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1.发明授权Multichannel communication protocol configured to extend the battery life of an implantable device 有权多通道通信协议被配置为延长可植入设备的电池寿命公开(公告)号：US06472991B1
公开(公告)日：2002-10-29
申请号：US09882603
申请日：2001-06-15
申请人： Joseph H. Schulman , John C. Gord , Paul D. DeRocco , Lawrence J. Karr , Dan Folkman , Andrew Barber
发明人： Joseph H. Schulman , John C. Gord , Paul D. DeRocco , Lawrence J. Karr , Dan Folkman , Andrew Barber
IPC分类号： G08B2100
CPC分类号： A61N1/37276 , A61N1/3787 , H04W52/0219 , Y02D70/26
摘要： A communication protocol that is configured to extend the battery life of devices that monitor and/or affect body parameters and is particularly useful in a system comprised of a system control unit (SCU) and one or more implanted devices. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. The time between battery rechargings is determined by the battery capacity and the device's power consumption. Accordingly, the present invention reduces their average power consumption by reducing the usage duty cycle of their power consuming transmit and receive modes used to communicate with the SCU. By dedicating addressable time slots to each of the implantable devices in the system and limiting their use of receive and transmit modes to time periods proximate to these time slots, the average power consumption is accordingly reduced.
摘要翻译： 配置为延长监视和/或影响身体参数的设备的电池寿命的通信协议，并且在由系统控制单元（SCU）和一个或多个植入设备组成的系统中特别有用。 每个这样的植入装置被配置为经由无线通信信道由SCU监视和/或控制。 电池充电之间的时间取决于电池容量和设备的功耗。 因此，本发明通过减少用于与SCU通信的功耗发送和接收模式的使用占空比来降低它们的平均功耗。 通过将可寻址时隙专用于系统中的每个可植入设备，并将接收和发射模式的使用限制在接近这些时隙的时间周期内，因此相应地降低了平均功耗。
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2.发明授权公开(公告)号：US07237712B2
公开(公告)日：2007-07-03
申请号：US11002592
申请日：2004-12-01
申请人： Paul DeRocco , John C. Gord , Einan Regev , Lawrence J. Karr , Farid David Imani
发明人： Paul DeRocco , John C. Gord , Einan Regev , Lawrence J. Karr , Farid David Imani
IPC分类号： G06F17/00
CPC分类号： A61N1/37276 , A61N1/3605 , A61N1/37252
摘要： An implantable device and a wireless communication integrated circuit (IC) implementable in the implantable device for communicating with a remote unit, wherein the communication IC is capable of self-initializing, namely initial booting without requiring an external general booting program to force the booting process. Moreover, the implantable device and the communication IC provide for checking of the validity and integrity of any program instructions received from the remote unit for the desired operation of the implantable device. The implantable device and the communication IC therein have power-saving capability in order to extend the operation of the implantable device between battery charges. A further embodiment provides a robust communication IC, whereby signal distortion or interference between the analog and digital components collectively residing on the same communication IC is minimized or eliminated.
摘要翻译： 一种可植入装置和可植入装置中用于与远程单元进行通信的无线通信集成电路（IC），其中通信IC能够自我初始化，即初始启动，而不需要外部的一般启动程序来强制引导过程 。 此外，可植入装置和通信IC提供用于检查从远程单元接收的用于可植入装置的所需操作的任何程序指令的有效性和完整性。 可植入装置和其中的通信IC具有省电能力，以便在电池充电之间延长可植入装置的操作。 另一实施例提供了一种鲁棒的通信IC，由此集中地驻留在同一通信IC上的模拟和数字组件之间的信号失真或干扰被最小化或消除。
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公开(公告)号：US07555328B2
公开(公告)日：2009-06-30
申请号：US11392163
申请日：2006-03-29
IPC分类号： A61B5/145
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensor may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
摘要翻译： 可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。 保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。 电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。 其上形成有电子电路和电极的基板是与其上形成有集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。 这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。 在一个实施例中，两个这样的衬底传感器可以背靠背放置，电极面向外。 根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。
