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公开(公告)号：US20100280493A1
公开(公告)日：2010-11-04
申请号：US11619575
申请日：2007-01-03
Applicant: Asha Nayak
Inventor： Asha Nayak
CPC classification number: A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2017/0243 , A61B2017/306 , A61B2017/308 , A61B2018/00392 , A61M5/14276 , A61N1/306 , A61N1/325 , A61N1/36014
Abstract: Methods and systems are disclosed for treating cardiac tissue by delivering a platelet composition which induces neovascularization in the cardiac tissue followed by a cell preparation which induces regeneration in the re-vascularized tissue. The platelet composition can additionally contain structural materials and/or bioactive agents.
Abstract translation: 公开了用于治疗心脏组织的方法和系统，该血小板组合物在心脏组织中诱导新生血管形成，随后是在再血管化的组织中诱导再生的细胞制备。 血小板组合物可另外含有结构材料和/或生物活性剂。
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公开(公告)号：US20070042016A1
公开(公告)日：2007-02-22
申请号：US11426211
申请日：2006-06-23
Applicant: Asha Nayak , James Keogh
Inventor： Asha Nayak , James Keogh
CPC classification number: A61L27/52 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2017/0243 , A61B2017/306 , A61B2017/308 , A61B2018/00392 , A61L2400/16 , A61L2430/20 , A61M5/19 , A61N1/306 , A61N1/36017 , A61N1/362
Abstract: Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.
Abstract translation: 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。
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公开(公告)号：US20060084839A1
公开(公告)日：2006-04-20
申请号：US11269976
申请日：2005-11-08
Applicant: Nicholas Mourlas , Christian Eversull , Stephen Leeflang , Asha Nayak , David Miller
Inventor： Nicholas Mourlas , Christian Eversull , Stephen Leeflang , Asha Nayak , David Miller
IPC: A61B1/00
CPC classification number: A61B1/00082 , A61B1/00096 , A61B1/005 , A61B1/018 , A61B1/05 , A61B2017/00243 , A61B2017/00907 , A61M25/0147
Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.
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4.发明授权In vivo localization and tracking of tissue penetrating catheters using magnetic resonance imaging 有权使用磁共振成像的组织穿透导管的体内定位和跟踪公开(公告)号：US08214015B2
公开(公告)日：2012-07-03
申请号：US11279773
申请日：2006-04-14
Applicant: Patrick Macaulay , Asha Nayak
Inventor： Patrick Macaulay , Asha Nayak
IPC: A61M25/00
CPC classification number: G01R33/287 , A61B5/02007 , A61B5/055 , A61B5/064 , A61B5/416 , A61B5/4839 , A61B5/6852 , A61B34/20 , A61B2034/107 , A61B2034/2051 , A61B2090/374 , A61M25/0029 , A61M25/007 , A61M25/0127 , A61M2025/0037 , A61M2025/0096
Abstract: Magnetic resonance image (MRI) guided tissue penetrating catheters and their methods of use. One or more MRI apparatus (e.g., one or more coils) are positioned on or in a catheter device that includes a tissue penetrator that may be used to form a penetration tract from a body lumen in which the catheter is positioned to a target location outside of that body lumen. The MRI apparatus (e.g., coil(s)) is/are used in conjunction with an MRI imaging system to indicate the position and/or rotational orientation of the penetrating catheter within the subject's body.
Abstract translation: 磁共振图像（MRI）引导组织穿透导管及其使用方法。 一个或多个MRI装置（例如，一个或多个线圈）被定位在导管装置上或导管装置中，该导管装置包括组织穿透器，所述组织穿透器可用于形成来自体腔的穿透管，其中导管定位在外部的目标位置 的体腔。 MRI装置（例如，线圈）与MRI成像系统结合使用以指示穿透导管在受检者体内的位置和/或旋转取向。
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公开(公告)号：US20080161757A1
公开(公告)日：2008-07-03
申请号：US11969085
申请日：2008-01-03
Applicant: Asha Nayak , Mario Maciel
Inventor： Asha Nayak , Mario Maciel
IPC: A61M37/00
CPC classification number: A61M5/19 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2018/00392 , A61M5/1782 , A61M5/204 , A61M5/284 , A61M5/3137 , A61M5/32 , A61M5/3294 , A61M5/3295 , A61M5/44 , A61M5/445 , A61M5/46 , A61M2005/3128 , A61M2005/3201 , A61M2205/3606 , A61M2205/3626 , A61M2205/3633 , A61M2205/3646
Abstract: Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes) attached to biaxial or coaxial injection cannula(s) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula(s). In some embodiments, the injector devices of the present invention may include a first set of finger grips at a first location and a second set of finger grips at a second location. Also, in some embodiments, the injector devices of the present invention may include depth slops for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the present invention may include refill manifolds with attached syringes or other reservoirs containing the component substances to facilitate refilling of the injectors.
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Patent Agency Ranking
公开(公告)号：US20070093748A1
公开(公告)日：2007-04-26
申请号：US11643359
申请日：2006-12-20
Applicant: Asha Nayak , James Keogh
Inventor： Asha Nayak , James Keogh
CPC classification number: A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2017/0243 , A61B2017/306 , A61B2017/308 , A61B2018/00392 , A61N1/306 , A61N1/325 , A61N1/36014
Abstract: Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.
