公开(公告)号：US06746002B2

公开(公告)日：2004-06-08

申请号：US10138186

申请日：2002-05-03

申请人： Thomas R. Jones

发明人： Thomas R. Jones

IPC分类号： B01D4700

CPC分类号： F02M17/22 ,  F02D19/0655 ,  F02D19/0668 ,  F02M31/18 ,  Y02T10/126 ,  Y02T10/36 ,  Y10S261/83

摘要： A fuel expansion system or carburetor for internal combustion engines utilizing the bubbling of air through use of a number of bubble tubes through a supply of liquid fuel. The resulting atomized, vaporized and expanded fuel is then mixed with air and fed into the engine for combustion.

摘要翻译： 一种用于内燃机的燃料膨胀系统或化油器，其通过使用多个气泡管通过液体燃料的供应而利用空气鼓泡。 然后将所产生的雾化，蒸发和膨胀的燃料与空气混合并供入发动机用于燃烧。

公开(公告)号：US5877004A

公开(公告)日：1999-03-02

申请号：US462334

申请日：1995-06-05

申请人： Thomas R. Jones ,  Viera P. Muzithras ,  Yakov Gluzman

发明人： Thomas R. Jones ,  Viera P. Muzithras ,  Yakov Gluzman

IPC分类号： C07K14/045 ,  C12N7/01 ,  C12N9/24 ,  C12Q1/34 ,  C12Q1/68 ,  C12N15/38

CPC分类号： C07K14/005 ,  C12N9/2402 ,  C12N9/2434 ,  C12Q1/34 ,  C12Q1/68 ,  C12Q1/6897 ,  C12Y302/01031 ,  C12N2710/16122 ,  G01N2333/045

摘要： This invention relates to a method for identifying non-essential genes of the human cytomegalovirus (HCMV) genome through the insertion of a .beta.-glucuronidase marker gene into a specified HCMV gene, such that, if the product of the HCMV gene is not expressed, the gene is identified as non-essential for replication of HCMV. This invention also relates to a method of screening for compounds which inhibit HCMV by the insertion of the .beta.-glucuronidase marker gene into a HCMV gene, such that the enzyme marker is expressed and cleaves a conjugate chemical substrate in an assay system to yield a detectable fluorescing product or to result in a color change. This invention further provides the gene responsible in HCMV early cytopathic effect.

摘要翻译： 本发明涉及通过将β-葡糖醛酸糖苷酶标记基因插入特定HCMV基因中鉴定人巨细胞病毒（HCMV）基因组的非必需基因的方法，使得如果HCMV基因的产物未被表达， 该基因被鉴定为对于HCMV的复制非必需的。 本发明还涉及通过将β-葡糖醛酸糖苷酶标记基因插入到HCMV基因中筛选抑制HCMV的化合物的方法，使得酶标记物在测定系统中表达并切割缀合物化学底物以产生可检测的 荧光产品或导致颜色变化。 本发明还提供了负责HCMV早期致细胞病变作用的基因。

公开(公告)号：US5843637A

公开(公告)日：1998-12-01

申请号：US463175

申请日：1995-06-05

申请人： Thomas R. Jones ,  Viera P. Muzithras ,  Yakov Gluzman

发明人： Thomas R. Jones ,  Viera P. Muzithras ,  Yakov Gluzman

IPC分类号： C07K14/045 ,  C12N7/01 ,  C12N9/24 ,  C12Q1/34 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C07K14/005 ,  C12N9/2402 ,  C12N9/2434 ,  C12Q1/34 ,  C12Q1/68 ,  C12Q1/6897 ,  C12Y302/01031 ,  C12N2710/16122 ,  G01N2333/045

摘要： This invention relates to a method for identifying non-essential genes of the human cytomegalovirus (HCMV) genome through the insertion of a .beta.-glucuronidase marker gene into a specified HCMV gene, such that, if the product of the HCMV gene is not expressed, the gene is identified as non-essential for replication of HCMV. This invention also relates to a method of screening for compounds which inhibit HCMV by the insertion of the .beta.-glucuronidase marker gene into a HCMV gene, such that the enzyme marker is expressed and cleaves a conjugate chemical substrate in an assay system to yield a detectable fluorescing product or to result in a color change. This invention further provides the gene responsible in HCMV early cytopathic effect.

