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公开(公告)号：US07312061B2
公开(公告)日：2007-12-25
申请号：US11233581
申请日：2005-09-23
申请人： Jessie English , Thierry Oliver Fischmann , Thomas Hesson , Alan William Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Shane Taremi
发明人： Jessie English , Thierry Oliver Fischmann , Thomas Hesson , Alan William Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Shane Taremi
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
摘要翻译： 本发明涉及ERK2多肽的结晶及其复合物，其特别用于结构辅助药物设计。
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32.发明授权Compositions of hepatitis C virus NS3/NS4A complex and methods for crystallizing same 失效丙型肝炎病毒NS3 / NS4A复合物的组合物及其结晶方法公开(公告)号：US06524589B1
公开(公告)日：2003-02-25
申请号：US09543376
申请日：2000-04-05
IPC分类号： A61K3929
CPC分类号： C07K14/005 , C07K2299/00 , C12N2770/24222
摘要： The invention relates to the purification and crystallization of hepatitis C virus (HCV) NS3/NS4A polypeptide complex. Also, crystallization conditions for NS3/NS4A are provided. Further, the atomic coordinates for the NS3/NS4A protein are disclosed. Examples of its use for the determination of the three-dimensional atomic structures of HCV NS3/NS4A with substrate(s) or substrate analog(s) or inhibitor complexes are also provided.
摘要翻译： 本发明涉及丙型肝炎病毒（HCV）NS3 / NS4A多肽复合物的纯化和结晶。 另外，提供NS3 / NS4A的结晶条件。 此外，公开了NS3 / NS4A蛋白的原子坐标。 还提供了其用于测定具有底物或底物类似物或抑制剂复合物的HCV NS3 / NS4A的三维原子结构的用途。
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公开(公告)号：US11014986B2
公开(公告)日：2021-05-25
申请号：US15553254
申请日：2016-02-22
申请人： Paul Reichert , Winifred W. Prosise , Giovanna Scapin , Xiaoyu Yang , Ramesh Kashi , Corey Strickland , Merck Sharp & Dohme Corp.
发明人： Paul Reichert , Winifred W. Prosise , Giovanna Scapin , Xiaoyu Yang , Ramesh Kashi , Corey Strickland
摘要： Crystals of pembrolizumab and structurally similar anti-PD-1 monoclonal antibodies are provided, as well as methods of producing such crystals, and uses of compositions comprising such antibody crystals, e.g. in treatment of cancers. The present invention satisfies these needs and more by providing pembrolizumab crystals and a method producing pembrolizumab crystals. One embodiment of the method of the invention produces crystals suitable for X-ray diffraction, and the inventors herein used such crystals to solve the three-dimensional structure of pembrolizumab to 2.3 A resolution.
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公开(公告)号：US08710188B2
公开(公告)日：2014-04-29
申请号：US13149011
申请日：2011-05-31
申请人： Brian M. Beyer , Alan W. Hruza , Richard N. Ingram , Vincent S. Madison , Andrew J. Prongay , Paul Reichert
发明人： Brian M. Beyer , Alan W. Hruza , Richard N. Ingram , Vincent S. Madison , Andrew J. Prongay , Paul Reichert
CPC分类号： C12Q1/56 , A61K38/00 , C07K2299/00 , C12N9/644 , C12Y304/21022 , G01N2500/04
摘要： The present invention relates to factor IXa complexes and crystals thereof as well as methods for identifying inhibitors of factor IXa.
摘要翻译： 本发明涉及因子IXa复合物及其晶体，以及鉴定因子IXa抑制剂的方法。
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35.发明授权公开(公告)号：US08048663B2
公开(公告)日：2011-11-01
申请号：US12815817
申请日：2010-06-15
申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31
摘要： The present invention relates to Pregnane X receptor (PXR) polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.
摘要翻译： 本发明涉及可用于例如结晶和用于鉴定PXR调节剂的测定中的孕烷X受体（PXR）多肽和晶体。
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公开(公告)号：US20100286372A1
公开(公告)日：2010-11-11
申请号：US12815817
申请日：2010-06-15
申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
IPC分类号： C07K14/00
CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31
摘要： The present invention relates, inter alia, to PXR polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.
摘要翻译： 本发明尤其涉及PXR多肽和晶体，其可用于例如结晶和用于鉴定PXR调节剂的测定。
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37.发明授权公开(公告)号：US07824491B2
公开(公告)日：2010-11-02
申请号：US12184770
申请日：2008-08-01
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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公开(公告)号：US20100267053A1
公开(公告)日：2010-10-21
申请号：US12784760
申请日：2010-05-21
申请人： ANDREW J. PRONGAY , Thierry O. Fischmann , Chandra Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
发明人： ANDREW J. PRONGAY , Thierry O. Fischmann , Chandra Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
摘要翻译： 本发明部分地提供AKT3多肽及其与编码多肽的核酸的使用方法。 例如，本文提供了用于筛选AKT3抑制剂的方法。
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公开(公告)号：US20080081360A1
公开(公告)日：2008-04-03
申请号：US11873831
申请日：2007-10-17
申请人： Jessie English , Thierry Fischmann , Thomas Hesson , Alan Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Taremi
发明人： Jessie English , Thierry Fischmann , Thomas Hesson , Alan Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Taremi
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
摘要翻译： 本发明涉及ERK2多肽的结晶及其复合物，其特别用于结构辅助药物设计。
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公开(公告)号：US06380172B1
公开(公告)日：2002-04-30
申请号：US09408382
申请日：1999-09-29
申请人： Patricia C. Weber , Ashit Kumar Ganguly , Paul Reichert , Charles W. McNemar , William T. Windsor , Eric W. Kaler
发明人： Patricia C. Weber , Ashit Kumar Ganguly , Paul Reichert , Charles W. McNemar , William T. Windsor , Eric W. Kaler
IPC分类号： A61K31715
摘要： This invention relates to pharmaceutical composition comprising a lipophilic oligosaccharide antibiotic in a substantially monomeric form.
摘要翻译： 本发明涉及包含基本上单体形式的亲脂寡糖抗生素的药物组合物。
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