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31.发明授权Apparatus for insufflating gas into a corporeal cavity of a human or animal body 有权用于将气体吹入人体或动物体的体腔的装置公开(公告)号：US06458093B1
公开(公告)日：2002-10-01
申请号：US09824480
申请日：2001-04-02
IPC分类号： A61M3700
CPC分类号： A61M37/00 , A61B2090/064 , A61M2202/02 , A61M2202/0225 , A61M2202/0007
摘要： A device for insufflating gas into a corporeal cavity of a human or animal body has a connection for a gas source, a measuring unit provided with sensors for the fill gas pressure and the fill gas flow, which are disposed outside said corporeal cavity, and a control unit, to which the output signal of the sensors are applied, and which triggers a pressure regulator which reduces the fill pressure of the gas source to a pre-set insufflation pressure, and a flow regulator which regulates the fill gas flow to a pre-set desired gas flow value in accordance with first a square function, and then, after reaching the preset flow rate, in accordance with a linear function.
摘要翻译： 用于将气体吹入人体或动物体的体腔的装置具有用于气体源的连接，设置有设置在所述体腔内的填充气体压力和填充气体流量的传感器的测量单元，以及 控制单元，其中施加传感器的输出信号，并且其触发压力调节器，其将气源的填充压力降低到预设的吹入压力;以及流量调节器，其将填充气体流量调节到预 根据第一个平方函数设置所需的气体流量值，然后根据线性函数达到预设流量。
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32.发明授权Low power current to frequency converter circuit for use in implantable sensors 失效用于可植入传感器的低功率电流至变频器电路
公开(公告)号：US5917346A
公开(公告)日：1999-06-29
申请号：US928868
申请日：1997-09-12
申请人： John C. Gord
发明人： John C. Gord
摘要： A low power current-to-frequency converter circuit provides an output frequency signal F.sub.OUT having a frequency that varies as a function of a low level analog input current signal. The analog input current signal is typically generated by an implantable sensor element, designed to sense a particular substance or parameter within body tissue or fluids to which the sensor is exposed, with the magnitude of the analog signal providing a measure of the sensed substance or parameter. Conversion of the low level analog current to the output frequency signal facilitates transmission of the data signal over a shared data bus and other digital processing of the data signal. The current-to-frequency converter circuit is fabricated from low power FET-based integrated circuits, typically realized on a single integrated circuit chip, and includes an operational amplifier having its positive input terminal connected to a storage capacitor that is charged by the analog input current signal, a voltage-controlled oscillator driven by the charge (voltage) on the storage capacitor that produces the output frequency signal, and a charge pump circuit that pumps a discrete amount of charge off of the storage capacitor during each cycle of the output frequency signal.
摘要翻译： 低功率电流 - 频率转换器电路提供具有作为低电平模拟输入电流信号的函数而变化的频率的输出频率信号FOUT。 模拟输入电流信号通常由可植入的传感器元件产生，该元件设计用于感测传感器暴露于身体组织或流体内的特定物质或参数，模拟信号的幅度提供所检测到的物质或参数的量度 。 将低电平模拟电流转换为输出频率信号有助于通过共享数据总线传输数据信号和数据信号的其他数字处理。 电流 - 频率转换器电路由通常在单个集成电路芯片上实现的低功率基于FET的集成电路制造，并且包括运算放大器，其正输入端连接到由模拟输入充电的存储电容器 电流信号，由产生输出频率信号的存储电容器上的充电（电压）驱动的压控振荡器，以及在输出频率的每个周期期间将离散量的电荷泵送到存储电容器的电荷泵电路 信号。
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公开(公告)号：US5522865A
公开(公告)日：1996-06-04
申请号：US322068
申请日：1994-10-12
CPC分类号： A61N1/36032 , A61N1/36185 , A61N1/37252 , H04R25/505 , H04R2460/03
摘要： A tissue stimulating system includes an external transmitter for transmitting a data signal to an implanted stimulator. The implanted stimulator includes a processor for generating stimulation signals for application to a plurality of tissue stimulating electrodes through respective isolated output channels. The implanted stimulator also includes a power supply that extracts a raw power signal from the data signal. A voltage downconverter generates at least four separate voltages from the extracted raw power signal by alternately connecting at least four capacitors in series across the raw power signal, thereby providing at least four output voltages, and then connecting the capacitors in parallel to transfer the charge stored thereon to a storage capacitor, which serves as the power source for portions of the stimulator. A selected one of the output voltages from the voltage downconverter is applied to an isolated refresh voltage capacitor in each output channel, where it controls a voltage controlled current source. The processor selectively monitors the electrodes and/or voltages generated in the stimulator and generates status indicating/measurement signals for transmission to the external transmitter. The external processor receives and processes the status indicating/measurement signals and uses the information therefrom to control the amount of power transmitted to the stimulator.
