公开(公告)号：US5612197A

公开(公告)日：1997-03-18

申请号：US442756

申请日：1995-05-17

申请人： Toyoo Ohda ,  Wataru Ohtani ,  Tomoshi Ohya ,  Shinobu Kuwae ,  Kenji Tomomitsu ,  Kaoru Kobayashi ,  Takao Ohmura

发明人： Toyoo Ohda ,  Wataru Ohtani ,  Tomoshi Ohya ,  Shinobu Kuwae ,  Kenji Tomomitsu ,  Kaoru Kobayashi ,  Takao Ohmura

IPC分类号： C12P21/00 ,  C07K14/765 ,  C12N1/19 ,  C12P21/02 ,  C12R1/84

CPC分类号： C12P21/02 ,  C07K14/765

摘要： A process for producing recombinant human serum albumin is disclosed, which comprises culturing a human serum albumin-producing host, prepared by gene manipulation techniques in a medium that contains an amino acid, preferably at least one amino acid selected from the group consisting of alanine, aspartic acid, glutamic acid, histidine, serine, tryptophan, valine, isoleucine, phenylalanine, cysteine and arginine, more preferably histidine. The process can significantly increase the yield of human serum albumin over that produced by known processes.

摘要翻译： 公开了一种生产重组人血清白蛋白的方法，其包括在含有氨基酸的培养基中培养产生人血清白蛋白的宿主，其通过基因操纵技术制备，优选至少一种选自丙氨酸， 天冬氨酸，谷氨酸，组氨酸，丝氨酸，色氨酸，缬氨酸，异亮氨酸，苯丙氨酸，半胱氨酸和精氨酸，更优选组氨酸。 该方法可以显着提高人血清白蛋白与已知方法产生的产量。

公开(公告)号：US5512705A

公开(公告)日：1996-04-30

申请号：US625374

申请日：1990-12-11

申请人： Kaoru Kobayashi

发明人： Kaoru Kobayashi

IPC分类号： G10H1/00 ,  G10H5/00 ,  G10H7/00 ,  G10H7/08 ,  H03G3/00

CPC分类号： G10H5/007 ,  Y10T24/45576 ,  Y10T24/45581

摘要： A musical tone synthesizing apparatus generates musical tones of acoustic musical instrument which has operator like a hammer, and a vibrating element such as a string or a vibrating plate. The apparatus has a loop circuit which comprises at least two delays of which total delay time of the two delays corresponds to pitch of a musical tone, a propagating circle for simulating the vibrating element, an exciting signal generator which generates signal in accordance with a non-linear relation between the operator and the vibrating element, and a delay controller which controls a ratio of the delay time between the two delays. By varying the ratio, the apparatus realizes the characteristics of the vibration in the vibrating elements of which struck positions by the operator change in accordance with pitch of tones to thereby generates musical tones with fidelity.

摘要翻译： 音乐合成装置产生具有锤子的操作者的乐器乐器，以及弦或振动板等振动元件。 该装置具有环路电路，其包括至少两个延迟，其中两个延迟的总延迟时间对应于音调的音调，用于模拟振动元件的传播圆，用于根据非音调产生信号的激励信号发生器 操作者和振动元件之间的线性关系，以及延迟控制器，其控制两个延迟之间的延迟时间的比率。 通过改变比例，装置实现了由操作者根据音调的音调而改变的振动元件的振动特性，从而以保真度产生乐音。

公开(公告)号：US5334512A

公开(公告)日：1994-08-02

申请号：US854841

申请日：1992-03-20

申请人： Kaoru Kobayashi ,  Shinobu Kuwae ,  Tomoshi Ooya ,  Hirotoshi Fukutsuka ,  Akinori Sumi ,  Wataru Ohtani ,  Takao Ohmura ,  Kazumasa Yokoyama

发明人： Kaoru Kobayashi ,  Shinobu Kuwae ,  Tomoshi Ooya ,  Hirotoshi Fukutsuka ,  Akinori Sumi ,  Wataru Ohtani ,  Takao Ohmura ,  Kazumasa Yokoyama

IPC分类号： C07K14/765 ,  C12N1/16 ,  C12N1/19 ,  C12N15/09 ,  C12N15/14 ,  C12P21/00 ,  C12R1/84 ,  C12N1/38 ,  C12N15/81 ,  C12P21/02

CPC分类号： C07K14/765 ,  C12N1/16

摘要： A method for producing human serum albumin which comprises cultivating a human serum albumin-producing host prepared by genetic engineering, in a medium containing a fatty acid having 10 to 26 carbon atoms, or its salt, and a method for cultivating the host. HSA production can be greatly increased by the present invention.

