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44 条记录 (耗时 0.07 秒)

    Nucleic acids encoding PAK5 polypeptidesm and methods of use thereof
    33.
    发明申请
    Nucleic acids encoding PAK5 polypeptidesm and methods of use thereof 审中-公开
    编码PAK5多肽的核酸及其使用方法

    公开(公告)号：US20070072261A1

    公开(公告)日：2007-03-29

    申请号：US10725330

    申请日：2003-12-02

    申请人： Gregory Plowman ,  Ricardo Martinez ,  David Whyte

    发明人： Gregory Plowman ,  Ricardo Martinez ,  David Whyte

    IPC分类号： C12P21/06 ,  C12N9/12 ,  C07H21/04

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Mammalian nucleic acid molecules encoding these kinases are particularly disclosed, and more specifically human sources of these nucleic acids are disclosed.

    摘要翻译： 本发明涉及编码STE20相关家族新型蛋白激酶ZC1，ZC2，ZC3，ZC4，STLK2，STLK3，STLK4，STLK5，STLK6，STLK7，KHS2，SULU1，SULU3，GEK2，PAK4的核酸分子和 PAK5，其片段和结构域，以及可用于诊断和治疗各种激酶相关疾病和病症的各种方法。 特别公开了编码这些激酶的哺乳动物核酸分子，更具体地公开了这些核酸的人源。

    Mammalian protein phosphatases
    37.
    发明申请
    Mammalian protein phosphatases 审中-公开
    哺乳动物蛋白磷酸酶

    公开(公告)号：US20050054070A1

    公开(公告)日：2005-03-10

    申请号：US10716442

    申请日：2003-11-20

    申请人： Gregory Plowman ,  David Whyte ,  Gerard Manning

    发明人： Gregory Plowman ,  David Whyte ,  Gerard Manning

    IPC分类号： A61K38/00 ,  C12N9/16 ,  C07H21/04

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.

    摘要翻译： 本发明涉及磷酸酶多肽，编码磷酸酶多肽的核苷酸序列，以及可用于诊断和治疗各种磷酸酶相关疾病和病症的各种产品和方法。 通过使用生物信息学策略，已经鉴定了MAP激酶磷酸酶PTP和STP的哺乳动物成员，并预测了其蛋白质结构。

    Human orthologues of wart
    38.
    发明授权
    Human orthologues of wart 失效
    疣的人类直向同源物

    公开(公告)号：US06495353B1

    公开(公告)日：2002-12-17

    申请号：US09233857

    申请日：1999-01-20

    申请人： Gregory Plowman ,  Peter Flanagan

    发明人： Gregory Plowman ,  Peter Flanagan

    IPC分类号： C12N900

    CPC分类号： C12N9/1205 ,  C07K2319/00 ,  C12Q1/485 ,  G01N33/574

    摘要： The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that modulate the function of an hWART polypeptide. Also disclosed are methods for diagnosing abnormal cell proliferative conditions in an organism using hWART-related molecules or compounds.

    摘要翻译： 本发明部分涉及hWART核酸分子。 本发明还部分涉及编码hWART全长蛋白质的部分的核酸分子，含有hWART核酸分子的核酸载体，含有此类核酸载体的重组细胞，从这些重组细胞纯化的多肽，对这些多肽的抗体，以及方法 鉴定调节hWART多肽功能的化合物。 还公开了使用hWART相关分子或化合物诊断生物体中异常细胞增殖状态的方法。

    Gaming System and Method with Wager Variability
    39.
    发明申请
    Gaming System and Method with Wager Variability 有权
    博弈系统与赌注变异法

    公开(公告)号：US20080081688A1

    公开(公告)日：2008-04-03

    申请号：US11865399

    申请日：2007-10-01

    申请人： Gregory Plowman

    发明人： Gregory Plowman

    IPC分类号： A63F13/00

    CPC分类号： G07F17/3244 ,  G07F17/3213 ,  G07F17/3225 ,  G07F17/34

    摘要： A gaming machine that provides a wagering game, including a user interface in communication with a game controller, through the operation of which a player selects one of a plurality of wager options that determine a number of symbols to be active and inactive in the wagering game. For at least one said wager option at least one, but not all of the plurality of symbols that define a possible said winning combination are rendered inactive for forming the winning combination.

    摘要翻译： 一种游戏机，其提供投注游戏，包括与游戏控制器通信的用户界面，所述游戏机通过玩家选择多个下注选项中的一个的操作来确定所述投注游戏中的活跃和不活动的符号数量 。 对于至少一个所述下注选项，定义可能的所述获胜组合的至少一个但不是全部的所述多个符号被赋予无效以形成所述获胜组合。