摘要翻译： 本发明涉及通过将β-葡糖醛酸糖苷酶标记基因插入特定HCMV基因中鉴定人巨细胞病毒（HCMV）基因组的非必需基因的方法，使得如果HCMV基因的产物未被表达， 该基因被鉴定为对于HCMV的复制非必需的。 本发明还涉及通过将β-葡糖醛酸糖苷酶标记基因插入到HCMV基因中筛选抑制HCMV的化合物的方法，使得酶标记物在测定系统中表达并切割缀合物化学底物以产生可检测的 荧光产品或导致颜色变化。 本发明还提供了负责HCMV早期致细胞病变作用的基因。

公开(公告)号：US5401407A

公开(公告)日：1995-03-28

申请号：US39045

申请日：1993-04-07

申请人： Thomas R. Jones ,  Reginald L. Phillips ,  Hugh R. Falcon-Steward

发明人： Thomas R. Jones ,  Reginald L. Phillips ,  Hugh R. Falcon-Steward

IPC分类号： B03B5/00 ,  B01D33/15 ,  B03B5/74 ,  B07B1/08 ,  B07B1/46 ,  B07B13/16

CPC分类号： B07B13/16 ,  B01D33/15 ,  B07B1/08

摘要： Apparatus for continuously separating relatively coarse particles from a suspension of a mixture of particles in a liquid, wherein the suspension is caused to pass through a screening medium which is rotating in its own plane and wherein the screening medium extends over and across the upper end of a rotary drum having generally downwardly depending side walls and wherein the side walls diverge outwardly in a downward direction.

摘要翻译： PCT No.PCT / GB91 / 02107 Sec。 371日期：1993年4月7日 102（e）日期1993年4月7日PCT 1991年11月28日PCT PCT。 出版物WO92 / 09375 日期：1992年6月11日。用于从液体中的颗粒混合物的悬浮液中连续分离相对粗糙的颗粒的装置，其中所述悬浮液通过在其自身平面中旋转的筛选介质，并且其中所述筛选介质延伸 在具有大致向下悬垂的侧壁的旋转滚筒的上端并跨过其顶端，并且其中侧壁沿向下的方向向外发散。

公开(公告)号：US5232678A

公开(公告)日：1993-08-03

申请号：US736488

申请日：1991-07-26

申请人： Ian S. Bleakley ,  Thomas R. Jones

发明人： Ian S. Bleakley ,  Thomas R. Jones

IPC分类号： C01F11/18 ,  C04B2/06 ,  C09C1/02 ,  C09C3/08 ,  D21H17/67 ,  D21H19/38

CPC分类号： C01F11/183 ,  C09C1/021 ,  C09C3/08 ,  D21H17/675 ,  D21H19/385 ,  C01P2002/10 ,  C01P2002/30 ,  C01P2004/54 ,  C01P2006/12 ,  C01P2006/60

摘要： The calcium carbonate is prepared by:(a) slaking quicklime in an aqueous medium;(b) carbonating and neutralizing the suspension of slaked lime formed in step (a) using a gas comprising carbon dioxide; and(c) separating the precipitated calcium carbonate formed in step (b) from the aqueous medium in which it is suspended. There is added 0.01% to 15% by weight, based on the weight of dry calcium oxide, of a reagent having one or more active hydrogen atoms (or a salt thereof), to the aqueous medium in which the quicklime is slaked in step (a).The reagent is selected from the group consisting of triethanolamine, mannitol, diethanolamine, bicine, morpholine, tri-isopropanolamine, N-ethyl diethanolamine, N,N-diethylethanolamine and sodium boroheptonate.

公开(公告)号：US5081145A

公开(公告)日：1992-01-14

申请号：US473551

申请日：1990-02-01

申请人： Yvan Guindon ,  John W. Gillard ,  Christiane Yoakim ,  Thomas R. Jones ,  Rejean Fortin

发明人： Yvan Guindon ,  John W. Gillard ,  Christiane Yoakim ,  Thomas R. Jones ,  Rejean Fortin

IPC分类号： C07D209/22

CPC分类号： C07D209/22

摘要： Indole-2-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, inflammation, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dismenorrhea and as cytoprotective agents.

摘要翻译： 吲哚-2-链烷酸被公开。 化合物作为前列腺素和血栓素拮抗剂，可用于治疗哮喘，炎症，腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产和死亡以及细胞保护剂。

公开(公告)号：US4963436A

公开(公告)日：1990-10-16

申请号：US229649

申请日：1988-08-08

申请人： Thomas R. Jones ,  Caryl Gould

发明人： Thomas R. Jones ,  Caryl Gould

IPC分类号： C01B33/26 ,  B01J20/16 ,  B01J39/14 ,  B01J47/00 ,  C01B33/38 ,  D21H17/68

CPC分类号： B01J20/16 ,  D21H17/68 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2998 ,  Y10T428/31663

