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公开(公告)号：US20110060400A1
公开(公告)日：2011-03-10
申请号：US12945684
申请日：2010-11-12
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/0077 , A61F2/90 , A61F2/915 , A61F2002/3008 , A61F2002/30329 , A61F2002/828 , A61F2002/91508 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91583 , A61F2210/0076 , A61F2220/0025 , A61F2230/0054 , A61F2240/001 , A61F2250/0068 , A61F2250/0098
摘要： A crack-resistant endoprosthesis for delivery in a body lumen can be comprised of a multilayered material. The multilayered material can include at least two layers having a boundary layer therebetween. The boundary layer is configured to inhibit cracks from propagating from a first layer-to a second layer. The different layers can be comprised of the same materials or different materials. It can be preferred that the multilayered material have layers that are comprised of resiliently-flexible materials, shape memory materials, and/or radiopaque materials.
摘要翻译： 用于在体腔中输送的抗裂内固定物可以由多层材料构成。 多层材料可以包括其间具有边界层的至少两层。 边界层被配置为抑制裂纹从第一层传播到第二层。 不同的层可以由相同的材料或不同的材料组成。 可以优选的是，多层材料具有由弹性柔性材料，形状记忆材料和/或不透射线材料构成的层。
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公开(公告)号：US07837726B2
公开(公告)日：2010-11-23
申请号：US11375381
申请日：2006-03-13
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/0077 , A61F2/90 , A61F2/915 , A61F2002/3008 , A61F2002/30329 , A61F2002/828 , A61F2002/91508 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91583 , A61F2210/0076 , A61F2220/0025 , A61F2230/0054 , A61F2240/001 , A61F2250/0068 , A61F2250/0098
摘要： A crack-resistant endoprosthesis for delivery in a body lumen can be comprised of a multilayered material. The multilayered material can include at least two layers having a boundary layer therebetween. The boundary layer is configured to inhibit cracks from propagating from a first layer-to a second layer. The different layers can be comprised of the same materials or different materials. It can be preferred that the multilayered material have layers that are comprised of resiliently-flexible materials, shape memory materials, and/or radiopaque materials.
摘要翻译： 用于在体腔中输送的抗裂内固定物可以由多层材料构成。 多层材料可以包括其间具有边界层的至少两层。 边界层被配置为抑制裂纹从第一层传播到第二层。 不同的层可以由相同的材料或不同的材料组成。 可以优选的是，多层材料具有由弹性柔性材料，形状记忆材料和/或不透射线材料构成的层。
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33.发明申请METHODS AND SYSTEMS FOR LASER CUTTING AND PROCESSING TUBING TO MAKE MEDICAL DEVICES 有权用于激光切割和加工管道以制造医疗装置的方法和系统公开(公告)号：US20100193485A1
公开(公告)日：2010-08-05
申请号：US12757842
申请日：2010-04-09
申请人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMore , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf Von Oepen , William E. Webler, JR. , Travis R. Yribarren
发明人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMore , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf Von Oepen , William E. Webler, JR. , Travis R. Yribarren
IPC分类号： B23K26/18
CPC分类号： B23K26/4005 , A61F2/07 , A61F2/91 , B23K26/16 , B23K26/38 , B23K26/40 , B23K26/402 , B23K2101/04 , B23K2101/06 , B23K2103/50
摘要： Methods for making devices include providing a tubular member to be formed into a device, placing a removable sacrificial block material in the lumen of the tubular member and laser cutting the tubular member. A doping material can be added to the melted portion of the tubular member to promote the formation of brittle slag. A fixture can be used to hold a cut workpiece in order to ream sacrificial material from the surface of the workpiece. Pressurized gas can be supplied to the inner lumen of the tubular member to cause slag to form on the outside surface, rather than the inner surface, of the tubular member. A tubular member made from nickel-titanium alloy can be tightly adhered to a sacrificial sleeve utilizing the phase changes associated with nickel-titanium. A rotating mandrel can be placed within the lumen of the tubular member during laser cutting. A mandrel which includes an enlarged diameter section causes the workpiece to expand slightly within its elastic deformation range to dislodge islands from the workpiece. Such a mandrel could be formed from a tubular member which has a central lumen that can be used to deliver a pressurized medium to “blast” islands from the workpiece.
