公开(公告)号：US20120088778A1

公开(公告)日：2012-04-12

申请号：US13270208

申请日：2011-10-10

Applicant: Adnan M.M. Mjalli ,  Robert C. Andrews ,  Ramesh Gopalaswamy ,  Anitha Hari ,  Kwasi S. Avor ,  Ghassan Qabaja ,  Xiao-Chuan Guo ,  Suparna Gupta ,  David R. Jones ,  Xin Chen

Inventor： Adnan M.M. Mjalli ,  Robert C. Andrews ,  Ramesh Gopalaswamy ,  Anitha Hari ,  Kwasi S. Avor ,  Ghassan Qabaja ,  Xiao-Chuan Guo ,  Suparna Gupta ,  David R. Jones ,  Xin Chen

IPC: A61K31/496 ,  A61K31/4725 ,  A61P27/02 ,  A61P9/10 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4164

CPC classification number: C07D233/64 ,  C07D235/08 ,  C07D235/12 ,  C07D235/14 ,  C07D235/18 ,  C07D235/30 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D453/02

Abstract: This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Abstract translation: 本发明提供某些化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物疾病中的用途。 本发明的化合物可用作晚期糖基化终产物（RAGE）的受体与其配体如晚期糖基化终产物（AGE），S100 /钙粒蛋白/ EN-RAGE，淀粉样蛋白和 两性霉素，以及由RAGE引起的人类疾病的管理，治疗，控制或辅助治疗。 这些疾病或疾病状态包括急性和慢性炎症，糖尿病晚期并发症的发展，例如血管通透性增加，肾病，动脉粥样硬化和视网膜病变，阿尔茨海默病的发展，勃起功能障碍和肿瘤侵袭和转移。

公开(公告)号：US08138363B2

公开(公告)日：2012-03-20

申请号：US12312293

申请日：2007-11-02

Applicant: Xin Chen ,  Howard W. Prokop ,  Stephen Howard Colmery

Inventor： Xin Chen ,  Howard W. Prokop ,  Stephen Howard Colmery

IPC: C07C231/00

CPC classification number: C07C231/02 ,  C10L1/224 ,  C10M133/16 ,  C10M2215/08 ,  C07C233/18

Abstract: The present invention relates to a process for the manufacture of alkanolamide containing compositions, and more particularly to a process of reacting a fatty acid and diethanolamine (DEA) which result in the formation of low levels of undesirable by products, particularly of bis-hydroxyethyl piperazine (BHEP).

Abstract translation: 本发明涉及一种制备含链烷醇酰胺的组合物的方法，更具体地说，涉及使脂肪酸和二乙醇胺（DEA）反应的方法，该方法导致产生低水平的不期望的产物，特别是双羟乙基哌嗪 （BHEP）。

公开(公告)号：US20110313160A1

公开(公告)日：2011-12-22

申请号：US13152752

申请日：2011-06-03

Applicant: Xin Chen ,  Jingyuan Ma ,  Jiangao Song ,  Imad Nashashibi

Inventor： Xin Chen ,  Jingyuan Ma ,  Jiangao Song ,  Imad Nashashibi

IPC: C07D417/14 ,  C07D401/04

CPC classification number: C07D417/14 ,  C07D401/04

Abstract: Processes and intermediates for the synthesis of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine are provided.

Abstract translation: 提供了合成5-乙基-2- {4- [4-（4-四唑-1-基 - 苯氧基甲基） - 噻唑-2-基] - 哌啶-1-基} - 嘧啶的方法和中间体。

公开(公告)号：US20110274985A1

公开(公告)日：2011-11-10

申请号：US12776922

申请日：2010-05-10

Applicant: Monica L. Usrey ,  Xin Chen ,  Jose A. Pena Hueso ,  Robert C. West ,  Robert J. Hamers

Inventor： Monica L. Usrey ,  Xin Chen ,  Jose A. Pena Hueso ,  Robert C. West ,  Robert J. Hamers

IPC: H01M6/16

CPC classification number: H01M10/052 ,  H01M2/1646 ,  H01M4/382 ,  H01M4/587 ,  H01M10/0569 ,  H01M2300/0014

Abstract: Disclosed are lithium/carbon monofluoride batteries suitable for long term use at highly elevated temperatures. Organosilicon electrolytes having low vapor pressure and high flash points are used, along with lithium salts and ceramic separators. Methods of using these batteries at high temperatures are also disclosed.