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4.发明授权System of implantable devices for monitoring and/or affecting body parameters 失效用于监测和/或影响身体参数的可植入装置的系统
公开(公告)号：US6164284A
公开(公告)日：2000-12-26
申请号：US48827
申请日：1998-03-25
IPC分类号： A61B5/00 , A61B5/053 , A61B5/07 , A61B19/00 , A61F2/50 , A61F2/70 , A61F2/72 , A61N1/372 , A61N1/378
CPC分类号： A61N1/37211 , A61B5/0031 , A61B5/053 , A61B5/07 , A61B5/145 , A61B5/14532 , A61B5/4519 , A61B5/4528 , A61B2560/0219 , A61B2562/08 , A61F2/72 , A61F2002/5058 , A61F2002/704 , A61F2002/705 , A61N1/37205 , A61N1/37252 , A61N1/37288 , A61N1/3787
摘要： A system for monitoring and/or affecting parameters of a patient's body and more particularly to such a system comprised of a system control unit (SCU) and one or more other devices, preferably battery-powered, implanted in the patient's body, i.e., within the envelope defined by the patient's skin. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. In accordance with the invention, the SCU comprises a programmable unit capable of (1) transmitting commands to at least some of a plurality of implanted devices and (2) receiving data signal from at least some of those implanted devices. In accordance with a preferred embodiment, the system operates in closed loop fashion whereby the commands transmitted by the SCU are dependent, in part, on the content of the data signals received by the SCU. In accordance with the invention, a preferred SCU is similarly implemented as a device capable of being implanted beneath a patient's skin, preferably having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm. Wireless communication between the SCU and the implanted devices is preferably implemented via a modulated sound signal, AC magnetic field, RF signal, or electric conduction.
摘要翻译： 一种用于监测和/或影响患者身体的参数的系统，更具体地涉及由系统控制单元（SCU）和一个或多个其它装置（优选由电池供电的）组成的系统，其被植入患者体内，即，在 由病人皮肤定义的信封。 每个这样的植入装置被配置为经由无线通信信道由SCU监视和/或控制。 根据本发明，SCU包括能够（1）向多个植入装置中的至少一些发送命令的可编程单元，以及（2）从至少某些植入装置接收数据信号。 根据优选实施例，系统以闭环方式操作，由此由SCU发送的命令部分地取决于由SCU接收的数据信号的内容。 根据本发明，优选的SCU类似地实施为能够植入患者皮肤下方的装置，优选具有小于60mm的轴向尺寸和小于6mm的横向尺寸。 优选地，经由调制声音信号，AC磁场，RF信号或电传导来实现SCU与植入装置之间的无线通信。
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公开(公告)号：US5776172A
公开(公告)日：1998-07-07
申请号：US450041
申请日：1995-05-25
CPC分类号： A61N1/36032 , A61N1/36185 , A61N1/37252 , H04R25/505 , H04R2460/03
摘要： An implantable cochlear stimulator (ICS) has eight output stages (212), each having a current source (212B) connected to a pair of electrodes, designated "A" and "B", through respective output coupling capacitors and an electrode switching matrix (212C). An indifferent electrode is connected to each output stage by way of an indifferent electrode switch (212D). The current source generates a precise stimulation current as a function of an analog control voltage. The analog control voltage, in turn, is generated by a logarithmic D/A converter. The D/A converter serially converts data words, received in a data frame from an external source, to respective analog control voltages that are applied sequentially to the current sources of each output stage. An output mode register (208) controls the switching matrix of each stage, as well as the indifferent electrode switch, to configure the electrodes for a desired stimulation configuration, e.g., bipolar stimulation (current flow between the pair of electrodes of the output stage), or monopolar stimulation (current flow between one of the electrodes of the output stage and the indifferent electrode). The voltage at the "A" and "B" electrode of each output stage may be selectively telemetered to the wearable system, as may the current flow through the indifferent electrode, thereby facilitating a measurement of the electrode impedance. The "A" and "B" electrodes of each output stage may be selectively shorted through a high or low resistance in order to discharge the output coupling capacitors.
