公开(公告)号：US10149622B2

公开(公告)日：2018-12-11

申请号：US15244792

申请日：2016-08-23

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/024 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/04 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0255 ,  A61B18/02 ,  A61B18/12 ,  A61B18/18 ,  A61B18/00

摘要： In a system and method of reconstructing cardiac activation information, pairs of cardiac signals obtained from a patient are accessed. The pairs have a first cardiac signal that is common among the pairs and second cardiac signals that are different among the pairs. The first cardiac signal and the second cardiac signals are processed to identify points of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to derivatives of the second cardiac signals. An activation onset time is assigned at a point in the first cardiac signal based on correspondence of the points of change to define a cardiac activation indicating a beat.

公开(公告)号：US10098560B2

公开(公告)日：2018-10-16

申请号：US14869687

申请日：2015-09-29

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC分类号： A61B5/024 ,  A61B5/042 ,  A61B5/00 ,  A61B5/046

摘要： A system and method are provided to define a driver of a source associated with a cardiac rhythm disorder of a human heart. A plurality of cardiac signals associated with sensors arranged spatially in relation to an area of the heart are processed to determine a sequence of arcs of rotation in relation to the sensors over a time interval. Rotational directions of the arcs of rotation in the sequence are determined. The area of the heart is identified as controlling the source when the rotational directions of the arcs of rotation in the sequence continue in a same rotational direction in excess of a threshold.

公开(公告)号：US09717436B2

公开(公告)日：2017-08-01

申请号：US14473112

申请日：2014-08-29

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Ruchir Sehra

IPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0472 ,  A61B5/0464 ,  A61B5/04 ,  A61B5/0255 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/4857 ,  A61B5/6852 ,  A61B5/7221 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7278

摘要： System, assembly and method are provided to facilitate reconstruction of cardiac information representing a complex rhythm disorder associated with a patient's heart to indicate a source of the heart rhythm disorder. The complex rhythm disorder can be treated by application of energy to modify the source of the rhythm disorder.

公开(公告)号：US09655535B2

公开(公告)日：2017-05-23

申请号：US15047266

申请日：2016-02-18

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/04 ,  A61B18/14 ,  A61B5/00 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/042 ,  A61B18/00

CPC分类号： A61B5/04012 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/4839 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M5/00 ,  A61N1/0565 ,  G06F19/00

摘要： A system and method to target a biological rhythm disorder, such as a heart rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the heart rhythm disorder.

公开(公告)号：US09549684B2

公开(公告)日：2017-01-24

申请号：US14965388

申请日：2015-12-10

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Ruchir Sehra

IPC分类号： A61B5/046 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/042 ,  A61B5/0472 ,  A61B5/0464 ,  A61B5/04 ,  A61B5/0255 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/4857 ,  A61B5/6852 ,  A61B5/7221 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7278

摘要： Reconstruction of cardiac information representing a complex rhythm disorder is facilitated by assigning activation onsets to non-discernible beats in low confidence signals based upon time associations relative to activation onsets in adjacent high confidence signals.

摘要翻译： 通过基于相邻相邻高置信度信号中的激活onsets的时间关联，将激活onsets分配给低置信度信号中的不可辨别的节拍，便于重建表示复杂节律紊乱的心脏信息。

公开(公告)号：US20160262635A1

公开(公告)日：2016-09-15

申请号：US15036414

申请日：2014-11-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Andrew D. McCullouch ,  Adarsh Krishnamurthy ,  Christopher Villongco ,  David Krummen ,  Sanjiv Narayan ,  Jeffrey Omens ,  Roy Kerckhoffs

IPC分类号： A61B5/02 ,  G06F19/00 ,  A61N1/39 ,  A61B5/00 ,  A61N1/362

CPC分类号： A61B5/02028 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0452 ,  A61B5/4836 ,  A61B5/7275 ,  A61B6/032 ,  A61B6/503 ,  A61B6/507 ,  A61B8/0883 ,  A61B8/48 ,  A61B8/483 ,  A61B8/485 ,  A61B8/5223 ,  A61B2576/023 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/39 ,  A61N1/395 ,  G09B23/303 ,  G16H50/50

摘要： in alternative embodiments, provided are compositions, medical devices or products of manufacture, systems, diagnostic tools, and methods, including computer implemented methods, for predicting the response of patients with dyssynchronous heart 10 failure (DHF) to cardiac resynchronization therapy (CRT), comprising: measuring or determining the fraction of the LV/septum performing negative work (MNW); and measuring or determining the coefficient of variation of external work density (COVW), wherein the MNW fraction performing negative work and coefficient of variation COVW (sd/mean) correlated strongly with observed reduction in end-systolic volume after CRT.