Abstract translation: 公开了适用于在高度升高的温度下长期使用的锂/碳一氟化物电池。 使用具有低蒸气压和高闪点的有机硅电解质以及锂盐和陶瓷分离器。 还公开了在高温下使用这些电池的方法。

公开(公告)号：US07998558B2

公开(公告)日：2011-08-16

申请号：US12394191

申请日：2009-02-27

Applicant: Xin Chen ,  Anping Liu ,  Ji Wang ,  Liming Wang ,  Wei Xu ,  Naiyue Zhou

Inventor： Xin Chen ,  Anping Liu ,  Ji Wang ,  Liming Wang ,  Wei Xu ,  Naiyue Zhou

IPC: B32B23/02 ,  B32B17/06

CPC classification number: B29C63/0026 ,  C03C27/06 ,  Y10T156/10 ,  Y10T428/24777 ,  Y10T428/24785 ,  Y10T428/24793 ,  Y10T428/24843 ,  Y10T428/24926 ,  Y10T428/31

Abstract: A glass sheet assembly includes a glass sheet having an edge surface and a shaped fiber. The shaped fiber has a first surface bonded to the edge surface of the glass sheet and a convex second surface not bonded to the edge surface for receiving a load.

Abstract translation: 玻璃板组件包括具有边缘表面和成形纤维的玻璃板。 成形纤维具有接合到玻璃板的边缘表面的第一表面和不结合到边缘表面的用于接收负载的凸形第二表面。

公开(公告)号：US20110190496A1

公开(公告)日：2011-08-04

申请号：US13085722

申请日：2011-04-13

Applicant: Xin Chen ,  Heather Coate ,  Andrew Philip Crew ,  Han-Qing Dong ,  Ayako Honda ,  Mark Joseph Mulvihill ,  Paula A.R. Tavares ,  Jing Wang ,  Douglas S. Werner ,  Kristen Michelle Mulvihill ,  Kam W. Siu ,  Bijoy Panicker ,  Apoorba Bharadwaj ,  Lee D. Arnold ,  Meizhong Jin ,  Brian Volk ,  Quinghua Weng ,  James David Beard

Inventor： Xin Chen ,  Heather Coate ,  Andrew Philip Crew ,  Han-Qing Dong ,  Ayako Honda ,  Mark Joseph Mulvihill ,  Paula A.R. Tavares ,  Jing Wang ,  Douglas S. Werner ,  Kristen Michelle Mulvihill ,  Kam W. Siu ,  Bijoy Panicker ,  Apoorba Bharadwaj ,  Lee D. Arnold ,  Meizhong Jin ,  Brian Volk ,  Quinghua Weng ,  James David Beard

IPC: C07D487/04 ,  C07F5/02 ,  C07D253/06

CPC classification number: C07D487/04 ,  A61K31/5025 ,  C07D253/07 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。

公开(公告)号：US20110160222A1

公开(公告)日：2011-06-30

申请号：US12830911

申请日：2010-07-06

Applicant: Xin Chen ,  Jingyuan Ma ,  Christopher J. Rabbat ,  Yan Zhu ,  Zuchun Zhao

Inventor： Xin Chen ,  Jingyuan Ma ,  Christopher J. Rabbat ,  Yan Zhu ,  Zuchun Zhao

IPC: A61K31/519 ,  C07D487/04 ,  A61K31/496 ,  A61P3/10 ,  A61P3/06

CPC classification number: C07D487/04

Abstract: Aryl 119 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

Abstract translation: 提供Aryl 119激动剂。 这些化合物可用于治疗代谢疾病，包括II型糖尿病和与血糖控制不良相关的疾病。

公开(公告)号：US07955871B2

公开(公告)日：2011-06-07

申请号：US12586143

申请日：2009-09-17

Applicant: Naijuan Wu ,  Xin Chen ,  Alex Ignatiev

Inventor： Naijuan Wu ,  Xin Chen ,  Alex Ignatiev

IPC: H01L21/00 ,  H01L29/76

CPC classification number: G11C13/0007 ,  G11C2213/31 ,  H01C7/006 ,  H01L45/04 ,  H01L45/12 ,  H01L45/1233 ,  H01L45/147

