公开(公告)号：US07119085B2

公开(公告)日：2006-10-10

申请号：US09816876

申请日：2001-03-23

申请人： Roy Hom ,  Shumeye S. Mamo ,  Jay Tung ,  Andrea Gailunas ,  Varghese John ,  Lawrence Y. Fang

发明人： Roy Hom ,  Shumeye S. Mamo ,  Jay Tung ,  Andrea Gailunas ,  Varghese John ,  Lawrence Y. Fang

IPC分类号： A61K31/55 ,  A61K31/535 ,  A61K31/35 ,  A61K31/34

CPC分类号： C07C237/22 ,  A61K38/00 ,  C07B2200/07 ,  C07C271/14 ,  C07C271/18 ,  C07C271/22 ,  C07C2601/14 ,  C07C2603/74 ,  C07D261/20 ,  C07D295/13 ,  C07D295/185 ,  C07D307/14 ,  C07D307/33 ,  C07D307/52 ,  C07K5/0207 ,  C07K7/02

摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.

公开(公告)号：US07067271B1

公开(公告)日：2006-06-27

申请号：US09724571

申请日：2000-11-28

申请人： John P. Anderson ,  Guriqbal Basi ,  Minh Tam Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

发明人： John P. Anderson ,  Guriqbal Basi ,  Minh Tam Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

IPC分类号： C12Q1/37 ,  C12N9/50 ,  C12N9/64 ,  C12N15/63

CPC分类号： C12N9/6478 ,  A01K2217/075 ,  A61K38/00

摘要： Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

公开(公告)号：US20060128715A1

公开(公告)日：2006-06-15

申请号：US11177348

申请日：2005-07-11

申请人： Jennifer Sealy ,  Roy Hom ,  Varghese John ,  Gary Probst ,  Jay Tung

发明人： Jennifer Sealy ,  Roy Hom ,  Varghese John ,  Gary Probst ,  Jay Tung

IPC分类号： A61K31/4965 ,  A61K31/513 ,  A61K31/50 ,  A61K31/381 ,  A61K31/416 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/165

CPC分类号： C07D239/74 ,  C07C233/36 ,  C07C237/18 ,  C07C251/44 ,  C07C251/54 ,  C07C251/58 ,  C07C251/84 ,  C07C255/31 ,  C07C255/61 ,  C07C2601/14 ,  C07D207/335 ,  C07D213/40 ,  C07D213/53 ,  C07D231/12 ,  C07D231/56 ,  C07D239/18 ,  C07D239/26 ,  C07D261/20 ,  C07D307/52 ,  C07D317/72 ,  C07D333/22 ,  C07D403/10 ,  C07D405/10 ,  C07D409/04 ,  C07D409/10

摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。

公开(公告)号：US07030239B2

公开(公告)日：2006-04-18

申请号：US10847819

申请日：2004-05-18

申请人： Roy Hom ,  Shumeye S. Mamo ,  Jay Tung ,  Andrea Gailunas ,  Varghese John ,  Lawrence Y. Fang

发明人： Roy Hom ,  Shumeye S. Mamo ,  Jay Tung ,  Andrea Gailunas ,  Varghese John ,  Lawrence Y. Fang

IPC分类号： C07D237/00 ,  C07D237/02 ,  C07D237/26 ,  C07D237/28 ,  C07D487/00

CPC分类号： C07C237/22 ,  A61K38/00 ,  C07B2200/07 ,  C07C271/14 ,  C07C271/18 ,  C07C271/22 ,  C07C2601/14 ,  C07C2603/74 ,  C07D261/20 ,  C07D295/13 ,  C07D295/185 ,  C07D307/14 ,  C07D307/33 ,  C07D307/52 ,  C07K5/0207 ,  C07K7/02

摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.

摘要翻译： 本发明涉及可用于治疗阿尔茨海默氏病和其他类似疾病的式（XII）的取代的羟基亚乙基化合物。

公开(公告)号：US20060014790A1

公开(公告)日：2006-01-19

申请号：US11038790

申请日：2005-01-21

申请人： Varghese John ,  Roy Hom ,  Jennifer Sealy ,  Jose Aquino ,  Gary Probst ,  Jay Tung ,  Lawrence Fang

发明人： Varghese John ,  Roy Hom ,  Jennifer Sealy ,  Jose Aquino ,  Gary Probst ,  Jay Tung ,  Lawrence Fang

IPC分类号： A61K31/445 ,  A61K31/38 ,  A61K31/165 ,  A61K31/381

CPC分类号： A61K31/38 ,  A61K31/165 ,  A61K31/381 ,  A61K31/445

摘要： The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

摘要翻译： 本发明涉及可用于治疗与淀粉样变性相关的疾病，病症和病症的乙酰基2-羟基-1,3-二氨基螺环己烷及其衍生物。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。

公开(公告)号：US20050239836A1

公开(公告)日：2005-10-27

申请号：US11075312

申请日：2005-03-09

申请人： Varghese John ,  Michel Maillard ,  John Tucker ,  Jose Aquino ,  Barbara Jagodzinska ,  Louis Brogley ,  Jay Tung ,  Simeon Bowers ,  Darren Dressen ,  Gary Probst ,  Neerav Shah

发明人： Varghese John ,  Michel Maillard ,  John Tucker ,  Jose Aquino ,  Barbara Jagodzinska ,  Louis Brogley ,  Jay Tung ,  Simeon Bowers ,  Darren Dressen ,  Gary Probst ,  Neerav Shah