摘要翻译： 植入式耳蜗刺激器（ICS）具有八个输出级（212），每个输出级通过相应的输出耦合电容和电极开关矩阵（212）连接到一对电极（A“和”B“）上， 212C）。 无电极通过无关电极开关（212D）连接到每个输出级。 电流源产生精确的刺激电流作为模拟控制电压的函数。 模拟控制电压又由对数D / A转换器产生。 D / A转换器将数据帧中从外部源接收的数据字串行地转换为顺序施加到每个输出级的当前源的相应模拟控制电压。 输出模式寄存器（208）控制每个级的开关矩阵以及无关电极开关，以将电极配置为期望的刺激配置，例如双极刺激（输出级的一对电极之间的电流） ，或单极刺激（电流在输出级的电极和无关电极之间）。 每个输出级的“A”和“B”电极处的电压可以选择性地遥测到可穿戴系统，电流可以通过无关电极，从而便于电极阻抗的测量。 每个输出级的“A”和“B”电极可以通过高电阻或低电阻选择性短路，以便放电输出耦合电容器。
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公开(公告)号：US5569307A
公开(公告)日：1996-10-29
申请号：US322066
申请日：1994-10-12
CPC分类号： A61N1/36032 , A61N1/36185 , A61N1/37252 , H04R25/505 , H04R2460/03
摘要： An external wearable processor (WP) of a cochlear stimulating system transmits a data signal to an implanted cochlear stimulator (ICS). The ICS is controlled through the data signal so that cochlear stimulation is provided by the ICS only after a determination is made that the WP is in proper signal contact therewith, and that the ICS is functioning properly. The ICS extracts a raw power signal from the data signal and generates different operating voltages from the extracted raw power signal. A detector generates a power bad signal whenever one of the operating voltages is less than a reference voltage. The ICS also detects and generates a carrier detect signal when the data signal is being received. Clock signals are generated within the ICS, and a phase locked loop (PLL) lock signal is generated when the clock signals are phase locked to the data signal. ICS circuitry further checks the parity of the incoming data signal and generates a parity alarm signal whenever a parity error is detected. A back telemetry carrier signal is transmitted from the ICS only when a prescribed combination of the carrier detect, PLL lock, power bad, and parity alarm signals exist. The back telemetry carrier signal, when received at the WP, is used as a handshake signal to signal the WP that the ICS is in proper signal communication with the WP, and that operation of the ICS can proceed.
摘要翻译： 耳蜗刺激系统的外部可穿戴处理器（WP）将数据信号传输到植入式耳蜗刺激器（ICS）。 通过数据信号控制ICS，使得只有在确定WP与其正确的信号接触之后，ICS才提供耳蜗刺激，并且ICS正常工作。 ICS从数据信号中提取原始功率信号，并从提取的原始功率信号中产生不同的工作电压。 每当工作电压之一小于参考电压时，检测器产生电力不良信号。 当接收到数据信号时，ICS还检测并产生载波检测信号。 在ICS内产生时钟信号，并且当时钟信号被锁相到数据信号时，产生锁相环（PLL）锁定信号。 ICS电路进一步检查输入数据信号的奇偶性，并且每当检测到奇偶校验错误时产生奇偶校验报警信号。 只有当载波检测，PLL锁定，电源不良和奇偶校验警报信号存在规定的组合时，才从ICS发送后向遥测载波信号。 背面遥测载波信号在WP接收时被用作握手信号，以向WP通知ICS与WP进行适当的信号通信，并且ICS的操作可以进行。
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公开(公告)号：US5193539A
公开(公告)日：1993-03-16
申请号：US812136
申请日：1991-12-18
IPC分类号： A61N1/372
CPC分类号： A61N1/372 , A61N1/37205 , H01L2224/45147 , H01L2224/48091 , H01L2224/49109
摘要： An addressable, implantable microstimulator is substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body, by expulsion through a hypodermic needle. Power and information for operating the microstimulator is received through a modulated, alternating magnetic field in which a coil is adapted to function as the secondary winding of a transformer. Electrical energy is stored in capacitor means and is released into the living body by controlled, stimulating pulses which pass through body fluids and tissue between the exposed electrodes of the microstimulator. Detection and decoding means within the microstimulator are provided for controlling the stimulating pulses in accordance with the modulation of the received, alternating magnetic field. Means for controllably recharging the capacitor is provided.