摘要翻译： 组织刺激系统包括用于将数据信号发送到植入的刺激器的外部发射器。 植入的刺激器包括用于通过相应的隔离输出通道产生刺激信号以用于多个组织刺激电极的处理器。 植入的刺激器还包括从数据信号中提取原始功率信号的电源。 电压下变频器通过在原始功率信号上交替地连接串联的至少四个电容器，从而提供至少四个输出电压，然后并联连接电容器以转移所存储的电荷，从而从提取的原始功率信号产生至少四个分离的电压 在其上用作用于刺激器的部分的电源的存储电容器。 来自电压下变频器的选择的一个输出电压被施加到每个输出通道中的隔离的刷新电压电容器，其中它控制电压控制的电流源。 处理器选择性地监视在刺激器中产生的电极和/或电压，并产生用于传输到外部发射器的状态指示/测量信号。 外部处理器接收并处理状态指示/测量信号，并使用其信息来控制发送到刺激器的功率量。
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公开(公告)号：US08555894B2
公开(公告)日：2013-10-15
申请号：US10920570
申请日：2004-08-18
申请人： Joseph H. Schulman , John C. Gord , James H. Wolfe
发明人： Joseph H. Schulman , John C. Gord , James H. Wolfe
IPC分类号： A61B19/00
CPC分类号： A61N1/37288 , A61B5/0008 , A61B5/0028 , A61B5/0031 , A61B5/053 , A61B5/07 , A61B5/076 , A61B5/1071 , A61B5/145 , A61B5/14532 , A61B5/1473 , A61B2560/0209 , A61B2560/0219 , A61B2562/08 , A61F2/72 , A61F2002/5058 , A61F2002/704 , A61F2002/705 , A61N1/37205 , A61N1/3787
摘要： A system for monitoring temperature in a body, the system comprising at least one implantable device, wherein the implantable device(s) is operable to sense temperature in the body and to generate status signals based on the sensed temperature in the body. The system further comprising a system control unit for wirelessly communicating with the implantable device(s), and the system control unit comprising a signal receiver for receiving the status signals, and also a programmable controller for producing notification signals based on the received status signals. A notification unit can alternatively communicate with the system control unit or the implantable device(s) for disclosing the sensed body temperature based on the notification signals.
