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公开(公告)号：US08945005B2
公开(公告)日：2015-02-03
申请号：US12447172
申请日：2007-10-25
IPC分类号： A61K9/00 , A61P43/00 , H01M6/32 , A61K49/00 , H01M10/04 , A61B5/07 , A61B5/145 , A61B5/1473 , A61B5/00 , H01M10/00 , A61J3/00
CPC分类号： A61K9/2072 , A61B5/073 , A61B5/14539 , A61B5/1473 , A61B5/4238 , A61B5/4833 , A61B5/4839 , A61B5/6861 , A61B2560/0214 , A61J3/007 , A61K49/00 , H01M10/0436
摘要： Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
摘要翻译： 提供了用于可摄取组合物的受控激活标识符，例如制药信息学组合物。 标识符包括受控激活元件，其响应于感兴趣的目标位置处的预定刺激的存在而提供对标识符的激活。 本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。
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公开(公告)号：US20100239616A1
公开(公告)日：2010-09-23
申请号：US12447172
申请日：2007-10-25
CPC分类号： A61K9/2072 , A61B5/073 , A61B5/14539 , A61B5/1473 , A61B5/4238 , A61B5/4833 , A61B5/4839 , A61B5/6861 , A61B2560/0214 , A61J3/007 , A61K49/00 , H01M10/0436
摘要： Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
摘要翻译： 提供了用于可摄取组合物的受控激活标识符，例如制药信息学组合物。 标识符包括受控激活元件，其响应于感兴趣的目标位置处的预定刺激的存在而提供对标识符的激活。 本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。
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公开(公告)号：US08956288B2
公开(公告)日：2015-02-17
申请号：US12527190
申请日：2008-02-14
申请人： Hooman Hafezi , Timothy Robertson , Eric Snyder , Brad Cozad
发明人： Hooman Hafezi , Timothy Robertson , Eric Snyder , Brad Cozad
IPC分类号： A61B1/00 , H01M4/66 , A61J3/07 , A61B5/07 , H01M8/08 , H01M4/02 , H01M6/34 , A61B5/00 , A61J3/00 , H01M4/00 , H01M8/00 , A61N1/378
CPC分类号： H01M4/668 , A61B5/0028 , A61B5/073 , A61B2560/0214 , A61J3/07 , A61N1/378 , G08C2200/00 , H01M4/02 , H01M6/34 , H01M8/08
摘要： Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.
摘要翻译： 提供了能够实现体内设备（如植入式和可摄取设备）的电源。 本发明的体内电源的方面包括固体支持物，第一高表面积电极和第二电极。 功率源的实施例被配置为在与目标生理部位接触时发射可检测信号。 还提供了制造和使用本发明的电源的方法。
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公开(公告)号：US08545436B2
公开(公告)日：2013-10-01
申请号：US13336956
申请日：2011-12-23
申请人： Timothy Robertson , Fataneh Omidvar , Yashar Behzadi , Lawrence Arne , Kenneth Rowberry , James Hutchison , Robert Leichner , George Savage , Andrew Thompson , Mark Zdeblick , Marc Kreidler , Hooman Hafezi , Robert Duck
发明人： Timothy Robertson , Fataneh Omidvar , Yashar Behzadi , Lawrence Arne , Kenneth Rowberry , James Hutchison , Robert Leichner , George Savage , Andrew Thompson , Mark Zdeblick , Marc Kreidler , Hooman Hafezi , Robert Duck
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61B5/0006 , A61B5/0028 , A61B5/02055 , A61B5/0404 , A61B5/04085 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/1112 , A61B5/145 , A61B5/14532 , A61B5/4094 , A61B2560/0209 , A61B2560/0412 , A61B2560/0468 , A61B2562/0219 , A61M5/1452 , A61M5/172 , G06F19/34 , G06F19/3418 , H04B13/005
摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.
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公开(公告)号：US20130030366A1
公开(公告)日：2013-01-31
申请号：US13639766
申请日：2011-04-07
CPC分类号： A61M31/002 , A61J3/07 , A61K9/4808 , Y10T156/10
摘要： The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.
摘要翻译： 本发明公开了一旦装置被周围的流体激活时，防止胶囊壁和其它材料干扰电子装置的性能的多种方法。 根据本发明的教导，可以使用赋形剂和薄膜制造微型可摄取装置（MID）。 根据本发明的各个方面，MID将具有围绕电子设备的涂层或层压，并且一旦胶囊被摄取以及从胶囊本身就将该装置与胶囊内的药物或药物分离并分离 因为胶囊壁在分解过程中开始崩溃。
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公开(公告)号：US08816847B2
公开(公告)日：2014-08-26
申请号：US13153312
申请日：2011-06-03
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/07 , A61B5/076 , A61B5/1473 , A61B5/4833 , A61B5/4839 , A61B5/681 , A61B5/6861 , A61B5/7282 , A61B2560/0214 , A61B2560/0462 , A61B2562/08 , A61B2562/162 , A61J3/007 , G06F19/00 , G06K7/10168 , H01Q1/273 , Y10T29/49117
摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.
