公开(公告)号：US20180264471A1

公开(公告)日：2018-09-20

申请号：US15982009

申请日：2018-05-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Thomas Fischer ,  Eloisa Lopez-Calle ,  Sascha Lutz ,  Josef Roedl ,  Juergen Spinke ,  Pamela Espindola ,  Thomas Manuel Keller ,  Thomas Dolbinow ,  Sabrina Adler ,  Erik Beiersdorf ,  Domenik Wensorra

IPC: B01L3/00

CPC classification number: B01L3/502753 ,  B01L3/5023 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/084 ,  G01N35/00069 ,  G01N2035/1032

Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.

公开(公告)号：US20180136243A1

公开(公告)日：2018-05-17

申请号：US15807802

申请日：2017-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Thomas Keller

IPC: G01N35/00 ,  G01N33/50 ,  B01L3/00

CPC classification number: G01N35/00584 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  G01F13/00 ,  G01N33/5005 ,  G01N35/00 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00495

Abstract: A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.

公开(公告)号：US20170095813A1

公开(公告)日：2017-04-06

申请号：US15352689

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz

IPC: B01L3/00 ,  G01N35/10 ,  G01N1/38 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00237 ,  G01N2035/00257 ,  G01N2035/1032 ,  G01N2035/1034

Abstract: An automatic analyzer cartridge spinnable around a rotational axis has a fluid chamber for receiving a fluid, an aliquoting chamber, a duct connecting the fluid chamber and the aliquoting chamber, a downstream fluidic element, a siphon for siphoning the fluid from the aliquoting chamber to the downstream fluidic element, a fluidic structure for processing a biological sample into the processed biological sample, and a measurement structure for enabling measurement of the processed biological sample. The siphon has a siphon entrance in the aliquoting chamber and a siphon exit in the downstream fluidic element, wherein the siphon has a bend, wherein the bend is the portion of the siphon closest to the rotational axis, wherein the siphon entrance starts at the bend, wherein the siphon entrance extends to a lower portion of the aliquoting chamber. This enables multiple aliquots of fluid to be removed from the aliquoting chamber by the siphon.

公开(公告)号：US20170095812A1

公开(公告)日：2017-04-06

申请号：US15352680

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00257 ,  G01N2035/1032

Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.