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公开(公告)号：US5900492A
公开(公告)日：1999-05-04
申请号：US982458
申请日：1997-12-02
IPC分类号： C07C69/757 , C07C211/27 , C07D307/93 , C07D307/00
CPC分类号： C07C69/757 , C07C211/27 , C07D307/93
摘要： A method for resolving optically impure 3-oxa-2-oxobicyclo�3.1.0!hexane-1-carboxylic acid esters. A method is provided for producing a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid.N-benzyl-.alpha.-phenylethylamine diastereomer salt. An enantiomer of N-benzyl-.alpha.-phenylethylamine is reacted with a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid to produce a precipitate that is enriched in one diastereomer of the salt. After isolating the optically active salt, the N-benzyl-.alpha.-phenylethylamine may be separated to produce the corresponding 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid. Under acidic conditions, the carboxylic acid and hydroxyl groups undergo ring closure to afford the optically active 3-oxa-2-oxobicyclo�3.1.0!hexane-1-carboxylic acid ester.
摘要翻译： 一种拆分光学上不纯的3-氧杂-2-氧代双环[3.1.0]己烷-1-羧酸酯的方法。 提供了制备1-烷氧基羰基-2-羟甲基环丙烷-1-羧酸N-苄基-α-苯乙胺非对映体盐的方法。 N-苄基-α-苯乙基胺的对映异构体与1-烷氧基羰基-2-羟甲基环丙烷-1-羧酸反应，产生富含一种盐的非对映异构体的沉淀物。 分离光学活性盐后，可以分离N-苄基-α-苯乙胺，生成相应的1-烷氧基羰基-2-羟甲基环丙烷-1-羧酸。 在酸性条件下，羧酸和羟基发生闭环，得到光学活性3-氧杂-2-氧代双环[3.1.0]己烷-1-羧酸酯。
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公开(公告)号：US5731353A
公开(公告)日：1998-03-24
申请号：US613005
申请日：1996-03-08
申请人： Koji Ohsumi , Takashi Tsuji , Yoshihiro Morinaga , Kazuo Ohishi
发明人： Koji Ohsumi , Takashi Tsuji , Yoshihiro Morinaga , Kazuo Ohishi
IPC分类号： C07C205/35 , C07C205/37 , C07C217/80 , C07C217/84 , C07C255/43 , A61K31/135
CPC分类号： C07C205/37 , C07C205/35 , C07C217/80 , C07C217/84 , C07C255/43
摘要： A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms; X represents a hydrogen atom or a nitrile group; Y represents an alkyloxy group having 1 to 3 carbon atoms, an alkyl group having 1 to 6 carbon atoms or a halogen atom.
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公开(公告)号：US5674906A
公开(公告)日：1997-10-07
申请号：US612416
申请日：1996-03-07
申请人： Toshihiro Hatanaka , Koji Ohsumi , Takashi Tsuji , Yukio Nihei , Ryusuke Nakagawa , Kazuo Ohishi
发明人： Toshihiro Hatanaka , Koji Ohsumi , Takashi Tsuji , Yukio Nihei , Ryusuke Nakagawa , Kazuo Ohishi
IPC分类号： C07C237/04 , C07C255/44 , C07D207/16 , A61K31/16 , A61K31/195 , A61K31/275 , A61K31/40
CPC分类号： C07D207/16 , C07C237/04 , C07C255/44
摘要： Stilbene compounds of the following formula (I) or their pharmaceutically acceptable salts are effective as carcinostatics and of low toxicity: ##STR1## wherein X represents a hydrogen atom or a nitrile group, and Y represents an amino acid acyl group.
摘要翻译： 下式（I）的二苯乙烯化合物或其药学上可接受的盐作为制癌剂和低毒性是有效的：其中X表示氢原子或腈基，Y表示氨基酸酰基。
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公开(公告)号：US09269579B2
公开(公告)日：2016-02-23
申请号：US14110143
申请日：2012-04-06
申请人： Akimasa Kinoshita , Takashi Tsuji , Fumikazu Imai
发明人： Akimasa Kinoshita , Takashi Tsuji , Fumikazu Imai
IPC分类号： H01L21/28 , H01L21/3205 , H01L21/04 , H01L29/16 , H01L29/45 , H01L29/47 , H01L29/66 , H01L29/872
CPC分类号： H01L21/0485 , H01L29/1608 , H01L29/45 , H01L29/47 , H01L29/6606 , H01L29/872
摘要： A surface of a silicon carbide substrate on which a graphite layer is formed is covered with a metal layer which can form carbide. Then, the silicon carbide substrate is annealed to cause reaction between a metal in the metal layer which can form carbide and carbon in the graphite layer so as to change the graphite layer between the metal layer which can form carbide and the silicon carbide substrate to a metal carbide layer. Thus, the graphite layer is removed. The adhesion between the metal layer which can form carbide and the silicon carbide substrate can be improved so that separation of the metal layer which can form carbide can be suppressed. Graphite deposits can be suppressed due to the removal of the graphite layer so that separation of a wiring metal film formed on a surface of the metal layer which can form carbide can be suppressed.
