利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

82 条记录 (耗时 0.038 秒)

    Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
    32.
    发明授权
    Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides 失效
    用固相结合的合成多肽测定爱泼斯坦 - 巴尔病毒感染

    公开(公告)号：US5116725A

    公开(公告)日：1992-05-26

    申请号：US117241

    申请日：1987-11-04

    申请人： John H. Vaughan ,  Dennis A. Carson ,  Gary Rhodes ,  Richard Houghten ,  Richard S. Smith ,  John E. Geltosky

    发明人： John H. Vaughan ,  Dennis A. Carson ,  Gary Rhodes ,  Richard Houghten ,  Richard S. Smith ,  John E. Geltosky

    IPC分类号： A61K39/00 ,  A61K39/245 ,  C07K14/05 ,  G01N33/569

    CPC分类号： A61K39/245 ,  A61K39/12 ,  C07K14/005 ,  C07K16/085 ,  G01N33/56983 ,  G01N33/56994 ,  A61K2039/55566 ,  A61K2039/6081 ,  A61K39/00 ,  C12N2710/16222 ,  C12N2710/16234 ,  G01N2333/05 ,  G01N2469/20 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S436/812 ,  Y10S436/823 ,  Y10S530/806 ,  Y10S530/81

    摘要： Antigens, immunogens, inocula, antibodies, and particularly diagnostic methods and systems relating to Epstein-Barr virus nuclear antigen (EBNA) are disclosed. The diagnostic methods and systems utilize a synthetic, random copolymer polypeptide containing about 8 to about 40 amino acid residues that includes the overlapping five and six amino acid residue sequences(i) --Gly--R.sup.1 --Gly--R.sup.2 --Gly--wherein R.sup.1 and R.sup.2 are amino acid residues selected from Ala, Asn, Arg, Gly, Leu, Pro, Ser, and Thr with the provision that R.sup.1 and R.sup.2 are not both Gly; and(ii) --Gly--Ala--Gly--Gly--Ala--Gly--.The polypeptide contains at least 50 mole percent Gly residues. The diagnostic method and system are particularly useful for assaying for the stage of mononucleois disease, and the presence of nasopharynegeal carcinoma. In an assay for determining the state of Epstein-Barr virus infection, the synthetic polypeptide is fixed to first and second solid phases supports which can be provided by a double-welled spoon having two adjacent solid phases. The solids phases are each coated with the synthetic polypeptide. After contacting each solid phase with a body sample, one is contacted with anti-human IgG anThis invention was made with the support of the U.S. Government, and the U.S. Government has certain rights in the invention.

    摘要翻译： 公开了与Epstein-Barr病毒核抗原（EBNA）有关的抗原，免疫原，接种物，抗体，特别是诊断方法和系统。 诊断方法和系统利用包含约8至约40个氨基酸残基的合成的无规共聚物多肽，其包括重叠的5和6个氨基酸残基序列（i）-Gly-R1-Gly-R2-Gly-，其中R1和R2 是选自Ala，Asn，Arg，Gly，Leu，Pro，Ser和Thr的氨基酸残基，其条件是R1和R2不同时为Gly; 和（ii）-Gly-Ala-Gly-Gly-Ala-Gly-。 该多肽含有至少50摩尔％的Gly残基。 诊断方法和系统对于单核因子疾病阶段和鼻咽癌的存在特别有用。 在用于确定爱泼斯坦 - 巴尔病毒感染状态的测定中，合成多肽固定在第一和第二固相载体上，该固相载体可由具有两个相邻固相的双孔勺提供。 固体相各自用合成多肽包被。 在将每个固相与体样品接触后，将其与具有连接的指示手段的抗人IgG抗体接触，另一个与具有连锁指示手段的抗人IgM抗体接触。 每个固相与成色反应物接触，通过比较每个固相产生的颜色强度，确定感染状态。

    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
    38.
    发明授权
    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas 有权
    Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标

    公开(公告)号：US07713526B2

    公开(公告)日：2010-05-11

    申请号：US10285976

    申请日：2002-11-01

    申请人： Chae-Seo Rhee ,  Malini Sen ,  Christina Wu ,  Lorenzo M. Leoni ,  Maripat Corr ,  Dennis A. Carson

    发明人： Chae-Seo Rhee ,  Malini Sen ,  Christina Wu ,  Lorenzo M. Leoni ,  Maripat Corr ,  Dennis A. Carson

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3061 ,  C07K2317/73 ,  C12Q1/6851 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the proliferation and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, the Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.

    摘要翻译： Wnt和卷曲（Fzd）家族的多种受体 - 配体对在胚胎发育过程中起重要作用，因此可能在由未成熟细胞产生的癌症中过表达。 研究了10个头颈鳞癌细胞系（HNSCC）中5个Wnt（Wnt-1,5a，7a，10b，13）和2个Fzd（Fzd-2,5）基因的mRNA水平和表达水平。 此外，使用抗Wnt-1抗体研究Wnt / Fzd信号通路。 这些结果表明，HNSCC细胞系过表达一个或多个Wnt和Fzd基因，HNSCC亚型的增殖和存活可能取决于Wnt / Fzd途径。 因此，Wnt和Fzd受体可能是这种常见癌症的免疫治疗的有用靶标。

    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
    39.
    发明授权
    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas 失效
    Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标

    公开(公告)号：US07682607B2

    公开(公告)日：2010-03-23

    申请号：US10381636

    申请日：2002-05-01

    申请人： Chae-Seo Rhee ,  Malini Sen ,  Christina Wu ,  Lorenzo M. Leoni ,  Maripat Corr ,  Dennis A. Carson

    发明人： Chae-Seo Rhee ,  Malini Sen ,  Christina Wu ,  Lorenzo M. Leoni ,  Maripat Corr ,  Dennis A. Carson

    IPC分类号： A61K39/395

    CPC分类号： C07K16/28 ,  C12Q1/6851 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the growth and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, The Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.

    摘要翻译： Wnt和卷曲（Fzd）家族的多种受体 - 配体对在胚胎发育过程中起重要作用，因此可能在由未成熟细胞产生的癌症中过表达。 研究了10个头颈鳞癌细胞系（HNSCC）中5个Wnt（Wnt-1,5a，7a，10b，13）和2个Fzd（Fzd-2,5）基因的mRNA水平和表达水平。 此外，使用抗Wnt-1抗体研究Wnt / Fzd信号通路。 这些结果表明，HNSCC细胞系过表达一个或多个Wnt和Fzd基因，HNSCC亚型的生长和存活可能取决于Wnt / Fzd途径。 因此，Wnt和Fzd受体可能是这种常见癌症的免疫治疗的有用靶标。