利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

46 条记录 (耗时 0.021 秒)

    Crystallized P38 complexes
    32.
    发明授权
    Crystallized P38 complexes 有权
    结晶P38复合物

    公开(公告)号：US06387641B1

    公开(公告)日：2002-05-14

    申请号：US09457040

    申请日：1999-12-08

    申请人： Steven Bellon ,  Guy Bemis ,  Keith Wilson ,  Matthew Fitzgibbon

    发明人： Steven Bellon ,  Guy Bemis ,  Keith Wilson ,  Matthew Fitzgibbon

    IPC分类号： C12Q148

    CPC分类号： C12N9/1205

    摘要： This invention provides certain crystallized, protein kinase-ligand complexes, in particular P38-ligand complexes, and their structure coordinates. The structure coordinates are based on the structure of a phosphorylated P38&ggr; complex which has now been solved and which reveals new structural information useful for understanding the activated states of other, related kinase proteins as described herein. The key structural features of the proteins, particularly the shape of the substrate binding site, are useful in methods for designing or identifying selective inhibitors of the protein kinases, particularly P38&ggr; and in solving the structures of other proteins with similar features. The structure coordinates may be encoded in a data storage medium for use with a computer for graphical three-dimensional representation of the structure and for computer-aided molecular design of new inhibitors.

    摘要翻译： 本发明提供某些结晶的蛋白激酶 - 配体复合物，特别是P38-配体复合物及其结构坐标。 结构坐标是基于已经被解决的磷酸化P38γ复合物的结构，并且揭示了可用于理解本文所述其它相关激酶蛋白的活化状态的新结构信息。 蛋白质的关键结构特征，特别是底物结合位点的形状，可用于设计或鉴定蛋白激酶，特别是P38gamma的选择性抑制剂和解决具有相似特征的其它蛋白质的结构的方法。 结构坐标可以编码在用于计算机的数据存储介质中用于结构的图形三维表示和用于新型抑制剂的计算机辅助分子设计。

    Manifold spacer
    33.
    发明授权
    Manifold spacer 失效
    歧管间隔

    公开(公告)号：US06269805B1

    公开(公告)日：2001-08-07

    申请号：US09504423

    申请日：2000-02-15

    申请人： Keith Wilson

    发明人： Keith Wilson

    IPC分类号： F02M2510

    CPC分类号： F02M35/10222 ,  F02M25/00 ,  F02M35/10032 ,  F02M35/10085 ,  F02M35/10236 ,  F02M35/10275 ,  F02M35/10301

    摘要： An insert adapted to be placed between a carburetor or a throttle body and an intake manifold of an internal combustion engine is provided with a fuel manifold, a nitrous oxide manifold, and one or more burst diaphragms in a wall of said insert. Said manifolds are arranged one over the other and across an opening in said insert. A plurality of orifices extend along the length of each manifold, and are arranged to direct flow outward, downward, and radially relative to the axial flow of the fuel-oxidizer mixture through the insert.

    摘要翻译： 适于放置在化油器或节气门体和内燃机的进气歧管之间的插入件在所述插入件的壁中设置有燃料歧管，一氧化二氮歧管和一个或多个爆裂隔膜。 所述歧管彼此排列并跨越所述插入件中的开口。 多个孔沿着每个歧管的长度延伸，并且被布置成相对于燃料 - 氧化剂混合物的轴向流动通过插入件向外，向下和径向地引导流动。

    Intake manifold
    34.
    发明授权
    Intake manifold 有权

    公开(公告)号：US09926894B2

    公开(公告)日：2018-03-27

    申请号：US15055773

    申请日：2016-02-29

    申请人： Keith Wilson

    发明人： Keith Wilson

    IPC分类号： F02M35/10 ,  F02M35/104 ,  F02M35/112

    CPC分类号： F02M35/10052 ,  F02M35/10078 ,  F02M35/10085 ,  F02M35/10091 ,  F02M35/10098 ,  F02M35/104 ,  F02M35/1045 ,  F02M35/112 ,  Y02T10/146

    摘要： A bolt-on replacement intake manifold has an asymmetrical plenum with a first end including an inlet, a closed terminal end, a concave top surface and a convex bottom surface; a flange; and a plurality of runners extending from the bottom surface of the plenum and terminating at the flange. The plenum defines an interior space in flow communication with the runners. The bottom surface of the plenum is wider than the top surface. The plenum initially widens from the inlet to the first runner and then begins to narrow from the first runner toward the last runner adjacent to the closed terminal end. The runners are tapered, curved, and vary in length. The intake manifold causes air to exit each of the plurality of runners at substantially the same angle. The manifold balances airflow across each runner and increases swirl inside the cylinders enhancing fuel economy, power output, and torque.

    System and method for reference number expansion
    36.
    发明授权
    System and method for reference number expansion 有权
    用于参考号扩展的系统和方法

    公开(公告)号：US08171037B1

    公开(公告)日：2012-05-01

    申请号：US11461728

    申请日：2006-08-01

    申请人： Scott Steen ,  Keith Wilson ,  James Lutz

    发明人： Scott Steen ,  Keith Wilson ,  James Lutz

    IPC分类号： G06F17/30

    CPC分类号： G06Q10/105

    摘要： Method and system are disclosed for expanding a reference number range without altering existing data storage length. Such reference numbers may include employee numbers, social security numbers, customer account numbers, and the like. The method/system takes advantage of the way decimal numbers are stored by computers to allow text to be used in numeric reference numbers. In one implementation, letters A-Z are used for the leftmost position, increasing the domain count of reference numbers from 10 to 36 for that position. A reference number expansion utility is then used to convert the additional reference numbers to and from the existing data storage format.