摘要翻译： 一种用于监测身体温度的系统，所述系统包括至少一个可植入装置，其中所述可植入装置可操作以感测身体中的温度并基于身体中感测的温度产生状态信号。 所述系统还包括用于与所述可植入装置进行无线通信的系统控制单元，所述系统控制单元包括用于接收状态信号的信号接收器，以及用于基于接收的状态信号产生通知信号的可编程控制器。 通知单元还可以与系统控制单元或可植入装置通信，用于基于通知信号公开感测体温。
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35.发明授权System and method suitable for treatment of a patient with a neurological deficit by sequentially stimulating neural pathways using a system of discrete implantable medical devices 有权适用于通过使用离散可植入医疗装置的系统顺序刺激神经通路来治疗患有神经缺陷的患者的系统和方法公开(公告)号：US07460911B2
公开(公告)日：2008-12-02
申请号：US11004758
申请日：2004-12-03
申请人： Gregoire Cosendai , Ytizhak Zilberman , Doug Kuschner , Anne Marie Ripley , Ruth Turk , Jane Burridge , Scott V. Notley , Ross Davis , Morten Hansen , Lee Jay Mandell , Joseph H. Schulman , Robert Dan Dell , John C. Gord
发明人： Gregoire Cosendai , Ytizhak Zilberman , Doug Kuschner , Anne Marie Ripley , Ruth Turk , Jane Burridge , Scott V. Notley , Ross Davis , Morten Hansen , Lee Jay Mandell , Joseph H. Schulman , Robert Dan Dell , John C. Gord
IPC分类号： A61N1/08
CPC分类号： A61B5/07 , A61B5/0031 , A61B5/053 , A61B5/145 , A61B5/14532 , A61B5/4519 , A61B5/4528 , A61B2560/0219 , A61B2562/08 , A61F2/72 , A61F2002/5058 , A61F2002/704 , A61F2002/705 , A61N1/37205 , A61N1/37211 , A61N1/37252 , A61N1/37288 , A61N1/3787
摘要： A system and method that facilitates stimulating neural pathways, e.g., muscles and/or associated nerves, of a patient's body for the purpose of therapeutic medical treatment by rehabilitating weakened muscles and using neuroplasticity to retrain sequential muscle movements and/or to provide the ability to directly deliver functional motor movements. Use of the present invention is of particular value for treating a patient following a stroke. More particularly, such systems are characterized by a plurality of discrete devices, preferably battery powered but may alternatively include RF-powered devices as well or in combination, configured for implanting within a patient's body via injection, each device being configured to affect a parameter, e.g., via nerve and/or muscle stimulation and/or to sense a body parameter, e.g., temperature, O2 content, physical position, electrical potential, etc., that operate under control of a system controller that coordinates the sequential stimulation via wireless commands to the implanted devices.
摘要翻译： 一种系统和方法，其有助于刺激患者身体的神经通路，例如肌肉和/或相关神经，以通过康复弱化的肌肉并使用神经可塑性来重新训练顺序的肌肉运动和/或提供 直接提供功能运动。 本发明的使用对于治疗中风后的患者是特别有价值的。 更具体地，这样的系统的特征在于多个分立的装置，优选地是电池供电的，但也可以包括RF供电的装置，或者组合地被配置用于经由注射植入到患者体内，每个装置被配置成影响参数， 例如经由神经和/或肌肉刺激和/或感测在通过无线命令协调顺序刺激的系统控制器的控制下操作的身体参数，例如温度，O 2含量，物理位置，电位等 到植入的装置。
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公开(公告)号：US07379774B2
公开(公告)日：2008-05-27
申请号：US10966637
申请日：2004-10-14
IPC分类号： A61N1/00
CPC分类号： H04L25/028 , A61N1/372 , A61N1/37205 , A61N1/3787 , H04L25/0266 , H04L25/0268 , H04L27/366
摘要： A system, method and power/data transmission device comprising a coil having a high Q, a low-voltage driver and a high-voltage driver switchably coupled to the coil. The low-voltage driver and the high-voltage driver are controlled by a microcontroller and switch at about the same time thereby providing a modulated data signal for transmission. Furthermore, the system includes at least one implantable microstimulator coupled to the transmission device.
