利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

121 条记录 (耗时 0.035 秒)

    Chemical cleaning of biological material
    31.
    发明授权
    Chemical cleaning of biological material 失效
    化学清洗生物材料

    公开(公告)号：US06599690B1

    公开(公告)日：2003-07-29

    申请号：US09450577

    申请日：1999-11-30

    申请人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Paul D. Kemp ,  Ryan Mercer ,  Linda Baker

    发明人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Paul D. Kemp ,  Ryan Mercer ,  Linda Baker

    IPC分类号： A01N102

    CPC分类号： A61L27/3687 ,  A61K35/12 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3695 ,  A61L2430/40 ,  Y10S623/917 ,  Y10S623/92

    摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

    摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。

    Method for promoting soft connective tissue growth and repair in mammals
    35.
    发明授权
    Method for promoting soft connective tissue growth and repair in mammals 失效
    促进哺乳动物软结缔组织生长和修复的方法

    公开(公告)号：US5092883A

    公开(公告)日：1992-03-03

    申请号：US626844

    申请日：1990-12-13

    申请人： Barry L. Eppley ,  Marilyn D. Krukowski ,  Philip A. Osdoby

    发明人： Barry L. Eppley ,  Marilyn D. Krukowski ,  Philip A. Osdoby

    IPC分类号： A61L27/20 ,  A61L27/50 ,  A61L27/58

    CPC分类号： A61L27/58 ,  A61L27/20 ,  A61L27/50 ,  Y10S623/917 ,  Y10S623/919

    摘要： A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate formation of hard tissue within long bones and foster bony repair of defects in parietal bones and in mandibular rami. Beads with positively charged surfaces engender formation of large quantities of soft dense connective tissue when implanted into defects in the cranium or when used as an onlay on the nasal bone surface. The use of such beads or other charged biodegradable materials and the use of other surface charged materials with different physical configurations provides significant improvement in hard and soft connective tissue repair, augmentation and replacement in medical fields such as orthopaedic and maxillofacial surgery.

    摘要翻译： 使用具有化学诱导的表面电荷的材料来促进哺乳动物硬和软结缔组织的形成。 该材料可以是珠子的形式，例如离子交换树脂。 具有负表面电荷的珠材料刺激长骨骼内的硬组织的形成，并促进顶骨骨骼和下颌骨中的缺损的骨修复。 具有带正电荷的表面的珠子当植入颅骨中的缺陷时或当用作鼻骨表面上的垫片时会形成大量的软密度结缔组织。 使用这种珠粒或其他带电的可生物降解的材料以及使用具有不同物理构型的其它表面带电材料可以显着改善硬和软结缔组织修复，在诸如矫形外科和颌面外科手术等医学领域的增补和更换。

    Multilayer bioreplaceable blood vessel prosthesis
    36.
    发明授权
    Multilayer bioreplaceable blood vessel prosthesis 失效
    多层生物可替代血管假体

    公开(公告)号：US4902289A

    公开(公告)日：1990-02-20

    申请号：US230110

    申请日：1988-08-09

    申请人： Ioannis V. Yannas

    发明人： Ioannis V. Yannas

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61L27/26 ,  A61L27/34 ,  A61L27/50 ,  B29C47/00

    CPC分类号： A61F2/062 ,  A61L27/26 ,  A61L27/34 ,  A61L27/507 ,  B29C47/0026 ,  B29C47/8895 ,  A61F2210/0004 ,  A61F2240/001 ,  A61F2310/00365 ,  B29C47/0023 ,  Y10S623/917

