公开(公告)号：US20120197413A1

公开(公告)日：2012-08-02

申请号：US12733976

申请日：2008-10-02

申请人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

发明人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

IPC分类号： A61F2/34 ,  F16C33/20 ,  B05D3/06

CPC分类号： A61L27/34 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61F2002/30003 ,  A61F2002/30026 ,  A61F2002/30065 ,  A61F2002/30673 ,  A61F2002/30685 ,  A61F2002/30934 ,  A61F2002/30971 ,  A61F2310/00011 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00179 ,  A61F2310/00389 ,  A61F2310/00916 ,  A61F2310/00976 ,  A61L27/50 ,  A61L2400/18 ,  A61L2430/24

摘要： The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

摘要翻译： 本发明的目的是提供一种滑动构件，假体和滑动构件的制造方法，其可以通过抑制滑动部的摩擦来抑制磨损残渣的产生，并且还可以在体内保持令人满意的机械特性。 一种滑动构件，包括：能够形成羟基的基底1; 以及层叠在基板1的适当部分上的生物相容性材料层4，其中通过表面处理在基材1的表面的至少所需部分上形成羟基，形成表面处理层2，同时生物相容性材料层 4由含有磷酸胆碱基团的聚合物形成，并且其中基材1和生物相容性材料层4分别通过由与由羟基和生物相容性材料共价键合的二氧化硅形成的粘合剂层3而接合。

公开(公告)号：US20120022665A1

公开(公告)日：2012-01-26

申请号：US13142058

申请日：2009-12-25

申请人： Masayuki Kyomoto ,  Kazuhiko Ishihara

发明人： Masayuki Kyomoto ,  Kazuhiko Ishihara

IPC分类号： A61F2/28 ,  C08J7/04 ,  F16C33/24

CPC分类号： A61L27/18 ,  C08F2/48 ,  C08F291/18 ,  Y10T428/31855 ,  C08L71/00

摘要： Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.

摘要翻译： 公开了具有优异的耐久性并能够长时间保持耐磨性的滑动构件。 进一步公开了一种减少聚合物基材的膜厚度的人造接头构件。 进一步公开了能够在引入身体后显示高润滑性，生物相容性和耐位错性的人造关节。 进一步公开了表现出优异的生物相容性的医疗器具材料和医疗器械。 滑动材料或医疗用具材料由聚合物层或生物相容性材料层（B）形成，所述聚合物层或生物相容性材料层（B）通过涂覆聚合物基材（A）的至少一部分表面而提供，所述聚合物基材（A）的表面具有酮基 聚合物基材（A）浸渍在含有单体（C），聚合物基材（A）的反应体系中，聚合物基材（A） 暴露于光，并且单体的聚合从聚合物基材（A）的表面引发。 使用滑动材料或医疗器具材料制造人造关节构件，人造关节，医疗器具材料和医疗器具。

公开(公告)号：US20110274940A1

公开(公告)日：2011-11-10

申请号：US13130125

申请日：2009-11-20

申请人： Masayuki Kyomoto ,  Kazuhiko Ishihara

发明人： Masayuki Kyomoto ,  Kazuhiko Ishihara

IPC分类号： B32B27/08 ,  C08F283/00 ,  C08G8/30 ,  C08J3/28

CPC分类号： C08F291/18 ,  C08F283/06 ,  Y10T428/31855 ,  C08F230/02 ,  C08F2/48

摘要： Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).

摘要翻译： 公开了一种接枝聚合方法，其解决了当单体在聚合物基材的表面上接枝聚合时涉及使用溶剂，自由基引发剂和高能辐射的问题。 接枝聚合方法的特征在于，通过将表面上具有酮基的聚合物基（ⅰ）浸渍到含有单体（ⅱ）的反应体系中，然后用光照射聚合物基体（i），得到聚合产物 单体的聚合从聚合物基质（i）的表面开始。

公开(公告)号：US07785372B2

公开(公告)日：2010-08-31

申请号：US10489112

申请日：2003-02-19

申请人： Kazuhiko Ishihara ,  Toru Moro ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Tomohiro Konno ,  Tomiharu Matsushita ,  Shuji Kusumoto

发明人： Kazuhiko Ishihara ,  Toru Moro ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Tomohiro Konno ,  Tomiharu Matsushita ,  Shuji Kusumoto

IPC分类号： A61F2/30

CPC分类号： A61F2/30 ,  A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2/468 ,  A61F2002/30673 ,  A61F2002/30685 ,  A61F2002/30934 ,  A61F2002/3611 ,  A61F2310/00017 ,  A61F2310/00029 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61L27/34 ,  A61L27/50 ,  A61L2430/24 ,  B29K2995/0087 ,  B29L2031/7532 ,  C08L101/02

摘要： An artificial joint member made of a polymeric material including a portion made of a polymeric substance has a sliding surface composed of a polymer having phosphoryl choline groups. With such an arrangement, the artificial joint member is provided with a sliding part capable of keeping a satisfactory lubricating state for a long time.

