合物可溶解至多约60重量％。 这种溶液特别适用于加载具有该活性化合物的药物载体。

    Bone implant comprising a magnesium-containing metallic material with reduced corrosion rate, and methods and kit for producing the bone implant
    32.
    发明申请
    Bone implant comprising a magnesium-containing metallic material with reduced corrosion rate, and methods and kit for producing the bone implant 有权
    包括具有降低的腐蚀速率的含镁金属材料的骨植入体，以及用于生产骨植入物的方法和试剂盒

    公开(公告)号：US20130150978A1

    公开(公告)日：2013-06-13

    申请号：US13704346

    申请日：2011-06-15

    申请人： Berthold Nies ,  Stefan Glorius

    发明人： Berthold Nies ,  Stefan Glorius

    IPC分类号： A61F2/28

    CPC分类号： A61F2/28 ,  A61L24/02 ,  A61L27/047 ,  A61L27/306 ,  A61L2430/02

    摘要： The invention relates to a bone implant which comprises a magnesium-containing metallic material having a reduced corrosion rate and inorganic bone cement, and to methods and a kit for producing the bone implant. With a method according to the invention, it is possible to obtain a bone implant which comprises inorganic bone cement and a magnesium-containing metallic material with a corrosion-inhibiting coating which contains magnesium-ammonium phosphates. In the method according to the invention, a magnesium-containing metallic material, of which the surface has a magnesium oxide layer and/or a magnesium salt layer, is combined with inorganic bone cement in order to generate a solid composite material that comprises the inorganic bone cement and the magnesium-containing metallic material. The inorganic bone cement contains inorganic powder constituents, which set in the presence of water to form a solid, and water-soluble phosphate-ion-containing salts, preferably water-soluble phosphate-ion-containing and ammonium-ion-containing salts. According to the invention, the magnesium-containing metallic material is brought into contact with water before and/or during the combination with the inorganic bone cement in the presence pt of water-soluble ammonium-ion-containing and phosphate-ion-containing salts. Moreover, the inorganic bone cement is set by being brought into contact with water.

    摘要翻译： 本发明涉及一种骨植入物，其包括具有降低的腐蚀速率的镁含量金属材料和无机骨水泥，以及用于生产骨植入物的方法和试剂盒。 利用根据本发明的方法，可以获得包含无机骨水泥和含镁金属材料的骨植入物，其中含有镁磷酸铵的腐蚀抑制涂层。 在根据本发明的方法中，将表面具有氧化镁层和/或镁盐层的含镁金属材料与无机骨水泥组合以产生包含无机骨料的固体复合材料 骨水泥和含镁金属材料。 无机骨水泥含有无机粉末成分，其在水存在下形成固体，以及水溶性磷酸盐离子盐，优选水溶性含磷酸根离子和含铵离子的盐。 根据本发明，在含有水溶性含铵离子和含磷酸根离子的盐的存在下，含镁金属材料在与无机骨水泥组合之前和/或期间与水接触。 此外，无机骨水泥通过与水接触来设定。

    Bioactive Bone Cement and Method for the Production Thereof
    33.
    发明申请
    Bioactive Bone Cement and Method for the Production Thereof 有权
    生物活性骨水泥及其生产方法

    公开(公告)号：US20080194729A1

    公开(公告)日：2008-08-14

    申请号：US11914382

    申请日：2006-05-09

    申请人： Berthold Nies

    发明人： Berthold Nies

    IPC分类号： A61L24/04

    CPC分类号： A61L24/06 ,  A61L24/001 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/02 ,  C08L33/08

    摘要： The invention relates to a novel bioactive and osteoconductive bone cement and a method for producing the same from polyacrylates or polymethylacrylates by addition of small amounts of polymerizable monomers containing anionic groups which cause the cement surface to mineralize after being incubated in simulated body fluid and in which the obtained mineralized layers contain calcium phosphate phases such that the formation of fibrous intermediate layers is prevented once the bone cement has been implanted in bones. Optionally, other additives, e.g. biocompatible calcium salts, and/or biocompatible buffering substances, or x-ray contrast agents, antibiotics, antimicrobial agents, and/or anti-inflammatory agents can be added in order to improve the properties of the cement for individual purposes. The invention also relates to the use of the bone cement according to the invention for anchoring prosthesis components in the bone, stiffening bones, filling and reconstructing all types of bone defects, as dowels for bone screws, or as an implant material for anchoring screws and other implants used for osteosynthesis.

    摘要翻译： 本发明涉及一种新型的生物活性和骨诱导性骨水泥及其制备方法，其中通过加入少量含有阴离子基团的可聚合单体，在模拟体液中孵育后使水泥表面矿化，从而生产聚丙烯酸酯或聚甲基丙烯酸酯，其中 所获得的矿化层含有磷酸钙相，使得一旦将骨水泥植入骨头中，就可以防止纤维状中间层的形成。 任选地，其它添加剂，例如。 可以加入生物相容性钙盐和/或生物相容性缓冲物质，或X射线造影剂，抗生素，抗微生物剂和/或抗炎剂，以改善用于个体目的的水泥的性质。 本发明还涉及根据本发明的骨粘固剂在骨中固定假体成分，加强骨骼，填充和重建所有类型的骨缺损的骨用途的用途，作为骨螺钉的榫钉，或者作为用于固定螺钉的植入材料，以及 其他用于骨接合术的植入物。

    Use of antiseptic active principles in pmma bone cements
    35.
    发明申请
    Use of antiseptic active principles in pmma bone cements 审中-公开
    在pmma骨水泥中使用防腐活性成分

    公开(公告)号：US20060275339A1

    公开(公告)日：2006-12-07

    申请号：US10564372

    申请日：2004-07-16

    申请人： Frank Schilke ,  Berthold Nies ,  Hanns Pietsch

    发明人： Frank Schilke ,  Berthold Nies ,  Hanns Pietsch

    IPC分类号： A61K31/155 ,  A61K9/14

    CPC分类号： A61L24/0015 ,  A61L24/06 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2430/02 ,  C08L33/12

    摘要： The invention concerns the use of polyhexamethylene biguanide in PMMA bone cements, which preferably do not contain antibiotics. The cements exhibit a concentration of active principle not exceeding 1 wt. % relative to the total weight of the cement, which is a concentration sufficiently high to prevent microbial colonization of the cement surface. The cements do not cause durable alteration of the healing process.