    摘要： Process for forming a multilayer blood vessel prosthesis. Each layer is formed from bioreplaceable materials which include those produced by contacting collagen with an aminopolysaccharide and subsequently covalently crosslinking the resluting polymer, polymers of hydroxyacetic acid and the like. Cross flow filtration molding and wet extrusion molding are two processes which are particularly useful for forming the inner layer of the blood vessel prosthesis. The outer layer of the blood vessel prosthesis is preferably formed by freeze drying a dispersion of the bioreplaceable material onto the inner layer(s). The disclosed blood vessel prosthesis is a multilayer structure with each layer having a porosity and other physicochemical and mechanical characteristics selected to maximize the effectiveness of the blood vessel. The prosthesis funcitons initially as a thromboresistant conduit with mechanical properties which match those of the adjacent natural blood vessel. Eventually, the prosthesis functions as a regeneration template which is replaced by new connective tissue that forms during the healing process following attachment of the prosthesis.

    摘要翻译： 用于形成多层血管假体的方法。 每个层由生物可替换材料形成，包括通过使胶原蛋白与氨基多糖接触而产生的材料，并随后共价交联树脂聚合物，羟基乙酸的聚合物等。 横流过滤成型和湿挤压成型是对于形成血管假体的内层特别有用的两个方法。 血管假体的外层优选通过将生物可替换材料的分散体冷冻干燥到内层上来形成。 所公开的血管假体是多层结构，每层具有选择的孔隙率和其他物理化学和机械特性，以最大化血管的有效性。 假体功能最初是具有与相邻天然血管相匹配的机械性质的抗血栓导管。 最后，假体作为再生模板发挥作用，该再生模板由附着假体后的愈合过程期间形成的新结缔组织代替。

    Tissue fixation with vapor
    37.
    发明授权
    Tissue fixation with vapor 失效
    用蒸气组织固定

    公开(公告)号：US4800603A

    公开(公告)日：1989-01-31

    申请号：US8836

    申请日：1987-01-30

    申请人： Norman R. Jaffe

    发明人： Norman R. Jaffe

    IPC分类号： A61F2/24 ,  A61F1/22

    CPC分类号： A61F2/2415 ,  Y10S623/917

    摘要： The invention provides for tissue fixation by subjecting the tissue to the vapor of a fixative while the tissue is unstressed. The tissue may be rotated during fixation to avoid collecting condensed fixative at localized areas of the tissue. Intermittent rinsing of the tissue during fixation is possible. The concentration of fixative in the vapor may be varied, increasing after an initial period. Specific rinsing and fixative solutions are disclosed.

    摘要翻译： 本发明通过在组织不受应力时将组织经受固定剂的蒸汽来提供组织固定。 组织可以在固定期间旋转，以避免在组织的局部区域收集凝固固定剂。 固定期间组织的间歇冲洗是可能的。 蒸气中固定剂的浓度可以变化，在初始阶段后增加。 公开了特定的冲洗和固定溶液。

    Reinforcing structure for cardiovascular graft
    38.
    发明授权
    Reinforcing structure for cardiovascular graft 失效
    心血管移植的加强结构

    公开(公告)号：US4629458A

    公开(公告)日：1986-12-16

    申请号：US705782

    申请日：1985-02-26

    申请人： Leonard Pinchuk

    发明人： Leonard Pinchuk

    IPC分类号： A61F2/06 ,  A61L27/48

    CPC分类号： A61F2/06 ,  A61L27/48 ,  Y10S623/917

    摘要： The reinforced tubular graft structure is particularly adapted for cardiovascular use and is made of collagenous tissue with a reinforcing fibrous structure surrounding the lumen. The fibrous structure comprises a coiled monofilament which can have a textured surface defined by randomly disposed strands of polymer on the outer surface of the monofilament. The coil can be embedded within the collagen or positioned about the collagen to form the graft structure.

    摘要翻译： 增强的管状移植结构特别适用于心血管使用，并且由具有围绕内腔的增强纤维结构的胶原组织制成。 纤维结构包括卷绕的单丝，其可以具有在单丝的外表面上由随机排列的聚合物股线限定的纹理表面。 线圈可以嵌入胶原蛋白内或围绕胶原定位以形成移植结构。