摘要:
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要:
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要:
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要:
A method for milling a tubular cemented in a wellbore includes deploying a bottomhole assembly (BHA) into the wellbore through the tubular, the BHA comprising a window mill; and extending arms of the window mill and radially cutting through the tubular, thereby forming a window through the tubular, wherein a body portion of each window mill arm engages and stabilizes from an inner surface of the tubular after a blade portion of each window mill arm cuts through the tubular.
摘要:
An imaging apparatus includes a print engine for printing on a print medium. A device is communicatively coupled with the print engine. The device is programmed to set a throughput rate for the print engine. A controller reads the device, and operates the print engine at the throughput rate designated by the device.
摘要:
The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要:
A structurally reinforced cross-car beam is comprised of a plastic material impregnated with long reinforcement fibers. The long reinforcement fibers have a length of at least three-quarters of an inch. The plastic material may be a thermoplastic and the reinforcement fibers may be comprised of glass fibers. The cross-car beam may also include a first portion comprised of a metallic material, such as magnesium, and a second portion comprised of the plastic material impregnated with long reinforcement fibers.
摘要:
Multi-compartmentalized ink cartridges for ink jet printers and improved methods for making the ink cartridges. The multi-compartmentalized ink cartridge includes a molded, open-topped body having an interior cavity and a printhead surface area opposite the interior cavity. A divider wall is integrally molded with the molded body structure and disposed in the interior cavity to provide at least three segregated ink chambers. The divider wall includes a first wall section and a second wall section attached substantially perpendicular to the first wall section. At least first, second, third molded ink flow paths connect each of the at least three segregated ink chambers with the printhead surface area. The second and third ink flow paths are oriented relative to their corresponding ink chambers for molding with a mold insert tool so that the cartridge body does not require a separately attached member to close mold insert tool insertion areas in the body.
摘要:
A method of manufacturing an infusion package 10 comprising a porous-walled container 12 for an infusible substance and a support for the container by means of which the container can be mounted on a rim of a drinking vessel. The method comprises (i) making cuts in at least one web of a semi-rigid material in a direction transverse to the web length to define a plurality of support members 14, each cut defining a first end 16 of one support member and a second end 20 of an adjacent support member such that the first end includes a projection 18 and the second end includes a recess 22 the cutting of which recess produces the projection; (ii) bringing two such support members into opposed relationship with the first end of one of the support members disposed opposite the second end of the other of the support members; (iii) positioning an end region of the container between the opposed support members; and (iv) securing that end region to the support members.
摘要:
An automated matrix removal module is configurable to automatically withdraw a portion of sample containing an interfering matrix. The module is further configurable to mix the portion of sample with a reagent selected to react with the matrix to form a precipitant and then filter the mixture of sample and precipitant reagent through a filter. Finally, the module is further configurable to flush the precipitant from the filter.