Abstract: A switchable resistive device has a multi-layer thin film structure interposed between an upper conductive electrode and a lower conductive electrode. The multi-layer thin film structure comprises a perovskite layer with one buffer layer on one side of the perovskite layer, or a perovskite layer with buffer layers on both sides of the perovskite layer. Reversible resistance changes are induced in the device under applied electrical pulses. The resistance changes of the device are retained after applied electric pulses. The functions of the buffer layer(s) added to the device include magnification of the resistance switching region, reduction of the pulse voltage needed to switch the device, protection of the device from being damaged by a large pulse shock, improvement of the temperature and radiation properties, and increased stability of the device allowing for multivalued memory applications.

Abstract translation: 可切换电阻器件具有介于上导电电极和下导电电极之间的多层薄膜结构。 多层薄膜结构体包括在钙钛矿层的一侧具有一个缓冲层的钙钛矿层或在钙钛矿层的两侧具有缓冲层的钙钛矿层。 在施加的电脉冲下在器件中产生可逆电阻变化。 器件的电阻变化在施加电脉冲后保持不变。 添加到器件中的缓冲层的功能包括电阻切换区域的放大率，切换器件所需的脉冲电压的降低，器件受到大脉冲冲击的损害，温度的改善以及 辐射性能和增加的设备的稳定性，允许多值存储器应用。

公开(公告)号：US07947945B2

公开(公告)日：2011-05-24

申请号：US12393415

申请日：2009-02-26

Applicant: Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Daniel Aloysius Nolan

Inventor： Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Daniel Aloysius Nolan

IPC: G02B6/00 ,  G01N21/00

CPC classification number: G02B6/02333 ,  G01D5/35358 ,  G01L1/242 ,  G01M11/083 ,  G02B6/02366 ,  G02B6/0365

Abstract: An embodiment of a sensor fiber includes: at least two fiber sections with a plurality of holes; and at least one other fiber section situated between said at least two fiber sections, wherein the at least one other fiber sections being without the plurality of holes.

Abstract translation: 传感器光纤的一个实施例包括：具有多个孔的至少两个光纤部分; 以及位于所述至少两个纤维部分之间的至少一个其它纤维部分，其中所述至少一个其它纤维部分没有多个孔。

公开(公告)号：US20100329508A1

公开(公告)日：2010-12-30

申请号：US12490538

申请日：2009-06-24

Applicant: Xin Chen ,  Xiangheng Yang

Inventor： Xin Chen ,  Xiangheng Yang

IPC: G06K9/00 ,  G06F17/30

CPC classification number: G06K9/00791 ,  G06K9/00697 ,  G06K9/00704 ,  G06K9/00798

Abstract: Systems, devices, features, and methods for detecting geographic features in images, such as, for example, to develop a navigation database are disclosed. For example, a method of detecting a path marking from collected images includes collecting a plurality of images of geographic areas along a path. An image of the plurality of images is selected. Components that represent an object on the path in the selected image are determined. In one embodiment, the determined components are independent or invariant to scale of the object. The determined components are compared to reference components in a data library. If the determined components substantially meet a matching threshold with the reference components, the object in the selected image is identified to be a path marking corresponding to the reference components in the data library.

Abstract translation: 公开了用于检测图像中的地理特征的系统，设备，特征和方法，例如开发导航数据库。 例如，从收集的图像中检测路径标记的方法包括沿着路径收集多个地理区域的图像。 选择多个图像的图像。 表示所选图像中路径上的对象的组件被确定。 在一个实施例中，所确定的分量对象的尺度是独立的或不变的。 将确定的组件与数据库中的参考组件进行比较。 如果确定的分量基本上满足与参考分量的匹配阈值，则所选图像中的对象被识别为对应于数据库中的参考分量的路径标记。