摘要翻译： 一种包括具有高Q的线圈，低电压驱动器和可切换地耦合到线圈的高压驱动器的系统，方法和功率/数据传输装置。 低电压驱动器和高电压驱动器由微控制器和大约相同的时间开关控制，从而提供用于传输的调制数据信号。 此外，该系统包括耦合到传输装置的至少一个可植入微型激励器。
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37.发明授权公开(公告)号：US07237712B2
公开(公告)日：2007-07-03
申请号：US11002592
申请日：2004-12-01
申请人： Paul DeRocco , John C. Gord , Einan Regev , Lawrence J. Karr , Farid David Imani
发明人： Paul DeRocco , John C. Gord , Einan Regev , Lawrence J. Karr , Farid David Imani
IPC分类号： G06F17/00
CPC分类号： A61N1/37276 , A61N1/3605 , A61N1/37252
摘要： An implantable device and a wireless communication integrated circuit (IC) implementable in the implantable device for communicating with a remote unit, wherein the communication IC is capable of self-initializing, namely initial booting without requiring an external general booting program to force the booting process. Moreover, the implantable device and the communication IC provide for checking of the validity and integrity of any program instructions received from the remote unit for the desired operation of the implantable device. The implantable device and the communication IC therein have power-saving capability in order to extend the operation of the implantable device between battery charges. A further embodiment provides a robust communication IC, whereby signal distortion or interference between the analog and digital components collectively residing on the same communication IC is minimized or eliminated.
摘要翻译： 一种可植入装置和可植入装置中用于与远程单元进行通信的无线通信集成电路（IC），其中通信IC能够自我初始化，即初始启动，而不需要外部的一般启动程序来强制引导过程 。 此外，可植入装置和通信IC提供用于检查从远程单元接收的用于可植入装置的所需操作的任何程序指令的有效性和完整性。 可植入装置和其中的通信IC具有省电能力，以便在电池充电之间延长可植入装置的操作。 另一实施例提供了一种鲁棒的通信IC，由此集中地驻留在同一通信IC上的模拟和数字组件之间的信号失真或干扰被最小化或消除。
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38.发明授权Multichannel communication protocol configured to extend the battery life of an implantable device 有权多通道通信协议被配置为延长可植入设备的电池寿命公开(公告)号：US06472991B1
公开(公告)日：2002-10-29
申请号：US09882603
申请日：2001-06-15
申请人： Joseph H. Schulman , John C. Gord , Paul D. DeRocco , Lawrence J. Karr , Dan Folkman , Andrew Barber
发明人： Joseph H. Schulman , John C. Gord , Paul D. DeRocco , Lawrence J. Karr , Dan Folkman , Andrew Barber
IPC分类号： G08B2100
CPC分类号： A61N1/37276 , A61N1/3787 , H04W52/0219 , Y02D70/26
摘要： A communication protocol that is configured to extend the battery life of devices that monitor and/or affect body parameters and is particularly useful in a system comprised of a system control unit (SCU) and one or more implanted devices. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. The time between battery rechargings is determined by the battery capacity and the device's power consumption. Accordingly, the present invention reduces their average power consumption by reducing the usage duty cycle of their power consuming transmit and receive modes used to communicate with the SCU. By dedicating addressable time slots to each of the implantable devices in the system and limiting their use of receive and transmit modes to time periods proximate to these time slots, the average power consumption is accordingly reduced.
摘要翻译： 配置为延长监视和/或影响身体参数的设备的电池寿命的通信协议，并且在由系统控制单元（SCU）和一个或多个植入设备组成的系统中特别有用。 每个这样的植入装置被配置为经由无线通信信道由SCU监视和/或控制。 电池充电之间的时间取决于电池容量和设备的功耗。 因此，本发明通过减少用于与SCU通信的功耗发送和接收模式的使用占空比来降低它们的平均功耗。 通过将可寻址时隙专用于系统中的每个可植入设备，并将接收和发射模式的使用限制在接近这些时隙的时间周期内，因此相应地降低了平均功耗。
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公开(公告)号：US06181969B2
公开(公告)日：2001-01-30
申请号：US09338700
申请日：1999-06-23
申请人： John C. Gord
发明人： John C. Gord
IPC分类号： A61N136
CPC分类号： A61N1/32 , A61N1/08 , A61N1/36036 , A61N1/37211 , A61N1/3906 , A61N1/3912
摘要： A programmable output current source for use within an implantable tissue or nerve stimulator, e.g., an implantable cochlear stimulator or spinal cord stimulator, includes parallel-connected P-FET current source sets connected between a positive voltage rail and an electrode node, and parallel-connected N-FET current source sets connected between the electrode node and a negative voltage rail. The N-FET current source sets include n N-FET current sources, where n is an integer 0, 1, 2, 3, 4, . . . , and wherein each N-FET current source, when enabled, respectively sinks a current 2nI from the electrode node to the negative rail, where I is a selectable fixed current. Similarly, the P-FET current source sets include n P-FET current sources, where n=0, 1, 2, 3, . . . n, and wherein each P-FET current source, when enabled, respectively sources a current 2nI from the positive voltage rail to the electrode node. An individual current pulse is formed by selecting an electrode pair, and enabling a desired combination of P-FET current sources so that a desired total current is sourced to one of the electrodes of the selected electrode pair, and at the same time enabling a corresponding combination of N-FET current sources so that the same total current is sunk from the other electrode of the selected electrode pair. Sequences of current pulses, e.g., biphasic or multiphasic stimulation pulse pairs, are formed by combining individual current pulses having the desired polarity and timing relationship.