    摘要翻译： 本发明涉及聚六亚甲基双胍在PMMA骨水泥中的应用，其优选不含有抗生素。 水泥表现出不超过1重量％的活性成分浓度。 相对于水泥的总重量，其是足够高的浓度以防止水泥表面的微生物定居。 水泥不会持续改变愈合过程。

    Device for the mixing and discharge of liquid and pulverulent materials for medical use
    37.
    发明申请
    Device for the mixing and discharge of liquid and pulverulent materials for medical use 审中-公开
    用于医疗用途的液体和粉状材料的混合和排放装置

    公开(公告)号：US20050111300A1

    公开(公告)日：2005-05-26

    申请号：US10954358

    申请日：2004-10-01

    申请人： Berthold Nies ,  Hutchappa Nagaraj

    发明人： Berthold Nies ,  Hutchappa Nagaraj

    IPC分类号： A61M5/142 ,  A61B17/88 ,  A61F2/28 ,  A61F2/46 ,  A61L27/00 ,  B01F3/18 ,  B01F11/00 ,  B01F13/00 ,  B01F15/02

    CPC分类号： A61B17/8833 ,  A61B17/8822 ,  A61B2017/8838 ,  B01F3/18 ,  B01F11/0054 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0279

    摘要： A device for the storage, mixing and discharge of liquid and pulverulent materials for medical use has a mixing cylinder (1), a perforated mixing plunger (8), which is axially and rotatably movable in the mixing cylinder (1) by means of an actuation rod (9), an axially displaceable discharge plunger (4), a sealable discharge aperture (3) in the mixing cylinder (1) and means for actuation of the discharge plunger (4). The discharge plunger (4) has in its interior a sealable storage chamber (14) for the accommodation of one of the materials to be mixed, so that pre-packaged amounts of the materials to be mixed can be introduced separately into the device, even without packaging, and stored over an extended period. The discharge plunger (4) engages with the mixing cylinder (1) via an actuation thread, so that rotation of the discharge plunger (4) relative to the mixing cylinder (1) enables discharge of the mixed materials. To this end, the mixing cylinder (1) has an external thread (6), which engages with an internal thread (7) of the hollow cylinder (5) partly surrounding the mixing cylinder (1), the hollow cylinder (5) having handling elements and being rigidly connected to the discharge plunger (4).

    摘要翻译： 用于医疗用途的液体和粉状材料的储存，混合和排放的装置具有混合缸（1），穿孔混合柱塞（8），该混合柱塞可以在混合缸（1）中轴向和可旋转地移动，借助于 致动杆（9），可轴向移动的排出柱塞（4），混合缸（1）中的可密封排出孔（3）和用于致动排放柱塞（4）的装置。 排出柱塞（4）在其内部具有可密封的储存室（14），用于容纳要混合的材料之一，使得预先包装的待混合材料量可以分开地引入到装置中，甚至 无需包装，并在长时间内储存。 排出柱塞（4）通过致动螺纹与混合缸（1）接合，使得排出柱塞（4）相对于混合缸（1）的旋转能够排出混合材料。 为此，混合缸（1）具有外螺纹（6），其与部分围绕混合缸（1）的中空圆柱体（5）的内螺纹（7）接合，中空圆柱体（5）具有 处理元件并刚性地连接到排出柱塞（4）。

    Bone cement paste containing an antibiotic
    38.
    发明授权
    Bone cement paste containing an antibiotic 失效
    骨水泥糊含有抗生素

    公开(公告)号：US06485754B1

    公开(公告)日：2002-11-26

    申请号：US09402120

    申请日：2000-01-18

    申请人： Robert Wenz ,  Berthold Nies

    发明人： Robert Wenz ,  Berthold Nies

    IPC分类号： A61K3342

    CPC分类号： A61L27/12 ,  A61F2310/00293 ,  A61L24/0015 ,  A61L24/02 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/602 ,  A61L2300/80 ,  A61L2400/06 ,  A61L2430/02

    摘要： The invention relates to an injectable curable bone cement paste based on bioresorbable hydroxyapatite-like compounds comprising calcium phosphate, which contains a cationic antibiotic in the form of a salt, preferably of its sulfate, the curable biodegradable bone cement releasing the antibiotic in biologically active concentrations with depot-like action over a long period of time. The bone cements according to the invention are suitable for the treatment of infectious inflammations of the bone and of the bone marrow, in particular as a result of bone defects and bone fractures.

    摘要翻译： 本发明涉及一种基于包含磷酸钙的生物再吸收性羟基磷灰石样化合物的可注射可固化骨水泥糊剂，其包含盐形式的阳离子抗生素，优选其硫酸盐，将可生物降解骨水泥释放出具有生物活性浓度的抗生素 在长时间内都有仓库式的行动。 根据本发明的骨粘固剂适用于治疗骨骼和骨髓的感染性炎症，特别是由于骨缺损和骨折。