摘要翻译： 制造装置的方法包括提供要形成装置的管状构件，将可移除的牺牲块材料放置在管状构件的内腔中并激光切割管状构件。 可以将掺杂材料添加到管状构件的熔融部分中以促进脆性炉渣的形成。 夹具可用于夹持切割的工件，以便从工件的表面获得牺牲材料。 加压气体可以供应到管状构件的内腔，以在管状构件的外表面而不是内表面上形成炉渣。 利用与镍 - 钛相关联的相变，由镍 - 钛合金制成的管状部件可以紧密地粘附到牺牲套管上。 在激光切割期间，旋转心轴可以放置在管状构件的内腔内。 包括扩大直径部分的心轴使得工件在其弹性变形范围内稍微膨胀以从工件移除岛。 这种心轴可以由管状构件形成，该管状构件具有可用于将加压介质输送到工件的“鼓风”岛的中心腔。
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34.发明申请Expandable Member Having A Covering Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权具有用于腔内药物递送的纤维基质覆盖物的可膨胀构件公开(公告)号：US20100076401A1
公开(公告)日：2010-03-25
申请号：US12237998
申请日：2008-09-25
申请人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
发明人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61L29/085 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , Y10T29/49826
摘要： The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same.
摘要翻译： 本发明一般涉及用于血管成形术和治疗剂递送的管腔内导管装置。 特别地，本发明涉及具有设置在其上的治疗剂的可膨胀构件的导管和用于递送治疗剂的纤维基质覆盖物及其使用方法。
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公开(公告)号：US07578831B2
公开(公告)日：2009-08-25
申请号：US11474111
申请日：2006-06-23
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1045 , A61M2025/1056 , A61M2025/107 , A61M2029/025
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译： 描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。 导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。 柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。 可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。 在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。 通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。 通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。
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36.发明申请公开(公告)号：US20080319528A1
公开(公告)日：2008-12-25
申请号：US11958311
申请日：2007-12-17
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2002/826 , A61F2002/828 , A61F2002/91508 , A61F2002/91516 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2220/0075 , A61F2250/0031 , A61F2250/0071
摘要： A modular endoprosthesis is configured to have improved flexibility during and after deployment by having separate endoprosthetic modules that are interconnected by flexible interconnectors. The modular endoprosthesis includes a plurality of separate endoprosthetic modules positioned adjacently so that a first end of a first endoprosthetic module is adjacent to an end of a second endoprosthetic module and a second end of the first endoprosthetic module is adjacent to an end of a third endoprosthetic module. Additionally, the modular endoprosthesis includes a plurality of flexible interconnectors coupled to the plurality of separate endoprosthetic modules so as to interconnect the first end of the first endoprosthetic module with the end of the second endoprosthetic module with a first flexible interconnector, and interconnect the second end of the first endoprosthetic module with the end of the third endoprosthetic module with a second flexible interconnector.
摘要翻译： 模块化内假体被配置为通过具有通过柔性互连器互连的单独的假体内模块来在部署期间和之后具有改善的灵活性。 模块化内假体包括多个分开的假体内模块，其相邻设置，使得第一内假体模块的第一端邻近第二内假体模块的端部，并且第一内假体模块的第二端邻近第三内假体的端部 模块。 另外，模块化内置假体包括耦合到多个单独的内假体模块的多个柔性互连器，以便将第一假体内模块的第一端与第二假体内模块的端部与第一柔性互连器相互连接，并将第二端 的第一假体内模块，其具有第二柔性互连器的第三假体内模块的端部。
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公开(公告)号：US08779328B2
公开(公告)日：2014-07-15
申请号：US12757842
申请日：2010-04-09
申请人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMorre , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf von Oepen , William E. Webler, Jr. , Travis R. Yribarren
发明人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMorre , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf von Oepen , William E. Webler, Jr. , Travis R. Yribarren
CPC分类号： B23K26/4005 , A61F2/07 , A61F2/91 , B23K26/16 , B23K26/38 , B23K26/40 , B23K26/402 , B23K2101/04 , B23K2101/06 , B23K2103/50
摘要： Methods for making devices include providing a tubular member to be formed into a device, placing a removable sacrificial block material in the lumen of the tubular member and laser cutting the tubular member. A tubular member made from nickel-titanium alloy can be tightly adhered to a sacrificial sleeve utilizing the phase changes associated with nickel-titanium. A mandrel which includes an enlarged diameter section causes the workpiece to expand slightly within its elastic deformation range to dislodge islands from the workpiece. Such a mandrel could be formed from a tubular member which has a central lumen that can be used to deliver a pressurized medium to “blast” islands from the workpiece.
