公开(公告)号：US10271786B2

公开(公告)日：2019-04-30

申请号：US15204455

申请日：2016-07-07

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/00 ,  A61B5/0452 ,  A61B5/024 ,  A61B5/042 ,  A61B5/04 ,  G06F19/00 ,  G16H10/60

摘要： Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.

公开(公告)号：US10271744B2

公开(公告)日：2019-04-30

申请号：US15136268

申请日：2016-04-22

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC分类号： A61B5/024 ,  A61B5/00 ,  A61B5/042 ,  A61B5/04 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/046

摘要： In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

公开(公告)号：US09955879B2

公开(公告)日：2018-05-01

申请号：US15177317

申请日：2016-06-08

申请人： The Regents of the University of California

发明人： Sanjiv Narayan ,  Wouter-Jan Rappel

IPC分类号： A61B5/04 ,  A61B5/024 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/00 ,  A61B18/14 ,  A61B5/0452 ,  A61B18/12 ,  A61B5/0245 ,  A61B5/044 ,  A61B5/042 ,  A61B7/04 ,  A61B8/08 ,  A61B18/00

CPC分类号： A61B5/02405 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04007 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7405 ,  A61B7/04 ,  A61B8/0883 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00839 ,  A61B2018/1435

摘要： A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals are sensed. A processor receives and analyzes the activation onsets of the cardiac information signals to determine an arrangement of activation onsets. A representation that indicates the clinical source of the rhythm disorder is generated based on the arrangement of the activation onsets.

公开(公告)号：US20140371614A1

公开(公告)日：2014-12-18

申请号：US14473572

申请日：2014-08-29

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/0452

CPC分类号： A61B5/4836 ,  A61B5/02405 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7239 ,  A61B5/7278 ,  A61B2562/0209 ,  A61B2562/046 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60

摘要： An example method of representing cardiac information associated with a heart rhythm disorder is disclosed. The method includes accessing a plurality of neighboring cardiac signals obtained from a patient. The method also includes eliminating far-field activations from the plurality of neighboring cardiac signals using one or more divergence criteria that define local activations in the plurality of neighboring cardiac signals, the divergence criteria being associated with divergence among the plurality of neighboring cardiac signals. The method further includes constructing a clinical representation of local activations in the plurality of neighboring cardiac signals.

摘要翻译： 公开了一种代表与心律失常相关的心脏信息的示例性方法。 该方法包括访问从患者获得的多个相邻心脏信号。 该方法还包括使用限定多个相邻心脏信号中的局部激活的一个或多个发散标准来消除来自多个相邻心脏信号的远场激活，该发散标准与多个相邻心脏信号之间的发散相关。 该方法还包括构建多个相邻心脏信号中局部激活的临床表示。

公开(公告)号：US20140228696A1

公开(公告)日：2014-08-14

申请号：US14257939

申请日：2014-04-21

申请人： The Regents of the University of California

发明人： Sanjiv Narayan ,  Wouter-Jan Rappel

IPC分类号： A61B5/024 ,  A61B5/044 ,  A61B5/04 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/00 ,  A61B5/0245

CPC分类号： A61B5/02405 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04007 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7405 ,  A61B7/04 ,  A61B8/0883 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00839 ,  A61B2018/1435

摘要： A system to detect a cause of a complex rhythm disorder in a human heart includes a plurality of sensors disposed spatially in relation to the heart, where the signals generated by the sensors are associated with activations of the heart. A processor collects and analyzes the signals to identify a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart.

摘要翻译： 用于检测人心脏中复杂节律障碍的原因的系统包括相对于心脏空间上布置的多个传感器，其中由传感器产生的信号与心脏的激活相关联。 处理器收集和分析信号以识别具有旋转或径向发射的激活轨迹的心脏区域，其中激活轨迹指示复合节律紊乱，并且基于与心脏的激活相关联的激活时间。

公开(公告)号：US20140066787A1

公开(公告)日：2014-03-06

申请号：US14074619

申请日：2013-11-07

申请人： Topera, Inc. ,  The Regents of the University of California

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/0205 ,  A61B5/0452

CPC分类号： A61B5/02405 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/743 ,  A61B18/02 ,  A61B18/12 ,  A61B18/18 ,  A61B2018/00577 ,  A61B2562/046

摘要： An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient. The first cardiac signal and the second cardiac signal are processed to determine whether there is a point of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to a derivative of the second cardiac signal above a threshold. An activation onset time is assigned in the first cardiac signal at the point of change to define a cardiac activation if the point of change is in the first cardiac signal.

