Abstract:
Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Abstract:
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
Abstract:
Embodiments of the present invention include methods and apparatus for dynamically controlling pressure within a wellbore while forming the wellbore. In one aspect, one or more pressure control apparatus are used to maintain desired pressure within the wellbore while drilling the wellbore. In another aspect, pressure is dynamically controlled while drilling using foam to maintain a substantially homogenous foam flow regime within the wellbore annulus for carrying cuttings from the wellbore.
Abstract:
A system and method for reducing repairs to radial seals used in a rotating control head used while drilling is disclosed. Also, a system and method to detect leaks in the rotating control head and a latching system to latch the rotating control head to a housing is disclosed.
Abstract:
A method and system for providing a dynamic mailing list are described. The method includes creating a calendar event and creating a dynamic mailing list with a reference to the event. Clients are added to the dynamic mailing list in accordance with a client's status with regard to the event. Access is allowed to the dynamic mailing list by clients in accordance with a client's status with regard to the event. Access to the dynamic mailing list allows a client to send a message to the clients on the dynamic mailing list. A message addressed to the dynamic mailing list is received and forwarded to the clients on the dynamic mailing list. The method and system also include storing messages sent to clients on the dynamic mailing list and sending stored messages to a client added to the dynamic mailing list after the stored messages have been originally sent.
Abstract:
A seal assembly for use with a rotating control head is provided. The seal assembly includes a rotatable member and a cavity formed between the rotatable member and a tubular radially inwardly disposed from the rotatable member. The cavity having a first surface and a second surface. The seal assembly further includes a seal member having a first end and a second end disposed between the first surface and the second surface of the cavity and sealable with the tubular between the first and the second ends due to deformation of the seal member.
Abstract:
There is provided a method of forming a tablet product. The method comprises closing off a perforation in a perforated plate; directing powder into said closed-off perforation by the sweeping action of a first director blade spaced from said perforated plate; compacting the powder to form a tablet; and transferring the so-formed tablet from the closed-off perforation. The method is characterized by relative rotary motion of the perforated plate and said first director blade. Suitable apparatus is also provided.
Abstract:
A method for milling a tubular cemented in a wellbore includes deploying a bottomhole assembly (BHA) into the wellbore through the tubular, the BHA comprising a window mill; and extending arms of the window mill and radially cutting through the tubular, thereby forming a window through the tubular, wherein a body portion of each window mill arm engages and stabilizes from an inner surface of the tubular after a blade portion of each window mill arm cuts through the tubular.
Abstract:
A method and apparatus for assembling a plurality of independently formed solid components is provided thereby forming a single delivery vehicle for a pharmaceutical or pharmaceutical-like product. The solid components can be held and fed to the apparatus via a plurality of magazines. Pusher rods and the like can be used for positioning each of the solid components. Where the components are connected via a bonding liquid, a sprayer is provided and compression pins or the like press the components with the bonding liquid together to form the final project. A rivet or other connection structure can also be used and driven through holes in each of the solid components to form the final product.
Abstract:
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).