公开(公告)号：US07790737B2

公开(公告)日：2010-09-07

申请号：US12045982

申请日：2008-03-11

申请人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

发明人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

IPC分类号： A61K31/505

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由下列通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤原子，低级烷基等，R 6表示烷基，环烷基等 ，R7和R8表示氢原子，低级烷基，（低级环烷基）（低级烷基）等，R9表示氢原子，卤素原子，低级烷氧基等，R10和R11表示氢原子 ，低级烷基，低级烷氧基，卤代（低级烷基）等，A表示6〜10个原子构成的杂环，对胆固醇酯转移蛋白（CETP）具有有效的抑制活性。

公开(公告)号：US07659271B2

公开(公告)日：2010-02-09

申请号：US12100831

申请日：2008-04-10

申请人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

发明人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

IPC分类号： C07D239/42 ,  A61K31/505

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7, R8, R9 and R10 represent hydrogen atom, a halogen atom, a lower alkyl group, a halo(lower alkyl) group and the like, R11 and R12 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl) (lower alkyl) group and the like, and R13 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由以下通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤代（低级烷基）基，氰基等，R 6表示烷基，环烷基和 R 7，R 8，R 9和R 10表示氢原子，卤素原子，低级烷基，卤代（低级烷基）等，R 11和R 12表示氢原子，低级烷基，（低级环烷基 ）（低级烷基）等，R 13表示对胆固醇酯转移蛋白（CETP）具有强抑制活性的氢原子，卤素原子，低级烷氧基等。

公开(公告)号：US07604042B2

公开(公告)日：2009-10-20

申请号：US10477632

申请日：2002-05-17

申请人： Koichi Yamazaki

发明人： Koichi Yamazaki

IPC分类号： F28F7/00 ,  F28F27/02 ,  C23C16/00

CPC分类号： C23C16/45565 ,  C23C16/4401 ,  C23C16/4557 ,  C23C16/45572 ,  C23C16/52 ,  H01L21/67109 ,  H01L21/67248

摘要： A processing apparatus is provided with a showerhead for introducing a process gas into a processing vessel, and heaters for heating the showerhead to an elevated temperature. The processing apparatus is provided with a main flow line for a cooling liquid, and a bypass flow line connected to the main flow line so as to bypass the showerhead. A cooling liquid control system for controlling the flow of the cooling liquid includes shutoff valves, and a valve controller. The cooling liquid control system controls the flow of the cooling liquid such that the cooling liquid is prevented from flowing through the cooling passage while the showerhead is being heated to the elevated temperature, and such that the cooling liquid is made to flow through both the cooling passage and the bypass flow line while the showerhead is being cooled to a reduced temperature.

摘要翻译： 处理装置设置有用于将处理气体引入处理容器的喷头，以及用于将喷头加热到升高的加热器。 处理装置具有用于冷却液的主流路和与主流路连接的旁通流路，以绕过喷头。 用于控制冷却液流动的冷却液控制系统包括截流阀和阀控制器。 冷却液控制系统控制冷却液的流动，使得在喷淋头被加热到高温的同时防止冷却液流过冷却通道，并使冷却液流过冷却 通道和旁路流动管线，同时将喷头冷却至降低的温度。

公开(公告)号：US07216496B2

公开(公告)日：2007-05-15

申请号：US10491748

申请日：2002-10-04

申请人： Koichi Yamazaki

发明人： Koichi Yamazaki

IPC分类号： F25B21/02 ,  F25B17/02 ,  F25D23/12

CPC分类号： H01L21/67248 ,  F25B21/02 ,  H01L21/67109

摘要： There is provided a heating medium circulating apparatus which is small and which does not require a very large installation space. In a heating medium circulating apparatus wherein a temperature controlling object being an object to be temperature-controlled, a main heat exchanger 88 for carrying out main heat exchange with a heating medium, and a circulating pump 84 are provided in a heating medium circulating system 78, a sub-heat exchanger 96 using a thermoelectric element 100 is provided in the heating medium circulating system downstream of the main heat exchanger to control the temperature of the heating medium. Thus, the apparatus itself is small, and the installation space is not very large.

