公开(公告)号：US09614768B2

公开(公告)日：2017-04-04

申请号：US13979449

申请日：2012-04-06

申请人： Wei Li

发明人： Wei Li

IPC分类号： H04L12/803 ,  H04L12/709 ,  H04L12/713 ,  H04L12/801 ,  H04L12/891

CPC分类号： H04L47/125 ,  H04L45/245 ,  H04L45/586 ,  H04L47/29 ,  H04L47/41 ,  Y02D50/30

摘要： According to an example, a stacking device in a distribution layer may monitor traffic in an aggregation link between the stacking device and a core layer. When a traffic unbalance is detected in the aggregation link, the stacking device may find a data flow that causes the traffic unbalance from data flows transferred over the aggregation link and an incoming interface through which the found data flow enters the stacking device. The stacking device may also reallocate a new MAC address to the incoming interface and may send the new MAC address allocated to the incoming interface to a terminal server, so as to enable the traffic unbalance to transit to traffic balance by way of the terminal server sending a data flow with the new MAC address as the destination MAC address.

公开(公告)号：US20160200722A1

公开(公告)日：2016-07-14

申请号：US14912761

申请日：2014-08-18

申请人： Duane DEMONG ,  Thomas J. GRESHOCK ,  Ronald K. CHANG ,  Xing DAI ,  Hong LIU ,  John A. MCCAULEY ,  Wei LI ,  Kallol BASU ,  Jack D. SCOTT ,  Michael MILLER ,  MERCK SHARP & DOHME CORP.

发明人： Duane DeMong ,  Thomas J. Greshock ,  Ronald K. Chang ,  Xing Dai ,  Hong Liu ,  John A. McCauley ,  Wei Li ,  Kallol Basu ,  Jack D. Scott ,  Michael Miller

IPC分类号： C07D471/04 ,  C07D498/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

摘要： The present invention is directed to azaindazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

摘要翻译： 本发明涉及作为LRRK2激酶的有效抑制剂并且可用于治疗或预防涉及LRRK2激酶的疾病（例如帕金森病）的唑烷化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK-2激酶的疾病中的用途。

公开(公告)号：US09285449B2

公开(公告)日：2016-03-15

申请号：US13517633

申请日：2012-06-14

申请人： Chunlei Liu ,  Wei Li ,  Bing Wu

发明人： Chunlei Liu ,  Wei Li ,  Bing Wu

IPC分类号： G06K9/00 ,  G01R33/561 ,  G01R33/44 ,  G01R33/48 ,  G01R33/565

CPC分类号： G01R33/5616 ,  G01R33/443 ,  G01R33/482 ,  G01R33/4822 ,  G01R33/4824 ,  G01R33/5611 ,  G01R33/56509 ,  G01R33/56536

摘要： Systems and methods for imaging and quantifying tissue magnetism with magnetic resonance imaging (MRI) are disclosed. According to an aspect, a method for MRI includes using an MRI system to acquire multiple image echoes of an object. The method also includes combining the image echoes. Further, the method includes generating an image of the object based on the combined image echoes for depicting a characteristic of the object.

摘要翻译： 公开了用磁共振成像（MRI）成像和定量组织磁性的系统和方法。 根据一个方面，MRI的方法包括使用MRI系统来获取对象的多个图像回波。 该方法还包括组合图像回波。 此外，该方法包括基于用于描绘对象的特征的组合图像回波来生成对象的图像。

公开(公告)号：US09252843B2

公开(公告)日：2016-02-02

申请号：US13881591

申请日：2010-10-27

申请人： Wei Li ,  Jun Yu ,  Gang Zhang

发明人： Wei Li ,  Jun Yu ,  Gang Zhang

IPC分类号： H04B5/00 ,  H04L29/06 ,  H04W4/00 ,  H04W80/02

CPC分类号： H04B5/0025 ,  G06K7/10237 ,  H04B5/0031 ,  H04L63/0492 ,  H04W4/80 ,  H04W80/02

摘要： A method and an apparatus for data transmission between a contactless front element and a security element are provided. The method includes: the contactless front element transparently transmits first data obtained from a contactless identification device to the security element through a single wire connection; the security element processes the first data to generate second data; the contactless front element transparently transmits the second data obtained from the security element through the single wire connection to the contactless identification device. Compared with the prior art, the method can transmit the contactless data in real time between the contactless front element and the security element. Thus the security element can directly respond instructions sent by a proximity coupling device during simulating Proximity Integrated Circuit Card, so that the contactless front element becomes a transparent transport channel, the time order compatibility problem can be avoided, and the safety problem can be surmounted.

