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    Methods for Identifying Modulating Compounds of Lymphangiogenesis, Means Therefore, Compounds and Uses Thereof
    7.
    发明申请
    Methods for Identifying Modulating Compounds of Lymphangiogenesis, Means Therefore, Compounds and Uses Thereof 审中-公开
    识别调节淋巴管生成化合物的方法，因此，其化合物和用途

    公开(公告)号：US20110289604A1

    公开(公告)日：2011-11-24

    申请号：US13109096

    申请日：2011-05-17

    申请人： Stefan Schulte-Merker ,  Benjamin M. Hogan

    发明人： Stefan Schulte-Merker ,  Benjamin M. Hogan

    IPC分类号： G01N33/48 ,  A01K67/027 ,  C12N5/10 ,  C07H21/04 ,  A61P43/00 ,  C07K16/18 ,  A61K31/708 ,  A61K39/395 ,  C07K14/435 ,  C12Q1/68 ,  C12N15/63

    CPC分类号： G01N33/5088 ,  G01N33/5029 ,  G01N33/5082 ,  G01N2333/4603 ,  G01N2333/515

    摘要： The invention relates to a method for testing whether a compound is capable of inhibiting the development of lymphatic channels or lymphangiogenesis and/or the migration of lymphangioblasts in an non-human animal, a non-human embryo or a cell culture, comprising steps of contacting a compound capable of interacting with a Ccbe1 gene, a transcript thereof or a ccbe1 protein with a non-human animal, a non-human embryo or a cell culture; determining whether said compound inhibits the development of lymphatic channels, lymphangiogenesis and/or migration of lymphangioblasts in said non-human animal, a non-human embryo or a cell culture. The invention further related to a method of determining whether an individual is a carrier of, or is suffering from, or at risk of suffering from, a lymph vessel disorder, and to a medicament comprising Ccbe1, or comprising a nucleic acid encoding Ccbe1, for the treatment of a lymph vessel disorder.

    摘要翻译： 本发明涉及一种用于测试化合物是否能够抑制非人动物，非人胚胎或细胞培养物中的淋巴管道或淋巴管生成和/或淋巴管生成细胞的迁移的方法，包括以下步骤： 能够与非人动物，非人胚胎或细胞培养物与Ccbe1基因，其转录物或ccbe1蛋白质相互作用的化合物; 确定所述化合物是否抑制所述非人动物，非人胚胎或细胞培养物中淋巴管道的发育，淋巴管生成和/或淋巴细胞迁移。 本发明还涉及一种确定个体是否是淋巴管病症的患者或患有或有风险患有淋巴管病症的方法，以及包含Ccbe1或包含编码Ccbe1的核酸的药物的方法，用于 治疗淋巴管病变。