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83 条记录 (耗时 0.087 秒)

    Polynucleotides encoding a human chemotactic protein
    31.
    发明授权
    Polynucleotides encoding a human chemotactic protein 失效
    编码人趋化蛋白的多核苷酸

    公开(公告)号：US6100389A

    公开(公告)日：2000-08-08

    申请号：US44855

    申请日：1998-03-20

    申请人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

    发明人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/12 ,  C12N15/19 ,  C12N1/20 ,  C12N5/10

    CPC分类号： C07K14/523 ,  A61K38/00

    摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Macrophage inflammatory protein-4 (MIP-4) polypeptides
    33.
    发明授权
    Macrophage inflammatory protein-4 (MIP-4) polypeptides 失效
    巨噬细胞炎症蛋白-4（MIP-4）多肽

    公开(公告)号：US06488925B2

    公开(公告)日：2002-12-03

    申请号：US09334923

    申请日：1999-06-17

    申请人： Steven M. Ruben ,  Haodong Li

    发明人： Steven M. Ruben ,  Haodong Li

    IPC分类号： A61K3819

    CPC分类号： C07K14/521 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N2799/026

    摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine &bgr;8(CK&bgr;8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP 1-&ggr; and chemokine &bgr;1(CK&bgr;1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

    摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人类单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP 1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF- 1，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

    Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
    34.
    发明授权
    Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby 失效
    骨髓祖细胞抑制因子-1（MPIF-1）多核苷酸和多肽

    公开(公告)号：US06001606A

    公开(公告)日：1999-12-14

    申请号：US722719

    申请日：1996-09-30

    申请人： Steven M. Ruben ,  Haodong Li

    发明人： Steven M. Ruben ,  Haodong Li

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N15/19 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C07K14/523 ,  C07K16/24 ,  A61K38/00 ,  Y10S930/14

    摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine .beta.8(CK.beta.8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-.gamma. and chemokine .beta.1(CK.beta.1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

    摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKβ8或ckb-8））的分离的核酸分子的治疗组合物和方法; 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKβ1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4），以及 MPIF-1，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

    Human cytokine polypeptide
    35.
    发明授权
    Human cytokine polypeptide 失效
    人细胞因子多肽

    公开(公告)号：US6008022A

    公开(公告)日：1999-12-28

    申请号：US820970

    申请日：1997-03-19

    申请人： Kui Su ,  Yi Li ,  Haodong Li

    发明人： Kui Su ,  Yi Li ,  Haodong Li

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/52 ,  C12N1/21 ,  C12N15/16 ,  C07H21/00 ,  C12N1/15 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C07K14/52 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： The invention relates to human cytokine polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及人细胞因子多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Connective Tissue Growth Factor-2
    36.
    发明申请
    Connective Tissue Growth Factor-2 审中-公开
    结缔组织生长因子-2

    公开(公告)号：US20070154908A1

    公开(公告)日：2007-07-05

    申请号：US11563870

    申请日：2006-11-28

    申请人： Haodong Li ,  Mark Adams

    发明人： Haodong Li ,  Mark Adams

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： 本发明涉及人CTGF-2多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法和针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了用于治疗性地增强连接和支持组织的修复，促进组织植入物的附着，固定和稳定以及增强伤口愈合的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Antibodies to human chemokine beta-9
    38.
    发明授权
    Antibodies to human chemokine beta-9 有权
    人趋化因子β-9的抗体

    公开(公告)号：US07097985B2

    公开(公告)日：2006-08-29

    申请号：US10329472

    申请日：2002-12-27

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： G01N33/53 ,  C07K16/24 ,  C12N5/12

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

    摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

    Extracellular/epidermal growth factor like protein
    40.
    发明申请
    Extracellular/epidermal growth factor like protein 失效
    细胞外/表皮生长因子如蛋白质

    公开(公告)号：US20050181477A1

    公开(公告)日：2005-08-18

    申请号：US11017065

    申请日：2004-12-21

    申请人： Henrik Olsen ,  Haodong Li

    发明人： Henrik Olsen ,  Haodong Li

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/485 ,  A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/485 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N2799/026

    摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    摘要翻译： 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括诱导DNA合成，刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。