公开(公告)号：US06772784B1

公开(公告)日：2004-08-10

申请号：US10365930

申请日：2003-04-11

Applicant: Thomas R. Jones ,  Zafar A. Khan

Inventor： Thomas R. Jones ,  Zafar A. Khan

IPC: G05D1620

CPC classification number: F15B13/0853 ,  B24B37/04 ,  B24B49/16 ,  F15B13/086 ,  F15B13/0871 ,  F15B13/0896 ,  F15B21/08 ,  F15B2211/526 ,  F15B2211/6313 ,  F15B2211/6653 ,  F15B2211/6656 ,  G05D16/2013 ,  Y10T137/2544 ,  Y10T137/5196 ,  Y10T137/87217

Abstract: A proportional pressure regulator assembly having a main body with a first inlet adapted for fluid communication with supply of positive pneumatic pressure, a second inlet adapted for fluid communication with a supply of negative pneumatic pressure, an outlet adapted for fluid communication with a pneumatically actuated device, and an exhaust port is provided. A fill regulator valve is included that is adapted to regulate the supply of positive pressure. A vacuum regulator valve is included that is adapted to regulate the supply of negative pressure. An exhaust valve is included that is operable to exhaust pressure from the outlet. A control circuit assembly is also provided that is adapted to receive a command signal and a feedback signal and to regulate the amount of positive pneumatic pressure through the fill regulator valve or the amount of negative pneumatic pressure through the vacuum regulator valve in response to the feedback signal.

Abstract translation: 一种比例压力调节器组件，其具有主体，该主体具有适于与供给正气动压力的流体连通的第一入口，适于与负气动压力供应源流体连通的第二入口，适于与气动致动装置 ，并设有排气口。 包括适用于调节正压供应的填充调节阀。 包括适于调节负压供应的真空调节阀。 包括排气阀，其可操作以从出口排出压力。 还提供了一种控制电路组件，其适于接收命令信号和反馈信号，并且响应于反馈来调节通过填充调节阀的正气压的量或通过真空调节阀的负气压的量 信号。

公开(公告)号：US5906935A

公开(公告)日：1999-05-25

申请号：US946598

申请日：1997-10-07

Applicant: Thomas R. Jones ,  Ann E. Campbell

Inventor： Thomas R. Jones ,  Ann E. Campbell

IPC: C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92 ,  C12N5/10 ,  C12N1/00 ,  C12N15/79

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

Abstract: Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.

Abstract translation: 用人巨细胞病毒（HCMV）感染人成纤维细胞导致I类MHC细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放阅读框 IRS1-US9和US11），其不能下调I类重链。 通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。 此外，确定了7-kb区域的两个亚区（A和B）各自含有足以引起重链下调的基因。 在次区域B中，涉及US11基因产物。 它编码胞质内H敏感的糖蛋白，其是胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

公开(公告)号：US5843458A

公开(公告)日：1998-12-01

申请号：US509214

申请日：1995-07-31

Applicant: Thomas R. Jones

Inventor： Thomas R. Jones

IPC: C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92 ,  C12N15/63

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

Abstract: Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. A recombinant mutant HCMV which fails to down-regulate class I heavy chain expression is described. A method of controlling down-regulation of MHC class I expression in a cytomegalovirus infected cell, a pharmaceutical composition, a vaccine composition, a method of preventing or reducing susceptibility to acute cytomegalovirus in an individual, and a virus based gene therapy vector are also described.

