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公开(公告)号:US09157860B2
公开(公告)日:2015-10-13
申请号:US11225968
申请日:2005-09-13
申请人: Steven J. Boege
发明人: Steven J. Boege
CPC分类号: G01J1/0411 , G01J3/0208 , G01N21/63 , G01N21/6452 , G01N21/6486 , G01N2021/6478
摘要: A luminescence detection system may include an excitation light source, a single element achromat, and a detector. The single element achromat may be configured to regulate the excitation light from the light source and direct the regulated light to a target, and the detector may be configured to detect luminescence generated by the target. The single element achromat may be configured to regulate the emission light from the target and direct the regulated light to a detector, and the excitation light source may be configured to direct the excitation light to the target. The single element achromat may be configured to regulate both the excitation light from the light source and the emission light from the target and direct the regulated light to, respectively, the target and a detector.
摘要翻译: 发光检测系统可以包括激发光源,单个元件消色差和检测器。 单元件消色差可以被配置为调节来自光源的激发光并将调节光引导到目标,并且检测器可以被配置为检测由目标产生的发光。 单元件消色差可以被配置为调节来自目标的发射光并将调节光引导到检测器,并且激发光源可以被配置为将激发光引导到目标。 单个元件消色差可以被配置为调节来自光源的激发光和来自目标的发射光,并将调节光分别指向目标和检测器。
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公开(公告)号:US20070190642A1
公开(公告)日:2007-08-16
申请号:US11675546
申请日:2007-02-15
申请人: Steven J. Boege
发明人: Steven J. Boege
CPC分类号: G01N21/645 , G01N21/6428 , G01N2021/6463
摘要: System and methods for concentrating collected flux in the form of excitation light or luminescence. The collected flux may be directed, propagated, and concentrated in various manners and may be localized into a generally small area. Concentrators may be advantageously implemented in flexible and efficient manners relative to conventional configurations where a single lens acts alone to direct the light to a detector.
摘要翻译: 以激发光或发光的形式集中收集的磁通的系统和方法。 收集的通量可以以各种方式引导,传播和浓缩,并且可以定位在通常较小的区域中。 相对于常规配置,集中器可以以柔性和有效的方式实现,其中单个透镜单独作用以将光引导到检测器。
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公开(公告)号:US07248359B2
公开(公告)日:2007-07-24
申请号:US11095407
申请日:2005-03-30
申请人: Steven J. Boege
发明人: Steven J. Boege
CPC分类号: G01J3/10 , G01J3/0205 , G01J3/021 , G01N21/6428 , G01N21/645 , G01N21/76 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G02B27/1086 , G02B27/126 , G02B27/143 , G02B27/144 , G02B27/145
摘要: Systems and methods for biological sample detection by combining and directing light with an optical blender that provides a composite beam from spatially and spectrally distinct non-parallel light sources.
摘要翻译: 通过组合和引导光与光学混合器的生物样品检测的系统和方法,其提供来自空间和光谱上不同的非平行光源的复合束。
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公开(公告)号:US20100035358A1
公开(公告)日:2010-02-11
申请号:US12575004
申请日:2009-10-07
申请人: Dennis A. Lehto , Steven J. Boege
发明人: Dennis A. Lehto , Steven J. Boege
CPC分类号: C12Q1/6874 , B01J2219/00286 , B01J2219/00306 , B01J2219/005 , B01J2219/00533 , B01J2219/00596 , B01J2219/00648 , B01L3/502 , B01L3/50851 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/10 , B01L2300/043 , B01L2300/0822 , B01L2300/0877 , B01L2300/1805 , B01L2300/1811 , B01L2300/1894 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N21/0332 , G01N21/05 , G01N2021/0346 , G01N2021/058 , G01N2201/02 , G03B27/42
摘要: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.
