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31.发明授权公开(公告)号：US09139542B2
公开(公告)日：2015-09-22
申请号：US14198975
申请日：2014-03-06
申请人： Weijiang Zhang , Michael R. Tracey , Junning Lee
发明人： Weijiang Zhang , Michael R. Tracey , Junning Lee
IPC分类号： C07D277/40 , C07D277/593
CPC分类号： C07D277/40 , C07D277/593
摘要： The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2 -amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.
摘要翻译： 本发明涉及（2Z）-2-（2-氨基-5-氯噻唑-4-基）-2-（3-N-叔丁氧基羰基氨基丙氧基亚氨基）乙酸的三乙胺盐的结晶形式。 本发明还涉及制备结晶形式的方法和中间体。 结晶形式可用作制备交联糖肽 - 头孢菌素抗生素的中间体。
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32.发明授权公开(公告)号：US09127027B2
公开(公告)日：2015-09-08
申请号：US14009658
申请日：2012-04-04
IPC分类号： A61K31/66 , C07F9/40 , C07C233/46 , C07C233/56 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D277/34 , C07D277/82 , C07D291/04 , C07C233/47 , C07C237/22 , C07C311/19 , C07D271/07 , C07D277/593 , C07D285/08
CPC分类号： C07F9/40 , C07C233/46 , C07C233/47 , C07C233/56 , C07C237/22 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/19 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/34 , C07D277/593 , C07D277/82 , C07D285/08 , C07D291/04
摘要： Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
摘要翻译： 作为EET激动剂的环氧二十碳三烯酸（EET）类似物的化合物和组合物，可用作治疗药物诱导的肾毒性，高血压和其它相关病症的药物。 进一步描述制备和使用化合物和组合物的方法。
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33.发明申请INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3 有权用于指定递送至表达ALPHA-V-BETA-3的细胞的整合拮抗剂公开(公告)号：US20150038523A1
公开(公告)日：2015-02-05
申请号：US14374680
申请日：2013-01-22
发明人： Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Agnieszka Kowalczyk , Achyutharao Sidduri
IPC分类号： C07D277/593 , C07D417/12 , C07C237/52 , C07D239/14 , C07D207/452
CPC分类号： C07D277/593 , A61K47/545 , A61K47/549 , A61K47/60 , C07C237/52 , C07C327/32 , C07D207/452 , C07D239/14 , C07D417/12
摘要： The invention relates to compounds of formula (I): wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-integrin antagonists to target cells expressing alpha-V-beta-3.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1，R 2和n在详细描述和权利要求书中定义。 特别地，本发明涉及用于制备和递送缀合部分的式（I）化合物，所述共轭部分例如小分子，肽，核酸，荧光部分和与α-V-β- 整合素拮抗剂靶向表达α-V-β-3的细胞。
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公开(公告)号：US08673911B2
公开(公告)日：2014-03-18
申请号：US12740616
申请日：2008-11-03
申请人： Tammy Mallais , Oscar Moradei , Alain Ajamian , Pierre Tessier , David Smil , Sylvie Frechette , Silvana Leit , Patrick Beaulieu , Robert Deziel , John Mancuso
发明人： Tammy Mallais , Oscar Moradei , Alain Ajamian , Pierre Tessier , David Smil , Sylvie Frechette , Silvana Leit , Patrick Beaulieu , Robert Deziel , John Mancuso
IPC分类号： A61K31/5377 , C07D413/02 , A61K31/4535 , C07D417/02 , C07D211/02 , C07D401/02 , C07D401/14 , A61K31/426 , A61K31/421 , A61K31/415 , A61K31/40 , A61K31/381 , C07D277/20 , C07D263/30 , C07D231/10 , C07D333/02
CPC分类号： C07D277/593 , C07C259/10 , C07C311/29 , C07D207/327 , C07D207/34 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D235/18 , C07D239/28 , C07D239/38 , C07D261/18 , C07D263/34 , C07D267/20 , C07D277/30 , C07D277/64 , C07D307/85 , C07D307/91 , C07D317/60 , C07D333/24 , C07D333/38 , C07D401/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
摘要翻译： 本发明涉及抑制HDAC酶活性的化合物和方法。 更具体地，本发明提供式（I），（I）和N-氧化物，水合物，溶剂合物，药学上可接受的盐，前药和络合物的化合物，以及外消旋和可比混合物，非对映异构体和对映异构体，其中L，M ，n，R，W，X和Y如说明书中所定义。
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公开(公告)号：US20130131085A1
公开(公告)日：2013-05-23
申请号：US13713903
申请日：2012-12-13
申请人： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
发明人： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
IPC分类号： C07D417/12 , C07D213/79 , C07D277/593
CPC分类号： A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
摘要： The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
摘要翻译： 本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。 本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。
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36.发明授权公开(公告)号：US08236832B2
公开(公告)日：2012-08-07
申请号：US12538396
申请日：2009-08-10
IPC分类号： A61K31/415 , A61K31/426 , C07D277/24 , C07D231/12
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含该化合物的药学上可接受的组合物，使用该化合物的方法和组合物治疗各种疾病，病症或病症。 本发明还涉及制备本发明化合物的方法。
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37.发明申请THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES 失效作为蛋白激酶抑制剂的THIAZOLES，IMIDAZOLES和PYRAZOLES有用公开(公告)号：US20090306155A1
公开(公告)日：2009-12-10
申请号：US12538396
申请日：2009-08-10
IPC分类号： A61K31/426 , C07D231/14 , C07D277/56 , C12N5/00 , A61P37/00 , A61P29/00 , A61P19/00 , A61P3/00 , A61P25/00 , A61P35/00 , A61K31/415
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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38.发明授权公开(公告)号：US07589214B2
公开(公告)日：2009-09-15
申请号：US11786464
申请日：2007-04-11
IPC分类号： C07D233/64 , A61K31/4164
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含该化合物的药学上可接受的组合物，使用该化合物的方法和组合物治疗各种疾病，病症或病症。 本发明还涉及制备本发明化合物的方法。
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39.发明申请公开(公告)号：US20070298065A1
公开(公告)日：2007-12-27
申请号：US11786464
申请日：2007-04-11
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/426 , A61K9/00 , A61P43/00 , C07D231/02 , C07D233/54 , C07D277/02 , C12N9/99
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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