摘要翻译： 在替代实施例中，提供了用于预测患有心脏再同步治疗（CRT）的同步心脏衰竭（DHF）的患者的反应的组合物，医疗装置或制造产品，系统，诊断工具和方法，包括计算机实现的方法， 包括：测量或确定执行负作业（MNW）的LV /隔膜的分数; 测量或确定外部工作密度（COVW）的变异系数，其中执行负作用的MNW分数和变异系数COVW（sd / mean）与观察到的CRT后收缩末容积的减少有很强的相关性。

公开(公告)号：US09393425B2

公开(公告)日：2016-07-19

申请号：US14135472

申请日：2013-12-19

申请人： The Regents of the University of California

发明人： Sanjiv Narayan

IPC分类号： A61B5/04 ,  A61N1/365 ,  A61B5/0402 ,  A61B5/00 ,  A61N1/362 ,  A61B5/0452 ,  A61B5/0245 ,  A61B18/14 ,  A61N1/36

CPC分类号： A61B5/7275 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/4836 ,  A61B5/4839 ,  A61B18/14 ,  A61B18/1492 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/36592 ,  G06F19/00

摘要： Systems and methods define an index of risk for cardiac disease by detecting cellular derangements that may lead to cardiomyopathy, heart rhythm disorders or ischemic heart disease. The markers include fluctuations or abnormal rate-behavior of electrical, mechanical or other measurable biosignals. The invention operates in modes that can be applied to prevent atrial fibrillation or the risk for ventricular arrhythmias. Alternative embodiments are applied to tissue outside the heart such as skeletal muscle, smooth muscle, the central nervous system, the respiratory system, the urogenital system and the gastrointestinal system.

摘要翻译： 系统和方法通过检测可能导致心肌病，心律失常或缺血性心脏病的细胞紊乱来定义心脏病风险指数。 标记包括电气，机械或其他可测量的生物信号的波动或异常速率行为。 本发明以可用于预防房颤或心室心律失常风险的模式运行。 替代实施例应用于心脏外的组织，例如骨骼肌，平滑肌，中枢神经系统，呼吸系统，泌尿生殖系统和胃肠系统。

公开(公告)号：US09375156B2

公开(公告)日：2016-06-28

申请号：US14257939

申请日：2014-04-21

申请人： The Regents of the University of California

发明人： Sanjiv Narayan ,  Wouter-Jan Rappel

IPC分类号： A61B5/04 ,  A61B5/024 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/046 ,  A61B5/0464 ,  A61B18/14 ,  A61B5/0452 ,  A61B18/12 ,  A61B5/0245 ,  A61B5/044 ,  A61B5/00 ,  A61B18/00

CPC分类号： A61B5/02405 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04007 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7405 ,  A61B7/04 ,  A61B8/0883 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00839 ,  A61B2018/1435

摘要： A system to detect a cause of a complex rhythm disorder in a human heart includes a plurality of sensors disposed spatially in relation to the heart, where the signals generated by the sensors are associated with activations of the heart. A processor collects and analyzes the signals to identify a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.

摘要翻译： 用于检测人心脏中复杂节律障碍的原因的系统包括相对于心脏空间上布置的多个传感器，其中由传感器产生的信号与心脏的激活相关联。 处理器收集和分析信号以识别具有旋转或径向发射的激活轨迹的心脏区域，其中激活轨迹指示复合节律紊乱，并且基于与心脏的激活相关联的激活时间。

公开(公告)号：US20160015283A1

公开(公告)日：2016-01-21

申请号：US14869687

申请日：2015-09-29

申请人： The Regents of the University of California ,  Topera, Inc

发明人： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC分类号： A61B5/024 ,  A61B5/04 ,  A61B5/042

CPC分类号： A61B5/0422 ,  A61B5/0002 ,  A61B5/046

摘要： A system and method are provided to define a driver of a source associated with a cardiac rhythm disorder of a human heart. A plurality of cardiac signals associated with sensors arranged spatially in relation to an area of the heart are processed to determine a sequence of arcs of rotation in relation to the sensors over a time interval. Rotational directions of the arcs of rotation in the sequence are determined. The area of the heart is identified as controlling the source when the rotational directions of the arcs of rotation in the sequence continue in a same rotational direction in excess of a threshold.

摘要翻译： 提供了一种系统和方法来定义与人心脏的心律失常相关联的源的驱动器。 处理与空间上相对于心脏区域布置的传感器相关联的多个心脏信号，以在时间间隔内确定相对于传感器的旋转弧的顺序。 确定顺序中的旋转圆弧的旋转方向。 当该序列中的旋转圆弧的旋转方向在相同旋转方向上超过阈值时，心脏的区域被识别为控制源。

公开(公告)号：US20150313548A1

公开(公告)日：2015-11-05

申请号：US14798363

申请日：2015-07-13

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/00 ,  A61B5/024

CPC分类号： A61B5/4836 ,  A61B5/02405 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7239 ,  A61B5/7278 ,  A61B2562/0209 ,  A61B2562/046 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60

摘要： An example method of representing cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals obtained from a patient. The method also includes eliminating far-field activations from the plurality of neighboring cardiac signals using one or more divergence criteria that define local activations in the plurality of neighboring cardiac signals, the divergence criteria being associated with divergence among the plurality of neighboring cardiac signals. The method further includes constructing a clinical representation of local activations in the plurality of neighboring cardiac signals.

摘要翻译： 表示与心律紊乱相关的心脏信息的示例性方法包括访问从患者获得的多个相邻心脏信号。 该方法还包括使用限定多个相邻心脏信号中的局部激活的一个或多个发散标准来消除来自多个相邻心脏信号的远场激活，该发散标准与多个相邻心脏信号之间的发散相关。 该方法还包括构建多个相邻心脏信号中局部激活的临床表示。