摘要翻译： 其上形成有石墨层的碳化硅衬底的表面被可形成碳化物的金属层覆盖。 然后，将碳化硅基板退火以在石墨层中形成碳化物和碳的金属层中的金属之间发生反应，从而将可形成碳化物的金属层与碳化硅衬底之间的石墨层改变为 金属碳化物层。 因此，除去石墨层。 可以改善可形成碳化物的金属层与碳化硅衬底之间的粘附性，从而可以抑制可形成碳化物的金属层的分离。 可以通过去除石墨层来抑制石墨沉积物，从而可以抑制形成在可形成碳化物的金属层的表面上的布线金属膜的分离。
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公开(公告)号：US08927284B2
公开(公告)日：2015-01-06
申请号：US13146029
申请日：2010-01-14
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3865
摘要： A method for producing a tooth having a desired length in one direction includes the steps of: placing a first cell aggregate and a second cell aggregate in the inside of a support while bringing the first and the second cell aggregates into close contact with each other; and culturing the first and the second cell aggregates in the inside of the support, in which the first cell aggregate is composed of one of mesenchymal cells or epithelial cells and the second cell aggregate is composed of the other, and the size of the tooth is controlled by adjusting the length of contact between the first cell aggregate and the second cell aggregate in one direction.
摘要翻译： 一种在一个方向上具有期望长度的牙齿的制造方法包括以下步骤：将第一细胞聚集体和第二细胞聚集体放置在支撑体的内部，同时使第一和第二细胞聚集体彼此紧密接触; 并且在第一细胞集合体由间充质细胞或上皮细胞之一构成的载体内部培养第一和第二细胞聚集体，第二细胞集合体由另一个组成，并且牙齿的尺寸为 通过在一个方向上调节第一细胞聚集体和第二细胞聚集体之间的接触长度来控制。
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公开(公告)号：US20140051241A1
公开(公告)日：2014-02-20
申请号：US14110143
申请日：2012-04-06
申请人： Akimasa Kinoshita , Takashi Tsuji , Fumikazu Imai
发明人： Akimasa Kinoshita , Takashi Tsuji , Fumikazu Imai
IPC分类号： H01L21/04
CPC分类号： H01L21/0485 , H01L29/1608 , H01L29/45 , H01L29/47 , H01L29/6606 , H01L29/872
摘要： A surface of a silicon carbide substrate on which a graphite layer is formed is covered with a metal layer which can form carbide. Then, the silicon carbide substrate is annealed to cause reaction between a metal in the metal layer which can form carbide and carbon in the graphite layer so as to change the graphite layer between the metal layer which can form carbide and the silicon carbide substrate to a metal carbide layer. Thus, the graphite layer is removed. The adhesion between the metal layer which can form carbide and the silicon carbide substrate can be improved so that separation of the metal layer which can form carbide can be suppressed. Graphite deposits can be suppressed due to the removal of the graphite layer so that separation of a wiring metal film formed on a surface of the metal layer which can form carbide can be suppressed.
摘要翻译： 其上形成有石墨层的碳化硅衬底的表面被可形成碳化物的金属层覆盖。 然后，将碳化硅基板退火以在石墨层中形成碳化物和碳的金属层中的金属之间发生反应，从而将可形成碳化物的金属层与碳化硅衬底之间的石墨层改变为 金属碳化物层。 因此，除去石墨层。 可以改善可形成碳化物的金属层与碳化硅衬底之间的粘附性，从而可以抑制可形成碳化物的金属层的分离。 可以通过去除石墨层来抑制石墨沉积物，从而可以抑制形成在可形成碳化物的金属层的表面上的布线金属膜的分离。
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公开(公告)号：US20130225548A1
公开(公告)日：2013-08-29
申请号：US13881191
申请日：2011-10-27
IPC分类号： C07D401/14 , C07D405/14 , C07D213/84
CPC分类号： C07D401/14 , C07D213/84 , C07D405/14 , C07D417/14
摘要： A main object of the present invention is to provide a novel pyridine derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. In formula [1], R represents an aryl group or a heteroaryl group, which may be substituted by an optionally substituted alkyl group, a hydroxy group, a halogen atom or a group represented by general formula [2]. In formula [2], -L1-L2-L3-RA [2] L1 and L3 independently represent a single bond, an alkylene group or a cycloalkylene group; L2 represents a single bond, O, or NRB; RB represents H or an optionally substituted alkyl group; and RA represents B, an amino group, a cyano group, a hydroxy group, an alkoxy group, an aryl group, a monoalkylamino group, a dialkylamino group, a carbamoyl group, an alkyloxycarbonyl group, a monoalkylaminocarbonyl group, a dialkylaminocarbonyl group, an alkylcarbonylamino group, and a saturated heterocyclic group, among other groups.
