公开(公告)号：US08956288B2

公开(公告)日：2015-02-17

申请号：US12527190

申请日：2008-02-14

申请人： Hooman Hafezi ,  Timothy Robertson ,  Eric Snyder ,  Brad Cozad

发明人： Hooman Hafezi ,  Timothy Robertson ,  Eric Snyder ,  Brad Cozad

IPC分类号： A61B1/00 ,  H01M4/66 ,  A61J3/07 ,  A61B5/07 ,  H01M8/08 ,  H01M4/02 ,  H01M6/34 ,  A61B5/00 ,  A61J3/00 ,  H01M4/00 ,  H01M8/00 ,  A61N1/378

CPC分类号： H01M4/668 ,  A61B5/0028 ,  A61B5/073 ,  A61B2560/0214 ,  A61J3/07 ,  A61N1/378 ,  G08C2200/00 ,  H01M4/02 ,  H01M6/34 ,  H01M8/08

摘要： Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.

摘要翻译： 提供了能够实现体内设备（如植入式和可摄取设备）的电源。 本发明的体内电源的方面包括固体支持物，第一高表面积电极和第二电极。 功率源的实施例被配置为在与目标生理部位接触时发射可检测信号。 还提供了制造和使用本发明的电源的方法。

公开(公告)号：US20130030366A1

公开(公告)日：2013-01-31

申请号：US13639766

申请日：2011-04-07

申请人： Timothy Robertson ,  Hooman Hafezi ,  Raymond Schmidt

发明人： Timothy Robertson ,  Hooman Hafezi ,  Raymond Schmidt

IPC分类号： A61M31/00 ,  B32B37/14

CPC分类号： A61M31/002 ,  A61J3/07 ,  A61K9/4808 ,  Y10T156/10

摘要： The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.

摘要翻译： 本发明公开了一旦装置被周围的流体激活时，防止胶囊壁和其它材料干扰电子装置的性能的多种方法。 根据本发明的教导，可以使用赋形剂和薄膜制造微型可摄取装置（MID）。 根据本发明的各个方面，MID将具有围绕电子设备的涂层或层压，并且一旦胶囊被摄取以及从胶囊本身就将该装置与胶囊内的药物或药物分离并分离 因为胶囊壁在分解过程中开始崩溃。

公开(公告)号：US08836513B2

公开(公告)日：2014-09-16

申请号：US13180507

申请日：2011-07-11

申请人： Hooman Hafezi ,  David O'Reilly ,  Patricia Johnson ,  Zahedeh Hatamkhany ,  Timothy Robertson

发明人： Hooman Hafezi ,  David O'Reilly ,  Patricia Johnson ,  Zahedeh Hatamkhany ,  Timothy Robertson

IPC分类号： H04Q5/22 ,  H01Q1/27 ,  A61B5/145 ,  A61J3/00 ,  A61B5/07 ,  A61B5/1473 ,  A61B5/00

CPC分类号： A61B5/073 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4839 ,  A61B5/6801 ,  A61B5/6861 ,  A61J3/007 ,  H01Q1/273

摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also be associated with food and communicate data about ingestion of food material to a receiver.

摘要翻译： 本发明的系统包括不同材料形式的导电元件，电子元件和部分电源。 当与导电流体接触时，产生电压电位并且电源完成，这激活了系统。 电子部件控制不同材料之间的电导，以产生独特的当前签名。 该系统还可以与食物相关联，并将关于摄取食物材料的数据传达给接收器。

公开(公告)号：US08784308B2

公开(公告)日：2014-07-22

申请号：US13319309

申请日：2010-12-02

申请人： Hooman Hafezi ,  Robert Duck ,  Timothy Robertson ,  Benedict Costello

发明人： Hooman Hafezi ,  Robert Duck ,  Timothy Robertson ,  Benedict Costello

IPC分类号： A61B5/00 ,  A61K9/48 ,  A61B5/06 ,  A61B5/07 ,  A61J3/00 ,  A61K9/00

CPC分类号： A61M37/00 ,  A61B5/06 ,  A61B5/073 ,  A61B5/42 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/6861 ,  A61B5/6871 ,  A61B5/6873 ,  A61J3/007 ,  A61J3/06 ,  A61J2200/30 ,  A61J2205/60 ,  A61K9/0097 ,  A61K9/2086 ,  A61K9/2886 ,  A61K9/4825 ,  A61K9/4833 ,  A61M31/002 ,  B30B11/34 ,  B32B38/0004 ,  B32B2250/02 ,  Y10S128/903 ,  Y10T156/10 ,  Y10T156/1066

摘要： A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention. In accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.

摘要翻译： 提供了一种系统和方法，用于将可摄入的电子设备固定在药品上，而不会损坏可摄取的电子设备。 该产品包括根据本发明的一个方面放置在产品上的可摄入电子设备。 根据本发明的另一方面，将可摄入电子设备放置在产品内部。 根据本发明公开了用于保护和/或涂覆电子标记以及将可摄入电子装置固定在产品上的各种实施例。

公开(公告)号：US08545402B2

公开(公告)日：2013-10-01

申请号：US12744642

申请日：2010-04-27

申请人： Hooman Hafezi ,  Kityee Au-Yeung ,  Robert Duck ,  Maria Holen ,  Timothy Robertson ,  Benedict Costello

发明人： Hooman Hafezi ,  Kityee Au-Yeung ,  Robert Duck ,  Maria Holen ,  Timothy Robertson ,  Benedict Costello