Abstract translation: 用人巨细胞病毒（HCMV）感染人成纤维细胞导致MHC类I细胞表面表达下调。描述了不能下调I型重链表达的重组突变体HCMV。 还描述了控制巨细胞病毒感染细胞中MHC I类表达下调的方法，药物组合物，疫苗组合物，预防或降低个体中急性巨细胞病毒敏感性的方法和基于病毒的基因治疗载体 。

公开(公告)号：US5629860A

公开(公告)日：1997-05-13

申请号：US242984

申请日：1994-05-16

Applicant: Thomas R. Jones ,  Steven L. Crain ,  Joseph J. Burkis

Inventor： Thomas R. Jones ,  Steven L. Crain ,  Joseph J. Burkis

IPC: G06F17/50 ,  G11C7/02

CPC classification number: G06F17/5072

Abstract: The present invention provides a method for determining timing delays associated with the placement and routing delays of an integrated circuit. In particular, the present invention determines the area of each region wherein a region includes a group or subgroup of circuit elements for use in designing an integrated circuit. Once the area for each region is obtained, substantially more accurate and more design specific wireload model and net parasitics can be obtained. The wireload models or net parasitics can then be supplied to other CAE tools to create a modified netlist. Moreover, the present invention provides a process which allows the user to account for the RC time constant effects of wire delay on a hierarchical block basis thereby improving the accuracy of the wire placement and routing delay estimate while preserving the performance benefits of a traditional simplified equation.

Abstract translation: 本发明提供一种用于确定与集成电路的布局和布线延迟相关联的定时延迟的方法。 特别地，本发明确定每个区域的区域，其中区域包括用于设计集成电路的电路元件的组或子组。 一旦获得了每个区域的面积，就可以获得更准确和更多的设计特定的线载模型和净寄生效应。 然后可以将线载模型或网络寄生效应提供给其他CAE工具，以创建修改的网表。 此外，本发明提供了一种允许用户在分层块的基础上考虑导线延迟的RC时间常数影响的过程，从而提高线路布局和路由延迟估计的精度，同时保持传统简化方程式的性能优点 。

公开(公告)号：US5366639A

公开(公告)日：1994-11-22

申请号：US910140

申请日：1992-07-14

Applicant: Thomas R. Jones ,  Reginald L. Phillips

Inventor： Thomas R. Jones ,  Reginald L. Phillips

IPC: B07B1/08 ,  B01D21/26

CPC classification number: B07B1/08 ,  B07B2230/04

Abstract: A method of and apparatus for continuously separating relatively coarse particles from a suspension of mixture of particles in a liquid by impinging the suspension upon the surface of a rotating screen so that liquid containing the relatively fine particles passes through the screen and the relatively coarse particles are flung radially outwardly to the periphery of the screen the preferred screen is a woven wire mesh with aperture sizes conveniently in the size range from about 0.020 mm to about 2.00 mm.

Abstract translation: PCT No.PCT / GB90 / 01115 Sec。 371日期：1992年7月14日 102（e）日期1992年7月14日PCT提交1990年7月20日PCT公布。 出版物WO91 / 01815 日期：1991年2月21日。一种用于通过将悬浮液撞击在旋转筛网的表面上而使液体中的颗粒混合物的悬浮液连续分离相对较粗颗粒的方法和装置，使得含有较细颗粒的液体通过 筛网，并且相对粗糙的颗粒径向向外排放到筛网的周边，优选的筛网是孔径尺寸在约0.020mm至约2.00mm的尺寸范围内的编织网。

公开(公告)号：US4826789A

公开(公告)日：1989-05-02

申请号：US022944

申请日：1987-03-06

Applicant: Thomas R. Jones ,  Caryl Gould

Inventor： Thomas R. Jones ,  Caryl Gould

IPC: C01B33/26 ,  B01J20/16 ,  B01J39/14 ,  B01J47/00 ,  C01B33/38 ,  D21H17/68 ,  C04B38/04 ,  C12N5/00 ,  C12N11/14

CPC classification number: B01J20/16 ,  D21H17/68 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2998 ,  Y10T428/31663

