公开(公告)号：US06577960B1

公开(公告)日：2003-06-10

申请号：US09615455

申请日：2000-07-13

申请人： Luis C. Rabelo ,  Mark Walker ,  Radoslaw R. Zakrewski

发明人： Luis C. Rabelo ,  Mark Walker ,  Radoslaw R. Zakrewski

IPC分类号： G01F1700

CPC分类号： G01F23/2962 ,  G01F23/0069 ,  G01F23/0076 ,  G01F23/266

摘要： Liquid gauging apparatus using a time delay neural network for determining a quantity of liquid in a container that is not directly measurable by sensors is disclosed. The apparatus comprises a plurality of sensors and a processor. Each of the sensors are capable of measuring a respective parameter of the liquid and for producing a time varying sensor output signal representative of the respective parameter measured thereby. The processor is programmed to process the sensor output signals by a time delay neural network algorithm to determine a current quantity of the liquid in the container based on current and past parameter measurements of the sensor output signals. Also disclosed is a method of training a time delay neural network algorithm for computing a quantity of liquid in a container from current and past liquid parameter sensor measurements. The method comprises the steps of: establishing a dynamic model of liquid behavior in the container and parameter measurements of the liquid behavior sensed by a plurality of sensors; deriving from the dynamic model training data sets for a plurality of liquid quantity values, each data set comprising current and past liquid parameter sensor measurement values corresponding to a liquid quantity value of the plurality, and the corresponding liquid quantity value; and training the time delay neural network algorithm with the derived training data sets.

摘要翻译： 公开了一种使用时间延迟神经网络来确定容器中不能被传感器直接测量的液体量的液体计量装置。 该装置包括多个传感器和处理器。 每个传感器能够测量液体的相应参数，并且用于产生表示由此测量的相应参数的时变传感器输出信号。 处理器被编程为通过时间延迟神经网络算法处理传感器输出信号，以基于传感器输出信号的当前和过去的参数测量来确定容器中液体的当前量。 还公开了一种训练用于从当前和过去的液体参数传感器测量计算容器中的液体量的时间延迟神经网络算法的方法。 该方法包括以下步骤：建立容器中液体行为的动态模型和由多个传感器感测的液体行为的参数测量; 从多个液体量值的动态模型训练数据集中得出的每个数据集包括与多个液体量值对应的当前和过去的液体参数传感器测量值和相应的液体量值; 并用导出的训练数据集训练时间延迟神经网络算法。

公开(公告)号：US09717303B2

公开(公告)日：2017-08-01

申请号：US13978695

申请日：2012-01-17

申请人： Mark Walker ,  Joachim Sedelmeier

发明人： Mark Walker ,  Joachim Sedelmeier

IPC分类号： A43B1/10 ,  A43B5/00 ,  A43B13/00 ,  A43B13/14 ,  A43B13/18 ,  A43B13/22 ,  A43B3/00

CPC分类号： A43B13/18 ,  A43B3/0057 ,  A43B13/141 ,  A43B13/181 ,  A43B13/223

摘要： An injection molded sole (10) has an upper ungrooved portion (2) and a lower tread portion (4). At least two, continuous, undulating S-shaped grooves (6) extend generally longitudinally of the tread portion between the toe and heel ends thereof, and a plurality of grooves extending generally transversely intersect the longitudinally extending undulating grooves. The grooves have a minimum depth of about 5 mm and define individual separated tread areas (28) which can be moved apart during flexing of the sole (10). The flexibility of the sole is such that when it is incorporated in footwear, it does not restrict rolling movements of the foot when walking so that a gait can be adopted which is akin to barefoot walking.

公开(公告)号：US09686370B2

公开(公告)日：2017-06-20

申请号：US13502658

申请日：2010-10-08

申请人： Mark Walker ,  Ian Hailey

发明人： Mark Walker ,  Ian Hailey

IPC分类号： H04M1/00 ,  H04L29/08 ,  H04W8/20 ,  H04W88/08

CPC分类号： H04L67/2804 ,  H04W8/20 ,  H04W88/08

摘要： A wireless access point may be in the form of a femtocell basestation in a cellular network. In order to establish a connection into the cellular network, an identity token is required for authorization. A remote service, accessible over a Wide Area Network such as the internet, can register with the access point. When a connected user attempts to connect to the remote service, information derived from the identity token is inserted into the data traffic. Where the identity token identifies the access point, the remote service can return location-specific information. Where the identity token identifies the connected user, the remote service can return subscriber-specific information. The access point can insert information derived directly from the identity token, or it can use the identity token to access a service identity registry, and can then insert the service identity into the data traffic.