摘要翻译： 可寻址的可植入微型刺激器基本上封装在对体液惰性的气密密封的壳体中，并且能够通过皮下注射针排出而能够植入生物体中的尺寸和形状。 用于操作微型激励器的功率和信息通过调制的交变磁场接收，其中线圈适于用作变压器的次级绕组。 电能存储在电容器装置中，并通过受微刺激器暴露的电极之间通过体液和组织的受控刺激脉冲释放到生物体内。 提供了微型激励器内的检测和解码装置，用于根据所接收的交变磁场的调制来控制刺激脉冲。 提供了用于可控地对电容器充电的装置。
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8.发明授权公开(公告)号：US07775444B2
公开(公告)日：2010-08-17
申请号：US11804150
申请日：2007-05-16
申请人： Paul DeRocco , John C. Gord , Einan Regev , Lawrence J. Karr , Farid David Imani
发明人： Paul DeRocco , John C. Gord , Einan Regev , Lawrence J. Karr , Farid David Imani
IPC分类号： G06K19/06
CPC分类号： A61N1/37276 , A61N1/3605 , A61N1/37252
摘要： A wireless implantable device for communicating with a remote unit, wherein the wireless device is capable of self-initializing, namely initial booting without requiring an external general booting program to force the booting process. The implantable device can download program instructions from the remote unit for the operation of the implantable device. Moreover, the implantable device provides for checking the validity and integrity of any program instructions received from the remote unit for the operation of the implantable device. The implantable device has power-saving capability in order to extend the operation of the implantable device between battery charges.
摘要翻译： 一种用于与远程单元通信的无线可植入装置，其中所述无线装置能够进行自初始化，即初始启动，而不需要外部的一般引导程序来强制引导过程。 可植入装置可以从远程单元下载程序指令以进行可植入装置的操作。 此外，可植入装置提供用于检查从远程单元接收的用于可植入装置的操作的任何程序指令的有效性和完整性。 该可植入装置具有省电能力，以便在电池充电之间延长可植入装置的操作。
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公开(公告)号：US08862235B1
公开(公告)日：2014-10-14
申请号：US11983674
申请日：2007-11-09
申请人： Howard H. Stover , John C. Gord , Charles L. Byers , Joseph H. Schulman , Guangqiang Jiang , Ross Davis
发明人： Howard H. Stover , John C. Gord , Charles L. Byers , Joseph H. Schulman , Guangqiang Jiang , Ross Davis
CPC分类号： A61B5/0478 , A61B5/0006 , A61B5/04012 , A61B5/686 , A61N1/36003 , A61N1/36017 , A61N1/36025 , A61N1/3605 , A61N1/36082
摘要： A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.
摘要翻译： 脑植入装置包括壳体，其包含耦合到导管的通信和控制电子器件，所述导管被配置用于监测来自大脑的运动皮质的信号并向大脑的感觉皮质提供刺激信号。 脑植入装置能够通过设置在壳体中的天线与外部通信和控制信号源进行无线通信。 导管是柔性的并且可以包含上部128个电导体，其借助于从导管延伸并适于与这些部位接触的多个导电突起，在装置电子设备和电动机和/或感觉皮质之间的相关部位提供电连接 。
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10.发明授权System of implantable devices for monitoring and/or affecting body parameters 有权用于监测和/或影响身体参数的可植入装置的系统公开(公告)号：US07513257B2
公开(公告)日：2009-04-07
申请号：US11187290
申请日：2005-07-21
CPC分类号： A61N1/37211 , A61B5/0031 , A61B5/053 , A61B5/07 , A61B5/145 , A61B5/14532 , A61B5/4519 , A61B5/4528 , A61B2560/0219 , A61B2562/08 , A61F2/72 , A61F2002/5058 , A61F2002/704 , A61F2002/705 , A61N1/37205 , A61N1/37252 , A61N1/37288 , A61N1/3787
摘要： A system for monitoring and/or affecting parameters of a patient's body and more particularly to such a system comprised of a system control unit (SCU) and one or more other devices, preferably battery-powered, implanted in the patient's body, i.e., within the envelope defined by the patient's skin. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. In accordance with the invention, the SCU comprises a programmable unit capable of (1) transmitting commands to at least some of a plurality of implanted devices and (2) receiving data signal from at least some of those implanted devices. In accordance with a preferred embodiment, the system operates in closed loop fashion whereby the commands transmitted by the SCU are dependent, in part, on the content of the data signals received by the SCU.
摘要翻译： 一种用于监测和/或影响患者身体的参数的系统，更具体地涉及由系统控制单元（SCU）和一个或多个其它装置（优选由电池供电的）组成的系统，其被植入患者体内，即，在 由病人皮肤定义的信封。 每个这样的植入装置被配置为经由无线通信信道由SCU监视和/或控制。 根据本发明，SCU包括能够（1）向多个植入装置中的至少一些发送命令的可编程单元，以及（2）从至少某些植入装置接收数据信号。 根据优选实施例，系统以闭环方式操作，由此由SCU发送的命令部分地取决于由SCU接收的数据信号的内容。
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