摘要翻译： 一种生产人血清白蛋白的方法，包括在含有10-26个碳原子的脂肪酸的培养基或其盐中培养通过基因工程制备的人血清白蛋白生产宿主及其培养方法。 通过本发明可以大大增加HSA的生产。

公开(公告)号：US5241127A

公开(公告)日：1993-08-31

申请号：US633051

申请日：1990-12-20

申请人： Kaoru Kobayashi

发明人： Kaoru Kobayashi

IPC分类号： G10H5/00

CPC分类号： G10H5/007 ,  G10H2250/451 ,  G10H2250/515 ,  G10H2250/521 ,  Y10S84/09 ,  Y10S84/10

摘要： The musical tone synthesizing apparatus simulating the musical tones of a natural musical instrument such as a piano. The apparatus contains a closed-loop circuit for simulating the vibration mechanism of the strings and a excitation circuit for generating excitation signals to the closed-loop circuit, so that the excitation circuit simulates the hammer striking the string. The apparatus also contains a scaling coefficient generating circuit for generating and supplying scaling coefficients to the excitation circuit, where the scaling coefficients represent the influence rate corresponding to the influence to be applied to the hammer by the string. In the excitation circuit, the excitation signals are multiplied by the scaling coefficients so that a slight difference of tone color is applied to the excitation signals with respect to tone pitch (or each key). For example, the scaling coefficient for comparatively lower tone pitch is set at a comparatively small value, because the hammer for lower tone pitch has relatively rounder shape and larger mass, and the felt thereof is formed relatively thicker, while the scaling coefficients for comparatively higher tone pitch is set at a comparatively large value. For this reason, the musical tone synthesizing apparatus generates a musical tone of which tone color is slightly different with respect to each tone pitch.

摘要翻译： 用于模拟钢琴等自然乐器的音调的乐音合成装置。 该装置包含用于模拟串的振动机制的闭环电路和用于向闭环电路产生激励信号的激励电路，使得励磁电路模拟撞击串的锤。 该装置还包括缩放系数产生电路，用于产生并向激励电路提供缩放系数，其中缩放系数表示与由弦施加到锤的影响相对应的影响速率。 在激励电路中，激励信号与缩放系数相乘，使得对于音调音调（或每个键）的激励信号，稍微的音色差异被施加。 例如，由于用于较低音调的音锤具有相对较大的形状和较大的质量，并且其毛毡形成得相对较厚，因此相对较低音调音调的缩放系数被设置为相对较小的值，而比例系数相对较高 色调设定为较大的值。 为此，乐音合成装置产生音色相对于每个音高略微不同的乐音。

公开(公告)号：US5229860A

公开(公告)日：1993-07-20

申请号：US580918

申请日：1990-09-11

申请人： Koichi Kido ,  Kaoru Kobayashi

发明人： Koichi Kido ,  Kaoru Kobayashi

IPC分类号： G02F1/133 ,  G09G3/36 ,  H04N5/21 ,  H04N5/66 ,  H04N9/64

CPC分类号： G09G3/3611 ,  H04N5/21 ,  H04N9/646 ,  G09G2320/0252 ,  G09G2320/0261 ,  G09G2340/16

摘要： An afterimage elimination circuit for a liquid crystal display apparatus provides a substantial improvement of the transient response characteristics of the liquid crystal display elements, by adding to an input video signal of the display apparatus a compensation signal, derived from that video signal, having a transient response that is determined in accordance with whether a change in the input video signal level will result in an increase or decrease of electric field strength applied to the display elements, to thereby achieve optimum compensation for both rise time and fall time response of the display elements.

摘要翻译： 用于液晶显示装置的余像消除电路通过向显示装置的输入视频信号添加从该视频信号导出的具有瞬变的补偿信号，提供了液晶显示元件的瞬态响应特性的实质性改善 响应是根据输入视频信号电平的变化是否导致施加到显示元件的电场强度的增加或减小而确定的，从而对显示元件的上升时间和下降时间响应都实现最佳补偿 。