公开(公告)号：US09375066B1

公开(公告)日：2016-06-28

申请号：US14603249

申请日：2015-01-22

申请人： Marvin Velazquez ,  Mark Walker

发明人： Marvin Velazquez ,  Mark Walker

IPC分类号： A45C11/16 ,  A45C13/02 ,  B65D43/22

CPC分类号： A45C11/16 ,  A45C13/005 ,  A45C13/02

摘要： A ring box having a rotating ring holder, wherein movement of one or more lids as the ring box is opened or closed drives rotation of the ring holder. In some embodiments the depth of the ring box in its closed configuration can be substantially similar to the depth of the ring holder.

摘要翻译： 具有旋转环保持器的环箱，其中打开或关闭作为环箱的一个或多个盖的运动驱动环保持器的旋转。 在一些实施例中，环形盒在其闭合构型中的深度可以基本上类似于环形支架的深度。

公开(公告)号：US20110250221A1

公开(公告)日：2011-10-13

申请号：US12674661

申请日：2008-08-22

申请人： Mark Walker ,  Jason Cole ,  Anna Henningham

发明人： Mark Walker ,  Jason Cole ,  Anna Henningham

IPC分类号： A61K39/09 ,  C07K7/08 ,  C07K14/315 ,  C07H21/00 ,  A61P31/04 ,  C12N5/10 ,  C12N1/00 ,  C07K16/12 ,  A61P37/04 ,  C07K7/06 ,  C12N15/63

CPC分类号： A61K39/092 ,  A61K2039/575 ,  C07K14/315 ,  C07K2317/50

摘要： Isolated proteins and immunogenic fragments thereof, for use in the treatment and prevention of a Group A Streptococcus infection are provided. In particular, the invention provides pharmaceutical compositions and methods of prophylactic and/or therapeutic treatment of a Group A Streptococcus infection.

摘要翻译： 提供了用于治疗和预防A组链球菌感染的分离的蛋白质及其免疫原性片段。 特别地，本发明提供了对A组链球菌感染的预防和/或治疗性治疗的药物组合物和方法。

公开(公告)号：US20090257416A1

公开(公告)日：2009-10-15

申请号：US12418517

申请日：2009-04-03

申请人： Mark Walker ,  Peter Keevill ,  Andrea Giustina ,  Uthay Thana

发明人： Mark Walker ,  Peter Keevill ,  Andrea Giustina ,  Uthay Thana

IPC分类号： H04W84/02

CPC分类号： H04W8/20 ,  H04W84/045 ,  H04W88/08

摘要： An access point has a connection to a wide area network, and is configured to allow a device to connect thereto, and includes an Application Programming Interface for allowing a remote application to connect to the access point over the wide area network, and to obtain information relating to the device connected to the access point. In particular, the access point is configured to allow a device to connect thereto over a wireless interface, and to provide bearer translation such that traffic over the wireless interface can be directed over the wide area network. The Application Programming Interface may then allow the application to obtain information relating to a connection status of a wireless device associated with the access point.

摘要翻译： 接入点具有与广域网的连接，并且被配置为允许设备连接到其上，并且包括用于允许远程应用通过广域网连接到接入点的应用编程接口，并且获得信息 涉及连接到接入点的设备。 具体地，接入点被配置为允许设备通过无线接口连接到其上，并且提供承载转换，使得无线接口上的业务可以被引导到广域网上。 然后，应用编程接口可以允许应用获得与与接入点相关联的无线设备的连接状态相关的信息。

