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公开(公告)号：US06287803B1
公开(公告)日：2001-09-11
申请号：US08965130
申请日：1997-11-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
IPC分类号： C12N1531
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号：US06248576B1
公开(公告)日：2001-06-19
申请号：US09493459
申请日：2000-01-28
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Riechard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Riechard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N904
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨醇脱氢酶多肽和编码组氨醇脱氢酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用组氨醇脱氢酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06346393B1
公开(公告)日：2002-02-12
申请号：US08965087
申请日：1997-11-06
申请人： Jason Craig Fedon , Michael Arthur Lonetto , Leslie Marie Palmer , Martin Rosenberg , Richard Lloyd Warren
发明人： Jason Craig Fedon , Michael Arthur Lonetto , Leslie Marie Palmer , Martin Rosenberg , Richard Lloyd Warren
IPC分类号： C12N1531
摘要： The invention provides RncS polypeptides and DNA (RNA) encoding RncS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RncS polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了RncS多肽和编码RncS多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用RncS多肽筛选抗菌化合物的方法。
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公开(公告)号：US06242249B1
公开(公告)日：2001-06-05
申请号：US09414664
申请日：1999-10-07
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
IPC分类号： C07H2104
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N9/90
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了tig多肽和编码tig多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用tig多肽筛选抗菌化合物的方法。
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公开(公告)号：US06228617B1
公开(公告)日：2001-05-08
申请号：US09464483
申请日：1999-12-15
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
IPC分类号： C12P2106
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N9/90
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
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公开(公告)号：US06274361B1
公开(公告)日：2001-08-14
申请号：US09080662
申请日：1998-05-18
申请人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N916
CPC分类号： C12N9/18
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US5866365A
公开(公告)日：1999-02-02
申请号：US869674
申请日：1997-06-05
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61P11/00 , A61P31/04 , C07K16/40 , C12N1/21 , C12N9/00 , C12N9/22 , C12N15/09 , C12N15/55 , C12Q1/00 , G01N33/566 , C12N1/20 , C12N15/00 , C12N15/11
CPC分类号： C12N9/22 , A61K38/00 , A61K39/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了rnc多肽和编码rnc多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用rnc多肽筛选抗菌化合物的方法。
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公开(公告)号：US06444208B1
公开(公告)日：2002-09-03
申请号：US09213011
申请日：1998-12-16
IPC分类号： C12N922
CPC分类号： C12N9/22 , A61K38/00 , A61K39/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了rnc多肽和编码rnc多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用rnc多肽筛选抗菌化合物的方法。
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公开(公告)号：US06251630B1
公开(公告)日：2001-06-26
申请号：US09213010
申请日：1998-12-16
IPC分类号： C12P2106
CPC分类号： C12N9/22 , A61K38/00 , A61K39/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides rnc polynucleotides which encode rnc polypeptides, polynucleotides related thereto, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing the claimed polynucleotides and polypeptides to screen for antibacterial compounds and for the detection of pathogens.
摘要翻译： 本发明提供编码rnc多肽，与其相关的多核苷酸的rnc多核苷酸，以及通过重组技术产生此类多肽的方法。 还提供了利用要求保护的多核苷酸和多肽筛选抗菌化合物和检测病原体的方法。
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公开(公告)号：US07422749B2
公开(公告)日：2008-09-09
申请号：US11698250
申请日：2007-01-25
申请人： Michael T. Black , Martin K. Burnham , Jason C. Fedon , John E. Hodgson , David J. Knowles , Michael A. Lonetto , Richard O. Nicholas , Leslie M. Palmer , Julie M. Pratt , Raymond W. Reichard , Martin Rosenberg , Christopher M. Traini , Judith Ward , Richard L. Warren
发明人： Michael T. Black , Martin K. Burnham , Jason C. Fedon , John E. Hodgson , David J. Knowles , Michael A. Lonetto , Richard O. Nicholas , Leslie M. Palmer , Julie M. Pratt , Raymond W. Reichard , Martin Rosenberg , Christopher M. Traini , Judith Ward , Richard L. Warren
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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