    摘要翻译： 公开了扩展参考号码范围而不改变现有数据存储长度的方法和系统。 这样的参考号码可以包括雇员号码，社会保险号码，客户帐号等。 方法/系统利用计算机存储的十进制数字的方式来允许在数字参考号中使用文本。 在一个实现中，字母A-Z用于最左边的位置，将该位置的参考号的域计数从10增加到36。 然后使用参考号码扩展实用程序将附加参考号码与现有数据存储格式进行转换。

    System and method for thermophilic anaerobic digester process
    37.
    发明申请
    System and method for thermophilic anaerobic digester process 审中-公开
    用于嗜热厌氧消化器的系统和方法

    公开(公告)号：US20100155313A1

    公开(公告)日：2010-06-24

    申请号：US12581527

    申请日：2009-10-19

    申请人： Keith Wilson ,  Jeff Stubbings ,  Rod Wade ,  Robert Knoop

    发明人： Keith Wilson ,  Jeff Stubbings ,  Rod Wade ,  Robert Knoop

    IPC分类号： C02F11/04 ,  C02F103/20 ,  C02F101/30

    CPC分类号： C02F11/04 ,  B09B3/00 ,  C02F2209/005 ,  C02F2209/02 ,  C02F2209/06 ,  C02F2209/10 ,  C02F2301/106 ,  C12M21/04 ,  C12M27/06 ,  C12M27/20 ,  C12M41/18 ,  C12M45/20 ,  Y02E50/343

    摘要： A new approach is proposed that contemplates systems and methods to support an environmentally-friendly, “green” thermophilic anaerobic digestion system. The system includes a thermophilic anaerobic digester as well as various independent modular anaerobic units to generate bio-methane from certain organic energy sources, including but not limited to, among other things, green municipal waste, restaurant and organic waste and effluents from industries such as breweries, grocery stores, food processing plants, granaries, wineries, pulp and paper mills, ethanol and biodiesel plants, fat and animal rendering, agricultural field crops, organic sludge accumulation within lagoons and waterways, marine organic matter and animal manure.

    摘要翻译： 提出了一种新方法，其中考虑了支持环保型“绿色”嗜热厌氧消化系统的系统和方法。 该系统包括嗜热厌氧消化器以及各种独立的模块化厌氧单元，以从某些有机能源产生生物甲烷，包括但不限于绿色城市废物，餐馆和有机废物以及来自行业的废水 啤酒厂，杂货店，食品加工厂，粮仓，酿酒厂，造纸厂，乙醇和生物柴油厂，脂肪和动物饲养，农田作物，泻湖和水道内的有机污泥积聚，海洋有机物和动物粪便。

    Apparatus and Method for Programming a Pacemaker
    38.
    发明申请
    Apparatus and Method for Programming a Pacemaker 有权
    用于编程起搏器的装置和方法

    公开(公告)号：US20090069859A1

    公开(公告)日：2009-03-12

    申请号：US11572339

    申请日：2005-07-21

    申请人： Zachary Ian Whinnett ,  Darrel P. Francis ,  Justin E. R. Davies ,  Keith Wilson ,  Jamil Mayet

    发明人： Zachary Ian Whinnett ,  Darrel P. Francis ,  Justin E. R. Davies ,  Keith Wilson ,  Jamil Mayet

    IPC分类号： A61N1/362

    CPC分类号： A61N1/37235 ,  A61B5/02241 ,  A61B5/024 ,  A61B5/7207 ,  A61B5/721 ,  A61N1/3627

    摘要： A pacemaker optimising apparatus comprising: a component (4) which noninvasively or invasively monitors a haemodynamic measurement continuously in an individual and a processor (15) for receiving the haemodynamic measure and generating a pacemaker programming signal in response to this. There is also provided a communication device (17) for sending the pacemaker programming signal to the control system of the pacemaker (2). There is also a method for an efficient process by which this apparatus can automatically use the haemodynamic measurements to determine the ideal settings for a particular pacemaker in a particular individual, and to updates the pacemaker's settings accordingly.

    摘要翻译： 一种起搏器优化装置，包括：组件（4），其在个体中不间断地或不间断地监测血液动力学测量，以及处理器（15），用于接收血液动力学测量并响应于此产生起搏器编程信号。 还提供了一种用于将起搏器编程信号发送到起搏器（2）的控制系统的通信装置（17）。 还有一种有效方法的方法，通过该方法，该装置可以自动使用血液动力学测量来确定特定个体中特定起搏器的理想设置，并相应地更新起搏器的设置。

    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
    40.
    发明申请
    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
    包含IMPDH样结合袋的分子和能够图形显示它们的编码数据存储介质

    公开(公告)号：US20070124083A1

    公开(公告)日：2007-05-31

    申请号：US11645289

    申请日：2006-12-21

    申请人： Keith Wilson ,  Michael Sintchak ,  Mark Fleming ,  David Armistead

    发明人： Keith Wilson ,  Michael Sintchak ,  Mark Fleming ,  David Armistead

    IPC分类号： G06F19/00

    CPC分类号： C12Q1/32 ,  C07K2299/00 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。