公开(公告)号：US20170121659A1

公开(公告)日：2017-05-04

申请号：US15403944

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  C12M1/34 ,  C12M3/00 ,  B01L3/00

CPC classification number: C12M23/16 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y15/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/00 ,  C12M41/40 ,  C12M41/46 ,  G01N33/5005

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US20250059590A1

公开(公告)日：2025-02-20

申请号：US18936042

申请日：2024-11-04

Applicant: President and Fellows of Harvard College

Inventor： George M. Church ,  Jehyuk Lee ,  Daniel Levner ,  Michael Super

IPC: C12Q1/6806 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53

Abstract: Methods of analyzing nucleic acids of a cell are provided.

公开(公告)号：US12187997B2

公开(公告)日：2025-01-07

申请号：US18346165

申请日：2023-06-30

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony M. Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: C12M3/06 ,  A01N1/02 ,  B01L3/00 ,  B01L9/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  G01N33/50

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20240425788A1

公开(公告)日：2024-12-26

申请号：US18755633

申请日：2024-06-26

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony M. Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: C12M3/06 ,  A01N1/02 ,  B01L3/00 ,  B01L9/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  G01N33/50

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US12173263B2

公开(公告)日：2024-12-24

申请号：US15105388

申请日：2014-12-19

Applicant: President and Fellows of Harvard College ,  Jose Fernandez-Alcon ,  Norman Wen ,  Richard Novak

Inventor： Jose Fernandez-Alcon ,  Norman Wen ,  Richard Novak ,  Donald E. Ingber ,  Geraldine A. Hamilton ,  Christopher Hinojosa ,  Karel Domansky ,  Daniel Levner ,  Guy Thompson, II ,  Kambez Hajipouran Benam ,  Remi Villenave ,  Thomas Umundum ,  Alfred Paris ,  Georg Bauer

IPC: C12M3/06 ,  B01D61/18 ,  B01D63/08 ,  B01D67/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

公开(公告)号：US20230146985A1

公开(公告)日：2023-05-11

申请号：US18146483

申请日：2022-12-27

Applicant: President and Fellows of Harvard College

Inventor： Daniel Levner ,  Je-Hyuk Lee ,  George M. Church ,  Michael Super

IPC: C12Q1/6806 ,  C12Q1/6874 ,  C12Q1/6869 ,  C12Q1/6844 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837

CPC classification number: C12Q1/6806 ,  C12Q1/6874 ,  C12Q1/6869 ,  C12Q1/6844 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837 ,  G01N33/53

Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.

公开(公告)号：US20220364030A1

公开(公告)日：2022-11-17

申请号：US17876283

申请日：2022-07-28

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  B01L3/00 ,  B82Y15/00 ,  C12M1/34 ,  G01N33/50 ,  C12M3/00 ,  C12M1/26

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US11293052B2

公开(公告)日：2022-04-05

申请号：US17238682

申请日：2021-04-23

Applicant: President and Fellows of Harvard College

Inventor： George M. Church ,  Jehyuk Lee ,  Daniel Levner ,  Michael Super

IPC: C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12P19/34

Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.

公开(公告)号：US20220025448A1

公开(公告)日：2022-01-27

申请号：US17498829

申请日：2021-10-12

Applicant: President and Fellows of Harvard College

Inventor： Daniel Levner ,  Je-Hyuk Lee ,  George M. Church ,  Michael Super

IPC: C12Q1/6837 ,  C12Q1/6804 ,  C12Q1/6816

Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.

公开(公告)号：US10954482B2

公开(公告)日：2021-03-23

申请号：US16134746

申请日：2018-09-18

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: A01N1/02 ,  B01L3/00 ,  C12M1/00 ,  C12M3/00 ,  C12M1/34 ,  B01L9/00 ,  C12M1/42 ,  C12M3/06 ,  G01N33/50

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.