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    MODIFIED TWO-COMPONENT GELATION SYSTEMS, METHODS OF USE AND METHODS OF MANUFACTURE
    31.
    发明申请
    MODIFIED TWO-COMPONENT GELATION SYSTEMS, METHODS OF USE AND METHODS OF MANUFACTURE 有权
    改性双组分凝胶系统，使用方法和制造方法

    公开(公告)号：US20080119385A1

    公开(公告)日：2008-05-22

    申请号：US11561328

    申请日：2006-11-17

    Applicant: Gene Michal ,  Shubhayu Basu

    Inventor： Gene Michal ,  Shubhayu Basu

    IPC: A61K38/02 ,  C07K14/475 ,  C07K14/78

    CPC classification number: A61K35/28 ,  A61K33/14 ,  A61K33/20 ,  A61K38/1858 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/26 ,  A61L27/3873 ,  A61L27/52 ,  C12Y304/21005 ,  A61K2300/00 ,  A61K38/00

    Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.

    Abstract translation: 生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。 例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分） 的至少两种不同的双组分凝胶化体系以形成第二混合物。 可以将第一混合物或第二混合物中的处理剂如细胞类型或生长因子加入。 在一些实施方案中，处理剂不加入任何混合物中。 可以将第一混合物与第二混合物共注射以在梗塞区域中形成生物支架，用于治疗它们。

    Methods and devices for forming treatment agent carriers
    33.
    发明授权
    Methods and devices for forming treatment agent carriers 有权
    用于形成治疗剂载体的方法和装置

    公开(公告)号：US08784894B2

    公开(公告)日：2014-07-22

    申请号：US11485934

    申请日：2006-07-12

    Applicant: Shubhayu Basu ,  Eugene T. Michal

    Inventor： Shubhayu Basu ,  Eugene T. Michal

    IPC: A61K38/18 ,  A61K9/14

    CPC classification number: A61K9/4833 ,  A61K9/145 ,  A61K9/5031 ,  A61K38/30

    Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

    Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

    NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN
    37.
    发明申请
    NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN 有权
    带有远距离提示灯的针式导管

    公开(公告)号：US20100004627A1

    公开(公告)日：2010-01-07

    申请号：US12167791

    申请日：2008-07-03

    Applicant: Florian N. Ludwig ,  Shubhayu Basu

    Inventor： Florian N. Ludwig ,  Shubhayu Basu

    IPC: A61M25/00 ,  A61M5/32

    CPC classification number: A61M25/0068 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0081 ,  A61M2025/009

    Abstract: A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.

    Abstract translation: 一种针导管，其构造成用于将药剂注射到患者体腔的壁中，其将针从导管的远侧末端引导到相对于轴的轴线成一定角度的体腔的壁中。 所产生的角度注射通道改善了药剂在体腔壁中的保留性，同时保持导管的远端部分基本上垂直于体腔壁，以最佳地推动注射部位处的组织。

    Methods and devices for forming treatment agent carriers
    39.
    发明申请
    Methods and devices for forming treatment agent carriers 有权
    用于形成治疗剂载体的方法和装置

    公开(公告)号：US20080014276A1

    公开(公告)日：2008-01-17

    申请号：US11485934

    申请日：2006-07-12

    Applicant: Shubhayu Basu ,  Eugene T. Michal

    Inventor： Shubhayu Basu ,  Eugene T. Michal

    IPC: A61K38/18 ,  A61K9/14

    CPC classification number: A61K9/4833 ,  A61K9/145 ,  A61K9/5031 ,  A61K38/30

    Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

    Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将其与生物可蚀塑料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

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