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89 条记录 (耗时 0.125 秒)

    Human transcription factor IIA
    31.
    发明授权
    Human transcription factor IIA 失效
    人转录因子IIA

    公开(公告)号：US06344543B1

    公开(公告)日：2002-02-05

    申请号：US08845011

    申请日：1997-04-22

    申请人： Paul A. Moore ,  Craig A. Rosen

    发明人： Paul A. Moore ,  Craig A. Rosen

    IPC分类号： C07K1600

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The small (&ggr;) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for regulating gene-specific and global transcription. Antagonists against such polypeptide and their use to inhibit transcription are also disclosed.

    摘要翻译： 人转录因子IIA的小（γ）亚基和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽调节基因特异性和全局转录的方法。 还公开了抗这种多肽的拮抗剂及其抑制转录的用途。

    Antibodies to HSDEK49 polypeptides
    32.
    发明授权
    Antibodies to HSDEK49 polypeptides 失效
    HSDEK49多肽的抗体

    公开(公告)号：US07968689B2

    公开(公告)日：2011-06-28

    申请号：US12198817

    申请日：2008-08-26

    申请人： Craig A. Rosen ,  Steven M. Ruben ,  Paul A. Moore

    发明人： Craig A. Rosen ,  Steven M. Ruben ,  Paul A. Moore

    IPC分类号： C07K16/00

    CPC分类号： C07K16/2803

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

    Treatment using antibodies to cytokine receptor common gamma chain like
    36.
    发明授权
    Treatment using antibodies to cytokine receptor common gamma chain like 有权
    治疗使用细胞因子受体常见γ链的抗体

    公开(公告)号：US07504105B2

    公开(公告)日：2009-03-17

    申请号：US10899107

    申请日：2004-07-27

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

    IPC分类号： A61K39/00 ,  C07K16/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7155

    摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.

    摘要翻译： 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地，本发明涉及一种编码新型人多肽的多核苷酸，命名为“细胞因子受体共同伽马链样”或“CRCGCL”。 本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。