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67 条记录 (耗时 0.092 秒)

    Tissue sealant compositions, vascular closure devices, and uses thereof
    31.
    发明授权
    Tissue sealant compositions, vascular closure devices, and uses thereof 有权
    组织密封剂组合物，血管闭合装置及其用途

    公开(公告)号：US09433700B2

    公开(公告)日：2016-09-06

    申请号：US13266161

    申请日：2010-04-27

    申请人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    IPC分类号： A61L24/10 ,  A61L24/00

    CPC分类号： A61L24/102 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/418 ,  A61L2300/442 ,  A61L2300/604 ,  A61L2400/04 ,  A61L2430/20 ,  A61L2430/34

    摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

    摘要翻译： 本发明提供组织密封剂组合物和脉管系统闭合装置，其可用于光学检测组织密封和/或凝块形成。 本发明的组合物和装置包括当组合物和/或装置结合到组织密封和/或凝块中时经历可观察到的变化的光学染料，例如荧光量子产率的变化和/或视觉颜色的变化，包括 发射和/或吸收波长的变化。 本发明的组织密封剂和血管闭合装置可用于可视化密封和/或血块形成，例如，在外科手术期间或之后，导管移除之后等。本发明还提供用于组织密封的形成和光学检测的方法 或脉管系统穿刺闭合件以及可用于组织密封或脉管系统穿刺闭合件的形成和光学检测的医疗套件。

    Modified Pyrazine Derivatives and Uses Thereof
    32.
    发明申请
    Modified Pyrazine Derivatives and Uses Thereof 有权
    改性吡嗪衍生物及其用途

    公开(公告)号：US20110250140A1

    公开(公告)日：2011-10-13

    申请号：US13140107

    申请日：2009-12-17

    申请人： Amruta Poreddy ,  William L. Neumann

    发明人： Amruta Poreddy ,  William L. Neumann

    IPC分类号： A61K49/00 ,  C07D241/26

    CPC分类号： A61K49/00 ,  A61K49/0013 ,  C07D241/26

    摘要： In some embodiments, the invention provides modified pyrazine derivatives containing a central pyrazine ring with two secondary amine groups attached directly to the central pyrazine ring and two amino carbonyl groups attached directly to the central pyrazine ring. The secondary amine groups are terminated by alkyl groups containing from 1 to 6 carbons. The amino carbonyl groups can be terminated by a wide range of substituents including, but not limited to, alkyl and alkylene groups, polyether groups, including poly(ethylene glycol) groups, secondary and tertiary amine groups, polyhydroxylated alkyl groups, amino carbonyl groups, amino thioketone groups, and combinations thereof. In some embodiments, the invention provides modified pyrazine derivatives useful as optical agents in a wide variety of biomedical imaging procedures, including diagnostic and imaging procedures. In an embodiment, for example, modified pyrazine derivatives are provided which are useful in monitoring organ and system functioning, for example in monitoring renal system functioning.

    摘要翻译： 在一些实施方案中，本发明提供了含有中间吡嗪环的改性吡嗪衍生物，其具有直接连接至中央吡嗪环的两个仲胺基团和直接连接至中央吡嗪环的两个氨基羰基基团。 仲胺基团被含有1至6个碳原子的烷基封端。 氨基羰基可以通过宽范围的取代基来终止，包括但不限于烷基和亚烷基，聚醚基团，包括聚（乙二醇）基团，仲和叔胺基团，多羟基化烷基基团，氨基羰基基团， 氨基硫酮基团及其组合。 在一些实施方案中，本发明提供了在多种生物医学成像方法中用作光学剂的改性吡嗪衍生物，包括诊断和成像程序。 在一个实施方案中，例如，提供了可用于监测器官和系统功能的修饰的吡嗪衍生物，例如在监测肾系统功能。

    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function
    35.
    发明申请
    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function 有权
    荧光吡嗪衍生物及其在肾功能评估中的应用方法

    公开(公告)号：US20090010851A1

    公开(公告)日：2009-01-08

    申请号：US11721186

    申请日：2005-12-22

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    IPC分类号： A61K49/00

    CPC分类号： C07D241/28 ,  A61K31/4965 ,  A61K49/0004 ,  A61K49/0021 ,  A61K49/0052 ,  C07D241/20 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    摘要翻译： 本发明涉及吡嗪衍生物，例如由式I和II表示的衍生物。 式I和II的X 1至X 4可以表征为吸电子基团，而式I和II的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有一个或两个吸收和发射至少约400nm的光谱能量（例如可见光和/或红外光）。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。

    99MTC(III) myocardial imaging agents and method of use
    39.
    发明授权
    99MTC(III) myocardial imaging agents and method of use 失效
    99MTC（III）心肌成像剂及使用方法

    公开(公告)号：US5112595A

    公开(公告)日：1992-05-12

    申请号：US632285

    申请日：1990-12-21

    申请人： Steven R. Woulfe ,  Edward A. Deutsch ,  Mary M. Dyszlewski ,  William L. Neumann

    发明人： Steven R. Woulfe ,  Edward A. Deutsch ,  Mary M. Dyszlewski ,  William L. Neumann

    IPC分类号： A61K51/04 ,  C07B59/00

    CPC分类号： C07B59/004 ,  A61K51/0478 ,  A61K2123/00

    摘要： A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans.

    摘要翻译： 一种用于人的心肌显像剂，其包含通过四齿配体连接在平面位置的Tc（III）复合物，其四个硬原子和两个呋喃酮环，并且在轴向位置由含有二烷基或醚部分的膦。 该药物在施用于人后表现出改善的生物分布，改进的标记和极快的血液清除。 该药物具有高心肌摄取，伴随着非常快速的肝胆清除和广泛的肾清除，以提供足够高的心/肝和心/肺比，其在人体中提供几乎理想的心肌图像。

    Synthesis of vicinal diamines
    40.
    发明授权
    Synthesis of vicinal diamines 失效
    邻氨基二胺的合成

    公开(公告)号：US5105014A

    公开(公告)日：1992-04-14

    申请号：US741012

    申请日：1991-08-06

    申请人： William L. Neumann

    发明人： William L. Neumann

    IPC分类号： C07C209/66 ,  C07C211/09 ,  C07C211/22 ,  C07C211/27

    CPC分类号： C07C209/66

    摘要： The present invention relates to an improved method of forming vicinal diamines. The method according to the present invention has the advantage of being highly stereoselective, capable of forming a wide variety of diamines including racemic and enantiomeric forms, and employing readily available starting and reaction materials.In particular the present invention relates to a method of forming vicinal diamines from a bis-imine precursor using nucleophilic additions of organometallic reagents.

    摘要翻译： 本发明涉及形成连位二胺的改进方法。 根据本发明的方法具有高度立体选择性的优点，能够形成各种各样的二胺，包括外消旋和对映体形式，并且使用容易得到的起始和反应物质。 特别地，本发明涉及使用亲核添加有机金属试剂从双亚胺前体形成连位二胺的方法。