摘要翻译： 本发明的主要目的是提供由以下通式[1]表示的新型吡啶衍生物或其药学上可接受的盐。 在式[1]中，R表示可被任意取代的烷基，羟基，卤素原子或通式[2]表示的基团取代的芳基或杂芳基。 在式[2]中，-L1-L2-L3-RA [2] L1和L3独立地表示单键，亚烷基或亚环烷基; L2表示单键，O或NRB; RB表示H或任选取代的烷基; RA表示B，氨基，氰基，羟基，烷氧基，芳基，单烷基氨基，二烷基氨基，氨基甲酰基，烷氧基羰基，单烷基氨基羰基，二烷基氨基羰基， 烷基羰基氨基和饱和杂环基等。
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公开(公告)号：US08507429B2
公开(公告)日：2013-08-13
申请号：US13152082
申请日：2011-06-02
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
摘要翻译： 本发明涉及一种与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽，优选表现出比GLP-1更高的控制血糖水平的活性。 本发明涉及：（a）GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽，其中至少一个氨基酸被添加了糖链的氨基酸取代。 （b）具有缺失，取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。
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公开(公告)号：US20130089827A1
公开(公告)日：2013-04-11
申请号：US13638963
申请日：2011-03-15
申请人： Takashi Tsuji , Kazuhisa Nakao , Masamitsu Oshima
发明人： Takashi Tsuji , Kazuhisa Nakao , Masamitsu Oshima
CPC分类号： A61D5/00 , A61C13/08 , A61L27/24 , A61L27/38 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L2430/12
摘要： A method for manufacturing a regenerated tooth unit comprising a step of disposing and culturing a regenerated tooth germ inside a spacer in vivo in the body of a mammal is provided, wherein said spacer is configured so as to enable prevention of said regenerated tooth germ being extended to more than the maximum tolerance; and configured such that the regenerated tooth germ disposed inside is communicatable with the exterior of the spacer.
摘要翻译： 一种再生牙齿单元的制造方法，其特征在于，具备在哺乳动物的体内将间隔物内的再生牙胚配置于培养体内的步骤，其特征在于，所述间隔件构成为能够防止所述再生牙胚延伸 超过最大容差; 并且构造成使得设置在内部的再生牙胚可以与间隔件的外部通信。
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40.发明申请METHOD FOR RESTORING MISSING TOOTH AND METHOD FOR PRODUCING RESTORATIVE MATERIAL 审中-公开恢复缺牙的方法和生产复原材料的方法公开(公告)号：US20110212414A1
公开(公告)日：2011-09-01
申请号：US13059847
申请日：2009-08-19
申请人： Takashi Tsuji , Etsuko Ikeda , Hiroaki Asai
发明人： Takashi Tsuji , Etsuko Ikeda , Hiroaki Asai
CPC分类号： A61L27/3834 , A61L27/3813 , A61L27/3865 , A61L27/3891
摘要： A method of producing a restorative material used to restore a tooth-deficient area in an oral cavity, the method comprising: positioning, in a support carrier, a first cell mass formed from either mesenchymal cells or epithelial cells and a second cell mass formed from the other of the mesenchymal cells or epithelial cells, one of the mesenchymal cells or epithelial cells being derived from a tooth germ and the first and second cell masses being not mixed with each other but made to closely contact each other; culturing the first and second cell masses to form a reconstructed tooth germ or tooth; and confirming directionality of the reconstructed tooth germ or tooth formed by the culturing so as to enable the reconstructed tooth germ or tooth to be embedded in the tooth-deficient area such that a tip of the tooth faces an interior of the oral cavity, the tooth germ or tooth whose directionality has been confirmed being used as a restorative material to obtain an equivalent of a missing tooth in the tooth-deficient area. A method for restoring a tooth-deficient area, the method comprising; embedding the reconstructed tooth germ or tooth obtained by the production method in the tooth-deficient area.
摘要翻译： 一种生产用于恢复口腔缺牙区域的修复材料的方法，所述方法包括：在载体载体中定位由间充质细胞或上皮细胞形成的第一细胞块和由 间质细胞或上皮细胞中的另一个，间充质细胞或上皮细胞之一来自牙胚，第一和第二细胞团彼此不混合但彼此紧密接触; 培养第一和第二细胞块以形成重建的牙胚或牙齿; 并且确定通过培养形成的重建牙胚或牙齿的方向性，以使重建的牙胚或牙齿能够嵌入牙齿缺损区域，使得牙齿的尖端面向口腔内部，牙齿 确定其方向性的胚芽或牙齿用作修复材料以获得缺牙区域中缺失牙齿的当量。 一种用于恢复牙缺陷区域的方法，所述方法包括： 将通过生产方法获得的重建牙胚或牙齿嵌入牙缺陷区域。
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