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1.发明申请公开(公告)号：US20070269378A1
公开(公告)日：2007-11-22
申请号：US10556440
申请日：2004-06-18
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yinsheng Jin , Lynn Bjerke , Timothy Heuer
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yinsheng Jin , Lynn Bjerke , Timothy Heuer
CPC分类号： G01N33/574 , A01K67/0275 , A01K2217/058 , A01K2227/40 , A01K2267/03 , A61K49/0008 , C12N9/1205 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041
摘要： Human NADK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morpho-genesis, comprising screening for agents that modulate the activity of NADK are provided.
摘要翻译： 人NADK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。 提供用于鉴定分支形态发生的调节剂的方法，包括筛选调节NADK活性的试剂。
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2.发明申请公开(公告)号：US20060257870A1
公开(公告)日：2006-11-16
申请号：US10532405
申请日：2003-10-22
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yisheng Jin , Bing Hai
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yisheng Jin , Bing Hai
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48
CPC分类号： G01N33/57438 , C12Q1/485 , G01N33/57446 , G01N2500/00
摘要： Human CDKL1 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CDKL1 are provided.
摘要翻译： 人CDKL1基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。 提供用于鉴定分支形态发生调节剂的方法，包括筛选调节CDKL1活性的试剂。
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3.发明申请公开(公告)号：US20070003927A1
公开(公告)日：2007-01-04
申请号：US10532406
申请日：2003-10-22
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Heinrich , Jochen Scheel , Torsten Will , Yisheng Jin , Joanne Adamkewicz
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Heinrich , Jochen Scheel , Torsten Will , Yisheng Jin , Joanne Adamkewicz
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5088 , A01K2217/05 , C12N9/1205 , C12Q1/485 , G01N33/5011 , G01N33/57438 , G01N33/57496
摘要： Human MAPK7 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAPK7 are provided.
摘要翻译： 人MAPK7基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MAPK7活性的试剂。
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公开(公告)号：US20080317738A1
公开(公告)日：2008-12-25
申请号：US10556637
申请日：2004-06-18
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号： A61K39/395 , G01N33/00 , C12Q1/48 , G01N33/566 , C12Q1/68 , C12Q1/02 , A01K67/027 , C12N5/06
CPC分类号： G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要： Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译： 人MYLK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MYLK活性的试剂。
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公开(公告)号：US08105785B2
公开(公告)日：2012-01-31
申请号：US10556637
申请日：2004-06-18
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号： G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要： Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译： 人MYLK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MYLK活性的试剂。
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公开(公告)号：US20080213247A1
公开(公告)日：2008-09-04
申请号：US10532547
申请日：2003-10-22
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
CPC分类号： C12N9/1205 , A01K2217/05
摘要： Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
摘要翻译： 人类MBM基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了鉴定分支形态发生调节剂的方法，包括筛选调节MBM活性的试剂。
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公开(公告)号：US07968681B2
公开(公告)日：2011-06-28
申请号：US12761346
申请日：2010-04-15
申请人： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Lui , Joshua Silverman , Richard Smith , Candace Swimmer
发明人： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Lui , Joshua Silverman , Richard Smith , Candace Swimmer
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要： Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译： 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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公开(公告)号：US07803907B2
公开(公告)日：2010-09-28
申请号：US11155989
申请日：2005-06-17
申请人： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
发明人： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要： Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译： 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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9.发明授权Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use 有权无脊椎动物TWIK通道的核酸和多肽及其使用方法公开(公告)号：US06511824B1
公开(公告)日：2003-01-28
申请号：US09362842
申请日：1999-07-28
申请人： Andrew Roy Buchman , Christian Burks , Helen Louise Francis-Lang , Lucile A. Gillett , Jonathan Cagampang Heller , Casey Casimir Kopczynski , Jonathan Scott Margolis , Darren Mark Platt , Bindu Priya Reddy , Candace Swimmer , John W. Winslow , Yuling Luo
发明人： Andrew Roy Buchman , Christian Burks , Helen Louise Francis-Lang , Lucile A. Gillett , Jonathan Cagampang Heller , Casey Casimir Kopczynski , Jonathan Scott Margolis , Darren Mark Platt , Bindu Priya Reddy , Candace Swimmer , John W. Winslow , Yuling Luo
IPC分类号： C12N1500
CPC分类号： C07K14/43581 , A01K67/0333 , A01K67/0336 , A01K67/0337 , A01K67/0339 , A01K2217/05 , A01K2217/075 , C07K14/705 , C07K14/70571
摘要： Tandem pore domain weak inward rectifying K+ (TWIK) channel nucleic acids and proteins that have been isolated from Drosophila melanogaster and Leptinotarsa are described. The TWIK channel nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects, coelomates, and pseudocoelomates, or cultured cells, resulting in TWIK channel expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with TWIK channel proteins. They can also be used in methods for studying TWIK channel activity and identifying other genes that modulate the function of, or interact with, the TWIK channel gene.
摘要翻译： 描述了从黑腹果蝇和Leptinotarsa分离的串联孔结构域弱内向整流K +（TWIK）通道核酸和蛋白质。 TWIK通道核酸和蛋白质可用于遗传修饰后生动物无脊椎动物生物体，如昆虫，群落和假细菌，或培养细胞，导致TWIK通道表达或错误表达。 遗传修饰的生物体或细胞可用于筛选测定以鉴定候选化合物，其是潜在的杀虫剂或与TWIK通道蛋白相互作用的治疗剂。 它们也可用于研究TWIK通道活性的方法，并鉴定调节TWIK通道基因功能或与之相互作用的其他基因。
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公开(公告)号：US20060234299A1
公开(公告)日：2006-10-19
申请号：US11281256
申请日：2005-11-16
申请人： Willem Stemmer , Martin Vogt , Joost Kolkman , Josh Silverman , Candace Swimmer
发明人： Willem Stemmer , Martin Vogt , Joost Kolkman , Josh Silverman , Candace Swimmer
IPC分类号： C40B40/10
CPC分类号： C07K14/485 , C07K1/047 , C07K2319/70 , G01N33/6845 , G01N2333/485 , G01N2333/70546 , G01N2500/04
摘要： Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
摘要翻译： 提供了包含单体域的特异性单体域和多聚物。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。
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