摘要翻译： 提供了一种用于非接触式前部元件和安全元件之间的数据传输的方法和装置。 该方法包括：非接触式前部元件通过单线连接将从非接触识别装置获得的第一数据透明地发送到安全元件; 所述安全元件处理所述第一数据以产生第二数据; 非接触式前部元件通过单线连接将从安全元件获得的第二数据透明地发送到非接触式识别装置。 与现有技术相比，该方法可以在非接触式前置元件和安全元件之间实时传输非接触式数据。 因此，在模拟接近集成电路卡期间，安全元件可以直接响应由邻近耦合装置发送的指令，使得非接触式前部元件变为透明传输通道，可以避免时间顺序兼容性问题，并且可以克服安全问题。

公开(公告)号：US09250237B2

公开(公告)日：2016-02-02

申请号：US13990396

申请日：2011-11-29

申请人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： A61K31/4353 ,  C07D498/04 ,  C07D515/04 ,  C07D471/04 ,  G01N33/566 ,  A61K31/436 ,  C07D498/14 ,  C07D515/14 ,  C07K17/08

CPC分类号： C07K7/645 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

摘要翻译： 提供了包含天然产物的已知蛋白质结合结构域的新型杂合环状文库。 还提供了使用部分分离的文库化合物制备这种文库和使用命中反卷积方法的合成方法。 这种方法适用于与整个人类蛋白质组一起使用以筛选结合和鉴定命中的这些文库。

公开(公告)号：US20150381450A1

公开(公告)日：2015-12-31

申请号：US14500960

申请日：2014-09-29

申请人： Bin Zhao ,  Wei Li

发明人： Bin Zhao ,  Wei Li

IPC分类号： H04L12/26 ,  H04M3/22 ,  H04L12/841 ,  H04M1/253

CPC分类号： H04L43/0864 ,  H04L12/18 ,  H04L12/1827 ,  H04L12/1831 ,  H04L41/5038 ,  H04L43/045 ,  H04L43/062 ,  H04L43/0852 ,  H04L43/10 ,  H04L43/50 ,  H04L45/123 ,  H04L47/283 ,  H04L47/722 ,  H04L51/34 ,  H04L65/1066 ,  H04L65/4038 ,  H04M1/2535 ,  H04M1/72547 ,  H04M3/2236 ,  H04M3/432 ,  H04M3/563 ,  H04M3/565 ,  H04M7/0084 ,  H04M2250/62 ,  H04M2250/74 ,  H04W4/16

摘要： Systems and methods for improving quality of a call over network (CON) are provided. Call quality may be improved via pathway testing to determine data path quality. This may be utilized to inform buffering lengths, and also may be utilized to choose the data pathway utilized for transmitting the data. Pathway testing may employ collecting microphone data on one device, transmitting it across the various pathways, and then comparing the quality at the endpoint compared to the initial data.

摘要翻译： 提供了通过网络（CON）提高质量的系统和方法。 呼叫质量可以通过路径测试来改善，以确定数据路径质量。 这可以用于通知缓冲长度，并且还可以用于选择用于发送数据的数据路径。 路径测试可以采用在一个设备上收集麦克风数据，通过各种路径传输麦克风数据，然后比较端点的质量与初始数据进行比较。

公开(公告)号：US09200246B2

公开(公告)日：2015-12-01

申请号：US13309209

申请日：2011-12-01

申请人： Donald Thomas ,  Wei Li ,  Ning Ke ,  Nan Li ,  Adrian Papas ,  Manfred Watzele ,  Alexander Seiler ,  Tianxing Wang ,  Yama Abassi ,  Xiaobo Wang

发明人： Donald Thomas ,  Wei Li ,  Ning Ke ,  Nan Li ,  Adrian Papas ,  Manfred Watzele ,  Alexander Seiler ,  Tianxing Wang ,  Yama Abassi ,  Xiaobo Wang

IPC分类号： C12M1/12 ,  C12Q1/02 ,  G01N33/543 ,  G01N21/25 ,  G01N21/64 ,  G01N33/487

CPC分类号： C12M25/04 ,  C12Q1/02 ,  G01N21/253 ,  G01N21/6452 ,  G01N33/48735 ,  G01N33/54373

摘要： An insert device and co-culture device assembly incorporating the insert device, which includes an insert chamber with two fluid impermeable side walls that extend from a microporous bottom to an open top to form an inner cavity. The first side wall is shaped to form a convex arc that follows between about half of a circumference of the well and less than an entire circumference of the well. The second side wall joins ends of the first side wall and protrudes inward towards a center of the convex arc. A flange extends outward from or beneath the top and is notched to form a gap adjacent to the second side wall, which forms an access port allowing access to the lower chamber with a micropipette tip when the insert device is inserted into a well of a single or multi-well plate.

