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120 条记录 (耗时 0.031 秒)

    INTRADERMAL DELIVERY OF SUBSTANCES
    32.
    发明申请
    INTRADERMAL DELIVERY OF SUBSTANCES 有权
    物质输送

    公开(公告)号：US20150182705A1

    公开(公告)日：2015-07-02

    申请号：US14657746

    申请日：2015-03-13

    申请人： Becton, Dickinson and Company

    发明人： Ronald J. Pettis ,  James A. Down ,  Noel J. Harvey

    IPC分类号： A61M5/46 ,  A61K38/29 ,  A61K38/28 ,  A61M5/158 ,  A61M5/32

    CPC分类号： A61M5/46 ,  A61K38/28 ,  A61K38/29 ,  A61M5/158 ,  A61M5/32 ,  A61M5/3286 ,  A61M5/3291 ,  A61M5/3295 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0061

    摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.

    摘要翻译： 本发明提供了将药物和其它物质的ID递送给人或动物的改进方法。 该方法使用放置在皮内空间中的小规格针，特别是微针，以将物质作为推注或通过输注递送至皮内空间。 已经发现，针出口在皮肤内的放置和针出口的暴露高度对于通过小规格针有效递送活性物质是至关重要的，以防止物质从皮肤泄漏并改善吸收在 皮内空间。 已经发现根据本发明的方法递送的激素药物的药代动力学与常规SC递送的药代动力学非常相似，表明根据本发明的方法的ID给药可能产生类似的临床结果（即， 具有类似功效），具有减少或消除患者疼痛的优点。 将针头出口放置在皮内空间内的适当深度并控制流体输送的体积和速率的输送装置能够将物质精确地输送到期望的位置而不泄漏。

    MULTI-BARREL SYRINGE INJECTION SYSTEM
    33.
    发明申请
    MULTI-BARREL SYRINGE INJECTION SYSTEM 有权
    多巴士注射系统

    公开(公告)号：US20150141956A1

    公开(公告)日：2015-05-21

    申请号：US14603613

    申请日：2015-01-23

    申请人： Muffin Incorporated

    发明人： Grant T. Hoffman ,  Robert Eells ,  Wen Hong Neoh ,  Jeffry S. Melsheimer

    IPC分类号： A61M5/19 ,  A61M5/32 ,  A61M5/31

    CPC分类号： A61M5/19 ,  A61M5/3137 ,  A61M5/3295 ,  A61M5/3297 ,  A61M2205/19

    摘要： An injection device for injecting a medicant into a plurality of tissue sites in a patient for a selected treatment is constructed and arranged such that the number of tissue sites is the total number for the selected treatment thereby requiring a single positioning step. The injection device includes a body having a syringe and a control linkage, the syringe including a plurality of barrels, and a cooperating plunger array including a plurality of plungers. Each barrel receives a corresponding plunger. The injection device further includes a plurality of injection needles connected to the syringe wherein one injection needle is connected to each barrel, a multi-lumen tip, a shaft connected to the multi-lumen tip and extending between said multi-lumen tip and said body. The control linkage is connected to each needle so as to move each needle between a deployed injection position and a retracted position.

    摘要翻译： 用于将药物注射到患者中的多个组织部位用于所选择的治疗的注射装置被构造和布置成使得组织部位的数量是所选择的治疗的总数，从而需要单个定位步骤。 注射装置包括具有注射器和控制连杆的本体，注射器包括多个筒体，以及包括多个柱塞的配合柱塞阵列。 每个桶都接收相应的柱塞。 注射装置还包括连接到注射器的多个注射针，其中一个注射针连接到每个镜筒，多腔尖端，连接到多内腔末端并在所述多腔尖端和所述主体之间延伸的轴 。 控制联动装置连接到每个针上，以便在展开的喷射位置和缩回位置之间移动每个针。

    MULTI-NEEDLE INJECTION DEVICE
    36.
    发明申请
    MULTI-NEEDLE INJECTION DEVICE 有权
    多针注射装置

    公开(公告)号：US20130281930A1

    公开(公告)日：2013-10-24

    申请号：US13866439

    申请日：2013-04-19

    申请人： COOK MEDICAL TECHNOLOGIES LLC

    发明人： Jennifer Rodenberg ,  William Bourdeau ,  Charles Baxter ,  Steven Charlebois ,  Zach Wagner ,  Sara Sherman