摘要翻译： 公开了一种处理心脏激活信息的示例系统和方法。 该方法包括访问从患者获得的第一心脏信号和第二心脏信号。 处理第一心脏信号和第二心脏信号以确定在第一心脏信号中是否存在相对于高于阈值的第二心脏信号的导数发散的第一心脏信号的导数的改变点。 如果变化点在第一心脏信号中，则在改变点的第一心脏信号中分配激活起始时间以定义心脏激活。

公开(公告)号：US10398326B2

公开(公告)日：2019-09-03

申请号：US14473990

申请日：2014-08-29

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC分类号： A61B5/024 ,  A61B18/12 ,  A61N1/32 ,  A61N1/368 ,  A61B5/00 ,  A61B5/042 ,  A61B18/00

摘要： An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance with therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element. A plurality of indexes of progressive rotational activations or progressive focal activations over time is formed. One or more indexes are selected from the plurality of indexes that indicate consistency of the successive rotational activations or the progressive focal activations in relation to a portion of the region of the heart.

公开(公告)号：US09668666B2

公开(公告)日：2017-06-06

申请号：US14944096

申请日：2015-11-17

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC分类号： A61B5/04 ,  A61B5/0255 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/00

CPC分类号： A61B5/04012 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/0402 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B2562/046

摘要： In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

公开(公告)号：US20170007176A1

公开(公告)日：2017-01-12

申请号：US15204455

申请日：2016-07-07

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/00 ,  G06F19/00 ,  A61B5/04 ,  A61B5/0452 ,  A61B5/024 ,  A61B5/042

CPC分类号： A61B5/4836 ,  A61B5/02405 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7239 ,  A61B5/7278 ,  A61B2562/0209 ,  A61B2562/046 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60

摘要： Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.

摘要翻译： 与心律紊乱相关的心脏信息的重建包括使用定义局部激活的一个或多个发散标准来访问多个相邻的心脏信号并消除来自相邻心脏信号的远场激活，其中发散标准与 多个相邻的心脏信号。 多个相邻心脏信号中的局部激活可用于构建心律失常的临床表现。

公开(公告)号：US20160302734A1

公开(公告)日：2016-10-20

申请号：US15193105

申请日：2016-06-27

申请人： The Regents of the University of California

发明人： Sanjiv Narayan

IPC分类号： A61B5/00 ,  A61B5/0472 ,  A61B5/042 ,  A61B5/0464 ,  A61N1/365 ,  A61B5/024 ,  A61B5/046

CPC分类号： A61B5/7275 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/4836 ,  A61B5/4839 ,  A61B18/14 ,  A61B18/1492 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/36592 ,  G06F19/00

摘要： A system for assessing risk associated with a suspected heart rhythm disorder includes at least one sensor for generating a signal received from a beating human heart over a plurality of time segments, and an analytic engine that receives the signal and calculates a change in the signal among at least a first time segment and a second time segment in response to a change in at least one of rate and regularity induced in the beating human heart. The analytic engine generates a risk score for the heart rhythm disorder based at least in part on the change in the signal. The system may further be configured to control modification of tissue of the beating human heart based on the risk score.

摘要翻译： 用于评估与疑似心律失常相关的风险的系统包括至少一个传感器，用于在多个时间段上产生从跳动的人的心脏接收的信号，以及分析引擎，其接收信号并计算信号的变化 至少第一时间段和第二时间段，以响应在所述殴打人心脏中引起的速率和规律性中的至少一个的变化。 分析引擎至少部分地基于信号的变化来产生心律失常的风险评分。 该系统还可以被配置为基于风险评分来控制对打击的人类心脏的组织的修改。