Optically active cyclic alcohol compound
    33.
    发明授权
    Optically active cyclic alcohol compound 有权
    光学活性环状醇化合物

    公开(公告)号:US08471028B2

    公开(公告)日:2013-06-25

    申请号:US13087588

    申请日:2011-04-15

    IPC分类号: C07D401/04

    摘要: The present invention relates to a method for preparing an optically active cyclic alcohol compound represented by general formula [I]: [wherein R represents a hydrogen atom or a protecting group for amino group, and * represents an asymmetric carbon atom.] which comprises a step of subjecting a cyclic ketone compound represented by general formula [II]: [wherein R has the same meaning as defined above.] to asymmetric reduction (A) in the presence of an optically active oxazaborolidine compound and a boron hydride compound, or (B) in the presence of an asymmetric transition metal complex obtained from a transition metal compound and an asymmetric ligand and a hydrogen donor, and relates to said compound.

    摘要翻译: 本发明涉及一种由通式[I]表示的光学活性环状醇化合物的制备方法:[其中R表示氢原子或氨基保护基,*表示不对称碳原子],其包含 在光学活性的恶唑硼烷化合物和硼氢化合物的存在下,将不饱和还原(A)进行不饱和还原(A)的步骤:(其中R具有与上述定义相同的含义) B)在由过渡金属化合物和不对称配体和氢供体获得的不对称过渡金属络合物的存在下,涉及所述化合物。

    Connector with a sealing ring having a bulge at its inner peripheral side of its main body
    34.
    发明授权
    Connector with a sealing ring having a bulge at its inner peripheral side of its main body 有权
    具有在其主体的内周侧具有凸起的密封环的连接器

    公开(公告)号:US08167634B2

    公开(公告)日:2012-05-01

    申请号:US13038763

    申请日:2011-03-02

    IPC分类号: H01R13/52

    摘要: A connector has a housing (40) including a terminal mounting portion (41), a receptacle (55) and a mounting flange (61) between the terminal mounting portion (41) and the receptacle (55). A seal ring (150) is mounted on a surface of the mounting flange (61) to be held in contact with a mounting wall (20) for sealing between the mounting flange (61) and the mounting wall (20). The seal ring (150) includes a ring main body (151) surrounding the outer periphery of the terminal mounting portion (41) and fixing portions (160) for fixing the ring main body (151) to the mounting flange (61). Each fixing portion (160) includes a bulge (161) at an inner peripheral side of the ring main body (151). A lock (165) projects from the bulge (161) toward a side opposite to a sealing surface and engages a locking hole (67) in the housing (40).

    摘要翻译: 连接器具有在端子安装部分(41)和插座(55)之间包括端子安装部分(41),插座(55)和安装凸缘(61)的壳体(40)。 密封环(150)安装在安装凸缘(61)的表面上,以与安装壁(20)保持接触,用于密封安装凸缘(61)和安装壁(20)之间。 密封环(150)包括围绕端子安装部分(41)的外周的环形主体(151)和用于将环形主体(151)固定到安装凸缘(61)的固定部分(160)。 每个固定部分(160)在环形主体(151)的内周侧包括凸起(161)。 锁(165)从凸起(161)向与密封表面相对的一侧突出,并与壳体(40)中的锁定孔(67)接合。

    Methods for producing solid-state imaging device and electronic device
    38.
    发明申请
    Methods for producing solid-state imaging device and electronic device 失效
    固态成像装置和电子装置的制造方法

    公开(公告)号:US20090263929A1

    公开(公告)日:2009-10-22

    申请号:US12382713

    申请日:2009-03-23

    IPC分类号: H01L31/00

    CPC分类号: H01L27/14812 H01L27/14831

    摘要: A method for producing a solid-state imaging device includes steps of: forming transfer electrodes on a substrate having a plurality of light-sensing portions through a gate insulating layer so that the light-sensing portions are exposed; forming a planarized insulating layer on the substrate to cover the transfer electrodes formed on the substrate; forming openings in the planarized insulating layer so that each of the transfer electrodes is partly exposed out of the planarized insulating layer at a predetermined position; forming a wiring material layer so that the openings are filled with the wiring material layer; forming a resist layer on the wiring material layer; exposing and developing the resist layer so that only the resist layer in a predetermined area covering the openings is left; and patterning the wiring material layer using the exposed and developed resist layer to form connection wirings connected to the transfer electrodes by the openings.

    摘要翻译: 一种制造固态成像装置的方法,包括以下步骤:通过栅极绝缘层,在具有多个光检测部分的基板上形成转印电极,使得光敏部分露出; 在所述基板上形成平坦化的绝缘层,以覆盖形成在所述基板上的转移电极; 在平坦化绝缘层中形成开口,使得每个传输电极在预定位置部分地暴露在平坦化绝缘层之外; 形成布线材料层,使得开口被布线材料层填充; 在所述布线材料层上形成抗蚀剂层; 曝光和显影抗蚀剂层,使得仅保留覆盖开口的预定区域中的抗蚀剂层; 并使用曝光和显影的抗蚀剂层图案化布线材料层,以形成通过开口连接到转印电极的连接布线。

    Crystals of triazaspiro[5.5]undecane derivative
    39.
    发明授权
    Crystals of triazaspiro[5.5]undecane derivative 失效
    三氮茚[5.5]十一烷衍生物的晶体

    公开(公告)号:US07361758B2

    公开(公告)日:2008-04-22

    申请号:US10527193

    申请日:2003-09-17

    IPC分类号: C07D471/10 A61K31/499

    CPC分类号: C07D471/10

    摘要: The present invention relates to a new crystal of triazaspiro[5.5]undecane derivatives. The crystal of a non-solvate of (3R)-1-butyl-2,5-dioxo-3-[(1R)-1-hydroxy-1-cyclohexylmethyl]-9-[4-(4-carboxyphenyloxy)phenylmethyl]-1,4,9-triazaspiro[5.5]undecane hydrochloride have safety as drug substance, and have possibility to supply at large scale. And the crystal have an antagonistic activity against the interaction between chemokine and chemokine receptor, therefore, it is useful for manufacture of an agent for treating and/or preventing diseases such as various inflammatory diseases, asthma, atopic dermatitis, nettle rash, allergy disease, nephritis, nephropathy, hepatitis, arthritis, chronic rheumatoid arthritis, autoimmune disease, transplanted organ rejection reactions, acquired immunodeficiency syndrome and the like.

    摘要翻译: 本发明涉及三氮杂螺[5.5]十一烷衍生物的新晶体。 (3R)-1-丁基-2,5-二氧代-3 - [(1R)-1-羟基-1-环己基甲基] -9- [4-(4-羧基苯氧基)苯基甲基] -1,4,9-三氮杂螺[5.5]十一烷盐酸盐作为药物具有安全性,具有大规模供应的可能性。 并且晶体对趋化因子和趋化因子受体之间的相互作用具有拮抗作用,因此可用于制备用于治疗和/或预防各种炎性疾病,哮喘,特应性皮炎,荨麻疹,过敏性疾病, 肾炎,肾病,肝炎,关节炎,慢性类风湿关节炎,自身免疫性疾病,移植器官排斥反应,获得性免疫缺陷综合征等。