摘要翻译： 提供了一种小型且不需要非常大的安装空间的加热介质循环装置。 在作为受温度对象的温度控制对象的加热介质循环装置中，在加热介质循环系统78中设置有用于与加热介质进行主热交换的主热交换器88和循环泵84 在主热交换器下游的加热介质循环系统中设置使用热电元件100的副热交换器96，以控制加热介质的温度。 因此，装置本身小，安装空间不是很大。

公开(公告)号：US6129721A

公开(公告)日：2000-10-10

申请号：US89176

申请日：1998-06-02

申请人： Kenzo Kataoka ,  Masaki Odaka ,  Akira Yuba ,  Koichi Yamazaki ,  Takashi Tsumanuma ,  Keiji Kaneda

发明人： Kenzo Kataoka ,  Masaki Odaka ,  Akira Yuba ,  Koichi Yamazaki ,  Takashi Tsumanuma ,  Keiji Kaneda

IPC分类号： A61B18/20 ,  A61B18/22 ,  A61C1/00 ,  A61N5/06 ,  A61N5/067 ,  G02B6/04 ,  G02B6/24 ,  G02B6/32 ,  A61B17/36

CPC分类号： A61N5/0603 ,  A61B18/22 ,  A61C1/0046 ,  G02B6/04 ,  G02B6/32 ,  A61N2005/0605 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/067 ,  G02B6/241

摘要： A medical laser treatment device comprises a handpiece having a handpiece body and a laser probe to be attached to the handpiece body, a laser light source, and a light transmission member which guides laser light to the handpiece. The laser probe has a fiber probe having an emission face through which the laser light is emitted to an irradiation region, an annular protection tube which covers the peripheral face of the fiber probe, and a holder which holds the fiber probe and the protection tube. The protection tube has a curved part extending with being curved. A first fiber curved part is formed in the fiber probe by passing the fiber probe through the protection tube. A second fiber curved part having a radius of curvature is smaller than that of the first fiber curved part is disposed in a tip end portion of a fiber probe.

摘要翻译： 一种医疗用激光治疗装置，具备：具有手持体的手持件和被安装在所述手持机体上的激光探头，激光光源以及将激光导向所述手持件的光传输部件。 激光探针具有具有发射面的发光面的光纤探测器，照射区域发射激光，覆盖光纤探针的周面的环状保护管和保持光纤探头和保护管的保持器。 保护管具有弯曲的部分，其弯曲地延伸。 通过使纤维探针通过保护管，在纤维探针中形成第一纤维弯曲部分。 具有曲率半径的第二纤维弯曲部分比第一纤维弯曲部分的纤维弯曲部分设置在纤维探针的末端部分中。

公开(公告)号：US5471424A

公开(公告)日：1995-11-28

申请号：US219303

申请日：1994-03-28

申请人： Masayuki Takada ,  Osamu Yamada ,  Toru Kuroda ,  Koichi Yamazaki ,  Kazuo Noda

发明人： Masayuki Takada ,  Osamu Yamada ,  Toru Kuroda ,  Koichi Yamazaki ,  Kazuo Noda

IPC分类号： G11B20/12 ,  G11B20/18 ,  G11C7/00 ,  G06K7/10

CPC分类号： G11B20/1215 ,  G11B20/18 ,  G11B20/1809

摘要： A write once type information recording medium having a recording format that includes sectors. Each Sector includes x pieces of p-bit frames. Each frame contains an f-bit synchronization signal region and a d-bit data region. Each bit of at least one x-bit packet in which a v-bit error correction code has been added to u-bit data, is distributed to each one of the data regions of the x pieces of frames. This makes it possible for the write once type information recording medium to have an increased data storage efficiency and an effective error correction capability for a burst error.

摘要翻译： 一种具有包括扇区的记录格式的一次写入型信息记录介质。 每个扇区包括x个p位帧。 每帧包含f位同步信号区域和d位数据区域。 向x位数据添加了v位纠错码的至少一个x位数据包的每一位被分配给x个帧的每个数据区。 这使得一次写入型信息记录介质可以提高数据存储效率和突发错误的有效纠错能力。