摘要翻译： 用于可植入组织或神经刺激器（例如植入式耳蜗刺激器或脊髓刺激器）内的可编程输出电流源包括连接在正电压轨道和电极节点之间的并联连接的P-FET电流源组， 连接的N-FET电流源组连接在电极节点和负电压轨道之间。 N-FET电流源组包括n个N-FET电流源，其中n是整数0,1,2,3,4。 。 。 ，并且其中每个N-FET电流源在使能时分别从电极节点向负轨道吸收电流2nI，其中I是可选择的固定电流。 类似地，P-FET电流源组包括n个P-FET电流源，其中n = 0,1,2,3。 。 。 n，并且其中每个P-FET电流源在使能时分别从正电压轨到电极节点发射电流2nI。 通过选择电极对形成单独的电流脉冲，并且能够实现期望的P-FET电流源的组合，使得期望的总电流被提供给所选择的电极对的电极中的一个，并且同时能够实现相应的 N-FET电流源的组合使得相同的总电流从所选择的电极对的另一个电极沉没。 通过组合具有所需极性和时序关系的各个电流脉冲来形成电流脉冲序列，例如双相或多相刺激脉冲对。
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公开(公告)号：US5938691A
公开(公告)日：1999-08-17
申请号：US103264
申请日：1998-06-23
CPC分类号： A61N1/3787 , A61N1/36032 , H04R25/505 , A61N1/37252 , H04R2460/03
摘要： A cochlea stimulation system includes a patient wearable system comprising an externally wearable signal processor (WP) and a headpiece in electronic communication with an implanted cochlear stimulator (ICS). The ICS comprises eight output stages each having two electrically isolated capacitor-coupled electrodes, designated "A" and "B", circuits for monitoring the voltages on these electrodes, and circuits for both transmitting status information to and receiving control information from the WP. Based upon information received from the WP, a processor within the ICS can control both the frequency and the widths of the output stimulation pulses applied to the electrodes and may select which electrodes to monitor. The ICS receives power and data signals telemetrically through the skin from the WP. To save power, the ICS may be "powered down" by the WP based upon the absence of audio information or "powered up" if audio is present. The WP communicates with the headpiece over a co-axial cable using one frequency for transmitting signals and a second different frequency for receiving signals.
摘要翻译： 耳蜗刺激系统包括患者穿戴式系统，其包括外部穿戴式信号处理器（WP）和与植入式耳蜗刺激器（ICS）电子通信的头盔。 ICS包括八个输出级，每个输出级具有两个电隔离的电容器耦合电极，标号为“A”和“B”，用于监视这些电极上的电压的电路，以及用于向WP发送状态信息和从WP接收控制信息的电路。 基于从WP接收的信息，ICS内的处理器可以控制施加到电极的输出刺激脉冲的频率和宽度，并且可以选择要监测哪些电极。 ICS通过WP的皮肤遥测地接收电力和数据信号。 为了节省电力，ICS可以基于没有音频信息或者如果存在音频“加电”，则由WP“掉电”。 WP通过同轴电缆与头戴式耳机通信使用一个频率传输信号和第二个不同的频率用于接收信号。
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