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    Modified two-component gelation systems, methods of use and methods of manufacture
    2.
    发明授权
    Modified two-component gelation systems, methods of use and methods of manufacture 有权
    改进的双组分凝胶化系统，使用方法和制造方法

    公开(公告)号：US08741326B2

    公开(公告)日：2014-06-03

    申请号：US11561328

    申请日：2006-11-17

    Applicant: Gene Michal ,  Shubhayu Basu

    Inventor： Gene Michal ,  Shubhayu Basu

    IPC: A61K9/127 ,  A61P7/00

    CPC classification number: A61K35/28 ,  A61K33/14 ,  A61K33/20 ,  A61K38/1858 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/26 ,  A61L27/3873 ,  A61L27/52 ,  C12Y304/21005 ,  A61K2300/00 ,  A61K38/00

    Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.

    Abstract translation: 生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。 例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分） 的至少两种不同的双组分凝胶化体系以形成第二混合物。 可以将第一混合物或第二混合物中的处理剂如细胞类型或生长因子加入。 在一些实施方案中，处理剂不加入任何混合物中。 可以将第一混合物与第二混合物共注射以在梗塞区域中形成生物支架，用于治疗它们。

    MODIFIED TWO-COMPONENT GELATION SYSTEMS, METHODS OF USE AND METHODS OF MANUFACTURE
    4.
    发明申请
    MODIFIED TWO-COMPONENT GELATION SYSTEMS, METHODS OF USE AND METHODS OF MANUFACTURE 有权
    改性双组分凝胶系统，使用方法和制造方法

    公开(公告)号：US20080119385A1

    公开(公告)日：2008-05-22

    申请号：US11561328

    申请日：2006-11-17

    Applicant: Gene Michal ,  Shubhayu Basu

    Inventor： Gene Michal ,  Shubhayu Basu

    IPC: A61K38/02 ,  C07K14/475 ,  C07K14/78

    CPC classification number: A61K35/28 ,  A61K33/14 ,  A61K33/20 ,  A61K38/1858 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/26 ,  A61L27/3873 ,  A61L27/52 ,  C12Y304/21005 ,  A61K2300/00 ,  A61K38/00

    Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.

    Abstract translation: 生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。 例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分） 的至少两种不同的双组分凝胶化体系以形成第二混合物。 可以将第一混合物或第二混合物中的处理剂如细胞类型或生长因子加入。 在一些实施方案中，处理剂不加入任何混合物中。 可以将第一混合物与第二混合物共注射以在梗塞区域中形成生物支架，用于治疗它们。

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