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    Medical device and method for producing the same
    6.
    发明授权
    Medical device and method for producing the same 有权
    医疗器械及其制造方法

    公开(公告)号：US09216241B2

    公开(公告)日：2015-12-22

    申请号：US12809690

    申请日：2008-12-19

    申请人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

    发明人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

    IPC分类号： A61L33/00 ,  A61L27/34 ,  A61L31/10 ,  A61K6/04 ,  A61K6/033

    CPC分类号： A61L33/0076 ,  A61K6/033 ,  A61K6/04 ,  A61L27/34 ,  A61L31/10 ,  Y10T428/31667 ,  A61K6/0023 ,  C08L33/08 ,  C08L33/10

    摘要： An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

    摘要翻译： 本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置，其能够发挥细胞粘附抑制作用。 一种医疗装置，包括：能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层，其中通过表面处理在至少所需位置上在基材的表面上形成羟基，同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成 ，并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。

    MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME
    9.
    发明申请
    MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME 有权
    医疗装置及其制造方法

    公开(公告)号：US20110027757A1

    公开(公告)日：2011-02-03

    申请号：US12809690

    申请日：2008-12-19

    申请人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

    发明人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

    IPC分类号： A61C8/00 ,  B32B3/00 ,  B32B13/12 ,  B05D1/18 ,  B05D3/06

    CPC分类号： A61L33/0076 ,  A61K6/033 ,  A61K6/04 ,  A61L27/34 ,  A61L31/10 ,  Y10T428/31667 ,  A61K6/0023 ,  C08L33/08 ,  C08L33/10

    摘要： An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

    摘要翻译： 本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置，其能够发挥细胞粘附抑制作用。 一种医疗装置，包括：能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层，其中通过表面处理在至少所需位置上在基材的表面上形成羟基，同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成 ，并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。

    MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE
    10.
    发明申请
    MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
    防止组织粘合的材料和预防联合合同的材料

    公开(公告)号：US20110059176A1

    公开(公告)日：2011-03-10

    申请号：US12744251

    申请日：2008-11-14

    申请人： Toru Moro ,  Kozo Nakamura ,  Hiroshi Kawaguchi ,  Noriyuki Ishiyama ,  Kazuhiko Ishihara ,  Tomohiro Konno ,  Tadashi Ohyama ,  Mizuna Yoshikawa

    发明人： Toru Moro ,  Kozo Nakamura ,  Hiroshi Kawaguchi ,  Noriyuki Ishiyama ,  Kazuhiko Ishihara ,  Tomohiro Konno ,  Tadashi Ohyama ,  Mizuna Yoshikawa

    IPC分类号： A61K9/14 ,  A61P41/00 ,  A61K31/785

    CPC分类号： A61K31/715 ,  A61K31/765 ,  A61K31/80

    摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.

    摘要翻译： 本发明提供了一种在外科手术时可以在患病区域制备的组织粘附防止材料，通过在适于温和条件的温和条件下，在包含水作为主要成分的介质中制备具有柔性结构和高溶质渗透性的三维聚合物结构 身体组织成分（即，在常温和常压下）而不进行化学反应或采用诸如加热或光或辐射照射的物理过程。 这使得可以提供能够有效地防止受影响的区域中的组织对周围组织的术后粘附和关节的可动部的挛缩的组织粘合防止材料和接合挛缩防止材料。 本发明的组织粘附防止材料和/或接合挛缩防止材料以包含具有多价羟基的化合物和含有磷酸胆碱基团的聚合物和苯基硼酸基的组成为主要成分。