摘要翻译： 制造装置的方法包括提供要形成装置的管状构件，将可移除的牺牲块材料放置在管状构件的内腔中并激光切割管状构件。 利用与镍 - 钛相关联的相变，由镍 - 钛合金制成的管状部件可以紧密地粘附到牺牲套管上。 包括扩大直径部分的心轴使得工件在其弹性变形范围内稍微膨胀以从工件移除岛。 这种心轴可以由管状构件形成，该管状构件具有可用于将加压介质输送到工件的“鼓风”岛的中心腔。
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公开(公告)号：US20120065719A1
公开(公告)日：2012-03-15
申请号：US13220123
申请日：2011-08-29
CPC分类号： A61F2/0095 , A61F2002/9505 , A61F2002/9583 , A61F2002/9665
摘要： Device shields for packaging and protecting medical devices during storage and deployment. A device shield includes a body or housing configured to maintain a medical device and at least a portion of a medical device delivery apparatus within the body or housing, and a limit element having a first constraining position and a second open position.
摘要翻译： 在存储和部署期间用于包装和保护医疗设备的设备屏蔽。 设备屏蔽包括被配置为将医疗设备和医疗设备传送设备的至少一部分保持在主体或外壳内的主体或外壳以及具有第一约束位置和第二打开位置的限制元件。
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公开(公告)号：US20110184509A1
公开(公告)日：2011-07-28
申请号：US12694821
申请日：2010-01-27
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/958 , A61F2/97 , A61F2002/9583 , A61F2250/0018
摘要： A sheath assembly is provided for protecting a stent mounted on a catheter. An inner tubular member is positioned over the stent without longitudinal movement of the inner tubular member along the stent surface thereby eliminating the possibility of scraping or scratching a drug coating or polymer coating on the stent surface or balloon surface. An outer tubular member slides over the inner tubular member to firmly compress it onto the stent for further protection. In use, the outer tubular member is removed from over the inner tubular member so that the two half-cylindrical portions of the inner tubular member can fall away from the stent without longitudinal movement along the stent surface.
摘要翻译： 提供护套组件用于保护安装在导管上的支架。 内部管状构件被定位在支架上方，而不沿着支架表面的内部管状构件的纵向移动，从而消除刮擦或刮擦支架表面或气囊表面上的药物涂层或聚合物涂层的可能性。 外部管状构件在内部管状构件上滑动以将其牢固地压缩到支架上用于进一步保护。 在使用中，外部管状构件从内部管状构件上方移除，使得内部管状构件的两个半圆柱形部分可以从支架脱落而不沿着支架表面纵向移动。
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公开(公告)号：US20090254051A1
公开(公告)日：2009-10-08
申请号：US12328731
申请日：2008-12-04
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A device and method is provided for localized agent delivery through a coronary vessel. In one configuration, the device includes an elongated member having a first and second end with a tip and an aperture positioned near the second end. An injection lumen places the first end of the elongated member in fluid communication with the aperture, permitting fluids such as contrast agent or therapeutic agents to be delivered therebetween. In an exemplary method, the device is tracked through a bend in the coronary anatomy, forcing the tip of the device toward the greater curve and through the vessel wall. The aperture may advanced to the desired location and agents may be delivered through the device into target tissue or space. Other configurations and embodiments of the device and method are presented,
摘要翻译： 提供了一种通过冠状动脉血管进行局部药剂输送的装置和方法。 在一种构造中，该装置包括细长构件，该细长构件具有带尖端的第一和第二端以及位于第二端附近的孔。 注射腔使细长构件的第一端与孔流体连通，允许诸如造影剂或治疗剂的流体在其间输送。 在示例性方法中，通过冠状动脉解剖结构中的弯曲来跟踪装置，迫使装置的尖端朝向更大的曲线并穿过血管壁。 孔可以前进到期望的位置，并且药剂可以通过装置输送到靶组织或空间中。 本发明提供了装置和方法的其他配置和实施例，
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