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338 条记录 (耗时 0.045 秒)

    C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS
    31.
    发明申请
    C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
    C2ORF18作为靶基因治疗癌症和诊断

    公开(公告)号：US20110098339A1

    公开(公告)日：2011-04-28

    申请号：US12921766

    申请日：2009-03-10

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    IPC分类号： A61K31/713 ,  G01N33/68 ,  C07H21/00 ,  C12N15/63 ,  A61P35/00

    CPC分类号： G01N33/57438 ,  A61K48/005 ,  C07K16/303 ,  C12N15/113 ,  C12N2310/14 ,  G01N2500/02

    摘要： Described herein are objective methods for detecting or diagnosing a predisposition to developing cancer, particularly pancreatic cancer. In one embodiment, the diagnostic method involves the step of determining an expression level of C2orf18 using anti-C2orf18 antibody. The present invention further provides methods of screening for therapeutic agents useful in the treatment of a C2orf18-associated disease, such as a cancer, e.g. pancreatic cancer, methods of inhibiting the cell growth and treating or alleviating their symptom. The invention also features products, such as polynucleotides, polypeptides, and vectors double-stranded molecules, antibodies, vectors and compositions composed thereof.

    摘要翻译： 本文描述了用于检测或诊断发展中的癌症，特别是胰腺癌的易感性的客观方法。 在一个实施方案中，诊断方法包括使用抗C2orf18抗体确定C2orf18的表达水平的步骤。 本发明还提供筛选用于治疗C2orf18相关疾病（例如癌症）的治疗剂的方法。 胰腺癌，抑制细胞生长和治疗或缓解其症状的方法。 本发明还包括产物，例如多核苷酸，多肽和载体双链分子，抗体，载体和由其组成的组合物。

    CXADRL1 polypeptides relating to human cancers
    32.
    发明授权
    CXADRL1 polypeptides relating to human cancers 失效
    涉及人类癌症的CXADRL1多肽

    公开(公告)号：US07847065B2

    公开(公告)日：2010-12-07

    申请号：US12175092

    申请日：2008-07-17

    申请人： Yusuke Nakamura ,  Yoichi Furukawa ,  Hideaki Tahara ,  Takuya Tsunoda

    发明人： Yusuke Nakamura ,  Yoichi Furukawa ,  Hideaki Tahara ,  Takuya Tsunoda

    IPC分类号： C07K14/435 ,  C07K7/00

    CPC分类号： C07K14/47 ,  C07K14/4748

    摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

    摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

    Optical disk reproducing apparatus with a disk identifying function
    33.
    发明授权
    Optical disk reproducing apparatus with a disk identifying function 有权
    具有盘识别功能的光盘再现装置

    公开(公告)号：US07821888B2

    公开(公告)日：2010-10-26

    申请号：US11723798

    申请日：2007-03-22

    申请人： Yusuke Nakamura ,  Masakazu Ikeda ,  Toshifumi Takeuchi

    发明人： Yusuke Nakamura ,  Masakazu Ikeda ,  Toshifumi Takeuchi

    IPC分类号： G11B15/02

    CPC分类号： G11B19/125 ,  G11B20/1426 ,  G11B2020/1457

    摘要： An optical disk reproducing apparatus has a circuit for detecting a difference in modulation scheme between two types of optical disks in a reproduction signal and a circuit for determining the modulation schemes of the disks on the basis of the difference. Thus the apparatus can reproduce the two optical disks with use of the circuit which determines the modulation schemes of the disks to be reproduced.

    摘要翻译： 光盘再现装置具有用于检测再现信号中的两种类型的光盘之间的调制方式的差异的电路和用于基于该差确定盘的调制方案的电路。 因此，该装置可以使用确定要再现的盘的调制方案的电路再现两个光盘。

    GENES AND POLYPEPTIDES RELATING TO HUMAN COLON CANCERS
    37.
    发明申请
    GENES AND POLYPEPTIDES RELATING TO HUMAN COLON CANCERS 失效
    与人类癌症相关的基因和多肽

    公开(公告)号：US20100016220A1

    公开(公告)日：2010-01-21

    申请号：US12175092

    申请日：2008-07-17

    申请人： Yusuke Nakamura ,  Yoichi Furukawa ,  Hideaki Tahara ,  Takuya Tsunoda

    发明人： Yusuke Nakamura ,  Yoichi Furukawa ,  Hideaki Tahara ,  Takuya Tsunoda

    IPC分类号： A61K38/16 ,  C07K14/435 ,  A61P35/04

    CPC分类号： C07K14/47 ,  C07K14/4748

    摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

    摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

    Optical Information Recording Method, Optical Information Reproduction Method and Optical Disk Device
    39.
    发明申请
    Optical Information Recording Method, Optical Information Reproduction Method and Optical Disk Device 有权
    光信息记录方法，光信息再现方法和光盘装置

    公开(公告)号：US20090316561A1

    公开(公告)日：2009-12-24

    申请号：US12485131

    申请日：2009-06-16

    申请人： Koichiro Nishimura ,  Yusuke Nakamura

    发明人： Koichiro Nishimura ,  Yusuke Nakamura

    IPC分类号： G11B7/135

    CPC分类号： G11B20/10009 ,  G11B7/00456 ,  G11B7/1267 ,  G11B20/10046 ,  G11B20/10055 ,  G11B20/10194 ,  G11B20/10212 ,  G11B20/10222 ,  G11B20/10481

    摘要： When a phase shift is to be evaluated, based on a difference between an output from a waveform equalization circuit to equalize an input reproduced signal to a predetermined target equalization characteristic and the target equalization characteristic, the phase shift of the reproduced signal relative to a channel clock, a group delay characteristic with respect to the frequency of the waveform equalization circuit is fixed. Hence, an equalized waveform as an output from the waveform equalization circuit can preserve phase shift information of the inputted reproduced signal to correctly detect the phase shift of the reproduced waveform using the equalized waveform. It is hence possible to realize, with high precision, optimal value learning of various parameters for the recording, reproduction, and servo by use of the phase shift as an index.

    摘要翻译： 当要评估相移时，基于来自波形均衡电路的输出之间的差以将输入再现信号均衡到预定的目标均衡特性和目标均衡特性，再现信号相对于通道的相移 时钟，相对于波形均衡电路的频率的组延迟特性是固定的。 因此，作为来自波形均衡电路的输出的均衡波形可以保存输入的再现信号的相移信息，以使用均衡波形来正确地检测再现波形的相移。 因此，通过使用相移作为指标，可以高精度地实现用于记录，再现和伺服的各种参数的最佳值学习。