摘要翻译： 包括插入装置的插入装置和共培养装置组件，其包括具有从微孔底部延伸到开口顶部以形成内腔的两个流体不可渗透侧壁的插入室。 第一侧壁成形为形成沿着井的圆周的大约一半且小于井的整个圆周的凸弧。 第二侧壁连接第一侧壁的端部并朝向凸弧的中心向内突出。 凸缘从顶部向下或从顶部向外延伸并且被切口以形成与第二侧壁相邻的间隙，当形成插入装置插入到单个孔中时，形成允许通过微量移液管尖端进入下腔室的进入口 或多孔板。

公开(公告)号：US08956992B2

公开(公告)日：2015-02-17

申请号：US13282594

申请日：2011-10-27

申请人： Gongshin Qi ,  Wei Li ,  Lei Wang

发明人： Gongshin Qi ,  Wei Li ,  Lei Wang

IPC分类号： B01J27/182 ,  B01J29/06 ,  C01B33/26 ,  B01J29/85 ,  C01B37/08 ,  C01B39/54 ,  B01J35/00 ,  B01D53/94

CPC分类号： B01J29/85 ,  B01D53/9418 ,  B01D2255/104 ,  B01D2255/20738 ,  B01D2255/20746 ,  B01D2255/20761 ,  B01D2255/50 ,  B01J35/002 ,  B01J2229/183 ,  B01J2229/186 ,  B01J2229/36 ,  C01B37/08 ,  C01B39/54

摘要： A method of replacing or exchanging non-metal charge balancing cations located at ion-exchanges sites within SAPO frameworks with cations of a transition metal using a solid state ion-exchange process. Transition metal-containing particles are formed on surfaces of SAPO particles, and thereafter the particles are heated in air to initiate the solid-state ion-exchange process. The transition metal-containing particles and the SAPO particles are heated to a temperature and for an amount of time to produce transition metal cations, and for the transition metal cations to replace at least a portion of the non-metal cations located within the SAPO frameworks.

摘要翻译： 一种使用固态离子交换工艺替代或交换位于SAPO框架内的离子交换位置的非金属电荷平衡阳离子与过渡金属的阳离子的方法。 在SAPO颗粒的表面上形成过渡金属的颗粒，然后在空气中加热颗粒以引发固态离子交换过程。 将含过渡金属的颗粒和SAPO颗粒加热到一定温度和一段时间以产生过渡金属阳离子，并且对于过渡金属阳离子替代位于SAPO框架内的至少一部分非金属阳离子 。

公开(公告)号：US20140324993A1

公开(公告)日：2014-10-30

申请号：US13994081

申请日：2013-04-28

申请人： Wei Li ,  Remyylyang Ho ,  Yi Shan

发明人： Wei Li ,  Remyylyang Ho ,  Yi Shan

IPC分类号： H04L12/58

CPC分类号： H04L12/1818 ,  H04L12/1822 ,  H04L51/20

摘要： The present invention provides a method and apparatus for establishing a chat group. The method performed by a server includes: obtaining an identifier of a user of a first client terminal, an identifier of a chat group to be established and a geographic position of the first terminal; beginning to establish a chat group; selecting at least one second client terminal from a predetermined geographic scope; and inviting a user of the at least one second client terminal to the chat group; receiving authentication information input by the user of the second client terminal from the second client terminal; determining whether the authentication information is correct; if the authentication information is correct, adding the user of the second client terminal into the chat group; and sending information of the second user to the first client terminal; finishing establishing the chat group when a preset finish condition is met.

摘要翻译： 本发明提供一种用于建立聊天组的方法和装置。 由服务器执行的方法包括：获取第一客户终端的用户的标识符，要建立的聊天组的标识符和第一终端的地理位置; 开始建立一个聊天组; 从预定的地理范围中选择至少一个第二客户终端; 以及向所述聊天组邀请所述至少一个第二客户终端的用户; 从所述第二客户终端接收由所述第二客户终端的用户输入的认证信息; 确定认证信息是否正确; 如果认证信息正确，则将第二客户终端的用户添加到聊天组中; 以及将所述第二用户的信息发送到所述第一客户终端; 当满足预设完成条件时，完成聊天组的建立。

公开(公告)号：US08859587B2

公开(公告)日：2014-10-14

申请号：US13697808

申请日：2010-05-14

申请人： Kunlun He ,  Song Li ,  Lili Wang ,  Xin Li ,  Wu Zhong ,  Guoliang Hu ,  Jie Wang ,  Ruijin Li ,  Chunlei Liu ,  Junhai Xiao ,  Long Long ,  Wei Li ,  Hua Chen

发明人： Kunlun He ,  Song Li ,  Lili Wang ,  Xin Li ,  Wu Zhong ,  Guoliang Hu ,  Jie Wang ,  Ruijin Li ,  Chunlei Liu ,  Junhai Xiao ,  Long Long ,  Wei Li ,  Hua Chen

IPC分类号： A61K31/04 ,  C07D215/40 ,  A61K31/47

CPC分类号： C07D215/40 ,  A61K31/47

摘要： The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I的丙烯酰胺化合物或其异构体，药学上可接受的盐和溶剂化物，其涉及包含所述化合物或其异构体，药学上可接受的盐和溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂， 以及该化合物或组合物用于预防和/或治疗与心肌细胞凋亡相关的疾病或病症的用途。