    IPC分类号： A61M5/32

    CPC分类号： A61M5/3295 ,  A61M25/0084 ,  A61M25/0097 ,  A61M2025/0008 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： A medical device and a method of treating stress urinary incontinence are provided. The device includes a cannula with a plurality of apertures. A plurality of needles is disposed within a lumen of the cannula. A handle includes a housing and a shifter mechanism to translate the plurality of needles from a first position in which the needles are disposed within the lumen of the cannula, to a second position in which a distal portion of each needle extends out of the lumen through respective apertures. The handle also includes a slot including a transversal track defining a potential range of rotational motion of the shifter mechanism with respect to the housing, and a plurality of longitudinal tracks defining a potential range of translational motion of the shifter mechanism with respect to the housing. The shifter mechanism may also rotate the cannula with respect to the handle.

    摘要翻译： 提供了一种医疗装置和治疗压力性尿失禁的方法。 该装置包括具有多个孔的套管。 多个针布置在套管的内腔内。 手柄包括壳体和换档器机构，用于将多个针从其中布置在套管内腔中的第一位置平移到第二位置，在第二位置，每个针的远端部分延伸出管腔通过 各孔。 手柄还包括一个槽，该槽包括限定换挡机构相对于壳体的旋转运动的潜在范围的横向轨道，以及多个纵向轨道，其限定换挡器机构相对于壳体的平移运动的潜在范围。 换档机构还可以相对于把手旋转套管。

    INTRADERMAL DELIVERY OF SUBSTANCES
    37.
    发明申请
    INTRADERMAL DELIVERY OF SUBSTANCES 有权

    公开(公告)号：US20130245601A1

    公开(公告)日：2013-09-19

    申请号：US13866381

    申请日：2013-04-19

    申请人： BECTON, DICKINSON AND COMPANY

    发明人： Ronald J. Pettis ,  James A. Down ,  Noel G. Harvey

    IPC分类号： A61M5/158

    CPC分类号： A61M5/46 ,  A61K38/28 ,  A61K38/29 ,  A61M5/158 ,  A61M5/32 ,  A61M5/3286 ,  A61M5/3291 ,  A61M5/3295 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0061

    摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.

    Devices and methods for injection of multiple-component therapies
    39.
    发明授权
    Devices and methods for injection of multiple-component therapies 有权
    用于注射多组分治疗的装置和方法

    公开(公告)号：US07699803B2

    公开(公告)日：2010-04-20

    申请号：US11969085

    申请日：2008-01-03

    申请人： Asha Nayak ,  Mario Maciel

    发明人： Asha Nayak ,  Mario Maciel

    IPC分类号： A61M5/30

    CPC分类号： A61M5/19 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2018/00392 ,  A61M5/1782 ,  A61M5/204 ,  A61M5/284 ,  A61M5/3137 ,  A61M5/32 ,  A61M5/3294 ,  A61M5/3295 ,  A61M5/44 ,  A61M5/445 ,  A61M5/46 ,  A61M2005/3128 ,  A61M2005/3201 ,  A61M2205/3606 ,  A61M2205/3626 ,  A61M2205/3633 ,  A61M2205/3646

    摘要： Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes) attached to biaxial or coaxial injection cannula(s) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula(s). In some embodiments, the injector devices of the present invention may include a first set of finger grips at a first location and a second set of finger grips at a second location. Also, in some embodiments, the injector devices of the present invention may include depth slops for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the present invention may include refill manifolds with attached syringes or other reservoirs containing the component substances to facilitate refilling of the injectors.

    摘要翻译： 用于将人体或动物受试者注射或以其他方式递送多组分疗法的装置和方法。 具有连接到双轴或同轴注射套管的注射器（例如，注射器）的装置被用于递送特定治疗的多个部件，使得那些部件在离开注射套管之前或之后不久就组合。 在一些实施例中，本发明的注射器装置可以包括在第一位置处的第一组手指夹具和在第二位置处的第二组手指夹具。 而且，在一些实施例中，本发明的注射器装置可以包括用于控制组织内深度的深度斜率，治疗物质在其内被输送。 此外，在一些实施例中，本发明的注射器装置可以包括具有连接的注射器的补充歧管或包含组分物质的其它储存器，以便于重新注入喷射器。