公开(公告)号：US20070266883A1

公开(公告)日：2007-11-22

申请号：US11434679

申请日：2006-05-16

申请人： Raymond Law ,  G. Donne ,  Mark Walker

发明人： Raymond Law ,  G. Donne ,  Mark Walker

IPC分类号： F42B27/00

CPC分类号： F42B27/08 ,  F42B12/60

摘要： A stingball delivery system, having a housing, a plurality of submunitions, and a plurality of stingballs contained within the housing. The housing has a cylindrical tube and a plurality of curved segments fitted to the cylindrical tube. The cylindrical tube has a fixed end cap and a removable end cap. The submunitions are stacked within the channel defined by cylindrical tube. When the removable end cap is ejected by a pyrotechnic fuze, a plurality of pyrotechnic charges eject the submunitions from the housing individually and sequentially. The ejection of each submunition exerts a force to raise the housing several feet into the air. Each of the submunitions includes a plurality of radially distributed barrels for packaging the stingballs therein. After the submunitions are ejected from the housing, the stingballs are pyrotechnically expelled from the submunitions along predetermined trajectories.

摘要翻译： 具有壳体，多个子弹药以及容纳在壳体内的多个乒乓球的刺球输送系统。 壳体具有圆柱形管和装配到圆柱形管的多个弯曲段。 圆柱形管具有固定的端盖和可移除的端盖。 子弹药堆叠在由圆柱管限定的通道内。 当可拆卸的端盖被烟火引信弹出时，多个烟火装置分别地和顺序地从壳体中弹出子弹药。 每个子弹药的弹出力都会将外壳抬高几英尺。 每个子弹药包括多个径向分布的桶，用于在其中包装刺球。 子弹药从房屋中弹出后，按照预定的轨迹将刺球从子弹药上排除。

公开(公告)号：US20070203979A1

公开(公告)日：2007-08-30

申请号：US11354524

申请日：2006-02-14

申请人： Mark Walker ,  Ylian Saint-Hilaire

发明人： Mark Walker ,  Ylian Saint-Hilaire

IPC分类号： G06F15/16

CPC分类号： H04M7/0069 ,  H04L65/1026 ,  H04L65/1036 ,  H04L65/1069 ,  H04M3/42314 ,  H04M7/006

摘要： In some embodiments a request for an outside line for a telephony call is identified by a requesting extension device coupled to a home network, telephony calls via an Internet connection are placed on behalf of the requesting extension device, inbound calls from the Internet connection are detected, and the inbound calls are routed from the Internet connection to an appropriate extension device coupled to the home network. Other embodiments are described and claimed.

摘要翻译： 在一些实施例中，用于电话呼叫的外线的请求由耦合到家庭网络的请求扩展装置识别，经由因特网连接的电话呼叫代表请求的扩展装置而被放置，检测到来自因特网连接的入站呼叫 ，并且入站呼叫从因特网连接路由到耦合到家庭网络的适当的分机设备。 描述和要求保护其他实施例。

公开(公告)号：US20050214757A1

公开(公告)日：2005-09-29

申请号：US10492634

申请日：2002-10-15

申请人： David Wilson ,  Thomas Hearn ,  Mark Walker

发明人： David Wilson ,  Thomas Hearn ,  Mark Walker

IPC分类号： C07K14/47 ,  C12Q1/68 ,  G01N33/68

CPC分类号： G01N33/6893 ,  A01K2217/05 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/042 ,  G01N2800/325

摘要： A method of diagnosing the presence of, or susceptibility to, retinal dystrophy, cardiomyopathy endocrinopathy, diabetes or Alstrom disease in an individual, which method comprises typing in a sample from the individual the ALMS1 protein or ALMS1 gene region of the individual, or detecting aberrant ALMS1 activity, and thereby determining whether the individual has, or is susceptible to, retinal dystrophy, cardiomyopathy, endocrinopathy, diabetes or Alstrom disease. Use of an agent that modulates (i) the ALMS1 protein, or (ii) a component that affects or is affected by ALMS1, in the manufacture of a medicament for prevention or treating retinal dystrophy, cardiomyopathy, endocrinopathy, diabetes or Alstrom disease.

