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52 条记录 (耗时 0.025 秒)

    Fidaxomicin purification method
    32.
    发明授权
    Fidaxomicin purification method 有权

    公开(公告)号：US10316052B2

    公开(公告)日：2019-06-11

    申请号：US15324555

    申请日：2015-07-07

    申请人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

    发明人： Huijun Ren ,  Daochao Li ,  Xuexiao Ying ,  Feng Chen ,  Linghui Zheng ,  Lingping Wang ,  Hua Bai

    IPC分类号： C07H1/06 ,  C07H17/08 ,  C12P19/62

    摘要： A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.

    Crystal forms of azetidinone compounds and preparing methods thereof
    38.
    发明授权
    Crystal forms of azetidinone compounds and preparing methods thereof 有权
    氮杂环丁酮化合物的结晶形式及其制备方法

    公开(公告)号：US09567298B2

    公开(公告)日：2017-02-14

    申请号：US14426085

    申请日：2013-09-05

    申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

    发明人： Hongyuan Wei ,  Chongjun Liu ,  Xuyang Zhao ,  Xiaojie Xu ,  Hua Bai ,  Yuncai Zhang

    IPC分类号： C07D205/08 ,  A61K31/397

    CPC分类号： C07D205/08 ,  A61K31/397 ,  C07B2200/13

    摘要： The present invention provides crystal forms of the compound of (3R,4S)-4-(4-hydroxyphenyl)-3-[3-(4-fluorophenyl)-4-hydroxybut-2(Z)-enyl]-1-(4-fluorophenyl)-2-azetidinone (formula A). The crystal forms can be characterized by X-ray powder diffraction (XRPD) spectra, differential scanning calorimetry (DSC) spectra, infrared absorption spectra and so on. Meanwhile, the present invention also provides methods for preparing the crystal forms of the compound of formula A, pharmaceutical compositions and uses thereof.

    摘要翻译： 本发明提供（3R，4S）-4-（4-羟基苯基）-3- [3-（4-氟苯基）-4-羟基丁-2（Z） - 烯基] -1-（ 4-氟苯基）-2-氮杂环丁酮（式A）。 可以通过X射线粉末衍射（XRPD）光谱，差示扫描量热法（DSC）光谱，红外吸收光谱等来表征晶体形态。 同时，本发明还提供了制备式A化合物的结晶形式的方法，药物组合物及其用途。

    4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid derivative, and preparation method and uses thereof
    39.
    发明授权
    4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid derivative, and preparation method and uses thereof 有权
    4 - （（取代苯基）二氟甲基）苯氧基羧酸衍生物及其制备方法和用途

    公开(公告)号：US09487470B2

    公开(公告)日：2016-11-08

    申请号：US14396455

    申请日：2013-04-25

    申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

    发明人： Hua Bai ,  Jian Hong ,  Lifeng Cai ,  Hegeng Wei ,  Xiaoyu Liu ,  Xiaohe Zheng

    IPC分类号： C07C69/712 ,  C07C59/68 ,  C07C51/363 ,  C07C59/135 ,  C07C67/307 ,  C07C69/78 ,  C07C319/16 ,  C07C323/16 ,  C07C323/56 ,  C07D307/33 ,  C07C69/94

    CPC分类号： C07C69/712 ,  C07C51/363 ,  C07C59/135 ,  C07C59/68 ,  C07C67/307 ,  C07C69/78 ,  C07C69/94 ,  C07C319/16 ,  C07C323/16 ,  C07C323/56 ,  C07D307/33

    摘要： The present invention discloses a 4-((substituted phenyl)difluoromethyl)phenoxycarboxylic acid derivative and preparation process and use thereof. More specifically, the present invention relates to a compound of the following formula I, which is defined in the specification. The compounds according to the present invention can be used as PPAR agonists, and demonstrates a strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in blood plasma, and thus the compound according to the present invention can be used in the preparation of a medicament for treating or preventing hyperlipoidemia or cardio-cerebrovascular diseases caused by hyperlipoidemia, such as diabetes, atherosclerosis, stroke, coronary heart disease, etc. The present invention also relates to a novel intermediate compound for the preparation of the compound of formula I and preparation method thereof.

    摘要翻译： 本发明公开了4 - （（取代苯基）二氟甲基）苯氧基羧酸衍生物及其制备方法和用途。 更具体地，本发明涉及在说明书中定义的下式I的化合物。 根据本发明的化合物可用作PPAR激动剂，并且对降低血浆中总胆固醇（TC），甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）的水平具有很强的作用， 因此根据本发明的化合物可用于制备用于治疗或预防高脂血症引起的高脂血症或心脑血管疾病如糖尿病，动脉粥样硬化，中风，冠心病等的药物。本发明还涉及 涉及用于制备式I化合物的新型中间体化合物及其制备方法。

    CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF
    40.
    发明申请
    CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF 有权
    AZETIDINONE化合物的晶体形式及其制备方法

    公开(公告)号：US20150218091A1

    公开(公告)日：2015-08-06

    申请号：US14426085

    申请日：2013-09-05

    申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

    发明人： Hongyuan Wei ,  Chongjun Liu ,  Xuyang Zhao ,  Xiaojie Xu ,  Hua Bai ,  Yuncai Zhang

    IPC分类号： C07D205/08

    CPC分类号： C07D205/08 ,  A61K31/397 ,  C07B2200/13

    摘要： The present invention provides crystal forms of the compound of (3R,4S)-4-(4-hydroxyphenyl)-3-[3-(4-fluorophenyl)-4-hydroxybut-2(Z)-enyl]-1-(4-fluorophenyl)-2-azetidinone (formula A). The crystal forms can be characterized by X-ray powder diffraction (XRPD) spectra, differential scanning calorimetry (DSC) spectra, infrared absorption spectra and so on. Meanwhile, the present invention also provides methods for preparing the crystal forms of the compound of formula A, pharmaceutical compositions and uses thereof.

    摘要翻译： 本发明提供（3R，4S）-4-（4-羟基苯基）-3- [3-（4-氟苯基）-4-羟基丁-2（Z） - 烯基] -1-（ 4-氟苯基）-2-氮杂环丁酮（式A）。 可以通过X射线粉末衍射（XRPD）光谱，差示扫描量热法（DSC）光谱，红外吸收光谱等来表征晶体形态。 同时，本发明还提供了制备式A化合物的结晶形式的方法，药物组合物及其用途。