公开(公告)号：US08251232B2

公开(公告)日：2012-08-28

申请号：US12955142

申请日：2010-11-29

申请人： Kazunori Nakaya ,  Koichi Yamazaki ,  Hiroyuki Ono ,  Tatsuo Arakawa

发明人： Kazunori Nakaya ,  Koichi Yamazaki ,  Hiroyuki Ono ,  Tatsuo Arakawa

IPC分类号： A47F1/04 ,  B65H75/34 ,  B65H75/48

CPC分类号： A47F1/126

摘要： An article advancing device and an article arrangement shelf with simple structures can be securely operated without electric power. The article advancing device includes elongated drawer members with flexible band-shaped sheets and stopper structures disposed at distal ends of the flexible band-shaped sheets to allow articles to be arranged on the elongated drawer members when pulled-out, rollers for fixing proximal ends of the band-shaped sheets in position and winding up the band-shaped sheets by predetermined driving force while allowing the band-shaped sheets to be freely pulled out, and a main body for housing the rollers and the wound up band-shaped sheets. The rollers are disposed in parallel to each other within the main body, and the elongated drawer members are disposed on the rollers respectively so as not to overlap each other in a width direction.

摘要翻译： 可以在没有电力的情况下可靠地操作具有简单结构的物品推进装置和物品布置架。 物品推进装置包括细长的抽屉构件，其具有柔性带状片和设置在柔性带状片的远端处的止挡结构，以允许制品在拉出时布置在细长的抽屉构件上，用于固定近端的辊 将带状片放置在适当位置，并且通过预定的驱动力卷绕带状片，同时允许带状片被自由拉出，以及用于容纳辊和卷绕带状片的主体。 辊子在主体内彼此平行地设置，并且细长的抽屉构件分别设置在辊子上，以便在宽度方向上彼此不重叠。

公开(公告)号：US20110250229A1

公开(公告)日：2011-10-13

申请号：US12921151

申请日：2009-03-03

申请人： Eckhard R. Podack ,  Koichi Yamazaki ,  Joseph D. Rosenblatt

发明人： Eckhard R. Podack ,  Koichi Yamazaki ,  Joseph D. Rosenblatt

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K39/0011 ,  A61K35/12 ,  A61K35/42 ,  A61K2039/5152 ,  A61K2039/5156

摘要： Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g., gp96), depletion of B cells in the subject, or both. Antigen (e.g., epitope derived from neoantigen or tumor antigen of allogeneic or syngeneic cancer cells) may induce a specific immune response in the subject. For example, the epitope bound in an immunogenic complex with the secreted heat shock protein may be obtained from allogeneic cancer cells coexpressing both secreted gp96 and antigen, or from syngeneic cancer cells of the subject expressing only antigen.

摘要翻译： 通过频繁施用分泌修饰的热休克蛋白（例如，gp96）的同种异体癌细胞的受试者，受试者中的B细胞的消耗或两者都可以改善基于细胞的免疫治疗（例如免疫或疫苗接种）。 抗原（例如衍生自同种异体或同基因癌细胞的新抗原或肿瘤抗原的表位）可诱导受试者的特异性免疫应答。 例如，与分泌的热休克蛋白结合在免疫原性复合物中的表位可以从共表达分泌的gp96和抗原的同种异体癌细胞或仅表达抗原的受试者的同基因癌细胞获得。

公开(公告)号：US08012989B2

公开(公告)日：2011-09-06

申请号：US12815905

申请日：2010-06-15

申请人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

发明人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

IPC分类号： A61K31/505

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由下列通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤原子，低级烷基等，R 6表示烷基，环烷基等 ，R7和R8表示氢原子，低级烷基，（低级环烷基）（低级烷基）等，R9表示氢原子，卤素原子，低级烷氧基等，R10和R11表示氢原子 ，低级烷基，低级烷氧基，卤代（低级烷基）等，A表示6〜10个原子构成的杂环，对胆固醇酯转移蛋白（CETP）具有有效的抑制活性。

公开(公告)号：US07919509B2

公开(公告)日：2011-04-05

申请号：US12394548

申请日：2009-02-27

申请人： Ayumu Okuda ,  Takayuki Matsuda ,  Toru Miura ,  Hidefumi Ozawa ,  Ayako Tosaka ,  Koichi Yamazaki ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Kimiyuki Shibuya

发明人： Ayumu Okuda ,  Takayuki Matsuda ,  Toru Miura ,  Hidefumi Ozawa ,  Ayako Tosaka ,  Koichi Yamazaki ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Kimiyuki Shibuya

IPC分类号： A61K31/4166 ,  A61K31/427 ,  A61K31/45 ,  A61K31/422 ,  A61K31/4525 ,  C07D405/12 ,  C07D417/12 ,  C07D413/12 ,  C07D407/12

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供一种新颖的LXR＆bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。