摘要翻译： 本发明的系统包括不同材料形式的导电元件，电子元件和部分电源。 当与导电流体接触时，产生电压电位并且电源完成，这激活了系统。 电子部件控制不同材料之间的电导，以产生独特的当前签名。 该系统可以用于各种不同的应用中，包括作为可摄取标识符的组分，例如可以在可摄入事件标记中发现的，例如启用药物信息学的药物组合物。
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公开(公告)号：US08730031B2
公开(公告)日：2014-05-20
申请号：US13180539
申请日：2011-07-11
申请人： Todd Thompson , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Timothy Robertson , Hooman Hafezi , George Savage
发明人： Todd Thompson , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Timothy Robertson , Hooman Hafezi , George Savage
IPC分类号： H04Q5/22
CPC分类号： A61B5/076 , A61B5/0028 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61B2560/0214 , A61J3/007 , A61N1/37288 , G06F19/00 , G06F19/3418 , H01Q1/273
摘要： The system of the present invention includes an implantable device that can detect high and low frequency current signature. The implantable device can communicate with a communication device that includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, the communication device is activated.
摘要翻译： 本发明的系统包括可以检测高频和低频电流签名的可植入装置。 可植入装置可以与包括导电元件，电子部件和不同材料形式的部分电源的通信装置通信。 当与导电流体接触时，通信装置被激活。
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公开(公告)号：US20120116359A1
公开(公告)日：2012-05-10
申请号：US13319309
申请日：2010-12-02
CPC分类号： A61M37/00 , A61B5/06 , A61B5/073 , A61B5/42 , A61B5/4833 , A61B5/4839 , A61B5/6861 , A61B5/6871 , A61B5/6873 , A61J3/007 , A61J3/06 , A61J2200/30 , A61J2205/60 , A61K9/0097 , A61K9/2086 , A61K9/2886 , A61K9/4825 , A61K9/4833 , A61M31/002 , B30B11/34 , B32B38/0004 , B32B2250/02 , Y10S128/903 , Y10T156/10 , Y10T156/1066
摘要： A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention. In accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.
摘要翻译： 提供了一种系统和方法，用于将可摄入的电子设备固定在药品上，而不会损坏可摄取的电子设备。 该产品包括根据本发明的一个方面放置在产品上的可摄入电子设备。 根据本发明的另一方面，将可摄入电子设备放置在产品内部。 根据本发明公开了用于保护和/或涂覆电子标记以及将可摄入电子装置固定在产品上的各种实施例。
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公开(公告)号：US09149423B2
公开(公告)日：2015-10-06
申请号：US13319977
申请日：2010-05-10
申请人： Robert Duck , George Savage , Patricia Johnson , Mark Zdeblick , Benedict Costello , Kityee Au-Yeung , Timothy Robertson , Hooman Hafezi
发明人： Robert Duck , George Savage , Patricia Johnson , Mark Zdeblick , Benedict Costello , Kityee Au-Yeung , Timothy Robertson , Hooman Hafezi
CPC分类号： A61K9/0004 , A61B5/073 , A61B5/1473 , A61J3/07 , A61K9/4808 , A61K49/00 , A61M31/002
摘要： Ingestible event markers comprising an identifier and an ingestible component are provided. The ingestible component may vary, where ingestible components of interest include osmotic ingestible components, liquid capsules, tablets, multi-layered ingestible component and multi-compartment ingestible components. In some instances, the identifier is mechanically stably associated with the ingestible component. Also provided are systems that include the ingestible event markers, as well as methods of using the ingestible event markers.
摘要翻译： 提供包含标识符和可摄入成分的可摄入事件标记。 可摄取组分可以变化，其中感兴趣的摄入成分包括渗透性可摄取组分，液体胶囊，片剂，多层可摄取组分和多室摄入组分。 在一些情况下，标识符与可摄入组分机械稳定地相关联。 还提供了包括可摄入事件标记的系统，以及使用可摄取事件标记的方法。
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公开(公告)号：US08858432B2
公开(公告)日：2014-10-14
申请号：US12524837
申请日：2008-02-01
申请人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B1/00 , H04B5/00 , H01M6/00 , H01Q1/27 , A61B5/07 , A61B5/00 , A61J3/00 , H01Q1/00 , A61B5/0205
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译： 提供了包含可摄入事件标记（即IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施方案包括标识符，其可以或可以不存在于生理上可接受的载体中。 标识符的特征在于与身体的目标内部生理部位（例如消化道内部靶位点）接触时被激活。 个人信号接收器被配置为与身体内部或身体上的生理位置相关联并且接收IEM的信号。 在使用期间，IEM广播由个人信号接收机接收的信号。
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