摘要： A particulate porous material suitable for use as a high surface area column packing material comprises particles substantially all of which are not smaller than 5 micrometers and not larger than 1 millimeter in diameter, and each particle is in the form of a substantially cellular body and consists predominantly of an open, three-dimensional matrix of crystal of mullite which define between them interconnecting pores having a width in the range of from 5 nanometers to about 2 micrometers. The particles can be coated with a reactive layer. There is also disclosed a process for producing the particulate porous material wherein a particulate product comprising particles substantially all of which are between 5 micrometers and 1 millimeter in diameter and consisting predominantly of a mixture of mullite crystals and silica is treated with a concentrated aqueous solution of an alkali metal hydroxide at a temperature of at least 50.degree. C.; and the treated particulate product is then washed, dewatered and dried. The particulate porous material may be used as a packing material for a chromatographic or ion exchange column, or for performing biochemical separations, and is particularly useful for immobilizing biological components such as biological macromolecules or biological cells.

公开(公告)号：US4664842A

公开(公告)日：1987-05-12

申请号：US771477

申请日：1985-09-03

申请人： Milburn I. Knudson, Jr. ,  Thomas R. Jones

发明人： Milburn I. Knudson, Jr. ,  Thomas R. Jones

IPC分类号： C01B33/44 ,  C10M113/16 ,  B01J13/00 ,  C07F5/06

CPC分类号： C01B33/44 ,  C10M113/16 ,  C10M2201/14 ,  C10M2215/04 ,  C10M2215/26

摘要： An improvement is disclosed for use in the process wherein an organophilic clay is manufactured by reacting a smectite-type clay with a higher alkyl-containing quarternary ammonium compound. According to the improvement of the invention, the gelling properties of the resulting organoclay are enhanced, by subjecting the clay as a pumpable slurry, to high-speed fluid shear, prior to the reaction thereof with the ammonium compound.

摘要翻译： 公开了一种用于该方法的改进，其中亲水性粘土是通过使蒙皂石型粘土与高级烷基季铵化合物反应来制造的。 根据本发明的改进，通过在与铵化合物反应之前将粘土作为可泵送浆料进行高速流体剪切，所得到的有机粘土的胶凝性能得到提高。

公开(公告)号：US5720957A

公开(公告)日：1998-02-24

申请号：US459586

申请日：1995-06-02

申请人： Thomas R. Jones ,  Ann E. Campbell

发明人： Thomas R. Jones ,  Ann E. Campbell

IPC分类号： C12N15/00 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/245 ,  A61K48/00 ,  A61P31/12 ,  C07K14/045 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/01 ,  C12N15/09 ,  C12N15/34 ,  C12N15/38 ,  C12N15/86 ,  C12N15/861 ,  C12R1/92

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N15/86 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5254 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2710/16151 ,  C12N2710/16161 ,  C12N2710/16162

摘要： Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which failed to down regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down regulation. In subregion B, the US11 gene product is involved. It encodes a endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.

摘要翻译： 用人巨细胞病毒（HCMV）感染人成纤维细胞导致I类MHC细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放阅读框 IRS1-US9和US11），其不能下调I类重链。 通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。 此外，确定了7-kb区域的两个亚区（A和B）各自含有足以引起重链下调的基因。 在次区域B中，涉及US11基因产物。 它编码胞质内H敏感的糖蛋白，其是胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

公开(公告)号：US5382370A

公开(公告)日：1995-01-17

申请号：US39046

申请日：1993-04-07

申请人： Thomas R. Jones ,  Reginald L. Phillips ,  Hugh R. Falcon-Steward

发明人： Thomas R. Jones ,  Reginald L. Phillips ,  Hugh R. Falcon-Steward

IPC分类号： B01D33/15 ,  B01D33/27 ,  B03B5/00 ,  B03B5/56 ,  B07B1/00 ,  B07B1/08 ,  B07B13/16 ,  B01D33/06 ,  B01D33/56 ,  B01D33/82

CPC分类号： B07B13/16 ,  B01D33/15 ,  B07B1/00 ,  B07B1/08 ,  Y10S209/906

摘要： A process for continuously separating relatively coarse particles from a suspension of a mixture of particles in a liquid wherein the suspension is caused to pass through a screening medium which is rotating in its own plane so that the coarse particles are retained on the surface of the screening medium; characterized in that atmospheric pressure above the screening medium is caused to be in excess of the pressure below that medium.

摘要翻译： PCT No.PCT / GB91 / 02106 Sec。 371日期：1993年4月7日 102（e）日期1993年4月7日PCT 1991年11月28日PCT PCT。 出版物WO92 / 09743 日期：1992年6月11日。一种用于将液体中的颗粒混合物的悬浮液中的相对粗粒子连续分离的方法，其中使悬浮液通过在其自身平面中旋转的筛分介质，使得粗颗粒为 保留在筛选介质的表面上; 其特征在于使筛选介质上方的大气压力超过该介质以下的压力。