摘要翻译： 由包含由聚合物制成的部分的聚合材料制成的人造关节构件具有由具有磷酰胆碱基团的聚合物组成的滑动表面。 通过这种布置，人造关节构件设置有能够长时间保持令人满意的润滑状态的滑动部。

公开(公告)号：US20100137133A1

公开(公告)日：2010-06-03

申请号：US12495936

申请日：2009-07-01

申请人： Katsuyuki Maeno ,  Kazuyuki Miyazawa ,  Akira Ishikubo ,  Kazuhiko Ishihara

发明人： Katsuyuki Maeno ,  Kazuyuki Miyazawa ,  Akira Ishikubo ,  Kazuhiko Ishihara

IPC分类号： B01J20/22

CPC分类号： B01J20/286 ,  B01D15/3804 ,  B01J20/28004 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3248 ,  B01J20/3259 ,  B01J20/3274 ,  B01J20/3285 ,  B01J2220/58 ,  C07F9/091 ,  G01N33/54393

摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.

摘要翻译： 本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，并且还具有与某种共价键合或吸附在表面上的某些目标物质具有特异亲和力的配体 无机粉末。 本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。

公开(公告)号：US07368252B2

公开(公告)日：2008-05-06

申请号：US10626502

申请日：2003-07-23

申请人： Kyoichi Sumida ,  Koji Wada ,  Kazuhiko Ishihara

发明人： Kyoichi Sumida ,  Koji Wada ,  Kazuhiko Ishihara

IPC分类号： G01N33/567

CPC分类号： G01N33/6842 ,  C08F30/02 ,  G01N33/57434 ,  G01N33/68

摘要： An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known agglutination accelerator; hardly generates non-specific turbidity; and hardly generates salting out even in a solution with a high salt concentration. The present invention relates to an immunoassay of a prostate-specific antigen comprising performing an antigen-antibody reaction in the presence of a polymer having a monomer unit derived from a monomer represented by the following general formula [2]: (wherein R1-R3 are each independently a hydrogen atom or an alkyl group optionally having a hydroxyl group; R4 is an alkylene group; R5 is an alkylene group optionally having a substituent and optionally having an oxygen atom in a chain; R6 is a hydrogen atom or a methyl group, and X is an oxygen atom or a —NH— group), and a kit of reagent for an immunoassay comprising a reagent containing an agglutination accelerator for the immunoassay.

摘要翻译： 本发明的目的是提供使用凝集促进剂的PSA的免疫测定法，凝集促进剂的凝集促进效果等于或大于已知的凝集促进剂; 几乎不产生非特异性浊度; 即使在盐浓度高的溶液中也难以产生盐析。 本发明涉及前列腺特异性抗原的免疫测定法，包括在具有来源于下述通式[2]表示的单体的单体单元的聚合物存在下进行抗原抗体反应：（其中R < 1〜3个O 3各自独立地为氢原子或任选具有羟基的烷基; R 4为亚烷基; R 5为 任选具有取代基且任选在链中具有氧原子的亚烷基; R 6是氢原子或甲基，X是氧原子或-NH - 组）和用于免疫测定的试剂盒，其包含含有用于免疫测定的凝集促进剂的试剂。

公开(公告)号：US20060177585A1

公开(公告)日：2006-08-10

申请号：US11300647

申请日：2005-12-14

申请人： Fumio Takagi ,  Kazuhiko Ishihara

发明人： Fumio Takagi ,  Kazuhiko Ishihara

IPC分类号： B05D5/00

CPC分类号： B01L3/0268 ,  B01J2219/00378 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2300/161

摘要： A method for discharging a liquid containing a biological material includes adding as a dispense stabilizer a polymer composed of phosphorylcholine-group-containing unsaturated compound units or a copolymer including same to the liquid containing the biological material; and discharging the liquid containing the dispense stabilizer using an inkjet system.