摘要翻译: 用于进行生物样品反应的装置可以包括多个流动池,其构造成安装到普通的显微镜平移台上,其中每个流动池被构造成容纳至少一个含有生物样品的样品架。 每个流动池还可以被配置为选择性地放置在打开位置,用于将至少一个样品保持器定位到流动室中,以及用于使包含在至少一个样品保持器中的生物样品反应的关闭位置。 多个流动池可以被配置为被选择性地彼此相对放置在打开位置和关闭位置。
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公开(公告)号:US20090139311A1
公开(公告)日:2009-06-04
申请号:US12244701
申请日:2008-10-02
申请人: Dennis A. Lehto , Steven J. Boege
发明人: Dennis A. Lehto , Steven J. Boege
CPC分类号: C12Q1/6874 , B01J2219/00286 , B01J2219/00306 , B01J2219/005 , B01J2219/00533 , B01J2219/00596 , B01J2219/00648 , B01L3/502 , B01L3/50851 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/10 , B01L2300/043 , B01L2300/0822 , B01L2300/0877 , B01L2300/1805 , B01L2300/1811 , B01L2300/1894 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N21/0332 , G01N21/05 , G01N2021/0346 , G01N2021/058 , G01N2201/02 , G03B27/42
摘要: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.
摘要翻译: 用于进行生物样品反应的装置可以包括多个流动池,其构造成安装到普通的显微镜平移台上,其中每个流动池被构造成容纳至少一个含有生物样品的样品架。 每个流动池还可以被配置为选择性地放置在打开位置,用于将至少一个样品保持器定位到流动室中,以及用于使包含在至少一个样品保持器中的生物样品反应的关闭位置。 多个流动池可以被配置为被选择性地彼此相对放置在打开位置和关闭位置。
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公开(公告)号:US08591836B2
公开(公告)日:2013-11-26
申请号:US12099644
申请日:2008-04-08
IPC分类号: B01L3/00
CPC分类号: B01L3/50851 , B01L3/50825 , B01L3/50853 , B01L2300/042 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/168 , C12Q1/6806 , G01N21/0303
摘要: A cover for a biological sample well tray, comprising a cap for sealing a sample well. The cap comprises a well lens for focusing light into the sample well and collecting light from the sample. In another aspect, the cap comprises an elongate portion configured to permit incoming light to pass into the sample well and out of the sample well. Various other aspects comprise a microcard for biological material, and an apparatus for a plurality of sample well strips. A method for testing a biological sample is also provided.
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公开(公告)号:US20080194014A1
公开(公告)日:2008-08-14
申请号:US12099644
申请日:2008-04-08
IPC分类号: C12M1/34
CPC分类号: B01L3/50851 , B01L3/50825 , B01L3/50853 , B01L2300/042 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/168 , C12Q1/6806 , G01N21/0303
摘要: A cover for a biological sample well tray, comprising a cap for sealing a sample well. The cap comprises a well lens for focusing light into the sample well and collecting light from the sample. In another aspect, the cap comprises an elongate portion configured to permit incoming light to pass into the sample well and out of the sample well. Various other aspects comprise a microcard for biological material, and an apparatus for a plurality of sample well strips. A method for testing a biological sample is also provided.
摘要翻译: 用于生物样品井托盘的盖子,包括用于密封样品井的盖子。 盖包括用于将光聚焦到样品阱中并收集来自样品的光的井透镜。 在另一方面,盖包括细长部分,该细长部分被配置成允许入射光进入样品阱并从样品阱中进入。 各种其它方面包括用于生物材料的微卡,以及用于多个样品阱条的装置。 还提供了用于测试生物样品的方法。
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公开(公告)号:US07221449B2
公开(公告)日:2007-05-22
申请号:US10879374
申请日:2004-06-28
申请人: Steven J. Boege
发明人: Steven J. Boege
IPC分类号: G01J3/30
CPC分类号: G01J3/02 , G01J3/0208 , G01J3/18 , G01J3/4406 , G01N21/645 , G01N2021/6478 , G02B19/0023 , G02B19/0028 , G02B19/0047
摘要: An optical device adapted to detect fluorescence from a biological sample. The optical device includes an optical relay to collect fluorescence emitted by the fluorophores and to direct the collected fluorescence towards a detector.
摘要翻译: 适于检测来自生物样品的荧光的光学装置。 光学装置包括光学继电器,用于收集由荧光团发出的荧光并将收集的荧光引向检测器。
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