摘要翻译： 诊断个体视网膜营养不良症，心肌病内分泌病，糖尿病或阿尔斯特罗姆病的存在或易感性的方法，该方法包括从个体的个体的样品中分离个体的ALMS1蛋白或ALMS1基因区域，或检测异常 ALMS1活性，从而确定个体是否具有视网膜营养不良，心肌病，内分泌病，糖尿病或阿尔斯特罗姆病。 在制备用于预防或治疗视网膜营养不良，心肌病，内分泌病，糖尿病或阿尔斯特罗姆病的药物中调节（i）ALMS1蛋白或（ii）影响或受ALMS1影响的组分）的药剂的用途的用途。

公开(公告)号：US20050003473A1

公开(公告)日：2005-01-06

申请号：US10900856

申请日：2004-07-28

申请人： Suzanne Bolten ,  Robert Clayton ,  Alan Easton ,  Leslie Engel ,  Dean Messing ,  John Ng ,  Beverly Reitz ,  Mark Walker ,  Ping Wang

发明人： Suzanne Bolten ,  Robert Clayton ,  Alan Easton ,  Leslie Engel ,  Dean Messing ,  John Ng ,  Beverly Reitz ,  Mark Walker ,  Ping Wang

IPC分类号： G01N33/536 ,  A61K35/74 ,  A61P9/00 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  C07K1/02 ,  C07K14/38 ,  C07K16/40 ,  C07K19/00 ,  C12N1/14 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N3/00 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12P21/08 ,  C12P33/10 ,  C12Q1/26 ,  G01N33/573 ,  C12P33/06 ,  C07H21/04 ,  C12N1/16 ,  C12N15/74 ,  C12P33/08

CPC分类号： C12N9/0083 ,  C07K14/38 ,  C07K16/40 ,  C12N1/14 ,  C12N3/00 ,  C12N9/0004 ,  C12N2799/026 ,  C12P33/10

摘要： The present invention relates to a novel cytochrome P450-like enzyme (Aspergillus ochraceus 11 alpha hydroxylase) and an oxidoreductase (Aspergillus ochraceus oxidoreductase) isolated from cDNA library generated from the mRNA of Aspergillus ochraceus spores. When the cDNA encoding the 11 alpha hydroxylase was co-expressed in Spodoptera frugiperda (Sf-9) insect cells with the cDNA encoding human oxidoreductase as an electron donor, it successfully catalyzed the conversion of the steroid substrate 4-androstene-3,17-dione (AD) to 11 alpha-hydroxy-AD as determined by HPLC analysis. The invention also relates to nucleic acid molecules associated with or derived from these cDNAs including complements, homologues and fragments thereof, and methods of using these nucleic acid molecules, to generate, for example, polypeptides and fragments thereof. The invention also relates to the generation of antibodies that recognizes the A. ochraceus 11 alpha hydroxylase and oxidoreductase and methods of using these antibodies to detect the presence of these native and recombinant polypeptides within unmodified and transformed host cells, respectively. The invention also provides methods of expressing the Aspergillus 11 alpha hydroxylase gene separately, or in combination with human or Aspergillus oxidoreductase, in heterologous host cells, to facilitate the bioconversion of steroid substrates to their 11 alpha hydroxy-counterparts.

摘要翻译： 本发明涉及从赭曲霉孢子的mRNA产生的cDNA文库中分离的新型细胞色素P450样酶（赭曲霉11α羟化酶）和氧化还原酶（赭曲霉氧化还原酶）。 当编码11α羟化酶的cDNA在草地贪夜蛾（Sf-9）昆虫细胞中以编码人氧化还原酶的cDNA作为电子给体共同表达时，其成功地催化类固醇底物4-雄甾烯-3,17- （AD）至11α-羟基-AD，通过HPLC分析测定。 本发明还涉及与这些cDNA相关或衍生的核酸分子，包括其互补序列，同系物和片段，以及使用这些核酸分子的方法，以产生例如其多肽及其片段。 本发明还涉及识别赭曲霉11α羟化酶和氧化还原酶的抗体的产生以及使用这些抗体分别在未修饰和转化的宿主细胞中检测这些天然和重组多肽的存在的方法。 本发明还提供在异源宿主细胞中单独或与人或曲霉属氧化还原酶组合表达曲霉11α羟化酶基因的方法，以促进类固醇底物对其11α羟基对应物的生物转化。