摘要翻译： 一种排出含有生物材料的液体的方法包括将含有含磷酰胆碱基的不饱和化合物单元的聚合物或包含其的共聚物作为分散稳定剂添加到含有生物材料的液体中; 并使用喷墨系统排出含有分配稳定剂的液体。

公开(公告)号：US20060160089A1

公开(公告)日：2006-07-20

申请号：US10551408

申请日：2004-03-30

申请人： Yoshihiro Ito ,  Hirokazu Hasuda ,  Tomohiro Konno ,  Kazuhiko Ishihara ,  Tetsuya Yamauchi

发明人： Yoshihiro Ito ,  Hirokazu Hasuda ,  Tomohiro Konno ,  Kazuhiko Ishihara ,  Tetsuya Yamauchi

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C08G63/48 ,  C12M1/34

CPC分类号： G01N33/54393

摘要： An agent for fixing (a) substance(s), which can fix various substances to be fixed on a substrate via covalent bonds and which has an excellent effect for the prevention of non-specific adsorption is disclosed. A polymer containing a plurality of phosphorylcholine groups and photoreactive groups in one molecule is used. The polymer binds to the substrate and to the substance to be fixed via the photoreactive groups, thereby the substance to be fixed is bound to the substrate via covalent bonds through the polymer, and non-specific adsorption is effectively prevented by the phosphorylcholine groups. Further, an agent for fixing (a) substance(s) for fixing the substance on a substrate, comprising a nonionic water-soluble macromolecule having at least 2 photoreactive groups in one molecule was also provided.

摘要翻译： 公开了一种用于固定（a）物质的试剂，其可以通过共价键固定各种待固定在基材上的物质，并且其具有优异的防止非特异性吸附的效果。 使用在一个分子中含有多个磷酸胆碱基团和光反应基团的聚合物。 聚合物通过光反应基团与基体和待固定的物质结合，通过共聚键将被固定的物质与基底结合，通过磷酸胆碱基团有效地防止非特异性吸附。 此外，还提供了用于将（a）用于将物质固定在基材上的物质（包括在一个分子中具有至少2个光反应性基团的非离子水溶性大分子）的试剂。

公开(公告)号：US06214957B1

公开(公告)日：2001-04-10

申请号：US09230828

申请日：1999-01-29

申请人： Daijiro Shiino ,  Kazunori Waki ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Daijiro Shiino ,  Kazunori Waki ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： C08F23002

CPC分类号： A61K8/06 ,  A61K8/04 ,  A61K8/8152 ,  A61K9/0014 ,  A61K47/32 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10 ,  B01F17/0064 ,  C08F30/02

摘要： Solubilizers, emulsifiers and dispersing agents having the effects of moisturizing the skin when used as washing agents and having the character of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or elevating the apparent concentration of a material to be emulsified or dispersed in solvents by increasing homogeneity of the emulsion or dispersion which contain as the active ingredient polymers obtained by polymerizing monomer compositions containing at least one hydrophilic monomer (a) having a group represented by general formula (1) in the side chain, wherein R1, R2 and R3 represent each H or C1-4 alkyl.

摘要翻译： 与作为洗涤剂一起使用时具有保湿皮肤作用的增溶剂，乳化剂和分散剂相比，​​在使用该材料的情况下，具有将要溶解，乳化或分散在包括水的溶剂中的物质的浓度提高的特征 或通过增加包含作为活性成分的乳液或分散体的均匀性来提高待乳化或分散在溶剂中的材料的表观浓度，所述乳液或分散体含有通过聚合含有至少一种所表示的基团的亲水性单体（a）的单体组合物而获得的聚合物 由侧链中的通式（1）表示，其中R 1，R 2和R 3表示每个H或C 1-4烷基。

公开(公告)号：US5658561A

公开(公告)日：1997-08-19

申请号：US284685

申请日：1995-01-24

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： A61L33/00 ,  B01D67/00 ,  C08F251/02 ,  C08F291/00 ,  C08L1/00 ,  A61K31/765 ,  A61F2/02 ,  A61K31/74 ,  A61K47/48

CPC分类号： B01D67/0088 ,  A61L33/0088 ,  B01D67/0093 ,  C08F251/02 ,  C08F291/00 ,  B01D2323/38

摘要： A method of producing a material bearing zwitterionic groups, such as phosphoryl choline groups, which comprises treating at least the surface of a substrate with a solution or dispersion of a polymer grafter with zwitterionic groups, and material produced by the method. The method is suitable for producing materials for use in contact with blood and in particular a regenerated cellulose membrane.

摘要翻译： PCT No.PCT / GB93 / 00298 Sec。 371日期1995年1月24日 102（e）日期1995年1月24日PCT提交1993年2月12日PCT公布。 公开号WO93 / 15775 日期1993年8月19日一种生产含有两性离子基团的物质如磷酰胆碱基团的方法，其包括用两性离子基团聚合物的溶液或分散体至少处理底物的表面，以及通过该方法制备的材料 。 该方法适用于生产与血液接触的材料，特别是再生纤维素膜。