IPC分类号： A61B5/00 ,  A61M37/00

CPC分类号： A61B5/073 ,  A61B5/0031 ,  A61B5/065 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4848 ,  A61B5/6861 ,  A61B5/6882 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2562/02 ,  A61B2562/162 ,  A61K9/0053 ,  A61K9/0097 ,  H01M2/025 ,  H01M2/14 ,  H01M6/34

摘要： Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

摘要翻译： 提供了具有高可靠性的可摄入事件标记。 可摄入事件标记的方面包括载体，控制电路，第一电化学材料，第二电化学材料和膜。 此外，可摄入事件标记可以包括赋予可摄取事件标记高度可靠性的一个或多个成分。 此外，可摄入事件标记可以包括活性剂。 在一些方面，活性剂，例如药物活性剂或诊断剂可以与膜结合。

公开(公告)号：US20100239616A1

公开(公告)日：2010-09-23

申请号：US12447172

申请日：2007-10-25

申请人： Hooman Hafezi ,  Timothy Robertson ,  Olivier Colliou

发明人： Hooman Hafezi ,  Timothy Robertson ,  Olivier Colliou

IPC分类号： A61K9/00 ,  A61P43/00 ,  H01M6/32

CPC分类号： A61K9/2072 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4238 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/6861 ,  A61B2560/0214 ,  A61J3/007 ,  A61K49/00 ,  H01M10/0436

摘要： Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

摘要翻译： 提供了用于可摄取组合物的受控激活标识符，例如制药信息学组合物。 标识符包括受控激活元件，其响应于感兴趣的目标位置处的预定刺激的存在而提供对标识符的激活。 本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。

公开(公告)号：US09597487B2

公开(公告)日：2017-03-21

申请号：US13639766

申请日：2011-04-07

申请人： Timothy Robertson ,  Hooman Hafezi ,  Raymond Schmidt

发明人： Timothy Robertson ,  Hooman Hafezi ,  Raymond Schmidt

IPC分类号： A61M31/00 ,  B32B37/14 ,  A61J3/07 ,  A61K9/48

CPC分类号： A61M31/002 ,  A61J3/07 ,  A61K9/4808 ,  Y10T156/10

摘要： The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.

公开(公告)号：US20110054265A1

公开(公告)日：2011-03-03

申请号：US12744642

申请日：2010-04-27

申请人： Hooman Hafezi ,  Kityee Au-Yeung ,  Robert Duck ,  Maria Holen ,  Timothy Robertson ,  Benedict Costello

发明人： Hooman Hafezi ,  Kityee Au-Yeung ,  Robert Duck ,  Maria Holen ,  Timothy Robertson ,  Benedict Costello

IPC分类号： A61B5/00 ,  A61M37/00

CPC分类号： A61B5/073 ,  A61B5/0031 ,  A61B5/065 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4848 ,  A61B5/6861 ,  A61B5/6882 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2562/02 ,  A61B2562/162 ,  A61K9/0053 ,  A61K9/0097 ,  H01M2/025 ,  H01M2/14 ,  H01M6/34

摘要： Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

摘要翻译： 提供了具有高可靠性的可摄入事件标记。 可摄入事件标记的方面包括载体，控制电路，第一电化学材料，第二电化学材料和膜。 此外，可摄入事件标记可以包括赋予可摄取事件标记高度可靠性的一个或多个成分。 此外，可摄入事件标记可以包括活性剂。 在一些方面，活性剂，例如药物活性剂或诊断剂可以与膜结合。

公开(公告)号：US08388533B2

公开(公告)日：2013-03-05

申请号：US12527403

申请日：2009-08-13

申请人： Hooman Hafezi ,  Eric Snyder ,  Benedict Costello

发明人： Hooman Hafezi ,  Eric Snyder ,  Benedict Costello

IPC分类号： A61B5/07

摘要： The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.

公开(公告)号：US07981259B2

公开(公告)日：2011-07-19

申请号：US11452839

申请日：2006-06-14

申请人： Hooman Hafezi ,  Aron Rosenfeld

发明人： Hooman Hafezi ,  Aron Rosenfeld

IPC分类号： C25D5/00 ,  C25D17/00 ,  C25D21/12 ,  B23H7/14 ,  C25B9/00 ,  C25B9/04 ,  C25B15/00 ,  C25C3/16 ,  C25C3/20 ,  C25F7/00

CPC分类号： C25D5/18 ,  C25D17/002 ,  C25D17/007 ,  C25D21/12

摘要： A method and apparatus for adjusting an electric field of an electrochemical processing cell are provided. In one embodiment, a capacitive element is disposed in the processing solution. The strength, shape, or direction of the electric field in the processing solution may be modulated by charging and discharging the capacitive element in a controlled manner. Because the electric field is modulated with out passing a current from the capacitive element to the processing solution, electrochemical reactions do not occur on the interface of the capacitive element and the processing solution, thus, reduces complications caused by unwanted electrochemical reactions.

摘要翻译： 提供了一种用于调整电化学处理单元的电场的方法和装置。 在一个实施例中，电容元件设置在处理溶液中。 可以通过以受控的方式对电容元件充电和放电来调制处理溶液中的电场的强度，形状或方向。 由于电场通过电流从电容元件传递到处理溶液而被调制，所以在电容元件和处理溶液的界面上不会发生电化学反应，从而减少由不需要的电化学反应引起的并发症。