公开(公告)号：US20140261897A1

公开(公告)日：2014-09-18

申请号：US14009517

申请日：2010-07-06

申请人： Jen-Chieh Wei ,  Zhiming Liu ,  Steven Z. Shi ,  Werner G. Kuhr

发明人： Jen-Chieh Wei ,  Zhiming Liu ,  Steven Z. Shi ,  Werner G. Kuhr

IPC分类号： C23C8/12 ,  C23C8/16

CPC分类号： H05K3/385 ,  C08J5/12 ,  C08J2363/00 ,  C09J5/02 ,  C09J2400/163 ,  C09J2400/166 ,  C09J2400/20 ,  C23C8/12 ,  C23C8/16 ,  C23C8/40 ,  C23C8/80 ,  C23C22/63 ,  C23C22/83 ,  H05K3/389 ,  H05K3/4673 ,  H05K2203/0315 ,  H05K2203/065 ,  H05K2203/1157

摘要： Embodiments of the present invention relate generally to methods of treating metal surfaces to enhance adhesion or binding to substrates, and devices formed thereby. In some embodiments of the present invention, methods of achieving improved bonding strength without roughening the topography of a metal surface are provided. The metal surface obtained by this method provides strong bonding to resin layers. The bonding interface between the treated metal and the resin layer exhibits resistance to heat, moisture, and chemicals involved in post-lamination process steps, and therefore can suitably be used in the production of PCB's. Methods according to some embodiments of the present invention are especially useful in the fabrication of high density multilayer PCB's, in particular for PCB's having circuits with line/spacing of equal to and less than 10 microns. Methods according to other embodiments of the present invention are particularly useful in the coating of metal surfaces in a wide variety of applications.

公开(公告)号：US07799598B2

公开(公告)日：2010-09-21

申请号：US12048427

申请日：2008-03-14

申请人： Werner G. Kuhr ,  Ritu Shrivastava ,  Antonio R. Gallo ,  Kenneth J. Mobley ,  Tom DeBolske

发明人： Werner G. Kuhr ,  Ritu Shrivastava ,  Antonio R. Gallo ,  Kenneth J. Mobley ,  Tom DeBolske

IPC分类号： H01L51/40

CPC分类号： H01L51/0006 ,  B82Y10/00 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/0016 ,  G11C2213/34 ,  H01L27/285 ,  H01L51/0595

摘要： Molecular memories, i.e., memories that incorporate molecules for charge storage, are disclosed. Molecular memory cells, molecular memory arrays, and electronic devices including molecular memory are also disclosed, as are processing systems and methods for manufacturing molecular memories. Methods of manufacturing molecular memories that enable semiconductor devices and interconnections to be manufactured monolithically with molecular memory are also disclosed.

摘要翻译： 公开了分子存储器，即结合用于电荷存储的分子的存储器。 还公开了分子记忆单元，分子存储器阵列和包括分子存储器的电子器件，以及用于制造分子存储器的处理系统和方法。 还公开了使半导体器件和互连能够与分子存储器一体制造的分子存储器的制造方法。

公开(公告)号：US06294392B1

公开(公告)日：2001-09-25

申请号：US09358204

申请日：1999-07-21

申请人： Werner G. Kuhr ,  Pankaj Singhal ,  Sara Ann Brazill

发明人： Werner G. Kuhr ,  Pankaj Singhal ,  Sara Ann Brazill

IPC分类号： G01N33543

CPC分类号： G01N33/54366 ,  B01L3/5027 ,  B01L2200/16 ,  B01L2300/0838 ,  C12Q1/6825 ,  G01N27/447 ,  C12Q2565/629

摘要： A flow-through microchannel (e.g. capillary) biosensor is described for the for the detection of multiple, different analytes (e.g. nucleic acids, proteins, sugars, etc.) targets in a sample by binding them to “complementary” binding partners (e.g. complementary nucleic acids, ligands, antibodies, etc.). The binding partners are immobilized in different sections of a microchannel (e.g. a fused silica capillary). After fabrication of the biosensor, a sample is flushed through the capillary, and any target analyte(s) contained within the sample are bound to the immobilized binding partner(s) on the microchannel wall forming bound complexes. Finally, the bound complexes are simultaneously denatured along the entire length of the capillary and flushed out past a detector poised downstream, and the analyte concentration is measured (e.g., using sinusoidal voltammetry). Direct electrochemical detection of underivatized DNA is accomplished by oxidizing its sugar backbone and the amine containing nucleobase at the copper electrode. The elution time of the desorbed target DNA(s) is used for the sequence identification of the target. Multiple genetic sequences can be diagnosed by using a single biosensor in this manner. The sensor is highly specific due to hybridization chemistry, and extremely sensitive due to electrochemical detection.

摘要翻译： 描述了流通微通道（例如毛细管）生物传感器，用于通过将样品中的多种不同分析物（例如核酸，蛋白质，糖等）结合至“互补”结合配偶体（例如互补的） 核酸，配体，抗体等）。 结合配偶体固定在微通道的不同部分（例如熔融石英毛细管）中。 在制造生物传感器之后，将样品冲洗通过毛细管，并且样品中包含的任何目标分析物与形成结合复合物的微通道壁上的固定结合配偶体结合。 最后，结合的复合物沿毛细管的整个长度同时变性，并通过下游的检测器冲洗出来，并测量分析物浓度（例如使用正弦伏安法）。 未衍生的DNA的直接电化学检测是通过在铜电极上氧化其糖骨架和含胺核碱基来实现的。 解吸的靶DNA的洗脱时间用于靶标的序列鉴定。 可以通过以这种方式使用单个生物传感器诊断多个遗传序列。 该传感器由于杂化化学而具有高度的特异性，并且由于电化学检测而非常敏感。

公开(公告)号：US5650061A

公开(公告)日：1997-07-22

申请号：US529661

申请日：1995-09-18

申请人： Werner G. Kuhr ,  John K. Cullison

发明人： Werner G. Kuhr ,  John K. Cullison

IPC分类号： G01N27/416 ,  G01N27/49 ,  G01N27/26

CPC分类号： G01N27/49

摘要： A large amplitude sine wave is applied as the excitation potential to a amperometric measurement to produce a current output that is a phase shifted sine wave containing faradaic information at many frequencies. A current obtained from a conventional potentiostat coupled to the electrode is coupled to a lock-in amplifier that monitors the signal at one frequency at a specified phase angle. Since most of the background remains at the fundamental frequency, a higher harmonic of the fundamental frequency of the sinusoidal sweep frequency is monitored. By locking in on the higher harmonic components, the faradaic signal is therefore distinguished from the background signal. The background is diminished thereby allowing signal recognition at low analyte concentrations and increasing the signal-to-noise ratio.

摘要翻译： 将大振幅正弦波作为电流测量的激励电位，以产生电流输出，该电流输出是包含许多频率的法拉第信息的相移正弦波。 从耦合到电极的常规恒电位仪获得的电流被耦合到锁定放大器，该锁定放大器以指定的相位角以一个频率监视信号。 由于大多数背景保持在基频，因此监视正弦扫描频率的基频的较高谐波。 通过锁定高次谐波分量，法拉第信号因此与背景信号不同。 背景减弱，从而允许在低分析物浓度下的信号识别并增加信噪比。