IPC分类号： A61K31/382 ,  A61K31/453 ,  C07D207/32 ,  C07D207/325 ,  C07D233/54 ,  C07D257/04 ,  C07D335/06 ,  C07D403/12 ,  C07D405/12 ,  C07D419/12 ,  C07D49/02

CPC分类号： C07D419/12 ,  C07C215/28 ,  C07C215/50 ,  C07C217/30 ,  C07C217/34 ,  C07C217/48 ,  C07C217/52 ,  C07C217/58 ,  C07C225/06 ,  C07C225/20 ,  C07C229/16 ,  C07C229/42 ,  C07C229/60 ,  C07C233/43 ,  C07C237/20 ,  C07C237/30 ,  C07C271/12 ,  C07C311/24 ,  C07C317/28 ,  C07C323/25 ,  C07C323/30 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/04 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2603/18 ,  C07C2603/74 ,  C07D207/323 ,  C07D207/325 ,  C07D213/38 ,  C07D215/42 ,  C07D231/12 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D233/88 ,  C07D239/42 ,  C07D239/48 ,  C07D249/04 ,  C07D249/06 ,  C07D249/14 ,  C07D257/04 ,  C07D263/34 ,  C07D271/113 ,  C07D275/02 ,  C07D277/42 ,  C07D285/08 ,  C07D285/10 ,  C07D285/135 ,  C07D307/52 ,  C07D309/14 ,  C07D311/74 ,  C07D333/36 ,  C07D335/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04

摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

公开(公告)号：US20050196839A1

公开(公告)日：2005-09-08

申请号：US11090399

申请日：2005-03-25

申请人： John Anderson ,  Guriqbal Basi ,  Minh Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

发明人： John Anderson ,  Guriqbal Basi ,  Minh Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

IPC分类号： A61K38/00 ,  C12N9/64 ,  H01Q1/36 ,  H01Q1/38 ,  H01Q3/44 ,  H01Q5/00 ,  H01Q9/04 ,  H01Q15/02 ,  C07H21/04

CPC分类号： C12N9/6478 ,  A01K2217/075 ,  A61K38/00 ,  H01Q1/364 ,  H01Q1/38 ,  H01Q3/44 ,  H01Q9/0407 ,  H01Q9/0442 ,  H01Q15/02

摘要： Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

公开(公告)号：US20050170489A1

公开(公告)日：2005-08-04

申请号：US11069377

申请日：2005-02-28

申请人： John Anderson ,  Guriqbal Basi ,  Minh Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

发明人： John Anderson ,  Guriqbal Basi ,  Minh Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

IPC分类号： A61K38/00 ,  C12N9/64 ,  H01Q1/36 ,  H01Q1/38 ,  H01Q3/44 ,  H01Q5/00 ,  H01Q9/04 ,  H01Q15/02

CPC分类号： C12N9/6478 ,  A01K2217/075 ,  A61K38/00 ,  H01Q1/364 ,  H01Q1/38 ,  H01Q3/44 ,  H01Q9/0407 ,  H01Q9/0442 ,  H01Q15/02

摘要： Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

摘要翻译： 公开了各种形式的纯化和重组形式的活性，分离的β-分泌酶。 这种酶涉及积聚在患有阿尔茨海默病的个体的脑中的淀粉样蛋白斑块成分的产生。 产生该酶的重组细胞单独或与其一些天然底物（β-APPwt和β-APPsw）组合也被公开，以及针对这种蛋白质的抗体。 这些组合物可用于选择调节β-分泌酶的化合物的方法。 β-分泌酶的抑制剂涉及作为治疗神经变性疾病如阿尔茨海默病的治疗剂。

公开(公告)号：US20050164327A1

公开(公告)日：2005-07-28

申请号：US11089918

申请日：2005-03-25

申请人： John Anderson ,  Guriqbal Basi ,  Minh Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

发明人： John Anderson ,  Guriqbal Basi ,  Minh Doan ,  Normand Frigon ,  Varghese John ,  Michael Power ,  Sukanto Sinha ,  Gwen Tatsuno ,  Jay Tung ,  Shuwen Wang ,  Lisa McConlogue

IPC分类号： A61K38/00 ,  C12N9/64 ,  H01Q1/36 ,  H01Q1/38 ,  H01Q3/44 ,  H01Q5/00 ,  H01Q9/04 ,  H01Q15/02 ,  C12Q1/37

CPC分类号： C12N9/6478 ,  A01K2217/075 ,  A61K38/00 ,  H01Q1/364 ,  H01Q1/38 ,  H01Q3/44 ,  H01Q9/0407 ,  H01Q9/0442 ,  H01Q15/02

摘要： Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

公开(公告)号：US07385085B2

公开(公告)日：2008-06-10

申请号：US11177324

申请日：2005-07-11

申请人： Varghese John ,  Michel Maillard ,  Barbara Jagodzinska ,  Jose Aquino ,  Gary Probst ,  Jay Tung

发明人： Varghese John ,  Michel Maillard ,  Barbara Jagodzinska ,  Jose Aquino ,  Gary Probst ,  Jay Tung

IPC分类号： C07C237/04

CPC分类号： C07D285/08 ,  C07C233/36 ,  C07C237/20 ,  C07C251/44 ,  C07C251/54 ,  C07C251/84 ,  C07C255/42 ,  C07C255/58 ,  C07C2601/04 ,  C07C2601/14 ,  C07D213/40 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D257/04 ,  C07D261/20 ,  C07D271/10 ,  C07D335/06 ,  C07D405/10

摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

摘要翻译： 本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。 淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。