Abstract translation: 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。
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公开(公告)号：US20070014784A1
公开(公告)日：2007-01-18
申请号：US11426219
申请日：2006-06-23
Applicant: Asha Nayak , James Keogh
Inventor： Asha Nayak , James Keogh
IPC: A61K39/395
CPC classification number: A61L27/52 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2017/0243 , A61B2017/306 , A61B2017/308 , A61B2018/00392 , A61L2400/16 , A61L2430/20 , A61M5/19 , A61N1/306 , A61N1/36017 , A61N1/362
Abstract: Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.
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公开(公告)号：US08057426B2
公开(公告)日：2011-11-15
申请号：US11969094
申请日：2008-01-03
Applicant: Asha Nayak , Mario Maciel
Inventor： Asha Nayak , Mario Maciel
IPC: A61M37/00
CPC classification number: A61M5/19 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2018/00392 , A61M5/1782 , A61M5/204 , A61M5/284 , A61M5/3137 , A61M5/32 , A61M5/3294 , A61M5/3295 , A61M5/44 , A61M5/445 , A61M5/46 , A61M2005/3128 , A61M2005/3201 , A61M2205/3606 , A61M2205/3626 , A61M2205/3633 , A61M2205/3646
Abstract: Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes) attached to biaxial or coaxial injection cannula(s) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula(s). In some embodiments, the injector devices of the present invention may include a first set of finger grips at a first location and a second set of finger grips at a second location. Also, in some embodiments, the injector devices of the present invention may include depth slops for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the present invention may include refill manifolds with attached syringes or other reservoirs containing the component substances to facilitate refilling of the injectors.
Abstract translation: 用于将人体或动物受试者注射或以其他方式递送多组分疗法的装置和方法。 具有连接到双轴或同轴注射套管的注射器（例如，注射器）的装置被用于递送特定治疗的多个部件，使得那些部件在离开注射套管之前或之后不久就组合。 在一些实施例中，本发明的注射器装置可以包括在第一位置处的第一组手指夹具和在第二位置处的第二组手指夹具。 而且，在一些实施例中，本发明的注射器装置可以包括用于控制组织内深度的深度斜率，治疗物质在其内被输送。 此外，在一些实施例中，本发明的注射器装置可以包括具有连接的注射器的补充歧管或包含组分物质的其它储存器，以便于重新注入喷射器。
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9.发明申请In Vivo Localization and Tracking of Tissue Penetrating Catheters Using Magnetic Resonance Imaging 有权使用磁共振成像的组织穿透导管的体内定位和跟踪公开(公告)号：US20060184011A1
公开(公告)日：2006-08-17
申请号：US11279773
申请日：2006-04-14
Applicant: Patrick Macaulay , Asha Nayak
Inventor： Patrick Macaulay , Asha Nayak
IPC: A61B5/05
CPC classification number: G01R33/287 , A61B5/02007 , A61B5/055 , A61B5/064 , A61B5/416 , A61B5/4839 , A61B5/6852 , A61B34/20 , A61B2034/107 , A61B2034/2051 , A61B2090/374 , A61M25/0029 , A61M25/007 , A61M25/0127 , A61M2025/0037 , A61M2025/0096
Abstract: Magnetic resonance image (MRI) guided tissue penetrating catheters and their methods of use. One or more MRI apparatus (e.g., one or more coils) are positioned on or in a catheter device that includes a tissue penetrator that may be used to form a penetration tract from a body lumen in which the catheter is positioned to a target location outside of that body lumen. The MRI apparatus (e.g., coil(s)) is/are used in conjunction with an MRI imaging system to indicate the position and/or rotational orientation of the penetrating catheter within the subject's body.
Abstract translation: 磁共振图像（MRI）引导组织穿透导管及其使用方法。 一个或多个MRI装置（例如，一个或多个线圈）被定位在导管装置上或导管装置中，该导管装置包括组织穿透器，所述组织穿透器可用于形成来自体腔的穿透管，其中导管定位在外部的目标位置 的体腔。 MRI装置（例如，线圈）与MRI成像系统结合使用以指示穿透导管在受检者体内的位置和/或旋转取向。
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10.发明申请公开(公告)号：US20060041243A1
公开(公告)日：2006-02-23
申请号：US11159752
申请日：2005-06-23
Applicant: Asha Nayak , Matthew Bonner , Paul Rothstein , Prasanga Hiniduma-Lokuge , James Keogh , Raymond Usher , Scott Jahns , Victor Chen
Inventor： Asha Nayak , Matthew Bonner , Paul Rothstein , Prasanga Hiniduma-Lokuge , James Keogh , Raymond Usher , Scott Jahns , Victor Chen
CPC classification number: A61B17/205 , A61B17/00491 , A61B17/0206 , A61B17/3478 , A61B2017/00247 , A61B2017/0243 , A61B2017/2936 , A61B2017/2939 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61M5/32 , A61M25/0084
Abstract: The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment/enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.
Abstract translation: 本发明公开了一种通过将物质注入心肌来治疗心肌缺血/缺血损伤的方法。 注射的物质通过提供结合生物治疗的机械加强或机械增强物有助于防止负性适应性重塑。 公开了许多注射用物质，包括多成分物质如血小板凝胶和其他物质。 所公开的物质可以含有增加/增强注射效果的添加剂。 本发明还公开了用于注入物质的装置。 该装置可以包括用于确保针不超过心肌内的所需深度的装置。 该装置还可以包括具有多个内腔的针，使得血小板凝胶的组分将在注射部位组合并开始在心肌中聚合。
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