公开(公告)号：US5187314A

公开(公告)日：1993-02-16

申请号：US634032

申请日：1990-12-26

申请人： Toshifumi Kunimoto ,  Kaoru Kobayashi

发明人： Toshifumi Kunimoto ,  Kaoru Kobayashi

IPC分类号： G10H1/00 ,  G10H5/00 ,  G10H7/00 ,  G10H7/08

CPC分类号： G10H5/007 ,  G10H2250/451 ,  G10H2250/515 ,  G10H2250/521 ,  Y10S84/26

摘要： A musical tone synthesizing apparatus generates musical tones by simulating the tone generation construction of a plucked-stringed instrument or string-striking type stringed instrument. The apparatus has a closed-loop circuit which simulate a tone generating element of the instrument, an excitation circuit which creates an excitation signal corresponding to the excitation given to the tone generating element in response to the time function. The time function is set in response to operational information of the tone generating operator. The excitation signal is supplied to the closed-loop circuit and circulates around closed-loop circuit and is delayed by a delay circuit having delay interval, and is fed back into the excitation circuit as the state of the tone generating element. By displacing the excitation signal within the predetermined range of time function, the digital computation may not be in the overflow state when computing the relative displacement between the tone generating element and the tone generating operator, and thus control stability of the excitation circuit can be obtained.

摘要翻译： 乐音合成装置通过模拟采摘乐器或弦式打弦乐器的乐音产生结构来产生乐音。 该装置具有模拟乐器的乐音产生元件的闭环电路，激励电路响应于时间功能产生对应于音调发生元件的激励的激励信号。 响应于乐音产生操作者的操作信息设置时间功能。 励磁信号被提供给闭环电路并在闭环电路周围循环，并被具有延迟间隔的延迟电路延迟，并作为音调发生元件的状态反馈到激励电路。 通过在时间函数的预定范围内移位激励信号，当计算音调生成元件和乐音发生操作者之间的相对位移时，数字计算可能不处于溢出状态，从而可以获得激励电路的控制稳定性 。

公开(公告)号：US20120194277A1

公开(公告)日：2012-08-02

申请号：US13353942

申请日：2012-01-19

申请人： Kazuo AKAIKE ,  Kaoru Kobayashi

发明人： Kazuo AKAIKE ,  Kaoru Kobayashi

IPC分类号： H03L9/00

CPC分类号： H03L1/026 ,  H03L7/18

摘要： To perform, in an oscillation device compensating an output frequency based on a detection result of ambient temperature, temperature compensation of the output frequency with high accuracy. First and second quartz-crystal oscillators are structured by using a common quartz-crystal piece, and when oscillation outputs of first and second oscillation circuits respectively connected to these quartz-crystal oscillators are set to f1, f2, and oscillation frequencies of the first and the second oscillation circuits at a reference temperature are set to f1r, f2r, respectively, a frequency difference being a difference between a value corresponding to a difference between f1 and f1r and a value corresponding to a difference between f2 and f2r is treated as a temperature at that time. Further, based on the frequency difference, a frequency compensation value is determined through polynomial approximation.

摘要翻译： 要在基于环境温度的检测结果对输出频率进行补偿的振荡装置中，以高精度进行输出频率的温度补偿。 第一和第二石英晶体振荡器通过使用共同的石英晶体片构成，并且当分别连接到这些石英晶体振荡器的第一和第二振荡电路的振荡输出被设置为f1，f2，以及第一和第二晶体振荡器的振荡频率 将参考温度下的第二振荡电路分别设定为f1r，f2r，将与f1和f1r之间的差值相对应的值与f2和f2r之间的差对应的频率差作为温度 那时候。 此外，基于频率差，通过多项式近似来确定频率补偿值。

公开(公告)号：US08155172B2

公开(公告)日：2012-04-10

申请号：US12213983

申请日：2008-06-26

申请人： Kaoru Kobayashi ,  Shigeru Takegishi

发明人： Kaoru Kobayashi ,  Shigeru Takegishi

IPC分类号： H04B1/00

CPC分类号： H04B1/7093 ,  H04B1/7075

摘要： Provided is a matched filter whose circuit scale can be made significantly smaller by reducing the number of multipliers for a despreading process and the number of adders for an accumulating process. For each in-phase/orthogonal component, the matched filter includes a dual-port RAM that separates written samples into 128 groups each of 32 samples which are collectively read out group by group in order at a speed faster than a write speed in write mode, a bit separating section that separates data read group by group into 32 samples and simultaneously outputs the 32 samples, and 32 despreading/accumulating circuits that, with 16 samples sequentially input from 16 groups being taken as one block, sequentially despread individual samples, accumulate despreading results, and output accumulated values for each block. The matched filter further includes an accumulating section that accumulates absolute values for each block from in-phase/orthogonal outputs of the despreading/accumulating circuits, and outputs correlation value data.