Abstract: A particulate porous material suitable for use as a high surface area column packing material comprises particles substantially all of which are not smaller than 5 micrometers and not larger than 1 millimeter in diameter, and each particle is in the form of a substantially cellular body and consists predominantly of an open, three-dimensional matrix of crystals of mullite which define between them interconnecting pores having a width in the range of from 5 nanometers to about 2 micrometers. The particles can be coated with a reactive layer. There is also disclosed a process for producing the particulate porous material wherein a particulate product comprising particles substantially all of which are between 5 micrometers and 1 millimeter in diameter and consisting predominantly of a mixture of mullite crystals and silica is treated with a concentrated aqueous solution of an alkali metal hydroxide at a temperature of at least 50.degree. C.; and the treated particulate product is then washed, dewatered and dried. The particulate porous material may be used as a packing material for a chromatographic or ion exchange column, or for performing biochemical separations, and is particularly useful for immobilizing biological components such as biological macromolecules or biological cells.

Abstract translation: 适合用作高表面积柱填充材料的颗粒状多孔材料包括基本上全部不小于5微米且不大于1毫米直径的颗粒，并且每个颗粒是基本上是细胞体的形式，并且包括 主要是由莫来石晶体的开放三维立方体构成，它们之间形成互连孔，宽度范围为5纳米至约2微米。 颗粒可以涂覆有反应层。 还公开了一种生产颗粒状多孔材料的方法，其中包括颗粒的颗粒产物，其基本上全部直径在5微米至1毫米之间，主要由莫来石晶体和二氧化硅的混合物用浓缩的水溶液 碱金属氢氧化物，温度至少为50℃。 然后将经处理的颗粒产物洗涤，脱水并干燥。 颗粒状多孔材料可以用作色谱或离子交换柱的包装材料，或用于进行生化分离，并且特别适用于固定生物成分如生物大分子或生物细胞。

公开(公告)号：US4569923A

公开(公告)日：1986-02-11

申请号：US551957

申请日：1983-11-15

Applicant: Milburn I. Knudson, Jr. ,  Thomas R. Jones

Inventor： Milburn I. Knudson, Jr. ,  Thomas R. Jones

IPC: C01B33/44 ,  C09C1/42

CPC classification number: C01B33/44

Abstract: An improvement is disclosed for use in the process wherein an organophilic clay is manufactured by reacting a sodium smectite-type clay with a higher alkyl-containing quaternary ammonium compound. According to the improvement of the invention, the gelling properties of the resulting organoclay are enhanced, by subjecting the clay to high energy pugmilling prior to the reaction thereof with the ammonium compound. This is preferably effected by passing the clay at 25 to 40 weight percent moisture content, through a pugmill which imparts at least 20 HP/hrs/ton of energy to the clay, after which the clay is subjected to the prior art processing.

Abstract translation: 公开了一种用于该方法的改进，其中亲水性粘土是通过使钠蒙皂石型粘土与高级烷基季铵化合物反应来制造的。 根据本发明的改进，通过在与铵化合物反应之前对粘土进行高能量的研磨，可以提高所得有机粘土的胶凝性能。 这优选通过使粘土以25-40重量％的水分含量通过将至少20 HP /小时/吨的能量赋予粘土的搅拌机进行，之后将粘土进行现有技术的处理。

公开(公告)号：US4174279A

公开(公告)日：1979-11-13

申请号：US891197

申请日：1978-03-29

Applicant: Norman O. Clark ,  Thomas R. Jones

Inventor： Norman O. Clark ,  Thomas R. Jones

IPC: C04B33/13 ,  B01D21/01

CPC classification number: C04B33/13

Abstract: In a method of dewatering by pressure filtration an aqueous suspension of a clay containing a small proportion of particles having an equivalent spherical diameter smaller than 1 micron, the improvement which comprises treating the aqueous suspension of the clay, prior to dewatering by pressure filtration at a pressure in excess of 150 pounds per square inch, with a water-soluble polyelectrolyte flocculant having a high density of positive charges.

Abstract translation: 在通过压力过滤的含有少量具有小于1微米当量球的小颗粒的粘土的水性悬浮液的脱水方法中，包括处理粘土的水性悬浮液，然后通过在 压力超过150磅/平方英寸，具有高电荷密度的水溶性聚电解质絮凝剂。