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31.发明授权Method and apparatus for detecting positively charged and negatively charged ionized particles 有权用于检测带正电荷和带负电荷的离子化颗粒的方法和装置公开(公告)号：US07728292B2
公开(公告)日：2010-06-01
申请号：US11467720
申请日：2006-08-28
CPC分类号： H01J49/025 , H01J49/0095
摘要： An ion detector includes collision surfaces for converting both positively and negatively charged ions into emitted secondary electrons. Secondary electrons may be detected using an electron detector, than may, for example include an electron multiplier. Conveniently, secondary electrons (or electrons emitted by the multiplier) may be detected using an electron pulse counter.
摘要翻译： 离子检测器包括用于将正电荷和带负电荷的离子转换成发射的二次电子的碰撞表面。 可以使用电子检测器检测二次电子，例如可以包括电子倍增器。 方便地，可以使用电子脉冲计数器检测二次电子（或乘法器发射的电子）。
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公开(公告)号：US20090065692A1
公开(公告)日：2009-03-12
申请号：US12230949
申请日：2008-09-08
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： A high pressure collision cell for use in a mass spectrometer. The high pressure collision cell has a cell length L selected to be in a range such that upon application of voltages to a pair of opposed elongate electrically conducting electrodes there is produced an electric field of sufficient strength across the collision cell length L in to aid in directing ions entering the collision cell to along a transverse flow axis. The pressure in the collision cell is maintained in a range from about 50 mTorr to 1000 mTorr and wherein the collision cell length L and the pressure are selected such that a target thickness, defined as a product of the collision cell length L and the pressure, is maintained in a range from about 0.2 to about 2 mm-Torr.
摘要翻译： 用于质谱仪的高压碰撞池。 高压碰撞池具有选择为在一定范围内的电池长度L，使得在向一对相对的细长导电电极施加电压时，产生跨越冲击电池长度L的足够强度的电场，以帮助 引导进入碰撞池的离子沿着横向流动轴。 碰撞池中的压力保持在约50mTorr至1000mTorr的范围内，并且其中选择碰撞池长度L和压力，使得定义为碰撞池长度L和压力的乘积的目标厚度， 维持在约0.2至约2mm-Torr的范围内。
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公开(公告)号：US07091477B2
公开(公告)日：2006-08-15
申请号：US10864106
申请日：2004-06-09
CPC分类号： H01J49/0422 , H01J49/04 , H01J49/044 , H01J49/0468 , H01J49/06 , H01J49/26 , Y10T436/24
摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
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公开(公告)号：US07049584B1
公开(公告)日：2006-05-23
申请号：US11184387
申请日：2005-07-19
IPC分类号： H01J49/26
CPC分类号： H01J49/147 , H01J49/0054
摘要： Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.
摘要翻译： 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。 最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。 然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。 本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。 因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。
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公开(公告)号：US06919562B1
公开(公告)日：2005-07-19
申请号：US10448477
申请日：2003-05-30
IPC分类号： H01J49/26
CPC分类号： H01J49/147 , H01J49/0054
摘要： Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.
摘要翻译： 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。 最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。 然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。 本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。 因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。
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公开(公告)号：US20050035287A1
公开(公告)日：2005-02-17
申请号：US10864106
申请日：2004-06-09
CPC分类号： H01J49/0422 , H01J49/04 , H01J49/044 , H01J49/0468 , H01J49/06 , H01J49/26 , Y10T436/24
摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
摘要翻译： 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。
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公开(公告)号：US06799355B2
公开(公告)日：2004-10-05
申请号：US10221479
申请日：2002-09-13
IPC分类号： H01J4940
CPC分类号： H01J49/004 , G01N27/624
摘要： A method and an apparatus for selectively transmitting ions produced by an inductively coupled plasma ionization technique is disclosed. Ions produced within the plasma source are provided to a FAIMS analyzer within a low pressure chamber of a mass spectrometer and in fluid communication with the plasma source for receiving ions therefrom. The ions are separated in FAIMS and at least some of the ions are provided to the mass spectrometer after separation.
摘要翻译： 公开了一种用于选择性地传输由电感耦合等离子体电离技术产生的离子的方法和装置。 在等离子体源内产生的离子被提供给质谱仪的低压室内的FAIMS分析仪，并与等离子体源流体连通以接收离子。 离子在FAIMS中分离，分离后至少有一些离子被提供给质谱仪。
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公开(公告)号：US06093929A
公开(公告)日：2000-07-25
申请号：US66556
申请日：1998-04-28
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4215 , H01J49/4285
摘要： A mass spectrometer system in which ions are mass selected in an RF-only quadrupole at relatively high pressure (1 to 7 torr) using FNF or SWIFT, and are then fragmented in a following collision cell which is in the same vacuum chamber, thus reducing pumping needs. The fragments can be mass analyzed in any desired way, including by another RF-only quadrupole in the same vacuum chamber and also using FNF or SWIFT. Triple MS can be performed in the same way.
摘要翻译： 使用FNF或SWIFT在相对较高压力（1至7托）的RF仅四极杆中质量选择离子的质谱仪系统，然后在处于相同真空室中的后续碰撞池中碎裂，从而减少 抽水需要。 可以以任何所需的方式对片段进行质量分析，包括在同一真空室中使用另一个仅RF的四极杆，并使用FNF或SWIFT。 三重MS可以以相同的方式执行。
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公开(公告)号：US09048076B2
公开(公告)日：2015-06-02
申请号：US14122534
申请日：2012-05-25
CPC分类号： H01J49/0459 , G01N1/22 , G01N1/24 , G01N2001/022 , G01N2001/024 , H01J49/00 , H01J49/02 , H01J49/04
摘要： Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapor molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.
摘要翻译： 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 该流动不间断地从受试者移动到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。
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