摘要翻译： 提供了一种匹配滤波器，其通过减少用于解扩处理的乘法器的数量和用于累积处理的加法器的数量，可以使其电路规模显着更小。 对于每个同相/正交分量，匹配滤波器包括双端口RAM，其将写入样本分成128组，每组32个采样中的每一个采样速率比写入模式的速度快 ，将数据逐个分组分离成32个样本并同时输出32个样本的位分离部分，以及从16个组顺序输入的16个样本作为一个块的32个解扩/累加电路，依次解扩个别样本，累积 解扩结果，并输出每个块的累积值。 匹配滤波器还包括累积部分，其累加解扩/累积电路的同相/正交输出中的每个块的绝对值，并输出相关值数据。

公开(公告)号：US08088802B2

公开(公告)日：2012-01-03

申请号：US12603194

申请日：2009-10-21

申请人： Atsushi Naganawa ,  Tetsuji Saito ,  Kaoru Kobayashi ,  Takayuki Maruyama ,  Yoshihiko Nakai ,  Shinsuke Hashimoto

发明人： Atsushi Naganawa ,  Tetsuji Saito ,  Kaoru Kobayashi ,  Takayuki Maruyama ,  Yoshihiko Nakai ,  Shinsuke Hashimoto

IPC分类号： A61K31/41 ,  C07D421/00 ,  C07D417/00 ,  C07D413/00 ,  C07D285/08 ,  C07D271/06 ,  C07D257/04 ,  C07D307/00

CPC分类号： C07D213/70 ,  C07D277/36 ,  C07D307/64 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.

摘要翻译： 式（I）的N-苯基芳基磺酰胺化合物（R1是COOH等; R2是氢，甲基等; R3和R4是甲基和甲基的组合等; R5是异丙基等; Ar是噻唑基， 吡啶基，5-甲基-2-呋喃基，各自任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。 式（I）化合物结合前列腺素E2受体，特别是EP1亚型受体，并拮抗它。 蛋白质结合的影响较小，因此具有令人满意的体内活性。 因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

公开(公告)号：US07336556B2

公开(公告)日：2008-02-26

申请号：US10519895

申请日：2003-07-02

申请人： Katsumi Okayama ,  Kaoru Kobayashi ,  Makoto Motoyoshi

发明人： Katsumi Okayama ,  Kaoru Kobayashi ,  Makoto Motoyoshi

IPC分类号： G11C8/02

CPC分类号： G11C11/16 ,  H01L27/228 ,  Y10S977/935

摘要： A non-volatile magnetic memory device is proposed, which provides sufficient magnetic shielding performance for external magnetic fields. A first magnetic shield layer 60a and a second magnetic shield layer 60b, both made of a soft magnetic metal, are formed respectively on the bottom surface of the transistor section 20, which is the mounting side of the MRAM device 10, and on the top surface of the bit line 50, which is opposite to the bottom surface of the mounting side of the MRAM device 10. On the second magnetic shield layer 60a, a passivation film 70 is formed. The magnetic flux penetrated from the external magnetic field, is suppressed below the inversion strength of the MRAM device 10, thereby improving reliability. Moreover, by using soft magnetic metal as the magnetic shield layers 60a, 60b, the magnetic shield layers can be formed by the sputtering technique, particularly composing elements can be partly shared as elements of the targets to be used for forming various layers composing the MRAM device 10 by the sputtering technique, thereby enabling to form various layers of the MRAM device 10 in a single sputtering chamber efficiently.

摘要翻译： 提出了一种非易失性磁存储器件，为外部磁场提供了足够的磁屏蔽性能。 分别在作为MRAM器件10的安装侧的晶体管部分20的底表面上分别形成由软磁性金属制成的第一磁屏蔽层60a和第二磁屏蔽层60b，并且在 位线50的与MRAM装置10的安装侧的底面相反的顶面。 在第二磁屏蔽层60a上形成钝化膜70。 从外部磁场穿透的磁通被抑制在MRAM装置10的反转强度以下，从而提高可靠性。 此外，通过使用软磁性金属作为磁屏蔽层60a，60b，可以通过溅射技术形成磁屏蔽层，特别地，组成元件可以部分地作为用于形成构成各种层的靶的元素 MRAM器件10通过溅射技术，从而能够有效地在单个溅射室中形成MRAM器件10的各个层。